Claims
- 1. Thiophene-containing prostaglandin endoperoxide analogs of the formula: ##STR21## wherein n equals a whole integer of from 0 to 7, X is carboxylic acid, or C.sub.1 -C.sub.8 ester, alcohol, ether or amide groups; Y is ethylene or cis or trans vinylene; A is methylene, ethylene, oxy, imino, or lower alkyl, phenyl or aryl substituted imino; D is methylene, ethylene, vinylene, methyleneoxy, alkylidenedioxy, iminooxy, dithio, or azo; B is ethylene, cis and trans vinylene, and ethynylene; R and R.sub.1 are hydrogen, lower alkyl and lower aryl or (CH.sub.2).sub.Z with Z being 2 to 5, and Q is hydroxy, methoxy, acetoxy or hydrogen, or Q and R.sub.1 are oxa.
- 2. The compounds of claim 1 wherein n is from 1 to 5.
- 3. The compounds of claim 2 wherein X is a carboxylic acid group.
- 4. The compounds of claim 1 wherein A is selected from the group of methylene or ethylene.
- 5. The compounds of claim 3 wherein B is selected from the group consisting of ethylene, and cis and trans vinylene.
- 6. A prostaglandin analog comprising: ##STR22## wherein R.sub.2 is selected from the group consisting of hydrogen and methyl.
Parent Case Info
This is a division of application Ser. No. 423,789, filed Sept. 27, 1982, now U.S. Pat. No. 4,520,207.
US Referenced Citations (2)
Divisions (1)
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Number |
Date |
Country |
Parent |
423789 |
Sep 1982 |
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