Synthetic bacterial analogs of mammalian oligomannose for eliciting neutralizing antibodies to the high-mannose patch on HIV Env

Information

• Research Project
• 9410721

• ApplicationId

  9410721

• Core Project Number

  R01AI134299

• Full Project Number

  1R01AI134299-01

• Serial Number

  134299

• FOA Number

  PA-16-160

• Sub Project Id

• Project Start Date

  9/1/2017 - 6 years ago

• Project End Date

  8/31/2021 - 2 years ago

• Program Officer Name

  MALASPINA, ANGELA

• Budget Start Date

  9/1/2017 - 6 years ago

• Budget End Date

  8/31/2018 - 5 years ago

• Fiscal Year

  2017

• Support Year

  01

• Suffix

• Award Notice Date

  8/30/2017 - 6 years ago

Organizations

• SIMON FRASER UNIVERSITY

PROJECT SUMMARY Iantriebcoedniteyse(anrAsbtsh)ewreithasvpeebceifeicnitaynfoinrcorleiagsoimngannuomsbe-etryopfergelpyocartnsonbtrhoeaHdlIyVcernovsesl-orepaecstpivieken(eEuntrva)l.izing Ifamcmedubnyizeaftfiorntstroaeteligcietsotlhigaotmcoaunlndoysie-lsdpseucicfhicnAbswisotuhled hthoesrteofroirgeinboefdtehseirgalbyclea.nOsn, we iotfhtihmemchuanllenges twoiltehrasnpceecimficeicthyafonrismasmpmosaslibalny olilmigiotimnganthneosfere. Fqourenecxyamorpdle,vAeblospemliceintetdofinBtcyeplilcsaclaepxapbelreimofepnrtoadl uancinmgaAlsbs bony gElnyvcoacnodnejuvgeantewihmemn uEnovg-beinsdpinrgesAebnstihnagvoelibgeoemnaonbntoasinideeds, saurechgeans ewriatlhlyruecnoamblbeitnoanbtinydeaoslitg, othmeaynanpopsear to ubtinildizienbsaucfftiecrieianltlylydaevridvetod tohliegvoisraucschanardidfaeilatnoaeloxgesrtomf oelaignoinmgafunlnnoeseutroaloivzienrgcoamcteivtihtye.sHe ecrhea,lwleengperso.pose WAsen3fo0c1usanindtAhsisn3ap3p2loicnatHioIVn gopn1a2f0a.irPlryoctontyspeircvfeodrpAabtschtaorfgheitginhg-mthaensneosleigolmycannsoastea-ntydpseugrlryocuandsiinsgthe PsiGmTi1la2r8nfAabmsilcyooufldAtbhsu,swohfifcehrepxrhoitbeictiponteanttenveuntmraolidzeinstgsaecrtuivmityA.bAtvitaecrcsi.necomponentcapableofeliciting oWliegonmotalnonogsaegaondiscuobvserqeudeantblyacmteardiael soylnigtohseatcichaanraildoegsthoaftitclwositehlyarDes3eamrmbl-elsiktehexDte1nasrimono. fOmneamofmthaelisaen tahneailropgsre, idnictthedfgoermrmolifnaenperoegdleyceoscsonrj.uMgaotre, icsrubcoiuanlldy,apvriedliymbinyamryemdabtearshofwthtehaPtGiTm1m28unAibzaftaimonilyofand tsrpaencsifgiecnAicbsanwiimthalHsIeVxptirers2sicnrgoassn-nuenuatrralnizgiendghauctmivaintyA.Hberrep,ewrteopireopwoitshethoiesxcpoanjudgoantethresueletsnicnougrlyacgaing- fidiresnt triefysualntso. pSptiemciaflicadljluy,vwanets+eceoknjtuogealtaebcormatbeionnatoiounr ctonmjuagxaimteizdesniAgnb raensdpuotnisliezse. tWraenaslgseonsieceakntimo dalissteoct AnAbbrse,swpohnicshesmatythinefoserrmumboaonsdtinregpsetrtaoteirgeieles.vFeilnsatollyc,owmepparoepsoimseiltaoriteisetsobuertwstereantetghyeienlimciatecdaqaunedsetxoisting assess the extent to which it may work in outbred systems. Ionf csruomss, -trheisacptrivoejencAt wbsiltlointvheshtigahtley wvuhlentehrearbglelyoclaignomiamnincorysecapnatscehrvoentHoIrVeaEdnivly. Itfrsigog, tehritshweodrekvceoloupldment inform strategies for targeting other glyco-epitopes on HIV-1.

IC Name

• Activity

  R01

• Administering IC

  AI

• Application Type

  1

• Direct Cost Amount

  305973

• Indirect Cost Amount

  24478

• Total Cost

  330451

• Sub Project Total Cost

• ARRA Funded

  False

• CFDA Code

  855

• Ed Inst. Type

• Funding ICs

  NIAID:330451\

• Funding Mechanism

  Non-SBIR/STTR RPGs

• Study Section

  VACC

• Study Section Name

  HIV/AIDS Vaccines Study Study Section

• Organization Name

  SIMON FRASER UNIVERSITY

• Organization Department

• Organization DUNS

  208032946

• Organization City

  BURNABY

• Organization State

  BC

• Organization Country

  CANADA

• Organization Zip Code

  V5A 1S6

• Organization District

  CANADA