Claims
- 1. A compound represented by the structural formula:
- 2. The compound of claim 1 wherein Y is a covalent bond or —C(R7R8)— and R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group.
- 3. The compound of claim 2 wherein R7 and R8 are both —H.
- 4. The compound of claim 1 wherein R1 is an aryl group or a substituted aryl group.
- 5. The compound of claim 1 wherein R2 is an alkyl group or a substituted lower alkyl group.
- 6. The compound of claim 2 wherein R2 is methyl or ethyl; R7 is —H; and R8 is —H or methyl.
- 7. The compound of claim 6 wherein R1 is phenyl or substituted phenyl.
- 8. The compound of claim 7 wherein R1 is phenyl and R2 is methyl.
- 9. The compound of claim 2 wherein R1 is an aliphatic group or a substituted aliphatic group.
- 10. The compound of claim 2 wherein R2 is an aliphatic group or a substituted aliphatic group.
- 11. The compound of claim 10 wherein R2 is a lower alkyl group or a substituted lower alkyl group.
- 12. The compound of claim 1 wherein R10 is H.
- 13. The compound of claim 2 wherein R10 is H.
- 14. A compound represented by the structural formula:
- 15. The compound of claim 14 wherein R5 is a hydrazine protecting group when R2 is an aryl group or a substituted aryl group.
- 16. The compound of claim 14 wherein R5 is —H or a hydrazine protecting group when R2 is an aliphatic or substituted aliphatic group and R10 is —H or an unsubstituted alkyl group.
- 17. The compound of claim 14 wherein R2 is an aliphatic group or a substituted aliphatic group.
- 18. The compound of claim 17 wherein R1 is an aryl group or a substituted aryl group.
- 19. The compound of claim 18 wherein R2 is an alkyl group or a substituted lower alkyl group.
- 20. The compound of Claiml9 wherein R2 is methyl or ethyl.
- 21. The compound of claim 14 wherein R1 is phenyl or substituted phenyl.
- 22. The compound of claim 21 wherein R1 is phenyl and R2 is methyl.
- 23. The compound of claim 21 wherein R1 is phenyl substituted with one or more groups selected from —OH, —Br, —Cl, —I, —F, —OR, —O—CORa, —CORa, —CN, —NO2, —COOH, —SO3H, —NH2, —NHRa, —N(RaRb), —COORa, —CHO, —CONH2, —CONHRa, —CON(RaRb), —NHCORa, —NRCORa, —NHCONH2, —NHCONRaH, —NHCON(RaRb), —NRcCONH2, —NRcCONRaH, —NRcCON(RaRb), —C(═NH)—NH2, —C(═NH)—NHRa, —C(═NH)—N(RaRb), —C(═NRc)—NH2, —C(═NRc)—NHRa, —C(═NRc)—N(RaRb), —NH—C(═NH)—NH2, —NH—C(═NH)—NHRa, —NH—C(═NH)—N(RaRb), —NH—C(═NRc)—NH2, —NH—C(═NRc)—NHRa, —NH—C(═NRc)—N(RaRb), —NRdH—C(═NH)—NH2, —NRd—C(═NH)—NHRa, —NRd—C(═NH)—N(RaRb), —NRd—C(═NRc)—NH2, —NRd—C(═NRc)—NHRa, —NRd—C(═NRc)—N(RaRb), —NHNH2, —NHNRa, —NHN(RaRb), —SO2NH2, —SO2NHRa, —SO2NRaRb, —CH═CHRa, —CH═CRaRb, —CRc═CRaRb,—CRc═CHRa, —CRc═CRaRb, —CCRa, —SH, —SRa, —S(O)Ra, —S(O)2Ra, alkyl groups, substituted alkyl group, non-aromatic heterocyclic group, substituted non-aromatic heterocyclic group, benzyl group, substituted benzyl group, aryl group or substituted aryl group wherein Ra-Rd each independently an alkyl group, substituted alkyl group, benzyl, substituted benzyl, aromatic or substituted aromatic group, or, —N(RaRb), taken together, can also form a substituted or unsubstituted non-aromatic heterocyclic group.
- 24. The compound of claim 23, wherein R2 is methyl.
- 25. The compound of claim 14 wherein R1 is a lower alkyl group and R2 is a phenyl group substituted with one or more groups selected from —OH, —Br, —Cl, —I, —F, —ORa, —O—CORa, —CORa, —CN, —NO2, —COOH, —SO3H, —NH2, —NHRa, —N(RaRb), —COORa, —CHO, —CONH2, —CONHRa, —CON(RaRb), —NHCORa, —NRCORa, —NHCONH2, —NHCONRaH, —NHCON(RaRb), —NRcCONH2, —NRcCONRaH, —NRcCON(RaRb), —C(═NH)—NH2, —C(═NH)—NHRa, —C(═NH)—N(RaRb), —C(═NRc)—NH2, —C(═NRc)—NHRa, —C(═NRc)—N(RaRb), —NH—C(═NH)—NH2, —NH—C(═NH)—NHRa, —NH—C(═NH)—N(RaRb), —NH—C(═NRc)—NH2, —NH—C(═NRc)—NHRa, —NH—C(═NRc)—N(RaRb), —NRdH—C(═NH) —NH2, —NRd—C(═NH)—NHRa, —NRd—C(═NH)—N(RaRb), —NRd—C(═NRc)—NH2, —NRd—C(═NRc)—NHRa, —NRd—C(═NRc)—N(RaRb), —NHNH2, —NHNHRa, —NHN(RaRb), —SO2NH2, —SO2NHRa, —SO2NRaRb, —CH═CHRa, —CH═CRaRb, —CRc═CRaRb, —CRc═CHRa, CRc═CRaRb, —CCRa, —SH, —SRa, —S(O)Ra, —S(O)2Ra, alkyl groups, substituted alkyl group, non-aromatic heterocyclic group, substituted non-aromatic heterocyclic group, benzyl group, substituted benzyl group, aryl group or substituted aryl group wherein Ra-Rd each are independently an alkyl group, substituted alkyl group, benzyl, substituted benzyl, aromatic or substituted aromatic group, or, —N(RaRb), taken together, can also form a substituted or unsubstituted non-aromatic heterocyclic group.
RELATED APPLICATIONS
[0001] This application is a continuation of U.S. patent application Ser. No. 10/193,076, filed Jul. 10, 2002, which claims the benefit of U.S. Provisional Application No. 60/304,318, filed Jul. 10, 2001. The entire teachings of these two applications are incorporated herein by reference.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60304318 |
Jul 2001 |
US |
Continuations (1)
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Number |
Date |
Country |
Parent |
10193076 |
Jul 2002 |
US |
Child |
10807919 |
Mar 2004 |
US |