Synthetic Oligosaccharides for Staphylococcus Vaccine

Abstract
The present invention synthetic oligo-β-(1→6)-glucosamine structures and a methodology which essentially allows for the synthesis of any oligo-β-(1→6)-glucosamine species having a definite number of monosaccharide units, including a set pattern of acetylated and non-acetylated residues. The invention further provides antibodies to these synthetic oligo-β-(1→6)-glucosamines as well as compositions thereof and methods for treating and preventing infections caused by bacteria expressing poly-β-(1→6)-glucosamines, such as Staphylococcus aureus.
Description
FIELD OF THE INVENTION

The present invention relates to synthetic oligo-β-(1→6)-glucosamine structures exhibiting a defined substitution pattern.


BACKGROUND

Staphylococcal infection can lead to a wide range of severe clinical disease manifestations and represents a major public healthcare concern. The cell walls of Staphylococci contain a diverse array of glycopeptides and glycolipids that serve both structural and virulence functions. The cell wall is comprised primarily of peptidoglycan, a peptide crosslinked polymer of poly-N-acetylglucosamine (PNAG), N-acetylmuramic acid, and glycolipids, including wall teichoic acids (WTA) and lipoteichoic acid (LTA).


Cell wall related factors possess many unique features making them particularly attractive therapeutic targets. Importantly, cell wall components are expressed in the initial colonization, local infection and systemic stages of disease. Unfortunately, a lack of consistent access to material, along with toxicity issues hinder cell-wall targeted vaccine development. For example, LTA is toxic and could not be used as the basis of a vaccine candidate without modification.


Recently, the properties of a cell wall associated polysaccharide, poly-1,6-N-acetylglucosamine (PNAG), also known as polysaccharide intercellular adhesion molecule (PIA), have been described. PNAG serves several key biological functions at various stages of the bacterial infection cycle including adhesion to bacterial and host surfaces, promotion of biofilm formation and protection against antibody-independent opsonic killing. The PNAG molecule and its derivatives are able to mediate all these functions due to a diverse distribution pattern of amine and acetylation modifications to the core structure (FIG. 1). The core structure is comprised of a glucosamine backbone which is only generated by bacterial pathogens. The backbone structure is modified with acetyl or amine groups with variable spacing.


The PNAG molecule has been used in vaccine studies (See Pier et al., U.S. Publication 2005/0118198). Data generated using purified PNAG-based material demonstrates the viability of this carbohydrate-based vaccine approach (Maira-Litran et al., Infect. Immun., 73:6752, 2005). However, in spite of the aforementioned PNAG-focused studies revealing that functional protection and opsonization activity is dependent on the presence of an amine-rich modified PNAG structure (<50% acetylated positions), the major component of biofilms is secreted PNAG that contains mostly (>95%) N-acetylated positions. Accordingly, carbohydrate-based vaccine development is in need of a better understanding of the requirements for maintaining an appropriate acetylation-amine balance in lead PNAG-based vaccine target selection.


A methodology for preparing synthetic PNAGs was described (Gening et al., Infect. Immun., 78:764, 2010, epub Nov. 30, 2009; WO 2010/011284 A2). The described synthetic PNAGs were limited to homogenous PNAG compositions that are fully acetylated or fully non-acetylated; neither of these references, nor those cited therein, described a methodology for synthesizing homogenous mixed PNAGs having a predetermined number and predetermined arrangement of acetylated and deacetylated residues. Moreover, although the previous purification-chemical process utilizing purified PNAG material that was subsequently chemically treated to yield an appropriate range of N-acetylated versus free amine positions on the PNAG molecule (Maira-Litran et al., supra), the purification-chemical process is only able to provide a range of heterogeneous material and therefore only average numbers on the degree of acetylation are available. Moreover, there is no information on the position of the acetylated residues. Accordingly, the prior art processes failed to provide oligosaccharides with spatially defined acetyl-amine positions, such as an amine every third position on the glucosamine polymer, for example. As such, the identification of a precise acetyl-amine sequence required to generate a desired immune response can neither be achieved by this method nor predicted a priori.


In view of the above, the present invention provides several benefits for vaccine development, especially against S. aureus, including production of homogenous antigen compositions with mixed acetyl/amine positions at high purity and at robust levels without contaminating carbohydrate structures that are an almost inevitable consequence of isolation from biological mixtures.


SUMMARY

The present invention provides oligosaccharides (oligo-β-(1→6)-glucosamine structures) 1a




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where R1 and R2 are each independently selected from H or C(O)CH3, where at least one R1 or R2 in the oligosaccharide is H and at least another is C(O)CH3; n is an integer of at least 3, X is a linker, and Y is H or a carrier; and wherein each occurrence R1 can be the same or different.


The present invention provides compositions and methods for synthesizing oligo-β-(1→6)-glucosamine structures and conjugates that have a specific number of monosaccharide units and a fixed, defined pattern of acetylated and non-acetylated residues.


The present invention further provides immunogenic and immunoprotective compositions containing synthetic oligo-β-(1→6)-glucosamines 1a and antibodies derived therefrom for diagnosing, treating, and preventing infections caused by bacteria such as Staphylococcus aureus and others.


The present invention further provides a method for chemoselectively deprotecting one of at least two different nitrogen protecting groups in an aminosugar, in particular in an oligo-β-(1→6)-glucosamine.





BRIEF DESCRIPTION OF THE DRAWINGS


FIG. 1 depicts an exemplary core structure of an oligo-β-(1→6)-glucosamine comprised of a glucosamine backbone unique to bacterial pathogens. The backbone structure can be modified with N-acetyl groups with variable spacing.



FIG. 2A depicts naturally-derived PNAG polysaccharides and FIG. 2B depicts a synthetic PNAG oligosaccharide, including potential conjugation sites in FIGS. 2A and 2B.



FIG. 3 depicts a reaction scheme for synthesizing four monosaccharide building blocks which can be used to synthesize any dPNAG/PNAG oligosaccharide.



FIGS. 4A-4D depict a series of reaction schemes for assembling disaccharide building blocks from the four monosaccharide building blocks depicted in FIG. 3.



FIGS. 5A and 5B depict a reaction scheme for synthesizing a 6-mer thiol oligosaccharide 37.



FIGS. 6A and 6B depict a reaction scheme for synthesizing a 12-mer thiol oligosaccharide 40.



FIG. 7 depicts a reaction scheme for synthesizing an 18-mer thiol oligosaccharide 34.



FIGS. 8A and 8B depict a reaction scheme for conjugating the 6-mer thiol oligosaccharide 37 to BSA (A) or KLH (B) to form a 6-Mix-BSA conjugate 41 or a 6-Mix-KLH conjugate 42, respectively. In the nomenclature used herein, e.g. “6-Mix,” “12-NH2” and “18-NHAc,” the number refers to the number of monosaccharide units, “Mix” refers to an oligosaccharide with a fixed pattern of both acetyl and amine groups at R1 and R2, “NH2” refers to an oligosaccharide with amine groups at R1 and R2, and “NHAc” refers to an oligosaccharide with acetyl groups at R1 and R2.



FIGS. 9A and 9B depict a reaction scheme for conjugating the 12-mer thiol oligosaccharide 40 to BSA (A) or KLH (B) to form a 12-Mix-BSA conjugate 43 or 12-Mix-KLH conjugate 44, respectively.



FIGS. 10A and 10B depict a reaction scheme for conjugating the 18-mer thiol oligosaccharide 34 to BSA (A) or KLH (B) to form an 18-Mix-BSA conjugate 45 or 18-Mix-KLH conjugate 46, respectively.



FIGS. 11A-11C depict IgG antibody titers as a function of antibody-antigen complex absorption (OD450) at the indicated serum dilutions obtained from 3 successive bleeds (pre-immune, 1st bleed, and final bleed) in rabbits immunized with KLH conjugates corresponding to: (A) 6-Mix-KLH 42; (B) 12-Mix-KLH 44; and (C) 18-Mix-KLH 46. In each case, the antisera were incubated on ELISA plates adsorbed with their corresponding BSA conjugate, specifically, (A) 6-Mix-BSA 41; (B) 12-Mix-BSA 43; and (C) 18-Mix-BSA 45.



FIGS. 11D-11F depict IgG antibody titers from antigen-specific antigen-KLH conjugate-derived antibodies recovered at three successive stages of affinity purification, including pre-affinity purification (3rd bleed), the flow-through fraction and the antibody-enriched (purified) fraction from rabbits immunized with KLH conjugates. Results are shown as a function of antibody-antigen complex absorption (OD450) at the indicated serum dilutions obtained from the above-described antibody-enriched fractions generated against antigen-KLH conjugates corresponding to: (A) 6-Mix-KLH 42; (B) 12-Mix-KLH 44; and (C) 18-Mix-KLH 46. In each case, the antisera were incubated on ELISA plates adsorbed with their corresponding BSA conjugate, specifically, (A) 6-Mix-BSA 41; (B) 12-Mix-BSA 43; and (C) 18-Mix-BSA 45.



FIGS. 12A-12G depict the results of a cross-ELISA assay examining the specificity and cross-reactivity between fully non-acetylated (6-NH2, 12-NH2, 18-NH2); mixed (6-Mix, 12-Mix, 18-Mix) and fully acetylated (6-NHAc, 12-NHAc, 18-NHAc) oligosaccharides 1a and antibodies derived therefrom. In FIGS. 12A-12G, antisera from rabbits immunized with the indicated antigen-KLH conjugates corresponding to (left to right) 6-NH2, 6-Mix, 6-NHAc, 12-NH2, 12-Mix, 12-NHAc, 18-NH2, 18-Mix, and 18-NHAc were incubated in each case with an ELISA plate adsorbed with a different antigen-BSA conjugate, specifically: (A) 6-NH2-BSA; (B) 6-Mix-BSA; (C) 6-NHAc-BSA; (D) 12-NH2-BSA; (E) 12-Mix-BSA; (F) 12-NHAc-BSA; (G) 18-Mix-BSA. Results are shown as a function of antibody-antigen complex absorption (OD450) representing the averages from two rabbit antiseras in each case at the indicated serum dilutions, whereby total OD450 is measured by subtracting away the background OD450 from KLH antibodies alone.



FIGS. 13A-13D depict the results of a whole-cell ELISA assay examining the binding of pre-immune sera (A, C) or immune sera (B, D) generated from rabbits immunized against (left to right) KLH control, non-acetylated (12-NH2); mixed (12-Mix) and non-acetylated (12-NHAc) oligo-β-(1→6)-glucosamines and S. epidermidis coated onto ELISA fixed with methanol (A, B) or formalin (C, D). Results are shown as a function of antibody-antigen complex absorption (OD450) at the indicated serum dilutions.





DETAILED DESCRIPTION
Definitions

In order to provide a clear and consistent understanding of the specification and claims, the following definitions are provided.


Units, prefixes, and symbols may be denoted in their SI accepted form. Numeric ranges recited herein are inclusive of the numbers defining the range and include and are supportive of each integer within the defined range. Unless otherwise noted, the terms “a” or “an” are to be construed as meaning “at least one of.” The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described. All documents, or portions of documents, cited in this application, including but not limited to patents, patent applications, articles, books, and treatises, are hereby expressly incorporated by reference in their entirety for any purpose.


As used herein, “oligosaccharide” refers to a compound containing two or more monosaccharide units. Oligosaccharides are considered to have a reducing end and a non-reducing end, whether or not the monosaccharide unit at the reducing end is in fact a reducing sugar. In accordance with accepted nomenclature, oligosaccharides are depicted herein with the non-reducing end on the left and the reducing end on the right. All oligosaccharides described herein are described with the name or abbreviation for the non-reducing monosaccharide (e.g., Gal), preceded by the configuration of the glycosidic bond (α or β) the ring bond, the ring position of the reducing monosaccharide involved in the bond, and then the name or abbreviation of the reducing monosaccharide (e.g., GlcNAc). The linkage between two sugars may be expressed, for example, as 2,3, 2→0.3, or 2-3. Each monosaccharide is a pyranose or furanose.


As used herein, “monosaccharide” or “monosaccharide unit” refers to a single sugar residue in an oligosaccharide, including derivatives therefrom. Within the context of an oligosaccharide, an individual monomer unit is a monosaccharide which is (or can be) bound through a hydroxyl group to another monosaccharide.


As used herein, “endotoxin-free” refers to an oligosaccharide that does not contain endotoxins or endotoxin components normally present in isolated bacterial carbohydrates and polysaccharides.


As used herein, “synthetic” refers to material which is substantially or essentially free from components, such as endotoxins, glycolipids, unrelated oligosaccharides, etc., which normally accompany a compound when it is isolated. Typically, synthetic compounds are at least about 90% pure, usually at least about 95%, and preferably at least about 99% pure. Purity can be indicated by a number of means well known in the art. Preferably, purity is measured by HPLC. The identity of the synthetic material can be determined by mass spectroscopy and/or NMR spectroscopy.


As used herein the term “linker” refers to either a bond or a moiety which at one end exhibits a grouping able to enter into a covalent bonding with a reactive functional group of the carrier, e.g. an amino, thiol, or carboxyl group, and at the other end a grouping likewise able to enter into a covalent bonding with a hydroxyl group or an amino group of an oligosaccharide according to the present invention. Between the two functional groups of the linker molecule there is a biocompatible bridging molecule of suitable length, e.g. substituted or unsubstituted heteroalkylene, arylalkylene, alkylene, alkenylene, or (oligo)alkylene glycol groups. Linkers preferably include a substituted or unsubstituted (C1-C10) alkylene group or an substituted or unsubstituted (C2-C10) alkenylene group.


As used herein, the term “percentage of N-acetylated monosaccharide units in the oligomer” refers to the number of N-acetylated monosaccharide units in the oligosaccharide z, the percentage of N-acetylated monosaccharide units is y, where y is z/(n+1)*100.


As used herein, the term “carrier” refers to a protein, peptide, lipid, polymer, dendrimer, virosome, virus-like particle (VLP), or combination thereof, which is coupled to the oligosaccharide to enhance the immunogenicity of the resulting oligosaccharide-carrier conjugate to a greater degree than the oligosaccharide alone.


As used herein, “protein carrier” refers to a protein, peptide or fragment thereof, which is coupled or conjugated to an oligosaccharide to enhance the immunogenicity of the resulting oligosaccharide-protein carrier conjugate to a greater degree than the oligosaccharide alone. For example, when used as a carrier, the protein carrier may serve as a T-dependent antigen which can activate and recruit T-cells and thereby augment T-cell dependent antibody production.


As used herein, “conjugated” refers to a chemical linkage, either covalent or non-covalent, that proximally associates an oligosaccharide with a carrier so that the oligosaccharide conjugate has increased immunogenicity relative to an unconjugated oligosaccharide.


As used herein, “conjugate” refers to an oligosaccharide chemically coupled to a carrier through a linker and/or a cross-linking agent.


As used herein, “passive immunity” refers to the administration of antibodies to a subject, whereby the antibodies are produced in a different subject (including subjects of the same and different species) such that the antibodies attach to the surface of the bacteria and cause the bacteria to be phagocytosed or killed.


As used herein, “protective immunity” means that a vaccine or immunization schedule that is administered to a animal induces an immune response that prevents, retards the development of, or reduces the severity of a disease that is caused by a pathogen or diminishes or altogether eliminates the symptoms of the disease. Protective immunity may be predicted based on the ability of serum antibody to activate complement-mediated bactericidal activity or confer passive protection against a bacterial infection in a suitable animal challenge model.


As used herein, “immunoprotective composition” refers to a composition formulated to provide protective immunity in a host.


As used herein, “in a sufficient amount to elicit an immune response” or “in an effective amount to stimulate an immune response” (e.g., to epitopes present in a preparation) means that there is a detectable difference between an immune response indicator measured before and after administration of a particular antigen preparation. Immune response indicators include but are not limited to: antibody titer or specificity, as detected by an assay such as enzyme-linked immunoassay (ELISA), bactericidal assay (e.g., to detect serum bactericidal antibodies), flow cytometry, immunoprecipitation, Ouchter-Lowry immunodiffusion; binding detection assays of, for example, spot, Western blot or antigen arrays; cytotoxicity assays, and the like.


As used herein, “antibody” encompasses polyclonal and monoclonal antibody preparations, as well as preparations including hybrid antibodies, altered antibodies, F(ab′)2 fragments, F(ab) molecules, Fv fragments, single chain fragment variable displayed on phage (scFv), single domain antibodies, chimeric antibodies, humanized antibodies, and functional fragments thereof which exhibit immunological binding properties of the parent antibody molecule.


As used herein, “monoclonal antibody” refers to an antibody composition having a homogeneous antibody population. The term is not limited by the manner in which it is made. The term encompasses whole immunoglobulin molecules, as well as Fab molecules, F(ab′)2 fragments, Fv fragments, single chain fragment variable displayed on phage (scFv), and other molecules that exhibit immunological binding properties of the parent monoclonal antibody molecule.


As used herein, “specifically binds to an antibody” or “specifically immunoreactive with”, when referring to an oligosaccharide, protein or peptide, refers to a binding reaction which is based on and/or is probative of the presence of the antigen in a sample which may also include a heterogeneous population of other molecules. Thus, under designated immunoassay conditions, the specified antibody or antibodies bind(s) to a particular antigen or antigens in a sample and does not bind in a significant amount to other molecules present in the sample. Specific binding to an antibody under such conditions may require an antibody or antiserum that is selected for its specificity for a particular antigen or antigens.


As used herein, “antigen” refers to any substance that may be specifically bound by an antibody molecule.


As used herein, “immunogen” and “immunogenic composition” refer to an antigenic composition capable of initiating lymphocyte activation resulting in an antigen-specific immune response.


As used herein the term “poly-N-acetyl glucosamine” or “PNAG” refers to an oligoglucosamine having 100% acetyl substitution.


As used herein the term “deacetylated poly-N-acetyl glucosamine” or “dPNAG” refers to an oligoglucosamine having less than 100% acetyl substitution. The dPNAG may comprise a mixture of dPNAGs with varying degree of acetylation.


As used herein, “epitope” refers to a site on an antigen to which specific B cells and/or T cells respond. The term is also used interchangeably with “antigenic determinant” or “antigenic determinant site.” B cell epitope sites on proteins, oligosaccharides, or other biopolymers may be composed of moieties from different parts of the macromolecule that have been brought together by folding. Epitopes of this kind are referred to as conformational or discontinuous epitopes, since the site is composed of segments the polymer that are discontinuous in the linear sequence but are continuous in the folded conformation(s). Epitopes that are composed of single segments of biopolymers or other molecules are termed continuous or linear epitopes. T cell epitopes are generally restricted to linear peptides. Antibodies that recognize the same epitope can be identified in a simple immunoassay showing the ability of one antibody to block the binding of another antibody to a target antigen.


As used herein, the term “in a first monosaccharide unit R1 is H, and in a second monosaccharide unit R1 or R2 is C(O)CH3, said second monosaccharide unit is located three monosaccharide units from the first monosaccharide unit” refers to a substitution pattern as illustrated in the following scheme:




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As used herein the term “# sequential C(O)CH3 groups are located in subsequent monosaccharide units” or “# sequential H groups are located in subsequent monosaccharide units” refers to structure, wherein the respective C(O)CH3 and H groups are located in adjacent monosaccharide units. The following example illustrates the structural motif for 3 sequential C(O)CH3 groups:




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As used herein the term “selective conversion” means that the selectivity of the specific reaction over another reaction is at least 10 fold, at least 100 fold or at least 1000 fold.


The term Ac means acetyl (—C(O)CH3).


The term TBS means tert-butyldimethylsilyl.


The term Troc means 2,2,2-trichloroethoxycarbonyl.


The term TCl means trichloroacetimidate.


The term Phth means phthaloyl.


The term TFA means trifluoroacetate.


The term TCA means trichloroacetate.


The term Cbz means benzyloxycarbonyl.


The term Bz means benzoyl.


The term Bn means benzyl.


The term TES means triethylsilyl.


The term TBDPS means tert-butyldiphenylsilyl.


The term MCA means monochloracetate.


The term Lev means levulinoyl.


The term ADMB means 4-O-acetyl 12,2 dimethylbutanoate.


The term Tr means triphenylmethyl.


The term DMT means dimethoxytrityl.


The term FMOC means 9-fluorenylmethyl carbonate.


The term Alloc means Allyloxycarbonyl.


The term Nap means napthyl.


The term SEt means thioethyl.


The term SPh means thiophenyl.


The term SToI means thiotolyl.


The term SAdm means thioadamantyl.


Synthetic Oligosaccharides


The present invention provides oligosaccharides 1a:




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where R1 and R2 are each independently H or COCH3, where at least one R1 or R2 in the oligosaccharide is H and at least another is COCH3; n is an integer of at least 3, X is a bond or a linker, and Y is H or a carrier; and where each occurrence of R1 can be the same or different.


In the oligosaccharide 1a, the number of acetylated monosaccharide units in the oligosaccharide is z and the percentage of acetylated monosaccharide units is y, where y is z/(n+1)*100.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is 75% or less.


In another embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is 70% or less.


In another embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is 60% or less.


In another embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is 50% or less.


In another embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is 40% or less.


In another embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is 30% or less.


In another embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is 20% or less.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is at least 15%.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is at least 20%.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is at least 30%.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is at least 40%.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is at least 45%.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is at least 50%.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is at least 55%.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is at least 60%.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is at least 65%.


In one embodiment the percentage of the N-acetylated monosaccharide units in the oligomer is between 10% and 70%, 20% to 70%, 30% to 70%, 30% to 60%, or 30% to 50%.


In one embodiment at least 3 of the R1 and R2 groups are C(O)CH3.


In one embodiment at least 3 of the R1 and R2 groups are H.


In one embodiment n is 5 and 3 of the R1 or R2 groups are C(O)CH3.


In one embodiment n is 6 or 7 and at least 4 of the R1 or R2 groups are C(O)CH3.


In one embodiment n is 8 or 9 and at least 5 of the R1 or R2 groups are C(O)CH3.


In one embodiment n is 10 or 11 and at least 6 of the R1 or R2 groups are C(O)CH3.


In one embodiment n is 5 and 3 of the R1 or R2 groups are H.


In one embodiment n is 6 or 7 and at least 4 of the R1 or R2 groups are H.


In one embodiment n is 8 or 9 and at least 5 of the R1 or R2 groups are H.


In one embodiment n is 10 or 11 and at least 6 of the R1 or R2 groups are H. In one embodiment the group X is a bond.


In another embodiment the group X is a linker.


In one embodiment the carrier group Y is H.


In another embodiment the carrier group Y is a carrier.


In one embodiment, the X is a bond and Y is —H.


Specific embodiments of the present invention are shown below:


Exemplary embodiments of the present invention are shown in the following Tables 1 to 9. tetrasaccharides (n=3, Table 1), pentasaccharides (n=4, Table 2), hexasaccharides (n=5, Table 3), heptasaccharides (n=6, Table 4), octasaccharides (n=7, Table 5), nonasaccharides (n=8, Table 6), decasaccharides (n=9, Table 7), undecasaccharides (n=10, Table 8), and dodecasaccharides (n=11, Table 9).


In the following tables, the nomenclature “n#, R1” (i.e., n1′R1)” identifies the monomeric unit in an oligosaccharide of (n+1) units. The first unit is attached to the monosaccharide bearing R2 and the second, third, etc. units follow.




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For example, when n is 3, the oligosaccharide (a tetrasaccharide) is shown below:









TABLE 1







Tetrasaccharides (Y is either H or a carrier)













Compound
R2
n1, R1
n2, R1
n3, R1






1001
H
H
H
acetyl



1002
H
H
Acetyl
H



1003
H
H
Acetyl
acetyl



1004
H
acetyl
H
H



1005
H
acetyl
H
acetyl



1006
H
acetyl
Acetyl
H



1007
H
acetyl
acetyl
acetyl



1008
acetyl
H
H
H



1009
acetyl
H
H
acetyl



1010
acetyl
H
acetyl
H



1011
acetyl
H
acetyl
acetyl



1012
acetyl
acetyl
H
H



1013
acetyl
acetyl
H
acetyl



1014
acetyl
acetyl
acetyl
H
















TABLE 2







(pentasaccharides) (Y is either H or a carrier)












Compound
R2
n1, R1
n2, R1
n3, R1
n4, R1





1015
H
H
H
H
acetyl


1016
H
H
H
acetyl
H


1017
H
H
H
acetyl
acetyl


1018
H
H
acetyl
H
H


1019
H
H
acetyl
H
acetyl


1020
H
H
acetyl
acetyl
H


1021
H
H
acetyl
acetyl
acetyl


1022
H
acetyl
H
H
H


1023
H
acetyl
H
H
acetyl


1024
H
acetyl
H
acetyl
H


1025
H
acetyl
H
acetyl
acetyl


1026
H
acetyl
acetyl
H
H


1027
H
acetyl
acetyl
H
acetyl


1028
H
acetyl
acetyl
acetyl
H


1029
H
acetyl
acetyl
acetyl
acetyl


1030
acetyl
H
H
H
H


1031
acetyl
H
H
H
acetyl


1032
acetyl
H
H
acetyl
H


1033
acetyl
H
H
acetyl
acetyl


1034
acetyl
H
acetyl
H
H


1035
acetyl
H
acetyl
H
acetyl


1036
acetyl
H
acetyl
acetyl
H


1037
acetyl
H
acetyl
acetyl
acetyl


1038
acetyl
acetyl
H
H
H


1039
acetyl
acetyl
H
H
acetyl


1040
acetyl
acetyl
H
acetyl
H


1041
acetyl
acetyl
H
acetyl
acetyl


1042
acetyl
acetyl
acetyl
H
H


1043
acetyl
acetyl
acetyl
H
acetyl


1044
acetyl
acetyl
acetyl
acetyl
H
















TABLE 3







(hexasaccharides) (Y is either H or a carrier)













Compound
R2
n1, R1
n2, R1
n3, R1
n4, R1
n5, R1





1045
H
H
H
H
H
acetyl


1046
H
H
H
H
acetyl
H


1047
H
H
H
H
acetyl
acetyl


1048
H
H
H
acetyl
H
H


1049
H
H
H
acetyl
H
acetyl


1050
H
H
H
acetyl
acetyl
H


1051
H
H
H
acetyl
acetyl
acetyl


1052
H
H
Acetyl
H
H
H


1053
H
H
Acetyl
H
H
acetyl


1054
H
H
Acetyl
H
acetyl
H


1055
H
H
Acetyl
H
acetyl
acetyl


1056
H
H
Acetyl
acetyl
H
H


1057
H
H
Acetyl
acetyl
H
acetyl


1058
H
H
Acetyl
acetyl
acetyl
H


1059
H
H
Acetyl
acetyl
acetyl
acetyl


1060
H
acetyl
H
H
H
H


1061
H
acetyl
H
H
H
acetyl


1062
H
acetyl
H
H
acetyl
H


1063
H
acetyl
H
H
acetyl
acetyl


1064
H
acetyl
H
acetyl
H
H


1065
H
acetyl
H
acetyl
H
acetyl


1066
H
acetyl
H
acetyl
acetyl
H


1067
H
acetyl
H
acetyl
acetyl
acetyl


1068
H
acetyl
Acetyl
H
H
H


1069
H
acetyl
Acetyl
H
H
acetyl


1070
H
acetyl
Acetyl
H
acetyl
H


1071
H
acetyl
Acetyl
H
acetyl
acetyl


1072
H
acetyl
Acetyl
acetyl
H
H


1073
H
acetyl
Acetyl
acetyl
H
acetyl


1074
H
acetyl
Acetyl
acetyl
acetyl
H


1075
H
acetyl
Acetyl
acetyl
acetyl
acetyl


1076
acetyl
H
H
H
H
H


1077
acetyl
H
H
H
H
acetyl


1078
acetyl
H
H
H
acetyl
H


1079
acetyl
H
H
H
acetyl
acetyl


1080
acetyl
H
H
acetyl
H
H


1081
acetyl
H
H
acetyl
H
acetyl


1082
acetyl
H
H
acetyl
acetyl
H


1083
acetyl
H
H
acetyl
acetyl
acetyl


1084
acetyl
H
Acetyl
H
H
H


1085
acetyl
H
Acetyl
H
H
acetyl


1086
acetyl
H
Acetyl
H
acetyl
H


1087
acetyl
H
Acetyl
H
acetyl
acetyl


1088
acetyl
H
Acetyl
acetyl
H
H


1089
acetyl
H
Acetyl
acetyl
H
acetyl


1090
acetyl
H
Acetyl
acetyl
acetyl
H


1091
acetyl
H
Acetyl
acetyl
acetyl
acetyl


1092
acetyl
acetyl
H
H
H
H


1093
acetyl
acetyl
H
H
H
acetyl


1094
acetyl
acetyl
H
H
acetyl
H


1095
acetyl
acetyl
H
H
acetyl
acetyl


1096
acetyl
acetyl
H
acetyl
H
H


1097
acetyl
acetyl
H
acetyl
H
acetyl


1098
acetyl
acetyl
H
acetyl
acetyl
H


1099
acetyl
acetyl
H
acetyl
acetyl
acetyl


1100
acetyl
acetyl
Acetyl
H
H
H


1101
acetyl
acetyl
Acetyl
H
H
acetyl


1102
acetyl
acetyl
Acetyl
H
acetyl
H


1103
acetyl
acetyl
Acetyl
H
acetyl
acetyl


1104
acetyl
acetyl
Acetyl
acetyl
H
H


1105
acetyl
acetyl
Acetyl
acetyl
H
acetyl


1106
acetyl
acetyl
Acetyl
acetyl
acetyl
H
















TABLE 4







(heptasaccharides) (Y is either H or a carrier)
















n1,
n2,






Compound
R2
R1
R1
n3, R1
n4, R1
n5, R1
n6, R1





1107
H
H
H
H
H
H
acetyl


1108
H
H
H
H
H
acetyl
H


1109
H
H
H
H
H
acetyl
acetyl


1110
H
H
H
H
acetyl
H
H


1111
H
H
H
H
acetyl
H
acetyl


1112
H
H
H
H
acetyl
acetyl
H


1113
H
H
H
H
acetyl
acetyl
acetyl


1114
H
H
H
acetyl
H
H
H


1115
H
H
H
acetyl
H
H
acetyl


1116
H
H
H
acetyl
H
acetyl
H


1117
H
H
H
acetyl
H
acetyl
acetyl


1118
H
H
H
acetyl
acetyl
H
H


1119
H
H
H
acetyl
acetyl
H
acetyl


1120
H
H
H
acetyl
acetyl
acetyl
H


1121
H
H
H
acetyl
acetyl
acetyl
acetyl


1122
H
H
acetyl
H
H
H
H


1123
H
H
acetyl
H
H
H
acetyl


1124
H
H
acetyl
H
H
acetyl
H


1125
H
H
acetyl
H
H
acetyl
acetyl


1126
H
H
acetyl
H
acetyl
H
H


1127
H
H
acetyl
H
acetyl
H
acetyl


1128
H
H
acetyl
H
acetyl
acetyl
H


1129
H
H
acetyl
H
acetyl
acetyl
acetyl


1130
H
H
acetyl
acetyl
H
H
H


1131
H
H
acetyl
acetyl
H
H
acetyl


1132
H
H
acetyl
acetyl
H
acetyl
H


1133
H
H
acetyl
acetyl
H
acetyl
acetyl


1134
H
H
acetyl
acetyl
acetyl
H
H


1135
H
H
acetyl
acetyl
acetyl
H
acetyl


1136
H
H
acetyl
acetyl
acetyl
acetyl
H


1137
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


1138
H
acetyl
H
H
H
H
H


1139
H
acetyl
H
H
H
H
acetyl


1140
H
acetyl
H
H
H
acetyl
H


1141
H
acetyl
H
H
H
acetyl
acetyl


1142
H
acetyl
H
H
acetyl
H
H


1143
H
acetyl
H
H
acetyl
H
acetyl


1144
H
acetyl
H
H
acetyl
acetyl
H


1145
H
acetyl
H
H
acetyl
acetyl
acetyl


1146
H
acetyl
H
acetyl
H
H
H


1147
H
acetyl
H
acetyl
H
H
acetyl


1148
H
acetyl
H
acetyl
H
acetyl
H


1149
H
acetyl
H
acetyl
H
acetyl
acetyl


1150
H
acetyl
H
acetyl
acetyl
H
H


1151
H
acetyl
H
acetyl
acetyl
H
acetyl


1152
H
acetyl
H
acetyl
acetyl
acetyl
H


1153
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


1154
H
acetyl
acetyl
H
H
H
H


1155
H
acetyl
acetyl
H
H
H
acetyl


1156
H
acetyl
acetyl
H
H
acetyl
H


1157
H
acetyl
acetyl
H
H
acetyl
acetyl


1158
H
acetyl
acetyl
H
acetyl
H
H


1159
H
acetyl
acetyl
H
acetyl
H
acetyl


1160
H
acetyl
acetyl
H
acetyl
acetyl
H


1161
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


1162
H
acetyl
acetyl
acetyl
H
H
H


1163
H
acetyl
acetyl
acetyl
H
H
acetyl


1164
H
acetyl
acetyl
acetyl
H
acetyl
H


1165
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


1166
H
acetyl
acetyl
acetyl
acetyl
H
H


1167
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


1168
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


1169
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


1170
acetyl
H
H
H
H
H
H


1171
acetyl
H
H
H
H
H
acetyl


1172
acetyl
H
H
H
H
acetyl
H


1173
acetyl
H
H
H
H
acetyl
acetyl


1174
acetyl
H
H
H
acetyl
H
H


1175
acetyl
H
H
H
acetyl
H
acetyl


1176
acetyl
H
H
H
acetyl
acetyl
H


1177
acetyl
H
H
H
acetyl
acetyl
acetyl


1178
acetyl
H
H
acetyl
H
H
H


1179
acetyl
H
H
acetyl
H
H
acetyl


1180
acetyl
H
H
acetyl
H
acetyl
H


1181
acetyl
H
H
acetyl
H
acetyl
acetyl


1182
acetyl
H
H
acetyl
acetyl
H
H


1183
acetyl
H
H
acetyl
acetyl
H
acetyl


1184
acetyl
H
H
acetyl
acetyl
acetyl
H


1185
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


1186
acetyl
H
acetyl
H
H
H
H


1187
acetyl
H
acetyl
H
H
H
acetyl


1188
acetyl
H
acetyl
H
H
acetyl
H


1189
acetyl
H
acetyl
H
H
acetyl
acetyl


1190
acetyl
H
acetyl
H
acetyl
H
H


1191
acetyl
H
acetyl
H
acetyl
H
acetyl


1192
acetyl
H
acetyl
H
acetyl
acetyl
H


1193
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


1194
acetyl
H
acetyl
acetyl
H
H
H


1195
acetyl
H
acetyl
acetyl
H
H
acetyl


1196
acetyl
H
acetyl
acetyl
H
acetyl
H


1197
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


1198
acetyl
H
acetyl
acetyl
acetyl
H
H


1199
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


1200
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


1201
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


1202
acetyl
acetyl
H
H
H
H
H


1203
acetyl
acetyl
H
H
H
H
acetyl


1204
acetyl
acetyl
H
H
H
acetyl
H


1205
acetyl
acetyl
H
H
H
acetyl
acetyl


1206
acetyl
acetyl
H
H
acetyl
H
H


1207
acetyl
acetyl
H
H
acetyl
H
acetyl


1208
acetyl
acetyl
H
H
acetyl
acetyl
H


1209
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


1210
acetyl
acetyl
H
acetyl
H
H
H


1211
acetyl
acetyl
H
acetyl
H
H
acetyl


1212
acetyl
acetyl
H
acetyl
H
acetyl
H


1213
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


1214
acetyl
acetyl
H
acetyl
acetyl
H
H


1215
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


1216
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


1217
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


1218
acetyl
acetyl
acetyl
H
H
H
H


1219
acetyl
acetyl
acetyl
H
H
H
acetyl


1220
acetyl
acetyl
acetyl
H
H
acetyl
H


1221
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


1222
acetyl
acetyl
acetyl
H
acetyl
H
H


1223
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


1224
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


1225
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


1226
acetyl
acetyl
acetyl
acetyl
H
H
H


1227
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


1228
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


1229
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


1230
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


1231
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


1232
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
















TABLE 5







(octasaccharides) (Y is either H or a carrier)


















n2,
n3,
n4,
n5,
n6,
n7,


Compound
R2
n1, R1
R1
R1
R1
R1
R1
R1





1233
H
H
H
H
H
H
H
acetyl


1234
H
H
H
H
H
H
acetyl
H


1235
H
H
H
H
H
H
acetyl
acetyl


1236
H
H
H
H
H
acetyl
H
H


1237
H
H
H
H
H
acetyl
H
acetyl


1238
H
H
H
H
H
acetyl
acetyl
H


1239
H
H
H
H
H
acetyl
acetyl
acetyl


1240
H
H
H
H
acetyl
H
H
H


1241
H
H
H
H
acetyl
H
H
acetyl


1242
H
H
H
H
acetyl
H
acetyl
H


1243
H
H
H
H
acetyl
H
acetyl
acetyl


1244
H
H
H
H
acetyl
acetyl
H
H


1245
H
H
H
H
acetyl
acetyl
H
acetyl


1246
H
H
H
H
acetyl
acetyl
acetyl
H


1247
H
H
H
H
acetyl
acetyl
acetyl
acetyl


1248
H
H
H
acetyl
H
H
H
H


1249
H
H
H
acetyl
H
H
H
acetyl


1250
H
H
H
acetyl
H
H
acetyl
H


1251
H
H
H
acetyl
H
H
acetyl
acetyl


1252
H
H
H
acetyl
H
acetyl
H
H


1253
H
H
H
acetyl
H
acetyl
H
acetyl


1254
H
H
H
acetyl
H
acetyl
acetyl
H


1255
H
H
H
acetyl
H
acetyl
acetyl
acetyl


1256
H
H
H
acetyl
acetyl
H
H
H


1257
H
H
H
acetyl
acetyl
H
H
acetyl


1258
H
H
H
acetyl
acetyl
H
acetyl
H


1259
H
H
H
acetyl
acetyl
H
acetyl
acetyl


1260
H
H
H
acetyl
acetyl
acetyl
H
H


1261
H
H
H
acetyl
acetyl
acetyl
H
acetyl


1262
H
H
H
acetyl
acetyl
acetyl
acetyl
H


1263
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


1264
H
H
acetyl
H
H
H
H
H


1265
H
H
acetyl
H
H
H
H
acetyl


1266
H
H
acetyl
H
H
H
acetyl
H


1267
H
H
acetyl
H
H
H
acetyl
acetyl


1268
H
H
acetyl
H
H
acetyl
H
H


1269
H
H
acetyl
H
H
acetyl
H
acetyl


1270
H
H
acetyl
H
H
acetyl
acetyl
H


1271
H
H
acetyl
H
H
acetyl
acetyl
acetyl


1272
H
H
acetyl
H
acetyl
H
H
H


1273
H
H
acetyl
H
acetyl
H
H
acetyl


1274
H
H
acetyl
H
acetyl
H
acetyl
H


1275
H
H
acetyl
H
acetyl
H
acetyl
acetyl


1276
H
H
acetyl
H
acetyl
acetyl
H
H


1277
H
H
acetyl
H
acetyl
acetyl
H
acetyl


1278
H
H
acetyl
H
acetyl
acetyl
acetyl
H


1279
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


1280
H
H
acetyl
acetyl
H
H
H
H


1281
H
H
acetyl
acetyl
H
H
H
acetyl


1282
H
H
acetyl
acetyl
H
H
acetyl
H


1283
H
H
acetyl
acetyl
H
H
acetyl
acetyl


1284
H
H
acetyl
acetyl
H
acetyl
H
H


1285
H
H
acetyl
acetyl
H
acetyl
H
acetyl


1286
H
H
acetyl
acetyl
H
acetyl
acetyl
H


1287
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


1288
H
H
acetyl
acetyl
acetyl
H
H
H


1289
H
H
acetyl
acetyl
acetyl
H
H
acetyl


1290
H
H
acetyl
acetyl
acetyl
H
acetyl
H


1291
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


1292
H
H
acetyl
acetyl
acetyl
acetyl
H
H


1293
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


1294
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


1295
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


1296
H
acetyl
H
H
H
H
H
H


1297
H
acetyl
H
H
H
H
H
acetyl


1298
H
acetyl
H
H
H
H
acetyl
H


1299
H
acetyl
H
H
H
H
acetyl
acetyl


1300
H
acetyl
H
H
H
acetyl
H
H


1301
H
acetyl
H
H
H
acetyl
H
acetyl


1302
H
acetyl
H
H
H
acetyl
acetyl
H


1303
H
acetyl
H
H
H
acetyl
acetyl
acetyl


1304
H
acetyl
H
H
acetyl
H
H
H


1305
H
acetyl
H
H
acetyl
H
H
acetyl


1306
H
acetyl
H
H
acetyl
H
acetyl
H


1307
H
acetyl
H
H
acetyl
H
acetyl
acetyl


1308
H
acetyl
H
H
acetyl
acetyl
H
H


1309
H
acetyl
H
H
acetyl
acetyl
H
acetyl


1310
H
acetyl
H
H
acetyl
acetyl
acetyl
H


1311
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


1312
H
acetyl
H
acetyl
H
H
H
H


1313
H
acetyl
H
acetyl
H
H
H
acetyl


1314
H
acetyl
H
acetyl
H
H
acetyl
H


1315
H
acetyl
H
acetyl
H
H
acetyl
acetyl


1316
H
acetyl
H
acetyl
H
acetyl
H
H


1317
H
acetyl
H
acetyl
H
acetyl
H
acetyl


1318
H
acetyl
H
acetyl
H
acetyl
acetyl
H


1319
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


1320
H
acetyl
H
acetyl
acetyl
H
H
H


1321
H
acetyl
H
acetyl
acetyl
H
H
acetyl


1322
H
acetyl
H
acetyl
acetyl
H
acetyl
H


1323
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


1324
H
acetyl
H
acetyl
acetyl
acetyl
H
H


1325
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


1326
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


1327
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


1328
H
acetyl
acetyl
H
H
H
H
H


1329
H
acetyl
acetyl
H
H
H
H
acetyl


1330
H
acetyl
acetyl
H
H
H
acetyl
H


1331
H
acetyl
acetyl
H
H
H
acetyl
acetyl


1332
H
acetyl
acetyl
H
H
acetyl
H
H


1333
H
acetyl
acetyl
H
H
acetyl
H
acetyl


1334
H
acetyl
acetyl
H
H
acetyl
acetyl
H


1335
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


1336
H
acetyl
acetyl
H
acetyl
H
H
H


1337
H
acetyl
acetyl
H
acetyl
H
H
acetyl


1338
H
acetyl
acetyl
H
acetyl
H
acetyl
H


1339
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


1340
H
acetyl
acetyl
H
acetyl
acetyl
H
H


1341
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


1342
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


1343
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


1344
H
acetyl
acetyl
acetyl
H
H
H
H


1345
H
acetyl
acetyl
acetyl
H
H
H
acetyl


1346
H
acetyl
acetyl
acetyl
H
H
acetyl
H


1347
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


1348
H
acetyl
acetyl
acetyl
H
acetyl
H
H


1349
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


1350
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


1351
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


1352
H
acetyl
acetyl
acetyl
acetyl
H
H
H


1353
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


1354
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


1355
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


1356
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


1357
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


1358
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


1359
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


1360
acetyl
H
H
H
H
H
H
H


1361
acetyl
H
H
H
H
H
H
acetyl


1362
acetyl
H
H
H
H
H
acetyl
H


1363
acetyl
H
H
H
H
H
acetyl
acetyl


1364
acetyl
H
H
H
H
acetyl
H
H


1365
acetyl
H
H
H
H
acetyl
H
acetyl


1366
acetyl
H
H
H
H
acetyl
acetyl
H


1367
acetyl
H
H
H
H
acetyl
acetyl
acetyl


1368
acetyl
H
H
H
acetyl
H
H
H


1369
acetyl
H
H
H
acetyl
H
H
acetyl


1370
acetyl
H
H
H
acetyl
H
acetyl
H


1371
acetyl
H
H
H
acetyl
H
acetyl
acetyl


1372
acetyl
H
H
H
acetyl
acetyl
H
H


1373
acetyl
H
H
H
acetyl
acetyl
H
acetyl


1374
acetyl
H
H
H
acetyl
acetyl
acetyl
H


1375
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


1376
acetyl
H
H
acetyl
H
H
H
H


1377
acetyl
H
H
acetyl
H
H
H
acetyl


1378
acetyl
H
H
acetyl
H
H
acetyl
H


1379
acetyl
H
H
acetyl
H
H
acetyl
acetyl


1380
acetyl
H
H
acetyl
H
acetyl
H
H


1381
acetyl
H
H
acetyl
H
acetyl
H
acetyl


1382
acetyl
H
H
acetyl
H
acetyl
acetyl
H


1383
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


1384
acetyl
H
H
acetyl
acetyl
H
H
H


1385
acetyl
H
H
acetyl
acetyl
H
H
acetyl


1386
acetyl
H
H
acetyl
acetyl
H
acetyl
H


1387
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


1388
acetyl
H
H
acetyl
acetyl
acetyl
H
H


1389
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


1390
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


1391
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


1392
acetyl
H
acetyl
H
H
H
H
H


1393
acetyl
H
acetyl
H
H
H
H
acetyl


1394
acetyl
H
acetyl
H
H
H
acetyl
H


1395
acetyl
H
acetyl
H
H
H
acetyl
acetyl


1396
acetyl
H
acetyl
H
H
acetyl
H
H


1397
acetyl
H
acetyl
H
H
acetyl
H
acetyl


1398
acetyl
H
acetyl
H
H
acetyl
acetyl
H


1399
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


1400
acetyl
H
acetyl
H
acetyl
H
H
H


1401
acetyl
H
acetyl
H
acetyl
H
H
acetyl


1402
acetyl
H
acetyl
H
acetyl
H
acetyl
H


1403
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


1404
acetyl
H
acetyl
H
acetyl
acetyl
H
H


1405
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


1406
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


1407
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


1408
acetyl
H
acetyl
acetyl
H
H
H
H


1409
acetyl
H
acetyl
acetyl
H
H
H
acetyl


1410
acetyl
H
acetyl
acetyl
H
H
acetyl
H


1411
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


1412
acetyl
H
acetyl
acetyl
H
acetyl
H
H


1413
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


1414
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


1415
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


1416
acetyl
H
acetyl
acetyl
acetyl
H
H
H


1417
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


1418
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


1419
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


1420
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


1421
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


1422
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


1423
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


1424
acetyl
acetyl
H
H
H
H
H
H


1425
acetyl
acetyl
H
H
H
H
H
acetyl


1426
acetyl
acetyl
H
H
H
H
acetyl
H


1427
acetyl
acetyl
H
H
H
H
acetyl
acetyl


1428
acetyl
acetyl
H
H
H
acetyl
H
H


1429
acetyl
acetyl
H
H
H
acetyl
H
acetyl


1430
acetyl
acetyl
H
H
H
acetyl
acetyl
H


1431
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


1432
acetyl
acetyl
H
H
acetyl
H
H
H


1433
acetyl
acetyl
H
H
acetyl
H
H
acetyl


1434
acetyl
acetyl
H
H
acetyl
H
acetyl
H


1435
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


1436
acetyl
acetyl
H
H
acetyl
acetyl
H
H


1437
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


1438
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


1439
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


1440
acetyl
acetyl
H
acetyl
H
H
H
H


1441
acetyl
acetyl
H
acetyl
H
H
H
acetyl


1442
acetyl
acetyl
H
acetyl
H
H
acetyl
H


1443
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


1444
acetyl
acetyl
H
acetyl
H
acetyl
H
H


1445
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


1446
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


1447
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


1448
acetyl
acetyl
H
acetyl
acetyl
H
H
H


1449
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


1450
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


1451
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


1452
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


1453
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


1454
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


1455
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


1456
acetyl
acetyl
acetyl
H
H
H
H
H


1457
acetyl
acetyl
acetyl
H
H
H
H
acetyl


1458
acetyl
acetyl
acetyl
H
H
H
acetyl
H


1459
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


1460
acetyl
acetyl
acetyl
H
H
acetyl
H
H


1461
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


1462
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


1463
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


1464
acetyl
acetyl
acetyl
H
acetyl
H
H
H


1465
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


1466
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


1467
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


1468
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


1469
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


1470
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


1471
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


1472
acetyl
acetyl
acetyl
acetyl
H
H
H
H


1473
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


1474
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


1475
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


1476
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


1477
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


1478
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


1479
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


1480
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


1481
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


1482
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


1483
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


1484
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


1485
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


1486
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
















TABLE 6







(nonasaccharides) (Y is either H or a carrier)




















n5,
n6


Compound
R2
n1, R1
n2, R1
n3, R1
n4, R1
R1
R1





1107
H
H
H
H
H
H
acetyl


1108
H
H
H
H
H
acetyl
H


1109
H
H
H
H
H
acetyl
acetyl


1110
H
H
H
H
acetyl
H
H


1111
H
H
H
H
acetyl
H
acetyl


1112
H
H
H
H
acetyl
acetyl
H


1113
H
H
H
H
acetyl
acetyl
acetyl


1114
H
H
H
acetyl
H
H
H


1115
H
H
H
acetyl
H
H
acetyl


1116
H
H
H
acetyl
H
acetyl
H


1117
H
H
H
acetyl
H
acetyl
acetyl


1118
H
H
H
acetyl
acetyl
H
H


1119
H
H
H
acetyl
acetyl
H
acetyl


1120
H
H
H
acetyl
acetyl
acetyl
H


1121
H
H
H
acetyl
acetyl
acetyl
acetyl


1122
H
H
acetyl
H
H
H
H


1123
H
H
acetyl
H
H
H
acetyl


1124
H
H
acetyl
H
H
acetyl
H


1125
H
H
acetyl
H
H
acetyl
acetyl


1126
H
H
acetyl
H
acetyl
H
H


1127
H
H
acetyl
H
acetyl
H
acetyl


1128
H
H
acetyl
H
acetyl
acetyl
H


1129
H
H
acetyl
H
acetyl
acetyl
acetyl


1130
H
H
acetyl
acetyl
H
H
H


1131
H
H
acetyl
acetyl
H
H
acetyl


1132
H
H
acetyl
acetyl
H
acetyl
H


1133
H
H
acetyl
acetyl
H
acetyl
acetyl


1134
H
H
acetyl
acetyl
acetyl
H
H


1135
H
H
acetyl
acetyl
acetyl
H
acetyl


1136
H
H
acetyl
acetyl
acetyl
acetyl
H


1137
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


1138
H
acetyl
H
H
H
H
H


1139
H
acetyl
H
H
H
H
acetyl


1140
H
acetyl
H
H
H
acetyl
H


1141
H
acetyl
H
H
H
acetyl
acetyl


1142
H
acetyl
H
H
acetyl
H
H


1143
H
acetyl
H
H
acetyl
H
acetyl


1144
H
acetyl
H
H
acetyl
acetyl
H


1145
H
acetyl
H
H
acetyl
acetyl
acetyl


1146
H
acetyl
H
acetyl
H
H
H


1147
H
acetyl
H
acetyl
H
H
acetyl


1148
H
acetyl
H
acetyl
H
acetyl
H


1149
H
acetyl
H
acetyl
H
acetyl
acetyl


1150
H
acetyl
H
acetyl
acetyl
H
H


1151
H
acetyl
H
acetyl
acetyl
H
acetyl


1152
H
acetyl
H
acetyl
acetyl
acetyl
H


1153
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


1154
H
acetyl
acetyl
H
H
H
H


1155
H
acetyl
acetyl
H
H
H
acetyl


1156
H
acetyl
acetyl
H
H
acetyl
H


1157
H
acetyl
acetyl
H
H
acetyl
acetyl


1158
H
acetyl
acetyl
H
acetyl
H
H


1159
H
acetyl
acetyl
H
acetyl
H
acetyl


1160
H
acetyl
acetyl
H
acetyl
acetyl
H


1161
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


1162
H
acetyl
acetyl
acetyl
H
H
H


1163
H
acetyl
acetyl
acetyl
H
H
acetyl


1164
H
acetyl
acetyl
acetyl
H
acetyl
H


1165
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


1166
H
acetyl
acetyl
acetyl
acetyl
H
H


1167
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


1168
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


1169
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


1170
acetyl
H
H
H
H
H
H


1171
acetyl
H
H
H
H
H
acetyl


1172
acetyl
H
H
H
H
acetyl
H


1173
acetyl
H
H
H
H
acetyl
acetyl


1174
acetyl
H
H
H
acetyl
H
H


1175
acetyl
H
H
H
acetyl
H
acetyl


1176
acetyl
H
H
H
acetyl
acetyl
H


1177
acetyl
H
H
H
acetyl
acetyl
acetyl


1178
acetyl
H
H
acetyl
H
H
H


1179
acetyl
H
H
acetyl
H
H
acetyl


1180
acetyl
H
H
acetyl
H
acetyl
H


1181
acetyl
H
H
acetyl
H
acetyl
acetyl


1182
acetyl
H
H
acetyl
acetyl
H
H


1183
acetyl
H
H
acetyl
acetyl
H
acetyl


1184
acetyl
H
H
acetyl
acetyl
acetyl
H


1185
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


1186
acetyl
H
acetyl
H
H
H
H


1187
acetyl
H
acetyl
H
H
H
acetyl


1188
acetyl
H
acetyl
H
H
acetyl
H


1189
acetyl
H
acetyl
H
H
acetyl
acetyl


1190
acetyl
H
acetyl
H
acetyl
H
H


1191
acetyl
H
acetyl
H
acetyl
H
acetyl


1192
acetyl
H
acetyl
H
acetyl
acetyl
H


1193
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


1194
acetyl
H
acetyl
acetyl
H
H
H


1195
acetyl
H
acetyl
acetyl
H
H
acetyl


1196
acetyl
H
acetyl
acetyl
H
acetyl
H


1197
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


1198
acetyl
H
acetyl
acetyl
acetyl
H
H


1199
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


1200
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


1201
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


1202
acetyl
acetyl
H
H
H
H
H


1203
acetyl
acetyl
H
H
H
H
acetyl


1204
acetyl
acetyl
H
H
H
acetyl
H


1205
acetyl
acetyl
H
H
H
acetyl
acetyl


1206
acetyl
acetyl
H
H
acetyl
H
H


1207
acetyl
acetyl
H
H
acetyl
H
acetyl


1208
acetyl
acetyl
H
H
acetyl
acetyl
H


1209
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


1210
acetyl
acetyl
H
acetyl
H
H
H


1211
acetyl
acetyl
H
acetyl
H
H
acetyl


1212
acetyl
acetyl
H
acetyl
H
acetyl
H


1213
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


1214
acetyl
acetyl
H
acetyl
acetyl
H
H


1215
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


1216
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


1217
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


1218
acetyl
acetyl
acetyl
H
H
H
H


1219
acetyl
acetyl
acetyl
H
H
H
acetyl


1220
acetyl
acetyl
acetyl
H
H
acetyl
H


1221
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


1222
acetyl
acetyl
acetyl
H
acetyl
H
H


1223
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


1224
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


1225
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


1226
acetyl
acetyl
acetyl
acetyl
H
H
H


1227
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


1228
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


1229
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


1230
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


1231
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


1232
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
















TABLE 7







(Decasaccharides) (Y is either H or a carrier)

















Compound
R2
n1, R1
n2, R1
n3, R1
n4, R1
n5, R1
n6, R1
n7, R1
n8, R1
n9, R1





1997
H
H
H
H
H
H
H
H
H
acetyl


1998
H
H
H
H
H
H
H
H
acetyl
H


1999
H
H
H
H
H
H
H
H
acetyl
acetyl


2000
H
H
H
H
H
H
H
acetyl
H
H


2001
H
H
H
H
H
H
H
acetyl
H
acetyl


2002
H
H
H
H
H
H
H
acetyl
acetyl
H


2003
H
H
H
H
H
H
H
acetyl
acetyl
acetyl


2004
H
H
H
H
H
H
acetyl
H
H
H


2005
H
H
H
H
H
H
acetyl
H
H
acetyl


2006
H
H
H
H
H
H
acetyl
H
acetyl
H


2007
H
H
H
H
H
H
acetyl
H
acetyl
acetyl


2008
H
H
H
H
H
H
acetyl
acetyl
H
H


2009
H
H
H
H
H
H
acetyl
acetyl
H
acetyl


2010
H
H
H
H
H
H
acetyl
acetyl
acetyl
H


2011
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


2012
H
H
H
H
H
acetyl
H
H
H
H


2013
H
H
H
H
H
acetyl
H
H
H
acetyl


2014
H
H
H
H
H
acetyl
H
H
acetyl
H


2015
H
H
H
H
H
acetyl
H
H
acetyl
acetyl


2016
H
H
H
H
H
acetyl
H
acetyl
H
H


2017
H
H
H
H
H
acetyl
H
acetyl
H
acetyl


2018
H
H
H
H
H
acetyl
H
acetyl
acetyl
H


2019
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


2020
H
H
H
H
H
acetyl
acetyl
H
H
H


2021
H
H
H
H
H
acetyl
acetyl
H
H
acetyl


2022
H
H
H
H
H
acetyl
acetyl
H
acetyl
H


2023
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


2024
H
H
H
H
H
acetyl
acetyl
acetyl
H
H


2025
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


2026
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


2027
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


2028
H
H
H
H
acetyl
H
H
H
H
H


2029
H
H
H
H
acetyl
H
H
H
H
acetyl


2030
H
H
H
H
acetyl
H
H
H
acetyl
H


2031
H
H
H
H
acetyl
H
H
H
acetyl
acetyl


2032
H
H
H
H
acetyl
H
H
acetyl
H
H


2033
H
H
H
H
acetyl
H
H
acetyl
H
acetyl


2034
H
H
H
H
acetyl
H
H
acetyl
acetyl
H


2035
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


2036
H
H
H
H
acetyl
H
acetyl
H
H
H


2037
H
H
H
H
acetyl
H
acetyl
H
H
acetyl


2038
H
H
H
H
acetyl
H
acetyl
H
acetyl
H


2039
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


2040
H
H
H
H
acetyl
H
acetyl
acetyl
H
H


2041
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


2042
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


2043
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


2044
H
H
H
H
acetyl
acetyl
H
H
H
H


2045
H
H
H
H
acetyl
acetyl
H
H
H
acetyl


2046
H
H
H
H
acetyl
acetyl
H
H
acetyl
H


2047
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


2048
H
H
H
H
acetyl
acetyl
H
acetyl
H
H


2049
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


2050
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


2051
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


2052
H
H
H
H
acetyl
acetyl
acetyl
H
H
H


2053
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


2054
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


2055
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


2056
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


2057
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


2058
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


2059
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2060
H
H
H
acetyl
H
H
H
H
H
H


2061
H
H
H
acetyl
H
H
H
H
H
acetyl


2062
H
H
H
acetyl
H
H
H
H
acetyl
H


2063
H
H
H
acetyl
H
H
H
H
acetyl
acetyl


2064
H
H
H
acetyl
H
H
H
acetyl
H
H


2065
H
H
H
acetyl
H
H
H
acetyl
H
acetyl


2066
H
H
H
acetyl
H
H
H
acetyl
acetyl
H


2067
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


2068
H
H
H
acetyl
H
H
acetyl
H
H
H


2069
H
H
H
acetyl
H
H
acetyl
H
H
acetyl


2070
H
H
H
acetyl
H
H
acetyl
H
acetyl
H


2071
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


2072
H
H
H
acetyl
H
H
acetyl
acetyl
H
H


2073
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


2074
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


2075
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


2076
H
H
H
acetyl
H
acetyl
H
H
H
H


2077
H
H
H
acetyl
H
acetyl
H
H
H
acetyl


2078
H
H
H
acetyl
H
acetyl
H
H
acetyl
H


2079
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


2080
H
H
H
acetyl
H
acetyl
H
acetyl
H
H


2081
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


2082
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


2083
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


2084
H
H
H
acetyl
H
acetyl
acetyl
H
H
H


2085
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


2086
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


2087
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


2088
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


2089
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


2090
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


2091
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


2092
H
H
H
acetyl
acetyl
H
H
H
H
H


2093
H
H
H
acetyl
acetyl
H
H
H
H
acetyl


2094
H
H
H
acetyl
acetyl
H
H
H
acetyl
H


2095
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


2096
H
H
H
acetyl
acetyl
H
H
acetyl
H
H


2097
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


2098
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


2099
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


2100
H
H
H
acetyl
acetyl
H
acetyl
H
H
H


2101
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


2102
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


2103
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


2104
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


2105
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


2106
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


2107
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


2108
H
H
H
acetyl
acetyl
acetyl
H
H
H
H


2109
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


2110
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


2111
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


2112
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


2113
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


2114
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


2115
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


2116
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


2117
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


2118
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


2119
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


2120
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


2121
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


2122
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


2123
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2124
H
H
acetyl
H
H
H
H
H
H
H


2125
H
H
acetyl
H
H
H
H
H
H
acetyl


2126
H
H
acetyl
H
H
H
H
H
acetyl
H


2127
H
H
acetyl
H
H
H
H
H
acetyl
acetyl


2128
H
H
acetyl
H
H
H
H
acetyl
H
H


2129
H
H
acetyl
H
H
H
H
acetyl
H
acetyl


2130
H
H
acetyl
H
H
H
H
acetyl
acetyl
H


2131
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


2132
H
H
acetyl
H
H
H
acetyl
H
H
H


2133
H
H
acetyl
H
H
H
acetyl
H
H
acetyl


2134
H
H
acetyl
H
H
H
acetyl
H
acetyl
H


2135
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


2136
H
H
acetyl
H
H
H
acetyl
acetyl
H
H


2137
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


2138
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


2139
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


2140
H
H
acetyl
H
H
acetyl
H
H
H
H


2141
H
H
acetyl
H
H
acetyl
H
H
H
acetyl


2142
H
H
acetyl
H
H
acetyl
H
H
acetyl
H


2143
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


2144
H
H
acetyl
H
H
acetyl
H
acetyl
H
H


2145
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


2146
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


2147
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


2148
H
H
acetyl
H
H
acetyl
acetyl
H
H
H


2149
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


2150
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


2151
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


2152
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


2153
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


2154
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


2155
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


2156
H
H
acetyl
H
acetyl
H
H
H
H
H


2157
H
H
acetyl
H
acetyl
H
H
H
H
acetyl


2158
H
H
acetyl
H
acetyl
H
H
H
acetyl
H


2159
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


2160
H
H
acetyl
H
acetyl
H
H
acetyl
H
H


2161
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


2162
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


2163
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


2164
H
H
acetyl
H
acetyl
H
acetyl
H
H
H


2165
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


2166
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


2167
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


2168
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


2169
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


2170
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


2171
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


2172
H
H
acetyl
H
acetyl
acetyl
H
H
H
H


2173
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


2174
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


2175
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


2176
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


2177
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


2178
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


2179
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


2180
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


2181
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


2182
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


2183
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


2184
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


2185
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


2186
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


2187
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2188
H
H
acetyl
acetyl
H
H
H
H
H
H


2189
H
H
acetyl
acetyl
H
H
H
H
H
acetyl


2190
H
H
acetyl
acetyl
H
H
H
H
acetyl
H


2191
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


2192
H
H
acetyl
acetyl
H
H
H
acetyl
H
H


2193
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


2194
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


2195
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


2196
H
H
acetyl
acetyl
H
H
acetyl
H
H
H


2197
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


2198
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


2199
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


2200
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


2201
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


2202
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


2203
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


2204
H
H
acetyl
acetyl
H
acetyl
H
H
H
H


2205
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


2206
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


2207
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


2208
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


2209
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


2210
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


2211
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


2212
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


2213
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


2214
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


2215
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


2216
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


2217
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


2218
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


2219
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


2220
H
H
acetyl
acetyl
acetyl
H
H
H
H
H


2221
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


2222
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


2223
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


2224
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


2225
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


2226
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


2227
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


2228
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


2229
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


2230
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


2231
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


2232
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


2233
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


2234
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


2235
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


2236
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


2237
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


2238
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


2239
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


2240
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


2241
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


2242
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


2243
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


2244
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


2245
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


2246
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


2247
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


2248
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


2249
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


2250
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


2251
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2252
H
acetyl
H
H
H
H
H
H
H
H


2253
H
acetyl
H
H
H
H
H
H
H
acetyl


2254
H
acetyl
H
H
H
H
H
H
acetyl
H


2255
H
acetyl
H
H
H
H
H
H
acetyl
acetyl


2256
H
acetyl
H
H
H
H
H
acetyl
H
H


2257
H
acetyl
H
H
H
H
H
acetyl
H
acetyl


2258
H
acetyl
H
H
H
H
H
acetyl
acetyl
H


2259
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


2260
H
acetyl
H
H
H
H
acetyl
H
H
H


2261
H
acetyl
H
H
H
H
acetyl
H
H
acetyl


2262
H
acetyl
H
H
H
H
acetyl
H
acetyl
H


2263
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


2264
H
acetyl
H
H
H
H
acetyl
acetyl
H
H


2265
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


2266
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


2267
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


2268
H
acetyl
H
H
H
acetyl
H
H
H
H


2269
H
acetyl
H
H
H
acetyl
H
H
H
acetyl


2270
H
acetyl
H
H
H
acetyl
H
H
acetyl
H


2271
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


2272
H
acetyl
H
H
H
acetyl
H
acetyl
H
H


2273
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


2274
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


2275
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


2276
H
acetyl
H
H
H
acetyl
acetyl
H
H
H


2277
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


2278
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


2279
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


2280
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


2281
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


2282
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


2283
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


2284
H
acetyl
H
H
acetyl
H
H
H
H
H


2285
H
acetyl
H
H
acetyl
H
H
H
H
acetyl


2286
H
acetyl
H
H
acetyl
H
H
H
acetyl
H


2287
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


2288
H
acetyl
H
H
acetyl
H
H
acetyl
H
H


2289
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


2290
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


2291
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


2292
H
acetyl
H
H
acetyl
H
acetyl
H
H
H


2293
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


2294
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


2295
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


2296
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


2297
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


2298
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


2299
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


2300
H
acetyl
H
H
acetyl
acetyl
H
H
H
H


2301
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


2302
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


2303
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


2304
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


2305
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


2306
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


2307
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


2308
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


2309
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


2310
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


2311
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


2312
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


2313
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


2314
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


2315
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2316
H
acetyl
H
acetyl
H
H
H
H
H
H


2317
H
acetyl
H
acetyl
H
H
H
H
H
acetyl


2318
H
acetyl
H
acetyl
H
H
H
H
acetyl
H


2319
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


2320
H
acetyl
H
acetyl
H
H
H
acetyl
H
H


2321
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


2322
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


2323
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


2324
H
acetyl
H
acetyl
H
H
acetyl
H
H
H


2325
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


2326
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


2327
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


2328
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


2329
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


2330
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


2331
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


2332
H
acetyl
H
acetyl
H
acetyl
H
H
H
H


2333
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


2334
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


2335
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


2336
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


2337
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


2338
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


2339
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


2340
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


2341
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


2342
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


2343
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


2344
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


2345
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


2346
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


2347
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


2348
H
acetyl
H
acetyl
acetyl
H
H
H
H
H


2349
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


2350
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


2351
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


2352
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


2353
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


2354
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


2355
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


2356
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


2357
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


2358
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


2359
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


2360
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


2361
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


2362
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


2363
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


2364
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


2365
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


2366
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


2367
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


2368
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


2369
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


2370
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


2371
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


2372
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


2373
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


2374
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


2375
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


2376
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


2377
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


2378
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


2379
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2380
H
acetyl
acetyl
H
H
H
H
H
H
H


2381
H
acetyl
acetyl
H
H
H
H
H
H
acetyl


2382
H
acetyl
acetyl
H
H
H
H
H
acetyl
H


2383
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


2384
H
acetyl
acetyl
H
H
H
H
acetyl
H
H


2385
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


2386
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


2387
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


2388
H
acetyl
acetyl
H
H
H
acetyl
H
H
H


2389
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


2390
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


2391
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


2392
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


2393
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


2394
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


2395
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


2396
H
acetyl
acetyl
H
H
acetyl
H
H
H
H


2397
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


2398
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


2399
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


2400
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


2401
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


2402
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


2403
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


2404
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


2405
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


2406
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


2407
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


2408
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


2409
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


2410
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


2411
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


2412
H
acetyl
acetyl
H
acetyl
H
H
H
H
H


2413
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


2414
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


2415
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


2416
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


2417
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


2418
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


2419
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


2420
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


2421
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


2422
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


2423
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


2424
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


2425
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


2426
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


2427
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


2428
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


2429
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


2430
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


2431
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


2432
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


2433
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


2434
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


2435
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


2436
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


2437
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


2438
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


2439
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


2440
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


2441
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


2442
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


2443
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2444
H
acetyl
acetyl
acetyl
H
H
H
H
H
H


2445
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


2446
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


2447
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


2448
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


2449
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


2450
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


2451
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


2452
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


2453
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


2454
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


2455
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


2456
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


2457
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


2458
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


2459
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


2460
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


2461
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


2462
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


2463
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


2464
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


2465
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


2466
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


2467
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


2468
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


2469
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


2470
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


2471
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


2472
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


2473
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


2474
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


2475
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


2476
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


2477
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


2478
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


2479
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


2480
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


2481
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


2482
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


2483
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


2484
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


2485
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


2486
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


2487
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


2488
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


2489
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


2490
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


2491
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


2492
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


2493
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


2494
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


2495
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


2496
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


2497
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


2498
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


2499
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


2500
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


2501
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


2502
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


2503
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


2504
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


2505
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


2506
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


2507
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2508
acetyl
H
H
H
H
H
H
H
H
H


2509
acetyl
H
H
H
H
H
H
H
H
acetyl


2510
acetyl
H
H
H
H
H
H
H
acetyl
H


2511
acetyl
H
H
H
H
H
H
H
acetyl
acetyl


2512
acetyl
H
H
H
H
H
H
acetyl
H
H


2513
acetyl
H
H
H
H
H
H
acetyl
H
acetyl


2514
acetyl
H
H
H
H
H
H
acetyl
acetyl
H


2515
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl


2516
acetyl
H
H
H
H
H
acetyl
H
H
H


2517
acetyl
H
H
H
H
H
acetyl
H
H
acetyl


2518
acetyl
H
H
H
H
H
acetyl
H
acetyl
H


2519
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl


2520
acetyl
H
H
H
H
H
acetyl
acetyl
H
H


2521
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl


2522
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H


2523
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


2524
acetyl
H
H
H
H
acetyl
H
H
H
H


2525
acetyl
H
H
H
H
acetyl
H
H
H
acetyl


2526
acetyl
H
H
H
H
acetyl
H
H
acetyl
H


2527
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl


2528
acetyl
H
H
H
H
acetyl
H
acetyl
H
H


2529
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl


2530
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H


2531
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


2532
acetyl
H
H
H
H
acetyl
acetyl
H
H
H


2533
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl


2534
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H


2535
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


2536
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H


2537
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


2538
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


2539
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


2540
acetyl
H
H
H
acetyl
H
H
H
H
H


2541
acetyl
H
H
H
acetyl
H
H
H
H
acetyl


2542
acetyl
H
H
H
acetyl
H
H
H
acetyl
H


2543
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl


2544
acetyl
H
H
H
acetyl
H
H
acetyl
H
H


2545
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl


2546
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H


2547
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


2548
acetyl
H
H
H
acetyl
H
acetyl
H
H
H


2549
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl


2550
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H


2551
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


2552
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H


2553
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


2554
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


2555
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


2556
acetyl
H
H
H
acetyl
acetyl
H
H
H
H


2557
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl


2558
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H


2559
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


2560
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H


2561
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


2562
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


2563
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


2564
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H


2565
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


2566
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


2567
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


2568
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


2569
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


2570
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


2571
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2572
acetyl
H
H
acetyl
H
H
H
H
H
H


2573
acetyl
H
H
acetyl
H
H
H
H
H
acetyl


2574
acetyl
H
H
acetyl
H
H
H
H
acetyl
H


2575
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl


2576
acetyl
H
H
acetyl
H
H
H
acetyl
H
H


2577
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl


2578
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H


2579
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


2580
acetyl
H
H
acetyl
H
H
acetyl
H
H
H


2581
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl


2582
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H


2583
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


2584
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H


2585
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


2586
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


2587
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


2588
acetyl
H
H
acetyl
H
acetyl
H
H
H
H


2589
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl


2590
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H


2591
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


2592
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H


2593
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


2594
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


2595
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


2596
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H


2597
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


2598
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


2599
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


2600
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


2601
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


2602
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


2603
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


2604
acetyl
H
H
acetyl
acetyl
H
H
H
H
H


2605
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl


2606
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H


2607
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


2608
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H


2609
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


2610
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


2611
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


2612
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H


2613
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


2614
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


2615
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


2616
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


2617
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


2618
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


2619
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


2620
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H


2621
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


2622
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


2623
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


2624
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


2625
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


2626
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


2627
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


2628
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


2629
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


2630
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


2631
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


2632
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


2633
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


2634
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


2635
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2636
acetyl
H
acetyl
H
H
H
H
H
H
H


2637
acetyl
H
acetyl
H
H
H
H
H
H
acetyl


2638
acetyl
H
acetyl
H
H
H
H
H
acetyl
H


2639
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl


2640
acetyl
H
acetyl
H
H
H
H
acetyl
H
H


2641
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl


2642
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H


2643
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


2644
acetyl
H
acetyl
H
H
H
acetyl
H
H
H


2645
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl


2646
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H


2647
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


2648
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H


2649
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


2650
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


2651
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


2652
acetyl
H
acetyl
H
H
acetyl
H
H
H
H


2653
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl


2654
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H


2655
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


2656
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H


2657
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


2658
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


2659
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


2660
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H


2661
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


2662
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


2663
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


2664
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


2665
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


2666
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


2667
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


2668
acetyl
H
acetyl
H
acetyl
H
H
H
H
H


2669
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl


2670
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H


2671
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


2672
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H


2673
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


2674
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


2675
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


2676
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H


2677
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


2678
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


2679
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


2680
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


2681
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


2682
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


2683
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


2684
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H


2685
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


2686
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


2687
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


2688
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


2689
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


2690
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


2691
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


2692
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


2693
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


2694
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


2695
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


2696
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


2697
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


2698
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


2699
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2700
acetyl
H
acetyl
acetyl
H
H
H
H
H
H


2701
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl


2702
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H


2703
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


2704
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H


2705
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


2706
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


2707
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


2708
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H


2709
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


2710
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


2711
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


2712
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


2713
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


2714
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


2715
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


2716
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H


2717
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


2718
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


2719
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


2720
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


2721
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


2722
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


2723
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


2724
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


2725
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


2726
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


2727
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


2728
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


2729
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


2730
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


2731
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


2732
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H


2733
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


2734
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


2735
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


2736
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


2737
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


2738
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


2739
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


2740
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


2741
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


2742
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


2743
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


2744
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


2745
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


2746
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


2747
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


2748
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


2749
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


2750
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


2751
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


2752
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


2753
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


2754
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


2755
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


2756
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


2757
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


2758
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


2759
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


2760
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


2761
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


2762
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


2763
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2764
acetyl
acetyl
H
H
H
H
H
H
H
H


2765
acetyl
acetyl
H
H
H
H
H
H
H
acetyl


2766
acetyl
acetyl
H
H
H
H
H
H
acetyl
H


2767
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl


2768
acetyl
acetyl
H
H
H
H
H
acetyl
H
H


2769
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl


2770
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H


2771
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


2772
acetyl
acetyl
H
H
H
H
acetyl
H
H
H


2773
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl


2774
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H


2775
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


2776
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H


2777
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


2778
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


2779
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


2780
acetyl
acetyl
H
H
H
acetyl
H
H
H
H


2781
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl


2782
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H


2783
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


2784
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H


2785
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


2786
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


2787
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


2788
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H


2789
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


2790
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


2791
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


2792
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


2793
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


2794
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


2795
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


2796
acetyl
acetyl
H
H
acetyl
H
H
H
H
H


2797
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl


2798
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H


2799
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


2800
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H


2801
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


2802
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


2803
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


2804
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H


2805
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


2806
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


2807
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


2808
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


2809
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


2810
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


2811
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


2812
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H


2813
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


2814
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


2815
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


2816
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


2817
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


2818
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


2819
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


2820
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


2821
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


2822
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


2823
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


2824
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


2825
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


2826
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


2827
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2828
acetyl
acetyl
H
acetyl
H
H
H
H
H
H


2829
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl


2830
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H


2831
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


2832
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H


2833
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


2834
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


2835
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


2836
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H


2837
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


2838
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


2839
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


2840
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


2841
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


2842
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


2843
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


2844
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H


2845
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


2846
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


2847
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


2848
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


2849
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


2850
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


2851
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


2852
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


2853
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


2854
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


2855
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


2856
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


2857
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


2858
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


2859
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


2860
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H


2861
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


2862
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


2863
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


2864
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


2865
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


2866
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


2867
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


2868
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


2869
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


2870
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


2871
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


2872
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


2873
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


2874
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


2875
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


2876
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


2877
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


2878
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


2879
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


2880
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


2881
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


2882
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


2883
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


2884
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


2885
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


2886
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


2887
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


2888
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


2889
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


2890
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


2891
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2892
acetyl
acetyl
acetyl
H
H
H
H
H
H
H


2893
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl


2894
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H


2895
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


2896
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H


2897
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


2898
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


2899
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


2900
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H


2901
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


2902
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


2903
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


2904
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


2905
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


2906
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


2907
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


2908
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H


2909
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


2910
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


2911
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


2912
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


2913
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


2914
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


2915
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


2916
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


2917
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


2918
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


2919
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


2920
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


2921
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


2922
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


2923
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


2924
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H


2925
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


2926
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


2927
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


2928
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


2929
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


2930
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


2931
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


2932
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


2933
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


2934
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


2935
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


2936
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


2937
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


2938
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


2939
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


2940
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


2941
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


2942
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


2943
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


2944
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


2945
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


2946
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


2947
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


2948
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


2949
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


2950
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


2951
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


2952
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


2953
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


2954
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


2955
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


2956
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H


2957
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


2958
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


2959
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


2960
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


2961
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


2962
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


2963
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


2964
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


2965
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


2966
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


2967
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


2968
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


2969
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


2970
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


2971
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


2972
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


2973
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


2974
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


2975
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


2976
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


2977
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


2978
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


2979
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


2980
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


2981
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


2982
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


2983
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


2984
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


2985
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


2986
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


2987
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


2988
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


2989
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


2990
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


2991
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


2992
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


2993
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


2994
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


2995
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


2996
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


2997
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


2998
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


2999
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


3000
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


3001
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


3002
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


3003
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


3004
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


3005
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


3006
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


3007
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


3008
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


3009
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


3010
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


3011
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


3012
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


3013
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


3014
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


3015
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


3016
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


3017
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


3018
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
















TABLE 8







(undecasaccharides) (Y is either H or a carrier)





























n10;


Compound
R2
n1, R1
n2, R1
n3, R1
n4, R1
n5, R1
n6, R1
n7, R1
n8, R1
n9, R1
R1





















3019
H
H
H
H
H
H
H
H
H
H
acetyl


3020
H
H
H
H
H
H
H
H
H
acetyl
H


3021
H
H
H
H
H
H
H
H
H
acetyl
acetyl


3022
H
H
H
H
H
H
H
H
acetyl
H
H


3023
H
H
H
H
H
H
H
H
acetyl
H
acetyl


3024
H
H
H
H
H
H
H
H
acetyl
acetyl
H


3025
H
H
H
H
H
H
H
H
acetyl
acetyl
acetyl


3026
H
H
H
H
H
H
H
acetyl
H
H
H


3027
H
H
H
H
H
H
H
acetyl
H
H
acetyl


3028
H
H
H
H
H
H
H
acetyl
H
acetyl
H


3029
H
H
H
H
H
H
H
acetyl
H
acetyl
acetyl


3030
H
H
H
H
H
H
H
acetyl
acetyl
H
H


3031
H
H
H
H
H
H
H
acetyl
acetyl
H
acetyl


3032
H
H
H
H
H
H
H
acetyl
acetyl
acetyl
H


3033
H
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


3034
H
H
H
H
H
H
acetyl
H
H
H
H


3035
H
H
H
H
H
H
acetyl
H
H
H
acetyl


3036
H
H
H
H
H
H
acetyl
H
H
acetyl
H


3037
H
H
H
H
H
H
acetyl
H
H
acetyl
acetyl


3038
H
H
H
H
H
H
acetyl
H
acetyl
H
H


3039
H
H
H
H
H
H
acetyl
H
acetyl
H
acetyl


3040
H
H
H
H
H
H
acetyl
H
acetyl
acetyl
H


3041
H
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


3042
H
H
H
H
H
H
acetyl
acetyl
H
H
H


3043
H
H
H
H
H
H
acetyl
acetyl
H
H
acetyl


3044
H
H
H
H
H
H
acetyl
acetyl
H
acetyl
H


3045
H
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


3046
H
H
H
H
H
H
acetyl
acetyl
acetyl
H
H


3047
H
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


3048
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


3049
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


3050
H
H
H
H
H
acetyl
H
H
H
H
H


3051
H
H
H
H
H
acetyl
H
H
H
H
acetyl


3052
H
H
H
H
H
acetyl
H
H
H
acetyl
H


3053
H
H
H
H
H
acetyl
H
H
H
acetyl
acetyl


3054
H
H
H
H
H
acetyl
H
H
acetyl
H
H


3055
H
H
H
H
H
acetyl
H
H
acetyl
H
acetyl


3056
H
H
H
H
H
acetyl
H
H
acetyl
acetyl
H


3057
H
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


3058
H
H
H
H
H
acetyl
H
acetyl
H
H
H


3059
H
H
H
H
H
acetyl
H
acetyl
H
H
acetyl


3060
H
H
H
H
H
acetyl
H
acetyl
H
acetyl
H


3061
H
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


3062
H
H
H
H
H
acetyl
H
acetyl
acetyl
H
H


3063
H
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


3064
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


3065
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


3066
H
H
H
H
H
acetyl
acetyl
H
H
H
H


3067
H
H
H
H
H
acetyl
acetyl
H
H
H
acetyl


3068
H
H
H
H
H
acetyl
acetyl
H
H
acetyl
H


3069
H
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


3070
H
H
H
H
H
acetyl
acetyl
H
acetyl
H
H


3071
H
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


3072
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


3073
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


3074
H
H
H
H
H
acetyl
acetyl
acetyl
H
H
H


3075
H
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


3076
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


3077
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


3078
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


3079
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


3080
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


3081
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3082
H
H
H
H
acetyl
H
H
H
H
H
H


3083
H
H
H
H
acetyl
H
H
H
H
H
acetyl


3084
H
H
H
H
acetyl
H
H
H
H
acetyl
H


3085
H
H
H
H
acetyl
H
H
H
H
acetyl
acetyl


3086
H
H
H
H
acetyl
H
H
H
acetyl
H
H


3087
H
H
H
H
acetyl
H
H
H
acetyl
H
acetyl


3088
H
H
H
H
acetyl
H
H
H
acetyl
acetyl
H


3089
H
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


3090
H
H
H
H
acetyl
H
H
acetyl
H
H
H


3091
H
H
H
H
acetyl
H
H
acetyl
H
H
acetyl


3092
H
H
H
H
acetyl
H
H
acetyl
H
acetyl
H


3093
H
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


3094
H
H
H
H
acetyl
H
H
acetyl
acetyl
H
H


3095
H
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


3096
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


3097
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


3098
H
H
H
H
acetyl
H
acetyl
H
H
H
H


3099
H
H
H
H
acetyl
H
acetyl
H
H
H
acetyl


3100
H
H
H
H
acetyl
H
acetyl
H
H
acetyl
H


3101
H
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


3102
H
H
H
H
acetyl
H
acetyl
H
acetyl
H
H


3103
H
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


3104
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


3105
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


3106
H
H
H
H
acetyl
H
acetyl
acetyl
H
H
H


3107
H
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


3108
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


3109
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


3110
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


3111
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


3112
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


3113
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


3114
H
H
H
H
acetyl
acetyl
H
H
H
H
H


3115
H
H
H
H
acetyl
acetyl
H
H
H
H
acetyl


3116
H
H
H
H
acetyl
acetyl
H
H
H
acetyl
H


3117
H
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


3118
H
H
H
H
acetyl
acetyl
H
H
acetyl
H
H


3119
H
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


3120
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


3121
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


3122
H
H
H
H
acetyl
acetyl
H
acetyl
H
H
H


3123
H
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


3124
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


3125
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


3126
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


3127
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


3128
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


3129
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


3130
H
H
H
H
acetyl
acetyl
acetyl
H
H
H
H


3131
H
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


3132
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


3133
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


3134
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


3135
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


3136
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


3137
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


3138
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


3139
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


3140
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


3141
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


3142
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


3143
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


3144
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


3145
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3146
H
H
H
acetyl
H
H
H
H
H
H
H


3147
H
H
H
acetyl
H
H
H
H
H
H
acetyl


3148
H
H
H
acetyl
H
H
H
H
H
acetyl
H


3149
H
H
H
acetyl
H
H
H
H
H
acetyl
acetyl


3150
H
H
H
acetyl
H
H
H
H
acetyl
H
H


3151
H
H
H
acetyl
H
H
H
H
acetyl
H
acetyl


3152
H
H
H
acetyl
H
H
H
H
acetyl
acetyl
H


3153
H
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


3154
H
H
H
acetyl
H
H
H
acetyl
H
H
H


3155
H
H
H
acetyl
H
H
H
acetyl
H
H
acetyl


3156
H
H
H
acetyl
H
H
H
acetyl
H
acetyl
H


3157
H
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


3158
H
H
H
acetyl
H
H
H
acetyl
acetyl
H
H


3159
H
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


3160
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


3161
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


3162
H
H
H
acetyl
H
H
acetyl
H
H
H
H


3163
H
H
H
acetyl
H
H
acetyl
H
H
H
acetyl


3164
H
H
H
acetyl
H
H
acetyl
H
H
acetyl
H


3165
H
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


3166
H
H
H
acetyl
H
H
acetyl
H
acetyl
H
H


3167
H
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


3168
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


3169
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


3170
H
H
H
acetyl
H
H
acetyl
acetyl
H
H
H


3171
H
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


3172
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


3173
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


3174
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


3175
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


3176
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


3177
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


3178
H
H
H
acetyl
H
acetyl
H
H
H
H
H


3179
H
H
H
acetyl
H
acetyl
H
H
H
H
acetyl


3180
H
H
H
acetyl
H
acetyl
H
H
H
acetyl
H


3181
H
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


3182
H
H
H
acetyl
H
acetyl
H
H
acetyl
H
H


3183
H
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


3184
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


3185
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


3186
H
H
H
acetyl
H
acetyl
H
acetyl
H
H
H


3187
H
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


3188
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


3189
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


3190
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


3191
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


3192
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


3193
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


3194
H
H
H
acetyl
H
acetyl
acetyl
H
H
H
H


3195
H
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


3196
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


3197
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


3198
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


3199
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


3200
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


3201
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


3202
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


3203
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


3204
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


3205
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


3206
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


3207
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


3208
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


3209
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3210
H
H
H
acetyl
acetyl
H
H
H
H
H
H


3211
H
H
H
acetyl
acetyl
H
H
H
H
H
acetyl


3212
H
H
H
acetyl
acetyl
H
H
H
H
acetyl
H


3213
H
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


3214
H
H
H
acetyl
acetyl
H
H
H
acetyl
H
H


3215
H
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


3216
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


3217
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


3218
H
H
H
acetyl
acetyl
H
H
acetyl
H
H
H


3219
H
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


3220
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


3221
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


3222
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


3223
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


3224
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


3225
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


3226
H
H
H
acetyl
acetyl
H
acetyl
H
H
H
H


3227
H
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


3228
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


3229
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


3230
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


3231
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


3232
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


3233
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


3234
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


3235
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


3236
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


3237
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


3238
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


3239
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


3240
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


3241
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


3242
H
H
H
acetyl
acetyl
acetyl
H
H
H
H
H


3243
H
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


3244
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


3245
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


3246
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


3247
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


3248
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


3249
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


3250
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


3251
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


3252
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


3253
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


3254
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


3255
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


3256
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


3257
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


3258
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


3259
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


3260
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


3261
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


3262
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


3263
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


3264
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


3265
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


3266
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


3267
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


3268
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


3269
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


3270
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


3271
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


3272
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


3273
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3274
H
H
acetyl
H
H
H
H
H
H
H
H


3275
H
H
acetyl
H
H
H
H
H
H
H
acetyl


3276
H
H
acetyl
H
H
H
H
H
H
acetyl
H


3277
H
H
acetyl
H
H
H
H
H
H
acetyl
acetyl


3278
H
H
acetyl
H
H
H
H
H
acetyl
H
H


3279
H
H
acetyl
H
H
H
H
H
acetyl
H
acetyl


3280
H
H
acetyl
H
H
H
H
H
acetyl
acetyl
H


3281
H
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


3282
H
H
acetyl
H
H
H
H
acetyl
H
H
H


3283
H
H
acetyl
H
H
H
H
acetyl
H
H
acetyl


3284
H
H
acetyl
H
H
H
H
acetyl
H
acetyl
H


3285
H
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


3286
H
H
acetyl
H
H
H
H
acetyl
acetyl
H
H


3287
H
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


3288
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


3289
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


3290
H
H
acetyl
H
H
H
acetyl
H
H
H
H


3291
H
H
acetyl
H
H
H
acetyl
H
H
H
acetyl


3292
H
H
acetyl
H
H
H
acetyl
H
H
acetyl
H


3293
H
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


3294
H
H
acetyl
H
H
H
acetyl
H
acetyl
H
H


3295
H
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


3296
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


3297
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


3298
H
H
acetyl
H
H
H
acetyl
acetyl
H
H
H


3299
H
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


3300
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


3301
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


3302
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


3303
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


3304
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


3305
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


3306
H
H
acetyl
H
H
acetyl
H
H
H
H
H


3307
H
H
acetyl
H
H
acetyl
H
H
H
H
acetyl


3308
H
H
acetyl
H
H
acetyl
H
H
H
acetyl
H


3309
H
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


3310
H
H
acetyl
H
H
acetyl
H
H
acetyl
H
H


3311
H
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


3312
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


3313
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


3314
H
H
acetyl
H
H
acetyl
H
acetyl
H
H
H


3315
H
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


3316
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


3317
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


3318
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


3319
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


3320
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


3321
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


3322
H
H
acetyl
H
H
acetyl
acetyl
H
H
H
H


3323
H
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


3324
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


3325
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


3326
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


3327
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


3328
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


3329
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


3330
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


3331
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


3332
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


3333
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


3334
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


3335
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


3336
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


3337
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3338
H
H
acetyl
H
acetyl
H
H
H
H
H
H


3339
H
H
acetyl
H
acetyl
H
H
H
H
H
acetyl


3340
H
H
acetyl
H
acetyl
H
H
H
H
acetyl
H


3341
H
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


3342
H
H
acetyl
H
acetyl
H
H
H
acetyl
H
H


3343
H
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


3344
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


3345
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


3346
H
H
acetyl
H
acetyl
H
H
acetyl
H
H
H


3347
H
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


3348
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


3349
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


3350
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


3351
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


3352
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


3353
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


3354
H
H
acetyl
H
acetyl
H
acetyl
H
H
H
H


3355
H
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


3356
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


3357
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


3358
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


3359
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


3360
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


3361
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


3362
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


3363
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


3364
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


3365
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


3366
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


3367
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


3368
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


3369
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


3370
H
H
acetyl
H
acetyl
acetyl
H
H
H
H
H


3371
H
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


3372
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


3373
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


3374
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


3375
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


3376
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


3377
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


3378
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


3379
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


3380
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


3381
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


3382
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


3383
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


3384
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


3385
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


3386
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


3387
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


3388
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


3389
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


3390
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


3391
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


3392
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


3393
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


3394
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


3395
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


3396
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


3397
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


3398
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


3399
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


3400
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


3401
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3402
H
H
acetyl
acetyl
H
H
H
H
H
H
H


3403
H
H
acetyl
acetyl
H
H
H
H
H
H
acetyl


3404
H
H
acetyl
acetyl
H
H
H
H
H
acetyl
H


3405
H
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


3406
H
H
acetyl
acetyl
H
H
H
H
acetyl
H
H


3407
H
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


3408
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


3409
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


3410
H
H
acetyl
acetyl
H
H
H
acetyl
H
H
H


3411
H
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


3412
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


3413
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


3414
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


3415
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


3416
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


3417
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


3418
H
H
acetyl
acetyl
H
H
acetyl
H
H
H
H


3419
H
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


3420
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


3421
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


3422
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


3423
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


3424
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


3425
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


3426
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


3427
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


3428
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


3429
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


3430
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


3431
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


3432
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


3433
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


3434
H
H
acetyl
acetyl
H
acetyl
H
H
H
H
H


3435
H
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


3436
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


3437
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


3438
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


3439
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


3440
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


3441
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


3442
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


3443
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


3444
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


3445
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


3446
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


3447
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


3448
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


3449
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


3450
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


3451
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


3452
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


3453
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


3454
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


3455
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


3456
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


3457
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


3458
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


3459
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


3460
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


3461
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


3462
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


3463
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


3464
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


3465
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3466
H
H
acetyl
acetyl
acetyl
H
H
H
H
H
H


3467
H
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


3468
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


3469
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


3470
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


3471
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


3472
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


3473
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


3474
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


3475
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


3476
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


3477
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


3478
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


3479
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


3480
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


3481
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


3482
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


3483
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


3484
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


3485
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


3486
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


3487
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


3488
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


3489
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


3490
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


3491
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


3492
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


3493
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


3494
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


3495
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


3496
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


3497
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


3498
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


3499
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


3500
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


3501
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


3502
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


3503
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


3504
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


3505
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


3506
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


3507
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


3508
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


3509
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


3510
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


3511
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


3512
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


3513
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


3514
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


3515
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


3516
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


3517
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


3518
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


3519
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


3520
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


3521
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


3522
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


3523
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


3524
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


3525
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


3526
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


3527
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


3528
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


3529
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3530
H
acetyl
H
H
H
H
H
H
H
H
H


3531
H
acetyl
H
H
H
H
H
H
H
H
acetyl


3532
H
acetyl
H
H
H
H
H
H
H
acetyl
H


3533
H
acetyl
H
H
H
H
H
H
H
acetyl
acetyl


3534
H
acetyl
H
H
H
H
H
H
acetyl
H
H


3535
H
acetyl
H
H
H
H
H
H
acetyl
H
acetyl


3536
H
acetyl
H
H
H
H
H
H
acetyl
acetyl
H


3537
H
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl


3538
H
acetyl
H
H
H
H
H
acetyl
H
H
H


3539
H
acetyl
H
H
H
H
H
acetyl
H
H
acetyl


3540
H
acetyl
H
H
H
H
H
acetyl
H
acetyl
H


3541
H
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl


3542
H
acetyl
H
H
H
H
H
acetyl
acetyl
H
H


3543
H
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl


3544
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H


3545
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


3546
H
acetyl
H
H
H
H
acetyl
H
H
H
H


3547
H
acetyl
H
H
H
H
acetyl
H
H
H
acetyl


3548
H
acetyl
H
H
H
H
acetyl
H
H
acetyl
H


3549
H
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl


3550
H
acetyl
H
H
H
H
acetyl
H
acetyl
H
H


3551
H
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl


3552
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H


3553
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


3554
H
acetyl
H
H
H
H
acetyl
acetyl
H
H
H


3555
H
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl


3556
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H


3557
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


3558
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H


3559
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


3560
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


3561
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


3562
H
acetyl
H
H
H
acetyl
H
H
H
H
H


3563
H
acetyl
H
H
H
acetyl
H
H
H
H
acetyl


3564
H
acetyl
H
H
H
acetyl
H
H
H
acetyl
H


3565
H
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl


3566
H
acetyl
H
H
H
acetyl
H
H
acetyl
H
H


3567
H
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl


3568
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H


3569
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


3570
H
acetyl
H
H
H
acetyl
H
acetyl
H
H
H


3571
H
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl


3572
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H


3573
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


3574
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H


3575
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


3576
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


3577
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


3578
H
acetyl
H
H
H
acetyl
acetyl
H
H
H
H


3579
H
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl


3580
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H


3581
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


3582
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H


3583
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


3584
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


3585
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


3586
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H


3587
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


3588
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


3589
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


3590
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


3591
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


3592
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


3593
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3594
H
acetyl
H
H
acetyl
H
H
H
H
H
H


3595
H
acetyl
H
H
acetyl
H
H
H
H
H
acetyl


3596
H
acetyl
H
H
acetyl
H
H
H
H
acetyl
H


3597
H
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl


3598
H
acetyl
H
H
acetyl
H
H
H
acetyl
H
H


3599
H
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl


3600
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H


3601
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


3602
H
acetyl
H
H
acetyl
H
H
acetyl
H
H
H


3603
H
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl


3604
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H


3605
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


3606
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H


3607
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


3608
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


3609
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


3610
H
acetyl
H
H
acetyl
H
acetyl
H
H
H
H


3611
H
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl


3612
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H


3613
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


3614
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H


3615
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


3616
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


3617
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


3618
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H


3619
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


3620
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


3621
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


3622
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


3623
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


3624
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


3625
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


3626
H
acetyl
H
H
acetyl
acetyl
H
H
H
H
H


3627
H
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl


3628
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H


3629
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


3630
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H


3631
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


3632
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


3633
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


3634
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H


3635
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


3636
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


3637
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


3638
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


3639
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


3640
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


3641
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


3642
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H


3643
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


3644
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


3645
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


3646
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


3647
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


3648
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


3649
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


3650
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


3651
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


3652
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


3653
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


3654
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


3655
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


3656
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


3657
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3658
H
acetyl
H
acetyl
H
H
H
H
H
H
H


3659
H
acetyl
H
acetyl
H
H
H
H
H
H
acetyl


3660
H
acetyl
H
acetyl
H
H
H
H
H
acetyl
H


3661
H
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl


3662
H
acetyl
H
acetyl
H
H
H
H
acetyl
H
H


3663
H
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl


3664
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H


3665
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


3666
H
acetyl
H
acetyl
H
H
H
acetyl
H
H
H


3667
H
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl


3668
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H


3669
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


3670
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H


3671
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


3672
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


3673
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


3674
H
acetyl
H
acetyl
H
H
acetyl
H
H
H
H


3675
H
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl


3676
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H


3677
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


3678
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H


3679
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


3680
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


3681
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


3682
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H


3683
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


3684
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


3685
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


3686
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


3687
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


3688
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


3689
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


3690
H
acetyl
H
acetyl
H
acetyl
H
H
H
H
H


3691
H
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl


3692
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H


3693
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


3694
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H


3695
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


3696
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


3697
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


3698
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H


3699
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


3700
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


3701
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


3702
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


3703
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


3704
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


3705
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


3706
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H


3707
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


3708
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


3709
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


3710
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


3711
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


3712
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


3713
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


3714
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


3715
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


3716
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


3717
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


3718
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


3719
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


3720
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


3721
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3722
H
acetyl
H
acetyl
acetyl
H
H
H
H
H
H


3723
H
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl


3724
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H


3725
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


3726
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H


3727
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


3728
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


3729
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


3730
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H


3731
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


3732
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


3733
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


3734
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


3735
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


3736
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


3737
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


3738
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H


3739
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


3740
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


3741
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


3742
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


3743
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


3744
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


3745
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


3746
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


3747
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


3748
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


3749
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


3750
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


3751
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


3752
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


3753
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


3754
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H


3755
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


3756
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


3757
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


3758
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


3759
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


3760
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


3761
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


3762
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


3763
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


3764
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


3765
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


3766
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


3767
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


3768
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


3769
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


3770
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


3771
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


3772
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


3773
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


3774
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


3775
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


3776
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


3777
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


3778
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


3779
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


3780
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


3781
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


3782
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


3783
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


3784
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


3785
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3786
H
acetyl
acetyl
H
H
H
H
H
H
H
H


3787
H
acetyl
acetyl
H
H
H
H
H
H
H
acetyl


3788
H
acetyl
acetyl
H
H
H
H
H
H
acetyl
H


3789
H
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl


3790
H
acetyl
acetyl
H
H
H
H
H
acetyl
H
H


3791
H
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl


3792
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H


3793
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


3794
H
acetyl
acetyl
H
H
H
H
acetyl
H
H
H


3795
H
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl


3796
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H


3797
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


3798
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H


3799
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


3800
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


3801
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


3802
H
acetyl
acetyl
H
H
H
acetyl
H
H
H
H


3803
H
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl


3804
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H


3805
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


3806
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H


3807
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


3808
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


3809
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


3810
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H


3811
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


3812
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


3813
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


3814
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


3815
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


3816
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


3817
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


3818
H
acetyl
acetyl
H
H
acetyl
H
H
H
H
H


3819
H
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl


3820
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H


3821
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


3822
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H


3823
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


3824
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


3825
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


3826
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H


3827
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


3828
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


3829
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


3830
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


3831
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


3832
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


3833
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


3834
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H


3835
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


3836
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


3837
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


3838
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


3839
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


3840
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


3841
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


3842
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


3843
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


3844
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


3845
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


3846
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


3847
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


3848
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


3849
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3850
H
acetyl
acetyl
H
acetyl
H
H
H
H
H
H


3851
H
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl


3852
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H


3853
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


3854
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H


3855
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


3856
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


3857
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


3858
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H


3859
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


3860
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


3861
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


3862
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


3863
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


3864
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


3865
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


3866
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H


3867
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


3868
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


3869
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


3870
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


3871
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


3872
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


3873
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


3874
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


3875
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


3876
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


3877
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


3878
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


3879
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


3880
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


3881
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


3882
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H


3883
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


3884
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


3885
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


3886
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


3887
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


3888
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


3889
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


3890
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


3891
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


3892
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


3893
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


3894
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


3895
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


3896
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


3897
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


3898
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


3899
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


3900
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


3901
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


3902
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


3903
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


3904
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


3905
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


3906
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


3907
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


3908
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


3909
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


3910
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


3911
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


3912
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


3913
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3914
H
acetyl
acetyl
acetyl
H
H
H
H
H
H
H


3915
H
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl


3916
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H


3917
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


3918
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H


3919
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


3920
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


3921
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


3922
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H


3923
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


3924
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


3925
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


3926
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


3927
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


3928
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


3929
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


3930
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H


3931
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


3932
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


3933
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


3934
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


3935
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


3936
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


3937
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


3938
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


3939
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


3940
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


3941
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


3942
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


3943
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


3944
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


3945
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


3946
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H


3947
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


3948
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


3949
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


3950
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


3951
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


3952
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


3953
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


3954
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


3955
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


3956
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


3957
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


3958
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


3959
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


3960
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


3961
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


3962
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


3963
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


3964
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


3965
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


3966
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


3967
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


3968
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


3969
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


3970
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


3971
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


3972
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


3973
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


3974
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


3975
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


3976
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


3977
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


3978
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H


3979
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


3980
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


3981
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


3982
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


3983
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


3984
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


3985
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


3986
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


3987
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


3988
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


3989
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


3990
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


3991
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


3992
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


3993
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


3994
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


3995
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


3996
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


3997
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


3998
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


3999
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


4000
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


4001
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


4002
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


4003
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


4004
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


4005
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


4006
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


4007
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


4008
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


4009
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


4010
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


4011
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


4012
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


4013
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


4014
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


4015
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


4016
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


4017
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


4018
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


4019
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


4020
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


4021
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


4022
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


4023
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


4024
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


4025
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


4026
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


4027
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


4028
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


4029
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


4030
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


4031
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


4032
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


4033
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


4034
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


4035
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


4036
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


4037
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


4038
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


4039
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


4040
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


4041
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4042
acetyl
H
H
H
H
H
H
H
H
H
H


4043
acetyl
H
H
H
H
H
H
H
H
H
acetyl


4044
acetyl
H
H
H
H
H
H
H
H
acetyl
H


4045
acetyl
H
H
H
H
H
H
H
H
acetyl
acetyl


4046
acetyl
H
H
H
H
H
H
H
acetyl
H
H


4047
acetyl
H
H
H
H
H
H
H
acetyl
H
acetyl


4048
acetyl
H
H
H
H
H
H
H
acetyl
acetyl
H


4049
acetyl
H
H
H
H
H
H
H
acetyl
acetyl
acetyl


4050
acetyl
H
H
H
H
H
H
acetyl
H
H
H


4051
acetyl
H
H
H
H
H
H
acetyl
H
H
acetyl


4052
acetyl
H
H
H
H
H
H
acetyl
H
acetyl
H


4053
acetyl
H
H
H
H
H
H
acetyl
H
acetyl
acetyl


4054
acetyl
H
H
H
H
H
H
acetyl
acetyl
H
H


4055
acetyl
H
H
H
H
H
H
acetyl
acetyl
H
acetyl


4056
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl
H


4057
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


4058
acetyl
H
H
H
H
H
acetyl
H
H
H
H


4059
acetyl
H
H
H
H
H
acetyl
H
H
H
acetyl


4060
acetyl
H
H
H
H
H
acetyl
H
H
acetyl
H


4061
acetyl
H
H
H
H
H
acetyl
H
H
acetyl
acetyl


4062
acetyl
H
H
H
H
H
acetyl
H
acetyl
H
H


4063
acetyl
H
H
H
H
H
acetyl
H
acetyl
H
acetyl


4064
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl
H


4065
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


4066
acetyl
H
H
H
H
H
acetyl
acetyl
H
H
H


4067
acetyl
H
H
H
H
H
acetyl
acetyl
H
H
acetyl


4068
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl
H


4069
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


4070
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H
H


4071
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


4072
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


4073
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


4074
acetyl
H
H
H
H
acetyl
H
H
H
H
H


4075
acetyl
H
H
H
H
acetyl
H
H
H
H
acetyl


4076
acetyl
H
H
H
H
acetyl
H
H
H
acetyl
H


4077
acetyl
H
H
H
H
acetyl
H
H
H
acetyl
acetyl


4078
acetyl
H
H
H
H
acetyl
H
H
acetyl
H
H


4079
acetyl
H
H
H
H
acetyl
H
H
acetyl
H
acetyl


4080
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl
H


4081
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


4082
acetyl
H
H
H
H
acetyl
H
acetyl
H
H
H


4083
acetyl
H
H
H
H
acetyl
H
acetyl
H
H
acetyl


4084
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl
H


4085
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


4086
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H
H


4087
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


4088
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


4089
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


4090
acetyl
H
H
H
H
acetyl
acetyl
H
H
H
H


4091
acetyl
H
H
H
H
acetyl
acetyl
H
H
H
acetyl


4092
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl
H


4093
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


4094
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H
H


4095
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


4096
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


4097
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


4098
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H
H


4099
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


4100
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


4101
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


4102
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


4103
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


4104
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


4105
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4106
acetyl
H
H
H
acetyl
H
H
H
H
H
H


4107
acetyl
H
H
H
acetyl
H
H
H
H
H
acetyl


4108
acetyl
H
H
H
acetyl
H
H
H
H
acetyl
H


4109
acetyl
H
H
H
acetyl
H
H
H
H
acetyl
acetyl


4110
acetyl
H
H
H
acetyl
H
H
H
acetyl
H
H


4111
acetyl
H
H
H
acetyl
H
H
H
acetyl
H
acetyl


4112
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl
H


4113
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


4114
acetyl
H
H
H
acetyl
H
H
acetyl
H
H
H


4115
acetyl
H
H
H
acetyl
H
H
acetyl
H
H
acetyl


4116
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl
H


4117
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


4118
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H
H


4119
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


4120
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


4121
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


4122
acetyl
H
H
H
acetyl
H
acetyl
H
H
H
H


4123
acetyl
H
H
H
acetyl
H
acetyl
H
H
H
acetyl


4124
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl
H


4125
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


4126
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H
H


4127
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


4128
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


4129
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


4130
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H
H


4131
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


4132
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


4133
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


4134
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


4135
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


4136
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


4137
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


4138
acetyl
H
H
H
acetyl
acetyl
H
H
H
H
H


4139
acetyl
H
H
H
acetyl
acetyl
H
H
H
H
acetyl


4140
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl
H


4141
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


4142
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H
H


4143
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


4144
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


4145
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


4146
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H
H


4147
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


4148
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


4149
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


4150
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


4151
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


4152
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


4153
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


4154
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H
H


4155
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


4156
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


4157
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


4158
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


4159
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


4160
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


4161
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


4162
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


4163
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


4164
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


4165
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


4166
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


4167
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


4168
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


4169
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4170
acetyl
H
H
acetyl
H
H
H
H
H
H
H


4171
acetyl
H
H
acetyl
H
H
H
H
H
H
acetyl


4172
acetyl
H
H
acetyl
H
H
H
H
H
acetyl
H


4173
acetyl
H
H
acetyl
H
H
H
H
H
acetyl
acetyl


4174
acetyl
H
H
acetyl
H
H
H
H
acetyl
H
H


4175
acetyl
H
H
acetyl
H
H
H
H
acetyl
H
acetyl


4176
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl
H


4177
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


4178
acetyl
H
H
acetyl
H
H
H
acetyl
H
H
H


4179
acetyl
H
H
acetyl
H
H
H
acetyl
H
H
acetyl


4180
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl
H


4181
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


4182
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H
H


4183
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


4184
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


4185
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


4186
acetyl
H
H
acetyl
H
H
acetyl
H
H
H
H


4187
acetyl
H
H
acetyl
H
H
acetyl
H
H
H
acetyl


4188
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl
H


4189
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


4190
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H
H


4191
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


4192
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


4193
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


4194
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H
H


4195
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


4196
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


4197
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


4198
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


4199
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


4200
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


4201
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


4202
acetyl
H
H
acetyl
H
acetyl
H
H
H
H
H


4203
acetyl
H
H
acetyl
H
acetyl
H
H
H
H
acetyl


4204
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl
H


4205
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


4206
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H
H


4207
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


4208
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


4209
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


4210
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H
H


4211
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


4212
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


4213
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


4214
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


4215
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


4216
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


4217
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


4218
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H
H


4219
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


4220
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


4221
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


4222
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


4223
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


4224
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


4225
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


4226
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


4227
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


4228
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


4229
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


4230
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


4231
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


4232
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


4233
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4234
acetyl
H
H
acetyl
acetyl
H
H
H
H
H
H


4235
acetyl
H
H
acetyl
acetyl
H
H
H
H
H
acetyl


4236
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl
H


4237
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


4238
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H
H


4239
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


4240
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


4241
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


4242
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H
H


4243
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


4244
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


4245
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


4246
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


4247
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


4248
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


4249
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


4250
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H
H


4251
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


4252
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


4253
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


4254
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


4255
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


4256
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


4257
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


4258
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


4259
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


4260
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


4261
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


4262
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


4263
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


4264
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


4265
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


4266
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H
H


4267
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


4268
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


4269
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


4270
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


4271
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


4272
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


4273
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


4274
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


4275
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


4276
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


4277
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


4278
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


4279
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


4280
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


4281
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


4282
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


4283
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


4284
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


4285
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


4286
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


4287
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


4288
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


4289
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


4290
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


4291
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


4292
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


4293
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


4294
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


4295
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


4296
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


4297
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4298
acetyl
H
acetyl
H
H
H
H
H
H
H
H


4299
acetyl
H
acetyl
H
H
H
H
H
H
H
acetyl


4300
acetyl
H
acetyl
H
H
H
H
H
H
acetyl
H


4301
acetyl
H
acetyl
H
H
H
H
H
H
acetyl
acetyl


4302
acetyl
H
acetyl
H
H
H
H
H
acetyl
H
H


4303
acetyl
H
acetyl
H
H
H
H
H
acetyl
H
acetyl


4304
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl
H


4305
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


4306
acetyl
H
acetyl
H
H
H
H
acetyl
H
H
H


4307
acetyl
H
acetyl
H
H
H
H
acetyl
H
H
acetyl


4308
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl
H


4309
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


4310
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H
H


4311
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


4312
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


4313
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


4314
acetyl
H
acetyl
H
H
H
acetyl
H
H
H
H


4315
acetyl
H
acetyl
H
H
H
acetyl
H
H
H
acetyl


4316
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl
H


4317
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


4318
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H
H


4319
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


4320
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


4321
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


4322
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H
H


4323
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


4324
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


4325
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


4326
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


4327
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


4328
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


4329
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


4330
acetyl
H
acetyl
H
H
acetyl
H
H
H
H
H


4331
acetyl
H
acetyl
H
H
acetyl
H
H
H
H
acetyl


4332
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl
H


4333
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


4334
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H
H


4335
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


4336
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


4337
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


4338
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H
H


4339
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


4340
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


4341
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


4342
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


4343
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


4344
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


4345
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


4346
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H
H


4347
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


4348
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


4349
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


4350
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


4351
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


4352
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


4353
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


4354
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


4355
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


4356
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


4357
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


4358
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


4359
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


4360
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


4361
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4362
acetyl
H
acetyl
H
acetyl
H
H
H
H
H
H


4363
acetyl
H
acetyl
H
acetyl
H
H
H
H
H
acetyl


4364
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl
H


4365
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


4366
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H
H


4367
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


4368
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


4369
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


4370
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H
H


4371
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


4372
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


4373
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


4374
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


4375
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


4376
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


4377
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


4378
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H
H


4379
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


4380
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


4381
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


4382
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


4383
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


4384
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


4385
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


4386
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


4387
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


4388
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


4389
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


4390
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


4391
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


4392
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


4393
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


4394
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H
H


4395
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


4396
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


4397
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


4398
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


4399
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


4400
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


4401
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


4402
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


4403
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


4404
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


4405
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


4406
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


4407
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


4408
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


4409
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


4410
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


4411
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


4412
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


4413
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


4414
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


4415
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


4416
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


4417
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


4418
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


4419
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


4420
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


4421
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


4422
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


4423
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


4424
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


4425
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4426
acetyl
H
acetyl
acetyl
H
H
H
H
H
H
H


4427
acetyl
H
acetyl
acetyl
H
H
H
H
H
H
acetyl


4428
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl
H


4429
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


4430
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H
H


4431
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


4432
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


4433
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


4434
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H
H


4435
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


4436
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


4437
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


4438
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


4439
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


4440
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


4441
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


4442
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H
H


4443
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


4444
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


4445
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


4446
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


4447
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


4448
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


4449
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


4450
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


4451
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


4452
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


4453
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


4454
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


4455
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


4456
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


4457
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


4458
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H
H


4459
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


4460
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


4461
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


4462
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


4463
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


4464
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


4465
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


4466
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


4467
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


4468
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


4469
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


4470
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


4471
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


4472
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


4473
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


4474
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


4475
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


4476
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


4477
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


4478
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


4479
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


4480
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


4481
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


4482
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


4483
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


4484
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


4485
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


4486
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


4487
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


4488
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


4489
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4490
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H
H


4491
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


4492
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


4493
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


4494
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


4495
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


4496
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


4497
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


4498
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


4499
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


4500
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


4501
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


4502
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


4503
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


4504
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


4505
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


4506
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


4507
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


4508
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


4509
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


4510
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


4511
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


4512
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


4513
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


4514
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


4515
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


4516
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


4517
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


4518
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


4519
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


4520
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


4521
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


4522
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


4523
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


4524
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


4525
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


4526
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


4527
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


4528
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


4529
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


4530
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


4531
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


4532
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


4533
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


4534
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


4535
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


4536
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


4537
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


4538
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


4539
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


4540
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


4541
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


4542
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


4543
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


4544
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


4545
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


4546
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


4547
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


4548
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


4549
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


4550
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


4551
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


4552
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


4553
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4554
acetyl
acetyl
H
H
H
H
H
H
H
H
H


4555
acetyl
acetyl
H
H
H
H
H
H
H
H
acetyl


4556
acetyl
acetyl
H
H
H
H
H
H
H
acetyl
H


4557
acetyl
acetyl
H
H
H
H
H
H
H
acetyl
acetyl


4558
acetyl
acetyl
H
H
H
H
H
H
acetyl
H
H


4559
acetyl
acetyl
H
H
H
H
H
H
acetyl
H
acetyl


4560
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl
H


4561
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl


4562
acetyl
acetyl
H
H
H
H
H
acetyl
H
H
H


4563
acetyl
acetyl
H
H
H
H
H
acetyl
H
H
acetyl


4564
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl
H


4565
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl


4566
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H
H


4567
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl


4568
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H


4569
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


4570
acetyl
acetyl
H
H
H
H
acetyl
H
H
H
H


4571
acetyl
acetyl
H
H
H
H
acetyl
H
H
H
acetyl


4572
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl
H


4573
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl


4574
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H
H


4575
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl


4576
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H


4577
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


4578
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H
H


4579
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl


4580
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H


4581
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


4582
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H


4583
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


4584
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


4585
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


4586
acetyl
acetyl
H
H
H
acetyl
H
H
H
H
H


4587
acetyl
acetyl
H
H
H
acetyl
H
H
H
H
acetyl


4588
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl
H


4589
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl


4590
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H
H


4591
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl


4592
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H


4593
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


4594
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H
H


4595
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl


4596
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H


4597
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


4598
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H


4599
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


4600
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


4601
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


4602
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H
H


4603
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl


4604
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H


4605
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


4606
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H


4607
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


4608
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


4609
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


4610
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H


4611
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


4612
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


4613
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


4614
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


4615
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


4616
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


4617
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4618
acetyl
acetyl
H
H
acetyl
H
H
H
H
H
H


4619
acetyl
acetyl
H
H
acetyl
H
H
H
H
H
acetyl


4620
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl
H


4621
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl


4622
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H
H


4623
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl


4624
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H


4625
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


4626
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H
H


4627
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl


4628
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H


4629
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


4630
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H


4631
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


4632
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


4633
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


4634
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H
H


4635
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl


4636
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H


4637
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


4638
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H


4639
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


4640
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


4641
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


4642
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H


4643
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


4644
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


4645
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


4646
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


4647
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


4648
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


4649
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


4650
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H
H


4651
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl


4652
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H


4653
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


4654
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H


4655
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


4656
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


4657
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


4658
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H


4659
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


4660
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


4661
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


4662
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


4663
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


4664
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


4665
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


4666
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H


4667
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


4668
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


4669
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


4670
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


4671
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


4672
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


4673
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


4674
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


4675
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


4676
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


4677
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


4678
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


4679
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


4680
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


4681
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4682
acetyl
acetyl
H
acetyl
H
H
H
H
H
H
H


4683
acetyl
acetyl
H
acetyl
H
H
H
H
H
H
acetyl


4684
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl
H


4685
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl


4686
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H
H


4687
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl


4688
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H


4689
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


4690
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H
H


4691
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl


4692
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H


4693
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


4694
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H


4695
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


4696
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


4697
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


4698
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H
H


4699
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl


4700
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H


4701
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


4702
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H


4703
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


4704
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


4705
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


4706
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H


4707
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


4708
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


4709
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


4710
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


4711
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


4712
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


4713
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


4714
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H
H


4715
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl


4716
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H


4717
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


4718
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H


4719
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


4720
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


4721
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


4722
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H


4723
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


4724
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


4725
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


4726
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


4727
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


4728
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


4729
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


4730
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H


4731
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


4732
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


4733
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


4734
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


4735
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


4736
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


4737
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


4738
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


4739
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


4740
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


4741
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


4742
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


4743
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


4744
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


4745
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4746
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H
H


4747
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl


4748
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H


4749
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


4750
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H


4751
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


4752
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


4753
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


4754
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H


4755
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


4756
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


4757
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


4758
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


4759
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


4760
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


4761
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


4762
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H


4763
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


4764
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


4765
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


4766
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


4767
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


4768
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


4769
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


4770
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


4771
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


4772
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


4773
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


4774
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


4775
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


4776
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


4777
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


4778
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H


4779
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


4780
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


4781
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


4782
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


4783
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


4784
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


4785
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


4786
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


4787
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


4788
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


4789
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


4790
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


4791
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


4792
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


4793
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


4794
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


4795
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


4796
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


4797
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


4798
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


4799
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


4800
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


4801
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


4802
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


4803
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


4804
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


4805
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


4806
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


4807
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


4808
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


4809
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4810
acetyl
acetyl
acetyl
H
H
H
H
H
H
H
H


4811
acetyl
acetyl
acetyl
H
H
H
H
H
H
H
acetyl


4812
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl
H


4813
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl


4814
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H
H


4815
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl


4816
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H


4817
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


4818
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H
H


4819
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl


4820
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H


4821
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


4822
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H


4823
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


4824
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


4825
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


4826
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H
H


4827
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl


4828
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H


4829
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


4830
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H


4831
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


4832
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


4833
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


4834
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H


4835
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


4836
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


4837
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


4838
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


4839
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


4840
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


4841
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


4842
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H
H


4843
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl


4844
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H


4845
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


4846
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H


4847
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


4848
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


4849
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


4850
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H


4851
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


4852
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


4853
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


4854
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


4855
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


4856
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


4857
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


4858
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H


4859
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


4860
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


4861
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


4862
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


4863
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


4864
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


4865
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


4866
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


4867
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


4868
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


4869
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


4870
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


4871
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


4872
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


4873
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4874
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H
H


4875
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl


4876
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H


4877
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


4878
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H


4879
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


4880
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


4881
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


4882
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H


4883
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


4884
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


4885
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


4886
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


4887
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


4888
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


4889
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


4890
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H


4891
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


4892
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


4893
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


4894
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


4895
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


4896
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


4897
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


4898
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


4899
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


4900
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


4901
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


4902
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


4903
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


4904
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


4905
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


4906
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H


4907
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


4908
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


4909
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


4910
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


4911
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


4912
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


4913
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


4914
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


4915
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


4916
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


4917
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


4918
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


4919
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


4920
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


4921
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


4922
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


4923
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


4924
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


4925
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


4926
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


4927
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


4928
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


4929
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


4930
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


4931
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


4932
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


4933
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


4934
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


4935
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


4936
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


4937
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


4938
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H
H


4939
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl


4940
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H


4941
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


4942
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H


4943
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


4944
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


4945
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


4946
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H


4947
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


4948
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


4949
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


4950
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


4951
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


4952
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


4953
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


4954
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H


4955
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


4956
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


4957
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


4958
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


4959
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


4960
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


4961
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


4962
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


4963
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


4964
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


4965
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


4966
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


4967
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


4968
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


4969
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


4970
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H


4971
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


4972
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


4973
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


4974
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


4975
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


4976
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


4977
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


4978
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


4979
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


4980
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


4981
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


4982
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


4983
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


4984
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


4985
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


4986
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


4987
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


4988
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


4989
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


4990
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


4991
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


4992
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


4993
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


4994
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


4995
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


4996
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


4997
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


4998
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


4999
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


5000
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


5001
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5002
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H


5003
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


5004
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


5005
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


5006
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


5007
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


5008
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


5009
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


5010
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


5011
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


5012
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


5013
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


5014
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


5015
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


5016
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


5017
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


5018
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


5019
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


5020
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


5021
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


5022
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


5023
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


5024
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


5025
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


5026
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


5027
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


5028
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


5029
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


5030
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


5031
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


5032
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


5033
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


5034
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


5035
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


5036
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


5037
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


5038
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


5039
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


5040
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


5041
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


5042
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


5043
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


5044
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


5045
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


5046
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


5047
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


5048
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


5049
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


5050
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


5051
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


5052
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


5053
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


5054
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


5055
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


5056
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


5057
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


5058
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


5059
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


5060
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


5061
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


5062
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


5063
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


5064
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
















TABLE 9







(duodecasaccharides) (Y is either H or a carrier)






























n10;
n11,



R2
n1, R1
n2, R1
n3, R1
n4, R1
n5, R1
n6, R1
n7, R1
n8, R1
n9, R1
R1
R1























5065
H
H
H
H
H
H
H
H
H
H
H
acetyl


5066
H
H
H
H
H
H
H
H
H
H
acetyl
H


5067
H
H
H
H
H
H
H
H
H
H
acetyl
acetyl


5068
H
H
H
H
H
H
H
H
H
acetyl
H
H


5069
H
H
H
H
H
H
H
H
H
acetyl
H
acetyl


5070
H
H
H
H
H
H
H
H
H
acetyl
acetyl
H


5071
H
H
H
H
H
H
H
H
H
acetyl
acetyl
acetyl


5072
H
H
H
H
H
H
H
H
acetyl
H
H
H


5073
H
H
H
H
H
H
H
H
acetyl
H
H
acetyl


5074
H
H
H
H
H
H
H
H
acetyl
H
acetyl
H


5075
H
H
H
H
H
H
H
H
acetyl
H
acetyl
acetyl


5076
H
H
H
H
H
H
H
H
acetyl
acetyl
H
H


5077
H
H
H
H
H
H
H
H
acetyl
acetyl
H
Acetyl


5078
H
H
H
H
H
H
H
H
acetyl
acetyl
acetyl
H


5079
H
H
H
H
H
H
H
H
acetyl
acetyl
acetyl
Acetyl


5080
H
H
H
H
H
H
H
acetyl
H
H
H
H


5081
H
H
H
H
H
H
H
acetyl
H
H
H
Acetyl


5082
H
H
H
H
H
H
H
acetyl
H
H
acetyl
H


5083
H
H
H
H
H
H
H
acetyl
H
H
acetyl
acetyl


5084
H
H
H
H
H
H
H
acetyl
H
acetyl
H
H


5085
H
H
H
H
H
H
H
acetyl
H
acetyl
H
acetyl


5086
H
H
H
H
H
H
H
acetyl
H
acetyl
acetyl
H


5087
H
H
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


5088
H
H
H
H
H
H
H
acetyl
acetyl
H
H
H


5089
H
H
H
H
H
H
H
acetyl
acetyl
H
H
acetyl


5090
H
H
H
H
H
H
H
acetyl
acetyl
H
acetyl
H


5091
H
H
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


5092
H
H
H
H
H
H
H
acetyl
acetyl
acetyl
H
H


5093
H
H
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


5094
H
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


5095
H
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


5096
H
H
H
H
H
H
acetyl
H
H
H
H
H


5097
H
H
H
H
H
H
acetyl
H
H
H
H
acetyl


5098
H
H
H
H
H
H
acetyl
H
H
H
acetyl
H


5099
H
H
H
H
H
H
acetyl
H
H
H
acetyl
acetyl


5100
H
H
H
H
H
H
acetyl
H
H
acetyl
H
H


5101
H
H
H
H
H
H
acetyl
H
H
acetyl
H
acetyl


5102
H
H
H
H
H
H
acetyl
H
H
acetyl
acetyl
H


5103
H
H
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


5104
H
H
H
H
H
H
acetyl
H
acetyl
H
H
H


5105
H
H
H
H
H
H
acetyl
H
acetyl
H
H
acetyl


5106
H
H
H
H
H
H
acetyl
H
acetyl
H
acetyl
H


5107
H
H
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


5108
H
H
H
H
H
H
acetyl
H
acetyl
acetyl
H
H


5109
H
H
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


5110
H
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


5111
H
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


5112
H
H
H
H
H
H
acetyl
acetyl
H
H
H
H


5113
H
H
H
H
H
H
acetyl
acetyl
H
H
H
acetyl


5114
H
H
H
H
H
H
acetyl
acetyl
H
H
acetyl
H


5115
H
H
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


5116
H
H
H
H
H
H
acetyl
acetyl
H
acetyl
H
H


5117
H
H
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


5118
H
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


5119
H
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


5120
H
H
H
H
H
H
acetyl
acetyl
acetyl
H
H
H


5121
H
H
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


5122
H
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


5123
H
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


5124
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


5125
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


5126
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


5127
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5128
H
H
H
H
H
acetyl
H
H
H
H
H
H


5129
H
H
H
H
H
acetyl
H
H
H
H
H
acetyl


5130
H
H
H
H
H
acetyl
H
H
H
H
acetyl
H


5131
H
H
H
H
H
acetyl
H
H
H
H
acetyl
acetyl


5132
H
H
H
H
H
acetyl
H
H
H
acetyl
H
H


5133
H
H
H
H
H
acetyl
H
H
H
acetyl
H
acetyl


5134
H
H
H
H
H
acetyl
H
H
H
acetyl
acetyl
H


5135
H
H
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


5136
H
H
H
H
H
acetyl
H
H
acetyl
H
H
H


5137
H
H
H
H
H
acetyl
H
H
acetyl
H
H
acetyl


5138
H
H
H
H
H
acetyl
H
H
acetyl
H
acetyl
H


5139
H
H
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


5140
H
H
H
H
H
acetyl
H
H
acetyl
acetyl
H
H


5141
H
H
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


5142
H
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


5143
H
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


5144
H
H
H
H
H
acetyl
H
acetyl
H
H
H
H


5145
H
H
H
H
H
acetyl
H
acetyl
H
H
H
acetyl


5146
H
H
H
H
H
acetyl
H
acetyl
H
H
acetyl
H


5147
H
H
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


5148
H
H
H
H
H
acetyl
H
acetyl
H
acetyl
H
H


5149
H
H
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


5150
H
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


5151
H
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


5152
H
H
H
H
H
acetyl
H
acetyl
acetyl
H
H
H


5153
H
H
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


5154
H
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


5155
H
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


5156
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


5157
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


5158
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


5159
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


5160
H
H
H
H
H
acetyl
acetyl
H
H
H
H
H


5161
H
H
H
H
H
acetyl
acetyl
H
H
H
H
acetyl


5162
H
H
H
H
H
acetyl
acetyl
H
H
H
acetyl
H


5163
H
H
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


5164
H
H
H
H
H
acetyl
acetyl
H
H
acetyl
H
H


5165
H
H
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


5166
H
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


5167
H
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


5168
H
H
H
H
H
acetyl
acetyl
H
acetyl
H
H
H


5169
H
H
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


5170
H
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


5171
H
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


5172
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


5173
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


5174
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


5175
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


5176
H
H
H
H
H
acetyl
acetyl
acetyl
H
H
H
H


5177
H
H
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


5178
H
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


5179
H
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


5180
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


5181
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


5182
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


5183
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


5184
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


5185
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


5186
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


5187
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


5188
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


5189
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


5190
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


5191
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5192
H
H
H
H
acetyl
H
H
H
H
H
H
H


5193
H
H
H
H
acetyl
H
H
H
H
H
H
acetyl


5194
H
H
H
H
acetyl
H
H
H
H
H
acetyl
H


5195
H
H
H
H
acetyl
H
H
H
H
H
acetyl
acetyl


5196
H
H
H
H
acetyl
H
H
H
H
acetyl
H
H


5197
H
H
H
H
acetyl
H
H
H
H
acetyl
H
acetyl


5198
H
H
H
H
acetyl
H
H
H
H
acetyl
acetyl
H


5199
H
H
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


5200
H
H
H
H
acetyl
H
H
H
acetyl
H
H
H


5201
H
H
H
H
acetyl
H
H
H
acetyl
H
H
acetyl


5202
H
H
H
H
acetyl
H
H
H
acetyl
H
acetyl
H


5203
H
H
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


5204
H
H
H
H
acetyl
H
H
H
acetyl
acetyl
H
H


5205
H
H
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


5206
H
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


5207
H
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


5208
H
H
H
H
acetyl
H
H
acetyl
H
H
H
H


5209
H
H
H
H
acetyl
H
H
acetyl
H
H
H
acetyl


5210
H
H
H
H
acetyl
H
H
acetyl
H
H
acetyl
H


5211
H
H
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


5212
H
H
H
H
acetyl
H
H
acetyl
H
acetyl
H
H


5213
H
H
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


5214
H
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


5215
H
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


5216
H
H
H
H
acetyl
H
H
acetyl
acetyl
H
H
H


5217
H
H
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


5218
H
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


5219
H
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


5220
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


5221
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


5222
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


5223
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


5224
H
H
H
H
acetyl
H
acetyl
H
H
H
H
H


5225
H
H
H
H
acetyl
H
acetyl
H
H
H
H
acetyl


5226
H
H
H
H
acetyl
H
acetyl
H
H
H
acetyl
H


5227
H
H
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


5228
H
H
H
H
acetyl
H
acetyl
H
H
acetyl
H
H


5229
H
H
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


5230
H
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


5231
H
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


5232
H
H
H
H
acetyl
H
acetyl
H
acetyl
H
H
H


5233
H
H
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


5234
H
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


5235
H
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


5236
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


5237
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


5238
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


5239
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


5240
H
H
H
H
acetyl
H
acetyl
acetyl
H
H
H
H


5241
H
H
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


5242
H
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


5243
H
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


5244
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


5245
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


5246
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


5247
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


5248
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


5249
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


5250
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


5251
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


5252
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


5253
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


5254
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


5255
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5256
H
H
H
H
acetyl
acetyl
H
H
H
H
H
H


5257
H
H
H
H
acetyl
acetyl
H
H
H
H
H
acetyl


5258
H
H
H
H
acetyl
acetyl
H
H
H
H
acetyl
H


5259
H
H
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


5260
H
H
H
H
acetyl
acetyl
H
H
H
acetyl
H
H


5261
H
H
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


5262
H
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


5263
H
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


5264
H
H
H
H
acetyl
acetyl
H
H
acetyl
H
H
H


5265
H
H
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


5266
H
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


5267
H
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


5268
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


5269
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


5270
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


5271
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


5272
H
H
H
H
acetyl
acetyl
H
acetyl
H
H
H
H


5273
H
H
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


5274
H
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


5275
H
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


5276
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


5277
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


5278
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


5279
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


5280
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


5281
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


5282
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


5283
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


5284
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


5285
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


5286
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


5287
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


5288
H
H
H
H
acetyl
acetyl
acetyl
H
H
H
H
H


5289
H
H
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


5290
H
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


5291
H
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


5292
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


5293
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


5294
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


5295
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


5296
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


5297
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


5298
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


5299
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


5300
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


5301
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


5302
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


5303
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


5304
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


5305
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


5306
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


5307
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


5308
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


5309
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


5310
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


5311
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


5312
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


5313
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


5314
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


5315
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


5316
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


5317
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


5318
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


5319
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5320
H
H
H
acetyl
H
H
H
H
H
H
H
H


5321
H
H
H
acetyl
H
H
H
H
H
H
H
acetyl


5322
H
H
H
acetyl
H
H
H
H
H
H
acetyl
H


5323
H
H
H
acetyl
H
H
H
H
H
H
acetyl
acetyl


5324
H
H
H
acetyl
H
H
H
H
H
acetyl
H
H


5325
H
H
H
acetyl
H
H
H
H
H
acetyl
H
acetyl


5326
H
H
H
acetyl
H
H
H
H
H
acetyl
acetyl
H


5327
H
H
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


5328
H
H
H
acetyl
H
H
H
H
acetyl
H
H
H


5329
H
H
H
acetyl
H
H
H
H
acetyl
H
H
acetyl


5330
H
H
H
acetyl
H
H
H
H
acetyl
H
acetyl
H


5331
H
H
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


5332
H
H
H
acetyl
H
H
H
H
acetyl
acetyl
H
H


5333
H
H
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


5334
H
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


5335
H
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


5336
H
H
H
acetyl
H
H
H
acetyl
H
H
H
H


5337
H
H
H
acetyl
H
H
H
acetyl
H
H
H
acetyl


5338
H
H
H
acetyl
H
H
H
acetyl
H
H
acetyl
H


5339
H
H
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


5340
H
H
H
acetyl
H
H
H
acetyl
H
acetyl
H
H


5341
H
H
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


5342
H
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


5343
H
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


5344
H
H
H
acetyl
H
H
H
acetyl
acetyl
H
H
H


5345
H
H
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


5346
H
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


5347
H
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


5348
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


5349
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


5350
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


5351
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


5352
H
H
H
acetyl
H
H
acetyl
H
H
H
H
H


5353
H
H
H
acetyl
H
H
acetyl
H
H
H
H
acetyl


5354
H
H
H
acetyl
H
H
acetyl
H
H
H
acetyl
H


5355
H
H
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


5356
H
H
H
acetyl
H
H
acetyl
H
H
acetyl
H
H


5357
H
H
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


5358
H
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


5359
H
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


5360
H
H
H
acetyl
H
H
acetyl
H
acetyl
H
H
H


5361
H
H
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


5362
H
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


5363
H
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


5364
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


5365
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


5366
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


5367
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


5368
H
H
H
acetyl
H
H
acetyl
acetyl
H
H
H
H


5369
H
H
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


5370
H
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


5371
H
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


5372
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


5373
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


5374
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


5375
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


5376
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


5377
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


5378
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


5379
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


5380
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


5381
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


5382
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


5383
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5384
H
H
H
acetyl
H
acetyl
H
H
H
H
H
H


5385
H
H
H
acetyl
H
acetyl
H
H
H
H
H
acetyl


5386
H
H
H
acetyl
H
acetyl
H
H
H
H
acetyl
H


5387
H
H
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


5388
H
H
H
acetyl
H
acetyl
H
H
H
acetyl
H
H


5389
H
H
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


5390
H
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


5391
H
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


5392
H
H
H
acetyl
H
acetyl
H
H
acetyl
H
H
H


5393
H
H
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


5394
H
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


5395
H
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


5396
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


5397
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


5398
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


5399
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


5400
H
H
H
acetyl
H
acetyl
H
acetyl
H
H
H
H


5401
H
H
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


5402
H
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


5403
H
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


5404
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


5405
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


5406
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


5407
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


5408
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


5409
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


5410
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


5411
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


5412
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


5413
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


5414
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


5415
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


5416
H
H
H
acetyl
H
acetyl
acetyl
H
H
H
H
H


5417
H
H
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


5418
H
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


5419
H
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


5420
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


5421
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


5422
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


5423
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


5424
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


5425
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


5426
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


5427
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


5428
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


5429
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


5430
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


5431
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


5432
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


5433
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


5434
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


5435
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


5436
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


5437
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


5438
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


5439
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


5440
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


5441
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


5442
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


5443
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


5444
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


5445
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


5446
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


5447
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5448
H
H
H
acetyl
acetyl
H
H
H
H
H
H
H


5449
H
H
H
acetyl
acetyl
H
H
H
H
H
H
acetyl


5450
H
H
H
acetyl
acetyl
H
H
H
H
H
acetyl
H


5451
H
H
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


5452
H
H
H
acetyl
acetyl
H
H
H
H
acetyl
H
H


5453
H
H
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


5454
H
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


5455
H
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


5456
H
H
H
acetyl
acetyl
H
H
H
acetyl
H
H
H


5457
H
H
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


5458
H
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


5459
H
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


5460
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


5461
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


5462
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


5463
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


5464
H
H
H
acetyl
acetyl
H
H
acetyl
H
H
H
H


5465
H
H
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


5466
H
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


5467
H
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


5468
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


5469
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


5470
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


5471
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


5472
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


5473
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


5474
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


5475
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


5476
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


5477
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


5478
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


5479
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


5480
H
H
H
acetyl
acetyl
H
acetyl
H
H
H
H
H


5481
H
H
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


5482
H
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


5483
H
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


5484
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


5485
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


5486
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


5487
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


5488
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


5489
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


5490
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


5491
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


5492
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


5493
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


5494
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


5495
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


5496
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


5497
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


5498
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


5499
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


5500
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


5501
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


5502
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


5503
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


5504
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


5505
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


5506
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


5507
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


5508
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


5509
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


5510
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


5511
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5512
H
H
H
acetyl
acetyl
acetyl
H
H
H
H
H
H


5513
H
H
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


5514
H
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


5515
H
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


5516
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


5517
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


5518
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


5519
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


5520
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


5521
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


5522
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


5523
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


5524
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


5525
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


5526
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


5527
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


5528
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


5529
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


5530
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


5531
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


5532
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


5533
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


5534
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


5535
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


5536
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


5537
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


5538
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


5539
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


5540
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


5541
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


5542
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


5543
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


5544
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


5545
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


5546
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


5547
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


5548
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


5549
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


5550
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


5551
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


5552
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


5553
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


5554
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


5555
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


5556
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


5557
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


5558
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


5559
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


5560
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


5561
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


5562
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


5563
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


5564
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


5565
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


5566
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


5567
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


5568
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


5569
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


5570
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


5571
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


5572
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


5573
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


5574
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


5575
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5576
H
H
acetyl
H
H
H
H
H
H
H
H
H


5577
H
H
acetyl
H
H
H
H
H
H
H
H
acetyl


5578
H
H
acetyl
H
H
H
H
H
H
H
acetyl
H


5579
H
H
acetyl
H
H
H
H
H
H
H
acetyl
acetyl


5580
H
H
acetyl
H
H
H
H
H
H
acetyl
H
H


5581
H
H
acetyl
H
H
H
H
H
H
acetyl
H
acetyl


5582
H
H
acetyl
H
H
H
H
H
H
acetyl
acetyl
H


5583
H
H
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl


5584
H
H
acetyl
H
H
H
H
H
acetyl
H
H
H


5585
H
H
acetyl
H
H
H
H
H
acetyl
H
H
acetyl


5586
H
H
acetyl
H
H
H
H
H
acetyl
H
acetyl
H


5587
H
H
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl


5588
H
H
acetyl
H
H
H
H
H
acetyl
acetyl
H
H


5589
H
H
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl


5590
H
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H


5591
H
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


5592
H
H
acetyl
H
H
H
H
acetyl
H
H
H
H


5593
H
H
acetyl
H
H
H
H
acetyl
H
H
H
acetyl


5594
H
H
acetyl
H
H
H
H
acetyl
H
H
acetyl
H


5595
H
H
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl


5596
H
H
acetyl
H
H
H
H
acetyl
H
acetyl
H
H


5597
H
H
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl


5598
H
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H


5599
H
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


5600
H
H
acetyl
H
H
H
H
acetyl
acetyl
H
H
H


5601
H
H
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl


5602
H
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H


5603
H
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


5604
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H


5605
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


5606
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


5607
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


5608
H
H
acetyl
H
H
H
acetyl
H
H
H
H
H


5609
H
H
acetyl
H
H
H
acetyl
H
H
H
H
acetyl


5610
H
H
acetyl
H
H
H
acetyl
H
H
H
acetyl
H


5611
H
H
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl


5612
H
H
acetyl
H
H
H
acetyl
H
H
acetyl
H
H


5613
H
H
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl


5614
H
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H


5615
H
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


5616
H
H
acetyl
H
H
H
acetyl
H
acetyl
H
H
H


5617
H
H
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl


5618
H
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H


5619
H
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


5620
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H


5621
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


5622
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


5623
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


5624
H
H
acetyl
H
H
H
acetyl
acetyl
H
H
H
H


5625
H
H
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl


5626
H
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H


5627
H
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


5628
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H


5629
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


5630
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


5631
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


5632
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H


5633
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


5634
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


5635
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


5636
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


5637
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


5638
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


5639
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5640
H
H
acetyl
H
H
acetyl
H
H
H
H
H
H


5641
H
H
acetyl
H
H
acetyl
H
H
H
H
H
acetyl


5642
H
H
acetyl
H
H
acetyl
H
H
H
H
acetyl
H


5643
H
H
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl


5644
H
H
acetyl
H
H
acetyl
H
H
H
acetyl
H
H


5645
H
H
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl


5646
H
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H


5647
H
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


5648
H
H
acetyl
H
H
acetyl
H
H
acetyl
H
H
H


5649
H
H
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl


5650
H
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H


5651
H
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


5652
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H


5653
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


5654
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


5655
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


5656
H
H
acetyl
H
H
acetyl
H
acetyl
H
H
H
H


5657
H
H
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl


5658
H
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H


5659
H
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


5660
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H


5661
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


5662
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


5663
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


5664
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H


5665
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


5666
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


5667
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


5668
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


5669
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


5670
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


5671
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


5672
H
H
acetyl
H
H
acetyl
acetyl
H
H
H
H
H


5673
H
H
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl


5674
H
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H


5675
H
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


5676
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H


5677
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


5678
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


5679
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


5680
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H


5681
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


5682
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


5683
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


5684
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


5685
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


5686
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


5687
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


5688
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H


5689
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


5690
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


5691
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


5692
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


5693
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


5694
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


5695
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


5696
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


5697
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


5698
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


5699
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


5700
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


5701
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


5702
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


5703
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5704
H
H
acetyl
H
acetyl
H
H
H
H
H
H
H


5705
H
H
acetyl
H
acetyl
H
H
H
H
H
H
acetyl


5706
H
H
acetyl
H
acetyl
H
H
H
H
H
acetyl
H


5707
H
H
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl


5708
H
H
acetyl
H
acetyl
H
H
H
H
acetyl
H
H


5709
H
H
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl


5710
H
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H


5711
H
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


5712
H
H
acetyl
H
acetyl
H
H
H
acetyl
H
H
H


5713
H
H
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl


5714
H
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H


5715
H
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


5716
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H


5717
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


5718
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


5719
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


5720
H
H
acetyl
H
acetyl
H
H
acetyl
H
H
H
H


5721
H
H
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl


5722
H
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H


5723
H
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


5724
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H


5725
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


5726
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


5727
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


5728
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H


5729
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


5730
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


5731
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


5732
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


5733
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


5734
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


5735
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


5736
H
H
acetyl
H
acetyl
H
acetyl
H
H
H
H
H


5737
H
H
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl


5738
H
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H


5739
H
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


5740
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H


5741
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


5742
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


5743
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


5744
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H


5745
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


5746
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


5747
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


5748
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


5749
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


5750
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


5751
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


5752
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H


5753
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


5754
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


5755
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


5756
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


5757
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


5758
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


5759
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


5760
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


5761
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


5762
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


5763
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


5764
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


5765
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


5766
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


5767
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5768
H
H
acetyl
H
acetyl
acetyl
H
H
H
H
H
H


5769
H
H
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl


5770
H
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H


5771
H
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


5772
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H


5773
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


5774
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


5775
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


5776
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H


5777
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


5778
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


5779
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


5780
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


5781
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


5782
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


5783
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


5784
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H


5785
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


5786
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


5787
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


5788
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


5789
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


5790
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


5791
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


5792
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


5793
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


5794
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


5795
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


5796
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


5797
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


5798
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


5799
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


5800
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H


5801
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


5802
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


5803
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


5804
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


5805
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


5806
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


5807
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


5808
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


5809
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


5810
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


5811
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


5812
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


5813
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


5814
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


5815
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


5816
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


5817
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


5818
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


5819
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


5820
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


5821
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


5822
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


5823
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


5824
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


5825
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


5826
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


5827
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


5828
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


5829
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


5830
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


5831
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5832
H
H
acetyl
acetyl
H
H
H
H
H
H
H
H


5833
H
H
acetyl
acetyl
H
H
H
H
H
H
H
acetyl


5834
H
H
acetyl
acetyl
H
H
H
H
H
H
acetyl
H


5835
H
H
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl


5836
H
H
acetyl
acetyl
H
H
H
H
H
acetyl
H
H


5837
H
H
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl


5838
H
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H


5839
H
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


5840
H
H
acetyl
acetyl
H
H
H
H
acetyl
H
H
H


5841
H
H
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl


5842
H
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H


5843
H
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


5844
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H


5845
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


5846
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


5847
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


5848
H
H
acetyl
acetyl
H
H
H
acetyl
H
H
H
H


5849
H
H
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl


5850
H
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H


5851
H
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


5852
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H


5853
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


5854
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


5855
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


5856
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H


5857
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


5858
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


5859
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


5860
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


5861
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


5862
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


5863
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


5864
H
H
acetyl
acetyl
H
H
acetyl
H
H
H
H
H


5865
H
H
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl


5866
H
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H


5867
H
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


5868
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H


5869
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


5870
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


5871
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


5872
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H


5873
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


5874
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


5875
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


5876
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


5877
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


5878
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


5879
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


5880
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H


5881
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


5882
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


5883
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


5884
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


5885
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


5886
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


5887
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


5888
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


5889
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


5890
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


5891
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


5892
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


5893
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


5894
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


5895
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5896
H
H
acetyl
acetyl
H
acetyl
H
H
H
H
H
H


5897
H
H
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl


5898
H
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H


5899
H
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


5900
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H


5901
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


5902
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


5903
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


5904
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H


5905
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


5906
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


5907
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


5908
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


5909
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


5910
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


5911
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


5912
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H


5913
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


5914
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


5915
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


5916
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


5917
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


5918
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


5919
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


5920
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


5921
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


5922
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


5923
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


5924
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


5925
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


5926
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


5927
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


5928
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H


5929
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


5930
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


5931
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


5932
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


5933
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


5934
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


5935
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


5936
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


5937
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


5938
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


5939
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


5940
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


5941
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


5942
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


5943
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


5944
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


5945
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


5946
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


5947
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


5948
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


5949
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


5950
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


5951
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


5952
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


5953
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


5954
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


5955
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


5956
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


5957
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


5958
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


5959
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


5960
H
H
acetyl
acetyl
acetyl
H
H
H
H
H
H
H


5961
H
H
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl


5962
H
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H


5963
H
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


5964
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H


5965
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


5966
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


5967
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


5968
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H


5969
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


5970
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


5971
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


5972
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


5973
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


5974
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


5975
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


5976
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H


5977
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


5978
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


5979
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


5980
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


5981
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


5982
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


5983
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


5984
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


5985
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


5986
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


5987
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


5988
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


5989
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


5990
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


5991
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


5992
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H


5993
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


5994
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


5995
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


5996
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


5997
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


5998
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


5999
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


6000
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


6001
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


6002
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


6003
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


6004
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


6005
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


6006
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


6007
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


6008
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


6009
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


6010
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


6011
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


6012
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


6013
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


6014
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


6015
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


6016
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


6017
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


6018
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


6019
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


6020
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


6021
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


6022
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


6023
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6024
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H


6025
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


6026
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


6027
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


6028
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


6029
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


6030
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


6031
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


6032
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


6033
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


6034
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


6035
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


6036
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


6037
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


6038
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


6039
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


6040
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


6041
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


6042
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


6043
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


6044
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


6045
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


6046
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


6047
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


6048
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


6049
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


6050
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


6051
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


6052
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


6053
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


6054
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


6055
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


6056
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


6057
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


6058
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


6059
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


6060
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


6061
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


6062
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


6063
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


6064
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


6065
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


6066
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


6067
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


6068
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


6069
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


6070
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


6071
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


6072
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


6073
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


6074
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


6075
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


6076
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


6077
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


6078
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


6079
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


6080
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


6081
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


6082
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


6083
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


6084
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


6085
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


6086
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


6087
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6088
H
acetyl
H
H
H
H
H
H
H
H
H
H


6089
H
acetyl
H
H
H
H
H
H
H
H
H
acetyl


6090
H
acetyl
H
H
H
H
H
H
H
H
acetyl
H


6091
H
acetyl
H
H
H
H
H
H
H
H
acetyl
acetyl


6092
H
acetyl
H
H
H
H
H
H
H
acetyl
H
H


6093
H
acetyl
H
H
H
H
H
H
H
acetyl
H
acetyl


6094
H
acetyl
H
H
H
H
H
H
H
acetyl
acetyl
H


6095
H
acetyl
H
H
H
H
H
H
H
acetyl
acetyl
acetyl


6096
H
acetyl
H
H
H
H
H
H
acetyl
H
H
H


6097
H
acetyl
H
H
H
H
H
H
acetyl
H
H
acetyl


6098
H
acetyl
H
H
H
H
H
H
acetyl
H
acetyl
H


6099
H
acetyl
H
H
H
H
H
H
acetyl
H
acetyl
acetyl


6100
H
acetyl
H
H
H
H
H
H
acetyl
acetyl
H
H


6101
H
acetyl
H
H
H
H
H
H
acetyl
acetyl
H
acetyl


6102
H
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl
H


6103
H
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


6104
H
acetyl
H
H
H
H
H
acetyl
H
H
H
H


6105
H
acetyl
H
H
H
H
H
acetyl
H
H
H
acetyl


6106
H
acetyl
H
H
H
H
H
acetyl
H
H
acetyl
H


6107
H
acetyl
H
H
H
H
H
acetyl
H
H
acetyl
acetyl


6108
H
acetyl
H
H
H
H
H
acetyl
H
acetyl
H
H


6109
H
acetyl
H
H
H
H
H
acetyl
H
acetyl
H
acetyl


6110
H
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl
H


6111
H
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


6112
H
acetyl
H
H
H
H
H
acetyl
acetyl
H
H
H


6113
H
acetyl
H
H
H
H
H
acetyl
acetyl
H
H
acetyl


6114
H
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl
H


6115
H
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


6116
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H
H


6117
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


6118
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


6119
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


6120
H
acetyl
H
H
H
H
acetyl
H
H
H
H
H


6121
H
acetyl
H
H
H
H
acetyl
H
H
H
H
acetyl


6122
H
acetyl
H
H
H
H
acetyl
H
H
H
acetyl
H


6123
H
acetyl
H
H
H
H
acetyl
H
H
H
acetyl
acetyl


6124
H
acetyl
H
H
H
H
acetyl
H
H
acetyl
H
H


6125
H
acetyl
H
H
H
H
acetyl
H
H
acetyl
H
acetyl


6126
H
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl
H


6127
H
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


6128
H
acetyl
H
H
H
H
acetyl
H
acetyl
H
H
H


6129
H
acetyl
H
H
H
H
acetyl
H
acetyl
H
H
acetyl


6130
H
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl
H


6131
H
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


6132
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H
H


6133
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


6134
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


6135
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


6136
H
acetyl
H
H
H
H
acetyl
acetyl
H
H
H
H


6137
H
acetyl
H
H
H
H
acetyl
acetyl
H
H
H
acetyl


6138
H
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl
H


6139
H
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


6140
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H
H


6141
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


6142
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


6143
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


6144
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H
H


6145
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


6146
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


6147
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


6148
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


6149
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


6150
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


6151
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6152
H
acetyl
H
H
H
acetyl
H
H
H
H
H
H


6153
H
acetyl
H
H
H
acetyl
H
H
H
H
H
acetyl


6154
H
acetyl
H
H
H
acetyl
H
H
H
H
acetyl
H


6155
H
acetyl
H
H
H
acetyl
H
H
H
H
acetyl
acetyl


6156
H
acetyl
H
H
H
acetyl
H
H
H
acetyl
H
H


6157
H
acetyl
H
H
H
acetyl
H
H
H
acetyl
H
acetyl


6158
H
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl
H


6159
H
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


6160
H
acetyl
H
H
H
acetyl
H
H
acetyl
H
H
H


6161
H
acetyl
H
H
H
acetyl
H
H
acetyl
H
H
acetyl


6162
H
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl
H


6163
H
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


6164
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H
H


6165
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


6166
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


6167
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


6168
H
acetyl
H
H
H
acetyl
H
acetyl
H
H
H
H


6169
H
acetyl
H
H
H
acetyl
H
acetyl
H
H
H
acetyl


6170
H
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl
H


6171
H
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


6172
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H
H


6173
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


6174
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


6175
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


6176
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H
H


6177
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


6178
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


6179
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


6180
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


6181
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


6182
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


6183
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


6184
H
acetyl
H
H
H
acetyl
acetyl
H
H
H
H
H


6185
H
acetyl
H
H
H
acetyl
acetyl
H
H
H
H
acetyl


6186
H
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl
H


6187
H
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


6188
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H
H


6189
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


6190
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


6191
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


6192
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H
H


6193
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


6194
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


6195
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


6196
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


6197
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


6198
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


6199
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


6200
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H
H


6201
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


6202
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


6203
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


6204
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


6205
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


6206
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


6207
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


6208
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


6209
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


6210
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


6211
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


6212
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


6213
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


6214
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


6215
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6216
H
acetyl
H
H
acetyl
H
H
H
H
H
H
H


6217
H
acetyl
H
H
acetyl
H
H
H
H
H
H
acetyl


6218
H
acetyl
H
H
acetyl
H
H
H
H
H
acetyl
H


6219
H
acetyl
H
H
acetyl
H
H
H
H
H
acetyl
acetyl


6220
H
acetyl
H
H
acetyl
H
H
H
H
acetyl
H
H


6221
H
acetyl
H
H
acetyl
H
H
H
H
acetyl
H
acetyl


6222
H
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl
H


6223
H
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


6224
H
acetyl
H
H
acetyl
H
H
H
acetyl
H
H
H


6225
H
acetyl
H
H
acetyl
H
H
H
acetyl
H
H
acetyl


6226
H
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl
H


6227
H
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


6228
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H
H


6229
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


6230
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


6231
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


6232
H
acetyl
H
H
acetyl
H
H
acetyl
H
H
H
H


6233
H
acetyl
H
H
acetyl
H
H
acetyl
H
H
H
acetyl


6234
H
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl
H


6235
H
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


6236
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H
H


6237
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


6238
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


6239
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


6240
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H
H


6241
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


6242
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


6243
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


6244
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


6245
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


6246
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


6247
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


6248
H
acetyl
H
H
acetyl
H
acetyl
H
H
H
H
H


6249
H
acetyl
H
H
acetyl
H
acetyl
H
H
H
H
acetyl


6250
H
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl
H


6251
H
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


6252
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H
H


6253
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


6254
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


6255
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


6256
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H
H


6257
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


6258
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


6259
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


6260
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


6261
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


6262
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


6263
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


6264
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H
H


6265
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


6266
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


6267
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


6268
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


6269
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


6270
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


6271
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


6272
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


6273
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


6274
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


6275
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


6276
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


6277
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


6278
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


6279
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6280
H
acetyl
H
H
acetyl
acetyl
H
H
H
H
H
H


6281
H
acetyl
H
H
acetyl
acetyl
H
H
H
H
H
acetyl


6282
H
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl
H


6283
H
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


6284
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H
H


6285
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


6286
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


6287
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


6288
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H
H


6289
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


6290
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


6291
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


6292
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


6293
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


6294
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


6295
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


6296
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H
H


6297
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


6298
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


6299
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


6300
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


6301
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


6302
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


6303
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


6304
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


6305
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


6306
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


6307
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


6308
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


6309
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


6310
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


6311
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


6312
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H
H


6313
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


6314
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


6315
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


6316
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


6317
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


6318
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


6319
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


6320
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


6321
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


6322
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


6323
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


6324
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


6325
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


6326
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


6327
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


6328
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


6329
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


6330
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


6331
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


6332
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


6333
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


6334
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


6335
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


6336
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


6337
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


6338
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


6339
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


6340
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


6341
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


6342
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


6343
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6344
H
acetyl
H
acetyl
H
H
H
H
H
H
H
H


6345
H
acetyl
H
acetyl
H
H
H
H
H
H
H
acetyl


6346
H
acetyl
H
acetyl
H
H
H
H
H
H
acetyl
H


6347
H
acetyl
H
acetyl
H
H
H
H
H
H
acetyl
acetyl


6348
H
acetyl
H
acetyl
H
H
H
H
H
acetyl
H
H


6349
H
acetyl
H
acetyl
H
H
H
H
H
acetyl
H
acetyl


6350
H
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl
H


6351
H
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


6352
H
acetyl
H
acetyl
H
H
H
H
acetyl
H
H
H


6353
H
acetyl
H
acetyl
H
H
H
H
acetyl
H
H
acetyl


6354
H
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl
H


6355
H
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


6356
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H
H


6357
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


6358
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


6359
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


6360
H
acetyl
H
acetyl
H
H
H
acetyl
H
H
H
H


6361
H
acetyl
H
acetyl
H
H
H
acetyl
H
H
H
acetyl


6362
H
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl
H


6363
H
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


6364
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H
H


6365
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


6366
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


6367
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


6368
H
acetyl
H
acetyl
H
H
H
,acetyl
acetyl
H
H
H


6369
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


6370
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


6371
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


6372
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


6373
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


6374
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


6375
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


6376
H
acetyl
H
acetyl
H
H
acetyl
H
H
H
H
H


6377
H
acetyl
H
acetyl
H
H
acetyl
H
H
H
H
acetyl


6378
H
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl
H


6379
H
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


6380
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H
H


6381
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


6382
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


6383
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


6384
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H
H


6385
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


6386
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


6387
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


6388
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


6389
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


6390
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


6391
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


6392
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H
H


6393
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


6394
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


6395
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


6396
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


6397
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


6398
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


6399
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


6400
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


6401
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


6402
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


6403
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


6404
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


6405
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


6406
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


6407
H
acetyl
H
acetyl
H
H,
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6408
H
acetyl
H
acetyl
H
acetyl
H
H
H
H
H
H


6409
H
acetyl
H
acetyl
H
acetyl
H
H
H
H
H
acetyl


6410
H
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl
H


6411
H
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


6412
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H
H


6413
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


6414
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


6415
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


6416
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H
H


6417
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


6418
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


6419
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


6420
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


6421
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


6422
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


6423
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


6424
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H
H


6425
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


6426
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


6427
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


6428
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


6429
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


6430
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


6431
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


6432
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


6433
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


6434
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


6435
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


6436
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


6437
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


6438
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


6439
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


6440
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H
H


6441
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


6442
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


6443
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


6444
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


6445
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


6446
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


6447
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


6448
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


6449
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


6450
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


6451
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


6452
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


6453
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


6454
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


6455
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


6456
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


6457
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


6458
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


6459
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


6460
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


6461
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


6462
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


6463
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


6464
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


6465
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


6466
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


6467
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


6468
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


6469
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


6470
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


6471
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6472
H
acetyl
H
acetyl
acetyl
H
H
H
H
H
H
H


6473
H
acetyl
H
acetyl
acetyl
H
H
H
H
H
H
acetyl


6474
H
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl
H


6475
H
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


6476
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H
H


6477
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


6478
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


6479
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


6480
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H
H


6481
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


6482
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


6483
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


6484
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


6485
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


6486
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


6487
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


6488
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H
H


6489
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


6490
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


6491
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


6492
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


6493
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


6494
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


6495
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


6496
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


6497
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


6498
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


6499
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


6500
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


6501
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


6502
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


6503
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


6504
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H
H


6505
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


6506
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


6507
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


6508
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


6509
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


6510
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


6511
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


6512
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


6513
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


6514
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


6515
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


6516
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


6517
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


6518
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


6519
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


6520
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


6521
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


6522
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


6523
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


6524
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


6525
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


6526
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


6527
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


6528
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


6529
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


6530
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


6531
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


6532
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


6533
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


6534
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


6535
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6536
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H
H


6537
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


6538
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


6539
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


6540
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


6541
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


6542
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


6543
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


6544
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


6545
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


6546
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


6547
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


6548
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


6549
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


6550
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


6551
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


6552
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


6553
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


6554
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


6555
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


6556
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


6557
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


6558
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


6559
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


6560
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


6561
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


6562
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


6563
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


6564
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


6565
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


6566
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


6567
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


6568
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


6569
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


6570
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


6571
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


6572
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


6573
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


6574
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


6575
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


6576
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


6577
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


6578
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


6579
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


6580
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


6581
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


6582
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


6583
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


6584
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


6585
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


6586
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


6587
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


6588
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


6589
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


6590
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


6591
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


6592
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


6593
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


6594
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


6595
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


6596
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


6597
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


6598
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


6599
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6600
H
acetyl
acetyl
H
H
H
H
H
H
H
H
H


6601
H
acetyl
acetyl
H
H
H
H
H
H
H
H
acetyl


6602
H
acetyl
acetyl
H
H
H
H
H
H
H
acetyl
H


6603
H
acetyl
acetyl
H
H
H
H
H
H
H
acetyl
acetyl


6604
H
acetyl
acetyl
H
H
H
H
H
H
acetyl
H
H


6605
H
acetyl
acetyl
H
H
H
H
H
H
acetyl
H
acetyl


6606
H
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl
H


6607
H
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl


6608
H
acetyl
acetyl
H
H
H
H
H
acetyl
H
H
H


6609
H
acetyl
acetyl
H
H
H
H
H
acetyl
H
H
acetyl


6610
H
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl
H


6611
H
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl


6612
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H
H


6613
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl


6614
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H


6615
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


6616
H
acetyl
acetyl
H
H
H
H
acetyl
H
H
H
H


6617
H
acetyl
acetyl
H
H
H
H
acetyl
H
H
H
acetyl


6618
H
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl
H


6619
H
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl


6620
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H
H


6621
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl


6622
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H


6623
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


6624
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H
H


6625
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl


6626
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H


6627
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


6628
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H


6629
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


6630
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


6631
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


6632
H
acetyl
acetyl
H
H
H
acetyl
H
H
H
H
H


6633
H
acetyl
acetyl
H
H
H
acetyl
H
H
H
H
acetyl


6634
H
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl
H


6635
H
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl


6636
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H
H


6637
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl


6638
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H


6639
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


6640
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H
H


6641
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl


6642
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H


6643
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


6644
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H


6645
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


6646
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


6647
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


6648
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H
H


6649
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl


6650
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H


6651
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


6652
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H


6653
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


6654
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


6655
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


6656
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H


6657
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


6658
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


6659
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


6660
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


6661
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


6662
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


6663
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6664
H
acetyl
acetyl
H
H
acetyl
H
H
H
H
H
H


6665
H
acetyl
acetyl
H
H
acetyl
H
H
H
H
H
acetyl


6666
H
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl
H


6667
H
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl


6668
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H
H


6669
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl


6670
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H


6671
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


6672
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H
H


6673
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl


6674
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H


6675
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


6676
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H


6677
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


6678
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


6679
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


6680
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H
H


6681
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl


6682
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H


6683
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


6684
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H


6685
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


6686
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


6687
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


6688
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H


6689
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


6690
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


6691
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


6692
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


6693
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


6694
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


6695
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


6696
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H
H


6697
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl


6698
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H


6699
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


6700
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H


6701
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


6702
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


6703
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


6704
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H


6705
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


6706
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


6707
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


6708
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


6709
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


6710
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


6711
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


6712
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H


6713
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


6714
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


6715
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


6716
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


6717
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


6718
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


6719
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


6720
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


6721
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


6722
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


6723
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


6724
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


6725
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


6726
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


6727
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6728
H
acetyl
acetyl
H
acetyl
H
H
H
H
H
H
H


6729
H
acetyl
acetyl
H
acetyl
H
H
H
H
H
H
acetyl


6730
H
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl
H


6731
H
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl


6732
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H
H


6733
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl


6734
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H


6735
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


6736
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H
H


6737
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl


6738
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H


6739
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


6740
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H


6741
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


6742
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


6743
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


6744
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H
H


6745
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl


6746
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H


6747
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


6748
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H


6749
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


6750
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


6751
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


6752
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H


6753
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


6754
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


6755
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


6756
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


6757
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


6758
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


6759
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


6760
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H
H


6761
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl


6762
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H


6763
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


6764
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H


6765
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


6766
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


6767
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


6768
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H


6769
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


6770
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


6771
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


6772
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


6773
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


6774
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


6775
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


6776
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H


6777
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


6778
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


6779
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


6780
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


6781
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


6782
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


6783
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


6784
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


6785
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


6786
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


6787
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


6788
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


6789
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


6790
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


6791
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6792
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H
H


6793
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl


6794
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H


6795
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


6796
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H


6797
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


6798
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


6799
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


6800
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H


6801
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


6802
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


6803
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


6804
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


6805
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


6806
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


6807
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


6808
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H


6809
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


6810
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


6811
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


6812
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


6813
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


6814
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


6815
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


6816
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


6817
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


6818
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


6819
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


6820
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


6821
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


6822
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


6823
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


6824
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H


6825
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


6826
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


6827
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


6828
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


6829
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


6830
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


6831
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


6832
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


6833
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


6834
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


6835
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


6836
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


6837
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


6838
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


6839
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


6840
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


6841
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


6842
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


6843
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


6844
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


6845
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


6846
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


6847
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


6848
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


6849
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


6850
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


6851
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


6852
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


6853
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


6854
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


6855
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6856
H
acetyl
acetyl
acetyl
H
H
H
H
H
H
H
H


6857
H
acetyl
acetyl
acetyl
H
H
H
H
H
H
H
acetyl


6858
H
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl
H


6859
H
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl


6860
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H
H


6861
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl


6862
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H


6863
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


6864
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H
H


6865
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl


6866
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H


6867
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


6868
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H


6869
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


6870
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


6871
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


6872
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H
H


6873
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl


6874
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H


6875
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


6876
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H


6877
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


6878
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


6879
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


6880
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H


6881
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


6882
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


6883
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


6884
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


6885
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


6886
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


6887
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


6888
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H
H


6889
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl


6890
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H


6891
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


6892
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H


6893
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


6894
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


6895
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


6896
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H


6897
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


6898
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


6899
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


6900
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


6901
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


6902
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


6903
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


6904
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H


6905
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


6906
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


6907
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


6908
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


6909
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


6910
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


6911
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


6912
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


6913
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


6914
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


6915
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


6916
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


6917
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


6918
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


6919
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6920
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H
H


6921
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl


6922
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H


6923
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


6924
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H


6925
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


6926
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


6927
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


6928
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H


6929
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


6930
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


6931
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


6932
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


6933
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


6934
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


6935
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


6936
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H


6937
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


6938
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


6939
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


6940
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


6941
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


6942
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


6943
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


6944
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


6945
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


6946
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


6947
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


6948
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


6949
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


6950
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


6951
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


6952
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H


6953
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


6954
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


6955
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


6956
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


6957
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


6958
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


6959
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


6960
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


6961
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


6962
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


6963
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


6964
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


6965
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


6966
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


6967
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


6968
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


6969
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


6970
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


6971
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


6972
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


6973
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


6974
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


6975
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


6976
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


6977
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


6978
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


6979
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


6980
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


6981
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


6982
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


6983
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


6984
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H
H


6985
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl


6986
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H


6987
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


6988
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H


6989
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


6990
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


6991
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


6992
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H


6993
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


6994
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


6995
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


6996
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


6997
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


6998
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


6999
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


7000
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H


7001
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


7002
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


7003
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


7004
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


7005
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


7006
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


7007
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


7008
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


7009
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


7010
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


7011
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


7012
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


7013
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


7014
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


7015
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


7016
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H


7017
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


7018
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


7019
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


7020
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


7021
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


7022
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


7023
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


7024
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


7025
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


7026
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


7027
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


7028
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


7029
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


7030
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


7031
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


7032
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


7033
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


7034
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


7035
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


7036
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


7037
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


7038
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


7039
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


7040
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


7041
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


7042
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


7043
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


7044
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


7045
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


7046
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


7047
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7048
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H


7049
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


7050
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


7051
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


7052
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


7053
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


7054
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


7055
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


7056
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


7057
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


7058
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


7059
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


7060
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


7061
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


7062
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


7063
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


7064
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


7065
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


7066
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


7067
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


7068
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


7069
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


7070
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


7071
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


7072
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


7073
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


7074
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


7075
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


7076
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


7077
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


7078
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


7079
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


7080
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


7081
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


7082
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


7083
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


7084
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


7085
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


7086
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


7087
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


7088
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


7089
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


7090
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


7091
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


7092
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


7093
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


7094
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


7095
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


7096
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


7097
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


7098
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


7099
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


7100
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


7101
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


7102
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


7103
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


7104
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


7105
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


7106
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


7107
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


7108
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


7109
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


7110
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


7111
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7112
acetyl
H
H
H
H
H
H
H
H
H
H
H


7113
acetyl
H
H
H
H
H
H
H
H
H
H
acetyl


7114
acetyl
H
H
H
H
H
H
H
H
H
acetyl
H


7115
acetyl
H
H
H
H
H
H
H
H
H
acetyl
acetyl


7116
acetyl
H
H
H
H
H
H
H
H
acetyl
H
H


7117
acetyl
H
H
H
H
H
H
H
H
acetyl
H
acetyl


7118
acetyl
H
H
H
H
H
H
H
H
acetyl
acetyl
H


7119
acetyl
H
H
H
H
H
H
H
H
acetyl
acetyl
acetyl


7120
acetyl
H
H
H
H
H
H
H
acetyl
H
H
H


7121
acetyl
H
H
H
H
H
H
H
acetyl
H
H
acetyl


7122
acetyl
H
H
H
H
H
H
H
acetyl
H
acetyl
H


7123
acetyl
H
H
H
H
H
H
H
acetyl
H
acetyl
acetyl


7124
acetyl
H
H
H
H
H
H
H
acetyl
acetyl
H
H


7125
acetyl
H
H
H
H
H
H
H
acetyl
acetyl
H
acetyl


7126
acetyl
H
H
H
H
H
H
H
acetyl
acetyl
acetyl
H


7127
acetyl
H
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


7128
acetyl
H
H
H
H
H
H
acetyl
H
H
H
H


7129
acetyl
H
H
H
H
H
H
acetyl
H
H
H
acetyl


7130
acetyl
H
H
H
H
H
H
acetyl
H
H
acetyl
H


7131
acetyl
H
H
H
H
H
H
acetyl
H
H
acetyl
acetyl


7132
acetyl
H
H
H
H
H
H
acetyl
H
acetyl
H
H


7133
acetyl
H
H
H
H
H
H
acetyl
H
acetyl
H
acetyl


7134
acetyl
H
H
H
H
H
H
acetyl
H
acetyl
acetyl
H


7135
acetyl
H
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


7136
acetyl
H
H
H
H
H
H
acetyl
acetyl
H
H
H


7137
acetyl
H
H
H
H
H
H
acetyl
acetyl
H
H
acetyl


7138
acetyl
H
H
H
H
H
H
acetyl
acetyl
H
acetyl
H


7139
acetyl
H
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


7140
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl
H
H


7141
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


7142
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


7143
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


7144
acetyl
H
H
H
H
H
acetyl
H
H
H
H
H


7145
acetyl
H
H
H
H
H
acetyl
H
H
H
H
acetyl


7146
acetyl
H
H
H
H
H
acetyl
H
H
H
acetyl
H


7147
acetyl
H
H
H
H
H
acetyl
H
H
H
acetyl
acetyl


7148
acetyl
H
H
H
H
H
acetyl
H
H
acetyl
H
H


7149
acetyl
H
H
H
H
H
acetyl
H
H
acetyl
H
acetyl


7150
acetyl
H
H
H
H
H
acetyl
H
H
acetyl
acetyl
H


7151
acetyl
H
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


7152
acetyl
H
H
H
H
H
acetyl
H
acetyl
H
H
H


7153
acetyl
H
H
H
H
H
acetyl
H
acetyl
H
H
acetyl


7154
acetyl
H
H
H
H
H
acetyl
H
acetyl
H
acetyl
H


7155
acetyl
H
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


7156
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl
H
H


7157
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


7158
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


7159
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


7160
acetyl
H
H
H
H
H
acetyl
acetyl
H
H
H
H


7161
acetyl
H
H
H
H
H
acetyl
acetyl
H
H
H
acetyl


7162
acetyl
H
H
H
H
H
acetyl
acetyl
H
H
acetyl
H


7163
acetyl
H
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


7164
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl
H
H


7165
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


7166
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


7167
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


7168
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H
H
H


7169
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


7170
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


7171
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


7172
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


7173
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


7174
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


7175
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7176
acetyl
H
H
H
H
acetyl
H
H
H
H
H
H


7177
acetyl
H
H
H
H
acetyl
H
H
H
H
H
acetyl


7178
acetyl
H
H
H
H
acetyl
H
H
H
H
acetyl
H


7179
acetyl
H
H
H
H
acetyl
H
H
H
H
acetyl
acetyl


7180
acetyl
H
H
H
H
acetyl
H
H
H
acetyl
H
H


7181
acetyl
H
H
H
H
acetyl
H
H
H
acetyl
H
acetyl


7182
acetyl
H
H
H
H
acetyl
H
H
H
acetyl
acetyl
H


7183
acetyl
H
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


7184
acetyl
H
H
H
H
acetyl
H
H
acetyl
H
H
H


7185
acetyl
H
H
H
H
acetyl
H
H
acetyl
H
H
acetyl


7186
acetyl
H
H
H
H
acetyl
H
H
acetyl
H
acetyl
H


7187
acetyl
H
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


7188
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl
H
H


7189
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


7190
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


7191
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


7192
acetyl
H
H
H
H
acetyl
H
acetyl
H
H
H
H


7193
acetyl
H
H
H
H
acetyl
H
acetyl
H
H
H
acetyl


7194
acetyl
H
H
H
H
acetyl
H
acetyl
H
H
acetyl
H


7195
acetyl
H
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


7196
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl
H
H


7197
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


7198
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


7199
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


7200
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H
H
H


7201
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


7202
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


7203
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


7204
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


7205
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


7206
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


7207
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


7208
acetyl
H
H
H
H
acetyl
acetyl
H
H
H
H
H


7209
acetyl
H
H
H
H
acetyl
acetyl
H
H
H
H
acetyl


7210
acetyl
H
H
H
H
acetyl
acetyl
H
H
H
acetyl
H


7211
acetyl
H
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


7212
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl
H
H


7213
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


7214
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


7215
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


7216
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H
H
H


7217
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


7218
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


7219
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


7220
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


7221
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


7222
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


7223
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


7224
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H
H
H


7225
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


7226
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


7227
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


7228
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


7229
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


7230
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


7231
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


7232
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


7233
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


7234
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


7235
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


7236
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


7237
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


7238
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


7239
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7240
acetyl
H
H
H
acetyl
H
H
H
H
H
H
H


7241
acetyl
H
H
H
acetyl
H
H
H
H
H
H
acetyl


7242
acetyl
H
H
H
acetyl
H
H
H
H
H
acetyl
H


7243
acetyl
H
H
H
acetyl
H
H
H
H
H
acetyl
acetyl


7244
acetyl
H
H
H
acetyl
H
H
H
H
acetyl
H
H


7245
acetyl
H
H
H
acetyl
H
H
H
H
acetyl
H
acetyl


7246
acetyl
H
H
H
acetyl
H
H
H
H
acetyl
acetyl
H


7247
acetyl
H
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


7248
acetyl
H
H
H
acetyl
H
H
H
acetyl
H
H
H


7249
acetyl
H
H
H
acetyl
H
H
H
acetyl
H
H
acetyl


7250
acetyl
H
H
H
acetyl
H
H
H
acetyl
H
acetyl
H


7251
acetyl
H
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


7252
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl
H
H


7253
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


7254
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


7255
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


7256
acetyl
H
H
H
acetyl
H
H
acetyl
H
H
H
H


7257
acetyl
H
H
H
acetyl
H
H
acetyl
H
H
H
acetyl


7258
acetyl
H
H
H
acetyl
H
H
acetyl
H
H
acetyl
H


7259
acetyl
H
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


7260
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl
H
H


7261
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


7262
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


7263
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


7264
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H
H
H


7265
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


7266
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


7267
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


7268
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


7269
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


7270
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


7271
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


7272
acetyl
H
H
H
acetyl
H
acetyl
H
H
H
H
H


7273
acetyl
H
H
H
acetyl
H
acetyl
H
H
H
H
acetyl


7274
acetyl
H
H
H
acetyl
H
acetyl
H
H
H
acetyl
H


7275
acetyl
H
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


7276
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl
H
H


7277
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


7278
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


7279
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


7280
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H
H
H


7281
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


7282
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


7283
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


7284
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


7285
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


7286
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


7287
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


7288
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H
H
H


7289
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


7290
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


7291
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


7292
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


7293
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


7294
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


7295
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


7296
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


7297
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


7298
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


7299
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


7300
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


7301
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


7302
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


7303
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7304
acetyl
H
H
H
acetyl
acetyl
H
H
H
H
H
H


7305
acetyl
H
H
H
acetyl
acetyl
H
H
H
H
H
acetyl


7306
acetyl
H
H
H
acetyl
acetyl
H
H
H
H
acetyl
H


7307
acetyl
H
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


7308
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl
H
H


7309
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


7310
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


7311
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


7312
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H
H
H


7313
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


7314
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


7315
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


7316
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


7317
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


7318
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


7319
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


7320
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H
H
H


7321
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


7322
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


7323
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


7324
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


7325
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


7326
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


7327
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


7328
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


7329
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


7330
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


7331
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


7332
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


7333
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


7334
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


7335
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


7336
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H
H
H


7337
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


7338
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


7339
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


7340
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


7341
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


7342
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


7343
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


7344
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


7345
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


7346
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


7347
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


7348
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


7349
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


7350
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


7351
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


7352
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


7353
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


7354
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


7355
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


7356
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


7357
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


7358
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


7359
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


7360
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


7361
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


7362
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


7363
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


7364
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


7365
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


7366
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


7367
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7368
acetyl
H
H
acetyl
H
H
H
H
H
H
H
H


7369
acetyl
H
H
acetyl
H
H
H
H
H
H
H
acetyl


7370
acetyl
H
H
acetyl
H
H
H
H
H
H
acetyl
H


7371
acetyl
H
H
acetyl
H
H
H
H
H
H
acetyl
acetyl


7372
acetyl
H
H
acetyl
H
H
H
H
H
acetyl
H
H


7373
acetyl
H
H
acetyl
H
H
H
H
H
acetyl
H
acetyl


7374
acetyl
H
H
acetyl
H
H
H
H
H
acetyl
acetyl
H


7375
acetyl
H
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


7376
acetyl
H
H
acetyl
H
H
H
H
acetyl
H
H
H


7377
acetyl
H
H
acetyl
H
H
H
H
acetyl
H
H
acetyl


7378
acetyl
H
H
acetyl
H
H
H
H
acetyl
H
acetyl
H


7379
acetyl
H
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


7380
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl
H
H


7381
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


7382
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


7383
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


7384
acetyl
H
H
acetyl
H
H
H
acetyl
H
H
H
H


7385
acetyl
H
H
acetyl
H
H
H
acetyl
H
H
H
acetyl


7386
acetyl
H
H
acetyl
H
H
H
acetyl
H
H
acetyl
H


7387
acetyl
H
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


7388
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl
H
H


7389
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


7390
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


7391
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


7392
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H
H
H


7393
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


7394
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


7395
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


7396
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


7397
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


7398
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


7399
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


7400
acetyl
H
H
acetyl
H
H
acetyl
H
H
H
H
H


7401
acetyl
H
H
acetyl
H
H
acetyl
H
H
H
H
acetyl


7402
acetyl
H
H
acetyl
H
H
acetyl
H
H
H
acetyl
H


7403
acetyl
H
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


7404
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl
H
H


7405
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


7406
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


7407
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


7408
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H
H
H


7409
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


7410
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


7411
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


7412
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


7413
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


7414
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


7415
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


7416
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H
H
H


7417
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


7418
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


7419
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


7420
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


7421
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


7422
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


7423
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


7424
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


7425
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


7426
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


7427
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


7428
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


7429
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


7430
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


7431
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7432
acetyl
H
H
acetyl
H
acetyl
H
H
H
H
H
H


7433
acetyl
H
H
acetyl
H
acetyl
H
H
H
H
H
acetyl


7434
acetyl
H
H
acetyl
H
acetyl
H
H
H
H
acetyl
H


7435
acetyl
H
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


7436
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl
H
H


7437
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


7438
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


7439
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


7440
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H
H
H


7441
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


7442
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


7443
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


7444
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


7445
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


7446
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


7447
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


7448
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H
H
H


7449
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


7450
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


7451
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


7452
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


7453
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


7454
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


7455
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


7456
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


7457
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


7458
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


7459
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


7460
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


7461
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


7462
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


7463
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


7464
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H
H
H


7465
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


7466
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


7467
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


7468
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


7469
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


7470
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


7471
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


7472
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


7473
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


7474
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


7475
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


7476
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


7477
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


7478
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


7479
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


7480
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


7481
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


7482
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


7483
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


7484
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


7485
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


7486
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


7487
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


7488
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


7489
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


7490
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


7491
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


7492
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


7493
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


7494
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


7495
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7496
acetyl
H
H
acetyl
acetyl
H
H
H
H
H
H
H


7497
acetyl
H
H
acetyl
acetyl
H
H
H
H
H
H
acetyl


7498
acetyl
H
H
acetyl
acetyl
H
H
H
H
H
acetyl
H


7499
acetyl
H
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


7500
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl
H
H


7501
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


7502
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


7503
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


7504
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H
H
H


7505
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


7506
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


7507
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


7508
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


7509
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


7510
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


7511
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


7512
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H
H
H


7513
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


7514
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


7515
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


7516
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


7517
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


7518
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


7519
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


7520
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


7521
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


7522
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


7523
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


7524
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


7525
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


7526
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


7527
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


7528
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H
H
H


7529
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


7530
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


7531
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


7532
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


7533
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


7534
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


7535
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


7536
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


7537
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


7538
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


7539
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


7540
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


7541
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


7542
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


7543
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


7544
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


7545
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


7546
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


7547
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


7548
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


7549
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


7550
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


7551
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


7552
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


7553
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


7554
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


7555
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


7556
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


7557
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


7558
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


7559
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7560
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H
H
H


7561
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


7562
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


7563
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


7564
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


7565
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


7566
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


7567
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


7568
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


7569
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


7570
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


7571
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


7572
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


7573
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


7574
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


7575
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


7576
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


7577
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


7578
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


7579
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


7580
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


7581
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


7582
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


7583
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


7584
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


7585
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


7586
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


7587
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


7588
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


7589
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


7590
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


7591
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


7592
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


7593
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


7594
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


7595
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


7596
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


7597
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


7598
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


7599
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


7600
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


7601
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


7602
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


7603
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


7604
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


7605
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


7606
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


7607
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


7608
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


7609
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


7610
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


7611
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


7612
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


7613
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


7614
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


7615
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


7616
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


7617
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


7618
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


7619
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


7620
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


7621
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


7622
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


7623
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7624
acetyl
H
acetyl
H
H
H
H
H
H
H
H
H


7625
acetyl
H
acetyl
H
H
H
H
H
H
H
H
acetyl


7626
acetyl
H
acetyl
H
H
H
H
H
H
H
acetyl
H


7627
acetyl
H
acetyl
H
H
H
H
H
H
H
acetyl
acetyl


7628
acetyl
H
acetyl
H
H
H
H
H
H
acetyl
H
H


7629
acetyl
H
acetyl
H
H
H
H
H
H
acetyl
H
acetyl


7630
acetyl
H
acetyl
H
H
H
H
H
H
acetyl
acetyl
H


7631
acetyl
H
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl


7632
acetyl
H
acetyl
H
H
H
H
H
acetyl
H
H
H


7633
acetyl
H
acetyl
H
H
H
H
H
acetyl
H
H
acetyl


7634
acetyl
H
acetyl
H
H
H
H
H
acetyl
H
acetyl
H


7635
acetyl
H
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl


7636
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl
H
H


7637
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl


7638
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H


7639
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


7640
acetyl
H
acetyl
H
H
H
H
acetyl
H
H
H
H


7641
acetyl
H
acetyl
H
H
H
H
acetyl
H
H
H
acetyl


7642
acetyl
H
acetyl
H
H
H
H
acetyl
H
H
acetyl
H


7643
acetyl
H
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl


7644
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl
H
H


7645
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl


7646
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H


7647
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


7648
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H
H
H


7649
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl


7650
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H


7651
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


7652
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H


7653
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


7654
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


7655
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


7656
acetyl
H
acetyl
H
H
H
acetyl
H
H
H
H
H


7657
acetyl
H
acetyl
H
H
H
acetyl
H
H
H
H
acetyl


7658
acetyl
H
acetyl
H
H
H
acetyl
H
H
H
acetyl
H


7659
acetyl
H
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl


7660
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl
H
H


7661
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl


7662
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H


7663
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


7664
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H
H
H


7665
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl


7666
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H


7667
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


7668
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H


7669
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


7670
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


7671
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


7672
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H
H
H


7673
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl


7674
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H


7675
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


7676
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H


7677
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


7678
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


7679
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


7680
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H


7681
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


7682
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


7683
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


7684
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


7685
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


7686
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


7687
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7688
acetyl
H
acetyl
H
H
acetyl
H
H
H
H
H
H


7689
acetyl
H
acetyl
H
H
acetyl
H
H
H
H
H
acetyl


7690
acetyl
H
acetyl
H
H
acetyl
H
H
H
H
acetyl
H


7691
acetyl
H
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl


7692
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl
H
H


7693
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl


7694
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H


7695
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


7696
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H
H
H


7697
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl


7698
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H


7699
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


7700
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H


7701
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


7702
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


7703
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


7704
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H
H
H


7705
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl


7706
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H


7707
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


7708
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H


7709
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


7710
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


7711
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


7712
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H


7713
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


7714
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


7715
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


7716
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


7717
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


7718
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


7719
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


7720
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H
H
H


7721
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl


7722
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H


7723
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


7724
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H


7725
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


7726
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


7727
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


7728
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H


7729
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


7730
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


7731
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


7732
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


7733
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


7734
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


7735
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


7736
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H


7737
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


7738
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


7739
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


7740
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


7741
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


7742
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


7743
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


7744
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


7745
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


7746
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


7747
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


7748
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


7749
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


7750
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


7751
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7752
acetyl
H
acetyl
H
acetyl
H
H
H
H
H
H
H


7753
acetyl
H
acetyl
H
acetyl
H
H
H
H
H
H
acetyl


7754
acetyl
H
acetyl
H
acetyl
H
H
H
H
H
acetyl
H


7755
acetyl
H
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl


7756
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl
H
H


7757
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl


7758
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H


7759
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


7760
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H
H
H


7761
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl


7762
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H


7763
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


7764
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H


7765
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


7766
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


7767
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


7768
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H
H
H


7769
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl


7770
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H


7771
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


7772
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H


7773
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


7774
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


7775
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


7776
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H


7777
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


7778
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


7779
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


7780
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


7781
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


7782
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


7783
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


7784
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H
H
H


7785
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl


7786
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H


7787
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


7788
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H


7789
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


7790
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


7791
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


7792
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H


7793
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


7794
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


7795
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


7796
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


7797
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


7798
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


7799
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


7800
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H


7801
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


7802
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


7803
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


7804
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


7805
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


7806
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


7807
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


7808
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


7809
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


7810
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


7811
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


7812
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


7813
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


7814
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


7815
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7816
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H
H
H


7817
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl


7818
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H


7819
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


7820
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H


7821
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


7822
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


7823
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


7824
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H


7825
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


7826
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


7827
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


7828
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


7829
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


7830
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


7831
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


7832
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H


7833
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


7834
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


7835
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


7836
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


7837
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


7838
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


7839
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


7840
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


7841
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


7842
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


7843
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


7844
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


7845
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


7846
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


7847
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


7848
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H


7849
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


7850
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


7851
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


7852
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


7853
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


7854
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


7855
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


7856
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


7857
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


7858
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


7859
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


7860
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


7861
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


7862
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


7863
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


7864
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


7865
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


7866
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


7867
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


7868
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


7869
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


7870
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


7871
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


7872
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


7873
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


7874
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


7875
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


7876
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


7877
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


7878
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


7879
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7880
acetyl
H
acetyl
acetyl
H
H
H
H
H
H
H
H


7881
acetyl
H
acetyl
acetyl
H
H
H
H
H
H
H
acetyl


7882
acetyl
H
acetyl
acetyl
H
H
H
H
H
H
acetyl
H


7883
acetyl
H
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl


7884
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl
H
H


7885
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl


7886
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H


7887
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


7888
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H
H
H


7889
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl


7890
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H


7891
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


7892
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H


7893
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


7894
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


7895
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


7896
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H
H
H


7897
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl


7898
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H


7899
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


7900
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H


7901
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


7902
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


7903
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


7904
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H


7905
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


7906
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


7907
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


7908
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


7909
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


7910
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


7911
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


7912
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H
H
H


7913
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl


7914
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H


7915
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


7916
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H


7917
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


7918
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


7919
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


7920
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H


7921
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


7922
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


7923
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


7924
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


7925
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


7926
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


7927
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


7928
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H


7929
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


7930
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


7931
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


7932
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


7933
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


7934
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


7935
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


7936
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


7937
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


7938
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


7939
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


7940
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


7941
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


7942
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


7943
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


7944
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H
H
H


7945
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl


7946
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H


7947
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


7948
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H


7949
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


7950
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


7951
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


7952
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H


7953
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


7954
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


7955
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


7956
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


7957
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


7958
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


7959
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


7960
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H


7961
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


7962
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


7963
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


7964
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


7965
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


7966
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


7967
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


7968
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


7969
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


7970
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


7971
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


7972
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


7973
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


7974
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


7975
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


7976
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H


7977
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


7978
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


7979
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


7980
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


7981
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


7982
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


7983
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


7984
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


7985
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


7986
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


7987
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


7988
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


7989
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


7990
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


7991
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


7992
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


7993
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


7994
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


7995
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


7996
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


7997
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


7998
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


7999
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


8000
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


8001
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


8002
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


8003
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


8004
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


8005
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


8006
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


8007
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8008
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H
H
H


8009
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl


8010
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H


8011
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


8012
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H


8013
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


8014
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


8015
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


8016
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H


8017
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


8018
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


8019
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


8020
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


8021
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


8022
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


8023
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


8024
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H


8025
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


8026
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


8027
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


8028
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


8029
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


8030
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


8031
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


8032
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


8033
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


8034
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


8035
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


8036
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


8037
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


8038
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


8039
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


8040
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H


8041
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


8042
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


8043
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


8044
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


8045
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


8046
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


8047
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


8048
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


8049
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


8050
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


8051
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


8052
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


8053
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


8054
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


8055
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


8056
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


8057
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


8058
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


8059
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


8060
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


8061
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


8062
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


8063
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


8064
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


8065
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


8066
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


8067
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


8068
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


8069
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


8070
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


8071
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8072
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H


8073
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


8074
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


8075
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


8076
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


8077
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


8078
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


8079
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


8080
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


8081
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


8082
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


8083
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


8084
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


8085
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


8086
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


8087
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


8088
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


8089
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


8090
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


8091
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


8092
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


8093
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


8094
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


8095
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


8096
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


8097
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


8098
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


8099
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


8100
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


8101
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


8102
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


8103
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


8104
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


8105
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


8106
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


8107
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


8108
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


8109
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


8110
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


8111
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


8112
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


8113
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


8114
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


8115
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


8116
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


8117
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


8118
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


8119
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


8120
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


8121
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


8122
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


8123
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


8124
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


8125
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


8126
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


8127
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


8128
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


8129
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


8130
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


8131
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


8132
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


8133
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


8134
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


8135
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8136
acetyl
acetyl
H
H
H
H
H
H
H
H
H
H


8137
acetyl
acetyl
H
H
H
H
H
H
H
H
H
acetyl


8138
acetyl
acetyl
H
H
H
H
H
H
H
H
acetyl
H


8139
acetyl
acetyl
H
H
H
H
H
H
H
H
acetyl
acetyl


8140
acetyl
acetyl
H
H
H
H
H
H
H
acetyl
H
H


8141
acetyl
acetyl
H
H
H
H
H
H
H
acetyl
H
acetyl


8142
acetyl
acetyl
H
H
H
H
H
H
H
acetyl
acetyl
H


8143
acetyl
acetyl
H
H
H
H
H
H
H
acetyl
acetyl
acetyl


8144
acetyl
acetyl
H
H
H
H
H
H
acetyl
H
H
H


8145
acetyl
acetyl
H
H
H
H
H
H
acetyl
H
H
acetyl


8146
acetyl
acetyl
H
H
H
H
H
H
acetyl
H
acetyl
H


8147
acetyl
acetyl
H
H
H
H
H
H
acetyl
H
acetyl
acetyl


8148
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl
H
H


8149
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl
H
acetyl


8150
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl
H


8151
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


8152
acetyl
acetyl
H
H
H
H
H
acetyl
H
H
H
H


8153
acetyl
acetyl
H
H
H
H
H
acetyl
H
H
H
acetyl


8154
acetyl
acetyl
H
H
H
H
H
acetyl
H
H
acetyl
H


8155
acetyl
acetyl
H
H
H
H
H
acetyl
H
H
acetyl
acetyl


8156
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl
H
H


8157
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl
H
acetyl


8158
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl
H


8159
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


8160
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H
H
H


8161
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H
H
acetyl


8162
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl
H


8163
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


8164
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H
H


8165
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


8166
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


8167
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


8168
acetyl
acetyl
H
H
H
H
acetyl
H
H
H
H
H


8169
acetyl
acetyl
H
H
H
H
acetyl
H
H
H
H
acetyl


8170
acetyl
acetyl
H
H
H
H
acetyl
H
H
H
acetyl
H


8171
acetyl
acetyl
H
H
H
H
acetyl
H
H
H
acetyl
acetyl


8172
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl
H
H


8173
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl
H
acetyl


8174
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl
H


8175
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


8176
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H
H
H


8177
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H
H
acetyl


8178
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl
H


8179
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


8180
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H
H


8181
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


8182
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


8183
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


8184
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H
H
H


8185
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H
H
acetyl


8186
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl
H


8187
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


8188
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H
H


8189
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


8190
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


8191
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


8192
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H
H


8193
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


8194
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


8195
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


8196
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


8197
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


8198
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


8199
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8200
acetyl
acetyl
H
H
H
acetyl
H
H
H
H
H
H


8201
acetyl
acetyl
H
H
H
acetyl
H
H
H
H
H
acetyl


8202
acetyl
acetyl
H
H
H
acetyl
H
H
H
H
acetyl
H


8203
acetyl
acetyl
H
H
H
acetyl
H
H
H
H
acetyl
acetyl


8204
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl
H
H


8205
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl
H
acetyl


8206
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl
H


8207
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


8208
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H
H
H


8209
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H
H
acetyl


8210
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl
H


8211
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


8212
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H
H


8213
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


8214
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


8215
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


8216
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H
H
H


8217
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H
H
acetyl


8218
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl
H


8219
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


8220
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H
H


8221
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


8222
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


8223
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


8224
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H
H


8225
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


8226
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


8227
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


8228
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


8229
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


8230
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


8231
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


8232
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H
H
H


8233
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H
H
acetyl


8234
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl
H


8235
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


8236
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H
H


8237
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


8238
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


8239
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


8240
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H
H


8241
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


8242
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


8243
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


8244
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


8245
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


8246
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


8247
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


8248
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H
H


8249
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


8250
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


8251
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


8252
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


8253
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


8254
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


8255
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


8256
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


8257
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


8258
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


8259
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


8260
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


8261
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


8262
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


8263
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8264
acetyl
acetyl
H
H
acetyl
H
H
H
H
H
H
H


8265
acetyl
acetyl
H
H
acetyl
H
H
H
H
H
H
acetyl


8266
acetyl
acetyl
H
H
acetyl
H
H
H
H
H
acetyl
H


8267
acetyl
acetyl
H
H
acetyl
H
H
H
H
H
acetyl
acetyl


8268
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl
H
H


8269
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl
H
acetyl


8270
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl
H


8271
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


8272
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H
H
H


8273
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H
H
acetyl


8274
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl
H


8275
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


8276
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H
H


8277
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


8278
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


8279
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


8280
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H
H
H


8281
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H
H
acetyl


8282
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl
H


8283
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


8284
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H
H


8285
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


8286
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


8287
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


8288
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H
H


8289
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


8290
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


8291
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


8292
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


8293
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


8294
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


8295
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


8296
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H
H
H


8297
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H
H
acetyl


8298
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl
H


8299
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


8300
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H
H


8301
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


8302
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


8303
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


8304
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H
H


8305
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


8306
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


8307
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


8308
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


8309
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


8310
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


8311
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


8312
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H
H


8313
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


8314
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


8315
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


8316
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


8317
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


8318
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


8319
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


8320
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


8321
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


8322
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


8323
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


8324
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


8325
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


8326
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


8327
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8328
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H
H
H


8329
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H
H
acetyl


8330
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl
H


8331
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


8332
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H
H


8333
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


8334
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


8335
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


8336
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H
H


8337
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


8338
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


8339
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


8340
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


8341
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


8342
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


8343
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


8344
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H
H


8345
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


8346
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


8347
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


8348
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


8349
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


8350
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


8351
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


8352
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


8353
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


8354
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


8355
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


8356
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


8357
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


8358
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


8359
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


8360
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H
H


8361
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


8362
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


8363
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


8364
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


8365
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


8366
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


8367
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


8368
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


8369
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


8370
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


8371
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


8372
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


8373
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


8374
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


8375
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


8376
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


8377
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


8378
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


8379
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


8380
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


8381
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


8382
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


8383
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


8384
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


8385
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


8386
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


8387
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


8388
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


8389
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


8390
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


8391
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8392
acetyl
acetyl
H
acetyl
H
H
H
H
H
H
H
H


8393
acetyl
acetyl
H
acetyl
H
H
H
H
H
H
H
acetyl


8394
acetyl
acetyl
H
acetyl
H
H
H
H
H
H
acetyl
H


8395
acetyl
acetyl
H
acetyl
H
H
H
H
H
H
acetyl
acetyl


8396
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl
H
H


8397
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl
H
acetyl


8398
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl
H


8399
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


8400
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H
H
H


8401
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H
H
acetyl


8402
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl
H


8403
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


8404
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H
H


8405
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


8406
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


8407
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


8408
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H
H
H


8409
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H
H
acetyl


8410
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl
H


8411
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


8412
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H
H


8413
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


8414
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


8415
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


8416
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H
H


8417
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


8418
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


8419
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


8420
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


8421
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


8422
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


8423
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


8424
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H
H
H


8425
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H
H
acetyl


8426
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl
H


8427
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


8428
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H
H


8429
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


8430
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


8431
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


8432
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H
H


8433
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


8434
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


8435
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


8436
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


8437
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


8438
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


8439
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


8440
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H
H


8441
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


8442
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


8443
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


8444
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


8445
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


8446
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


8447
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


8448
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


8449
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


8450
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


8451
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


8452
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


8453
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


8454
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


8455
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8456
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H
H
H


8457
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H
H
acetyl


8458
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl
H


8459
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


8460
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H
H


8461
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


8462
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


8463
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


8464
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H
H


8465
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


8466
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


8467
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


8468
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


8469
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


8470
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


8471
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


8472
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H
H


8473
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


8474
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


8475
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


8476
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


8477
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


8478
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


8479
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


8480
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


8481
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


8482
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


8483
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


8484
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


8485
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


8486
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


8487
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


8488
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H
H


8489
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


8490
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


8491
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


8492
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


8493
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


8494
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


8495
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


8496
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


8497
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


8498
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


8499
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


8500
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


8501
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


8502
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


8503
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


8504
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


8505
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


8506
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


8507
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


8508
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


8509
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


8510
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


8511
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


8512
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


8513
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


8514
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


8515
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


8516
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


8517
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


8518
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


8519
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8520
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H
H
H


8521
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H
H
acetyl


8522
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl
H


8523
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


8524
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H
H


8525
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


8526
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


8527
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


8528
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H
H


8529
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


8530
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


8531
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


8532
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


8533
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


8534
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


8535
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


8536
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H
H


8537
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


8538
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


8539
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


8540
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


8541
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


8542
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


8543
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


8544
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


8545
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


8546
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


8547
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


8548
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


8549
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


8550
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


8551
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


8552
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H
H


8553
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


8554
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


8555
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


8556
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


8557
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


8558
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


8559
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


8560
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


8561
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


8562
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


8563
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


8564
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


8565
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


8566
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


8567
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


8568
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


8569
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


8570
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


8571
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


8572
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


8573
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


8574
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


8575
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


8576
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


8577
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


8578
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


8579
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


8580
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


8581
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


8582
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


8583
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8584
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H
H


8585
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


8586
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


8587
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


8588
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


8589
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


8590
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


8591
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


8592
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


8593
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


8594
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


8595
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


8596
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


8597
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


8598
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


8599
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


8600
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


8601
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


8602
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


8603
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


8604
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


8605
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


8606
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


8607
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


8608
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


8609
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


8610
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


8611
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


8612
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


8613
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


8614
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


8615
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


8616
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


8617
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


8618
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


8619
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


8620
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


8621
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


8622
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


8623
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


8624
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


8625
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


8626
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


8627
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


8628
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


8629
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


8630
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


8631
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


8632
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


8633
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


8634
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


8635
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


8636
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


8637
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


8638
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


8639
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


8640
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


8641
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


8642
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


8643
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


8644
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


8645
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


8646
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


8647
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8648
acetyl
acetyl
acetyl
H
H
H
H
H
H
H
H
H


8649
acetyl
acetyl
acetyl
H
H
H
H
H
H
H
H
acetyl


8650
acetyl
acetyl
acetyl
H
H
H
H
H
H
H
acetyl
H


8651
acetyl
acetyl
acetyl
H
H
H
H
H
H
H
acetyl
acetyl


8652
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl
H
H


8653
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl
H
acetyl


8654
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl
H


8655
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl
acetyl


8656
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H
H
H


8657
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H
H
acetyl


8658
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl
H


8659
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl
acetyl


8660
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H
H


8661
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H
acetyl


8662
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
H


8663
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl
acetyl


8664
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H
H
H


8665
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H
H
acetyl


8666
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl
H


8667
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl
acetyl


8668
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H
H


8669
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H
acetyl


8670
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
H


8671
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl
acetyl


8672
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H
H


8673
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H
acetyl


8674
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
H


8675
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl
acetyl


8676
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
H


8677
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H
acetyl


8678
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
H


8679
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


8680
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H
H
H


8681
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H
H
acetyl


8682
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl
H


8683
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl
acetyl


8684
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H
H


8685
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H
acetyl


8686
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
H


8687
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl
acetyl


8688
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H
H


8689
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H
acetyl


8690
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
H


8691
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl
acetyl


8692
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
H


8693
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H
acetyl


8694
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
H


8695
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


8696
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H
H


8697
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H
acetyl


8698
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
H


8699
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl
acetyl


8700
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
H


8701
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H
acetyl


8702
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
H


8703
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


8704
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
H


8705
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H
acetyl


8706
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
H


8707
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


8708
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
H


8709
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


8710
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


8711
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8712
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H
H
H


8713
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H
H
acetyl


8714
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl
H


8715
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl
acetyl


8716
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H
H


8717
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H
acetyl


8718
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
H


8719
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl
acetyl


8720
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H
H


8721
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H
acetyl


8722
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
H


8723
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl
acetyl


8724
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
H


8725
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H
acetyl


8726
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
H


8727
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


8728
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H
H


8729
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H
acetyl


8730
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
H


8731
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl
acetyl


8732
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
H


8733
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H
acetyl


8734
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
H


8735
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


8736
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
H


8737
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H
acetyl


8738
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
H


8739
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


8740
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
H


8741
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


8742
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


8743
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


8744
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H
H


8745
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H
acetyl


8746
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
H


8747
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl
acetyl


8748
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
H


8749
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H
acetyl


8750
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
H


8751
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


8752
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
H


8753
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H
acetyl


8754
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
H


8755
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


8756
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
H


8757
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


8758
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


8759
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


8760
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
H


8761
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H
acetyl


8762
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
H


8763
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


8764
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
H


8765
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


8766
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


8767
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


8768
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
H


8769
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


8770
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


8771
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


8772
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


8773
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


8774
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


8775
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8776
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H
H
H


8777
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H
H
acetyl


8778
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl
H


8779
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl
acetyl


8780
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H
H


8781
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H
acetyl


8782
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
H


8783
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl
acetyl


8784
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H
H


8785
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H
acetyl


8786
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
H


8787
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl
acetyl


8788
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
H


8789
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H
acetyl


8790
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
H


8791
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


8792
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H
H


8793
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H
acetyl


8794
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
H


8795
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl
acetyl


8796
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
H


8797
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H
acetyl


8798
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
H


8799
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


8800
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
H


8801
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H
acetyl


8802
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
H


8803
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


8804
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
H


8805
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


8806
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


8807
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


8808
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H
H


8809
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H
acetyl


8810
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
H


8811
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl
acetyl


8812
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
H


8813
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H
acetyl


8814
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
H


8815
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


8816
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
H


8817
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H
acetyl


8818
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
H


8819
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


8820
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
H


8821
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


8822
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


8823
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


8824
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
H


8825
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H
acetyl


8826
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
H


8827
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


8828
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
H


8829
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


8830
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


8831
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


8832
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
H


8833
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


8834
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


8835
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


8836
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


8837
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


8838
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


8839
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8840
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H
H


8841
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H
acetyl


8842
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
H


8843
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl
acetyl


8844
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
H


8845
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H
acetyl


8846
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
H


8847
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


8848
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
H


8849
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H
acetyl


8850
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
H


8851
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


8852
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
H


8853
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


8854
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


8855
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


8856
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
H


8857
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H
acetyl


8858
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
H


8859
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


8860
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
H


8861
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


8862
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


8863
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


8864
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
H


8865
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


8866
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


8867
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


8868
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


8869
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


8870
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


8871
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


8872
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
H


8873
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H
acetyl


8874
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
H


8875
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


8876
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
H


8877
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


8878
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


8879
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


8880
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
H


8881
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


8882
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


8883
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


8884
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


8885
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


8886
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


8887
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


8888
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
H


8889
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


8890
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


8891
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


8892
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


8893
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


8894
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


8895
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


8896
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


8897
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


8898
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


8899
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


8900
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


8901
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


8902
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


8903
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8904
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H
H
H


8905
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H
H
acetyl


8906
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl
H


8907
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl
acetyl


8908
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H
H


8909
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H
acetyl


8910
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
H


8911
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl
acetyl


8912
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H
H


8913
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H
acetyl


8914
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
H


8915
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl
acetyl


8916
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
H


8917
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H
acetyl


8918
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
H


8919
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl
acetyl


8920
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H
H


8921
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H
acetyl


8922
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
H


8923
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl
acetyl


8924
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
H


8925
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H
acetyl


8926
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
H


8927
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl
acetyl


8928
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
H


8929
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H
acetyl


8930
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
H


8931
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl
acetyl


8932
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
H


8933
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H
acetyl


8934
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
H


8935
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


8936
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H
H


8937
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H
acetyl


8938
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
H


8939
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl
acetyl


8940
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
H


8941
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H
acetyl


8942
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
H


8943
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl
acetyl


8944
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
H


8945
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H
acetyl


8946
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
H


8947
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl
acetyl


8948
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
H


8949
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H
acetyl


8950
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
H


8951
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


8952
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
H


8953
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H
acetyl


8954
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
H


8955
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl
acetyl


8956
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
H


8957
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H
acetyl


8958
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
H


8959
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


8960
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
H


8961
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H
acetyl


8962
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
H


8963
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


8964
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
H


8965
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


8966
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


8967
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


8968
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H
H


8969
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H
acetyl


8970
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
H


8971
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl
acetyl


8972
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
H


8973
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H
acetyl


8974
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
H


8975
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl
acetyl


8976
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
H


8977
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H
acetyl


8978
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
H


8979
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl
acetyl


8980
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
H


8981
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H
acetyl


8982
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
H


8983
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


8984
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
H


8985
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H
acetyl


8986
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
H


8987
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl
acetyl


8988
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
H


8989
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H
acetyl


8990
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
H


8991
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


8992
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
H


8993
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H
acetyl


8994
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
H


8995
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


8996
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
H


8997
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


8998
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


8999
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


9000
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
H


9001
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H
acetyl


9002
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
H


9003
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl
acetyl


9004
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
H


9005
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H
acetyl


9006
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
H


9007
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


9008
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
H


9009
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H
acetyl


9010
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
H


9011
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


9012
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
H


9013
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


9014
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


9015
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


9016
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
H


9017
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H
acetyl


9018
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
H


9019
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


9020
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
H


9021
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


9022
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


9023
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


9024
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
H


9025
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


9026
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


9027
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


9028
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


9029
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


9030
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H


9031
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


9032
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H
H


9033
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H
acetyl


9034
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
H


9035
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl
acetyl


9036
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
H


9037
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H
acetyl


9038
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
H


9039
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl
acetyl


9040
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
H


9041
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H
acetyl


9042
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
H


9043
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl
acetyl


9044
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
H


9045
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H
acetyl


9046
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
H


9047
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl
acetyl


9048
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
H


9049
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H
acetyl


9050
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
H


9051
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl
acetyl


9052
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
H


9053
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H
acetyl


9054
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
H


9055
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl
acetyl


9056
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
H


9057
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H
acetyl


9058
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
H


9059
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl
acetyl


9060
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
H


9061
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H
acetyl


9062
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
H


9063
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl
acetyl


9064
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
H


9065
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H
acetyl


9066
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
H


9067
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl
acetyl


9068
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
H


9069
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H
acetyl


9070
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
H


9071
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl
acetyl


9072
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
H


9073
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H
acetyl


9074
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
H


9075
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl
acetyl


9076
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
H


9077
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H
acetyl


9078
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
H


9079
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl
acetyl


9080
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
H


9081
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H
acetyl


9082
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
H


9083
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl
acetyl


9084
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
H


9085
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H
acetyl


9086
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
H


9087
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl
acetyl


9088
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
H


9089
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H
acetyl


9090
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
H


9091
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl
acetyl


9092
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
H


9093
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H
acetyl


9094
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
H


9095
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl


9096
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
H


9097
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H
acetyl


9098
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
H


9099
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl
acetyl


9100
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
H


9101
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H
acetyl


9102
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
H


9103
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl
acetyl


9104
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
H


9105
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H
acetyl


9106
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
H


9107
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl
acetyl


9108
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
H


9109
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H
acetyl


9110
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
H


9111
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl
acetyl


9112
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
H


9113
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H
acetyl


9114
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
H


9115
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl
acetyl


9116
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
H


9117
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H
acetyl


9118
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
H


9119
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl
acetyl


9120
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
H


9121
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H
acetyl


9122
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
H


9123
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl
acetyl


9124
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
H


9125
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H
acetyl


9126
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
H


9127
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl
acetyl


9128
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
H


9129
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H
acetyl


9130
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
H


9131
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl
acetyl


9132
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
H


9133
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H
acetyl


9134
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
H


9135
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl
acetyl


9136
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
H


9137
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H
acetyl


9138
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
H


9139
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl
acetyl


9140
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
H


9141
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H
acetyl


9142
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
H


9143
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl
acetyl


9144
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
H


9145
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H
acetyl


9146
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
H


9147
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl
acetyl


9148
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
H


9149
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H
acetyl


9150
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
H


9151
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl
acetyl


9152
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
H


9153
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H
acetyl


9154
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
H


9155
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl
acetyl


9156
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
H


9157
acetyl
acetyl
acetyl
acetyl
Acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H
acetyl


9158
acetyl
acetyl
acetyl
acetyl
Acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
acetyl
H









The synthetic oligosaccharide of the present invention comprises a linker X. In one embodiment, the linker X is a bond. In another embodiment the linker at one end exhibits a grouping able to enter into a covalent bonding with a reactive functional group of the carrier, e.g. an amino, thiol, or carboxyl group, and at the other end a grouping likewise able to enter into a covalent bonding with a hydroxyl group or an amino group of an oligosaccharide according to the present invention. Between the two functional groups of the linker molecule there is a biocompatible bridging molecule of suitable length, e.g. substituted or unsubstituted heteroalkylene, arylalkylene, alkylene, alkenylene, or (oligo)alkylene glycol groups. Linkers preferably comprises an substituted or unsubstituted (C1-C10) alkylene group or an substituted or unsubstituted (C2-C10) alkenylene group.


In one embodiment the linker is —(CH2)pS—, where p is an integer selected from the group consisting of 3, 4, 5, 6, 7, 8, 9, 10.


In one embodiment, the present invention provides oligosaccharides 1b or 1d:




embedded image


where R1, R2, n, and Y are defined as in oligosaccharide 1a; and p is an integer from 1 to 10.


Oligosaccharides 1a and 1b/d have a definite number of monosaccharide units. As indicated above, the number of monosaccharide units may be expressed by n+1. In one embodiment, n may be between about 3 and 100, preferably between about 3 and 50. In other embodiments, n is between about 5 and 25 units, about 6 and 30 units, about 6 and 24 units, and about 6 and 18 units. In another embodiment n may be 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17.


Oligosaccharides of the present invention may be further defined by the percentage of acetylated residues to non-acetylated residues and by the pattern (e.g. spacing) of acetylated residues relative to non-acetylated residues. For example, in oligosaccharides 1a and 1b/d the number of COCH3 groups in R1 and R2 may be defined by z, whereby and the percentage of acetylated monosaccharide units is y, where y is z/(n+1)*100. In one embodiment, y is 90% or less, 80% or less, 70% or less, 60% or less, 50% or less, 40% or less, 30% or less, 20% or less, or 10% or less. In another embodiment, y may be 40% or less, 30% or less, 20% or less, 15% or less, 10% or less, 5% or less etc. In another embodiment, y may be at least 10%, at least 20%, at least 30%, at least 40%, at least 50%, at least 60%, at least 70%, at least 80%, at least 90%, or any combination of less than the above disclosed y values or at least equal to any of the above described y values.


In another embodiment, the oligosaccharides of the present invention may include a run of consecutive acetylated residues in one portion, a second run of consecutive non-acetylated residues in another portion, and/or singularly placed acetylated or non-acetylated residues elsewhere throughout.


The present invention essentially allows the synthesis of oligosaccharides having a specific, fixed acetylated pattern. More particularly, they may be characterized by structures in which individual acetylation positions and oligosaccharide length are engineered into a fixed, predetermined pattern. As such, the oligosaccharides of the present invention are distinguished from those produced by existing methods that result at best in heterogeneous populations of mixed sequence oligo-β-(1→6)-glucosamines in which the individual position(s) of acetylated residues is varied from one oligosaccharide to another, and where the number or percent of acetylated residues in the population is an average.


The following embodiments exemplify the oligosaccharides 1a of the present invention:




embedded image


In oligosaccharides 37, 40, and 34, X and Y are as defined for oligosaccharide 1a. In particular, 37, 40, and 34 exemplify thiol oligosaccharides which may be conjugated to any carrier (Y) according to the present invention. By way of example, 37, 40, and 34 may be conjugated to form BSA conjugates such as 41, 43, and 45, respectively, or they may be conjugated to form KLH conjugates such as 42, 44, and 46, respectively.


Exemplary bacteria known or suspected to express oligo-β-(1→6)-glucosamine PNAG- and/or dPNAG structures include, but are not limited to Staphylococcus species, such as S. aureus and S. epidermidis; Escherichia coli; Yersinia species (spp.), such as Y. pestis, Y. pseudotuberculosis, and Y. entercolitica; Bordetella spp., including B. pertussis, B. bronchiseptica, and B. parapertussis; Aggregatibacter actinomycetemcomitans, Actinobacillus pleuropneumoniae; Acinetobacter spp.; Burkholderia spp.; Stenatrophomonas maltophilia, Klebsiella spp., and Shigella spp. Accordingly, specific dPNAG/PNAG oligosaccharides may be modified, depending on the specific compositional makeup, including acetylation profiles of these antigens in their respective bacterial species.


Suitable linkers comprise at one end a grouping able to enter into a covalent bonding with a reactive functional group of the carrier, e.g. an amino, thiol, or carboxyl group, and at the other end a grouping likewise able to enter into a covalent bonding with a hydroxyl group of an oligosaccharide according to the present invention. Between the two functional groups of the linker molecule there is a biocompatible bridging molecule of suitable length, e.g. substituted or unsubstituted heteroalkylene, arylalkylene, alkylene, alkenylene, or (oligo)alkylene glycol groups. Linkers preferably comprise substituted or unsubstituted (C1-C10)alkylene or (C2-C10)alkenylene groups.


If present, linkers or their respective precursors are able to react with thiol groups on the carrier are, for example, maleimide and carboxyl groups; preferred groupings able to react with aldehyde or carboxyl groups are, for example, amino or thiol groups. Preferred covalent attachments between linkers and carriers include thioethers from reaction of a thiol with an α-halo carbonyl or α-halo nitrile, including reactions of thiols with maleimide; hydrazides from reaction of a hydrazide or hydrazine with an activated carbonyl group (e.g. activated NHS-ester or acid halide); triazoles from reaction of an azide with an alkyne (e.g. via “click chemistry”); and oximes from reaction of a hydroxylamine and an aldehyde or ketone as disclosed, for example, in Lees et al., Vaccine, 24:716, 2006. Although amine-based conjugation chemistries could be used in principle for coupling linkers and/or spacers to the oligosaccharides described herein, these approaches would typically sacrifice uniformity inasmuch as the oligosaccharides of the present invention typically contain a plurality of amines bonded to second carbon of the respective monosaccharide units.


Further suitable linker molecules are known to skilled workers and commercially available or can be designed as required and depending on the functional groups present and can be prepared by known methods.


Suitable carriers are known in the art (See e.g., Remington's Pharmaceutical Sciences (18th ed., Mack Easton, Pa. (1990)) and may include, for example, proteins, peptides, lipids, polymers, dendrimers, virosomes, virus-like particles (VLPs), or combinations thereof, which by themselves may not display particular antigenic properties, but can support immunogenic reaction of a host to the oligosaccharides of the present invention (antigens) displayed at the surface of the carrier(s).


Preferably, the carrier is a protein carrier, including but are not limited to, bacterial toxoids, toxins, exotoxins, and nontoxic derivatives thereof, such as tetanus toxoid, tetanus toxin Fragment C, diphtheria toxoid, CRM (a nontoxic diphtheria toxin mutant) such as CRM 197, cholera toxoid, Staphylococcus aureus exotoxins or toxoids, Escherichia coli heat labile enterotoxin, Pseudomonas aeruginosa exotoxin A, including recombinantly produced, genetically detoxified variants thereof; bacterial outer membrane proteins, such as Neisseria meningitidis serotype B outer membrane protein complex (OMPC), outer membrane class 3 porin (rPorB) and other porins; keyhole limpet hemocyanine (KLH), hepatitis B virus core protein, thyroglobulin, albumins, such as bovine serum albumin (BSA), human serum albumin (HSA), and ovalbumin; pneumococcal surface protein A (PspA), pneumococcal adhesin protein (PsaA); purified protein derivative of tuberculin (PPD); transferrin binding proteins, polyamino acids, such as poly(lysine:glutamic acid); peptidyl agonists of TLR-5 (e.g. flagellin of motile bacteria like Listeria); and derivatives and/or combinations of the above carriers. Preferred carriers for use in humans include tetanus toxoid, CRM 197, and OMPC.


Depending on the type of bonding between the linker and the carrier, and the structural nature of the carrier and oligosaccharide, a carrier may display on average, for example, 1 to 500, 1 to 100, 1 to 20, or 3 to 9 oligosaccharide units on its surface.


Methods for attaching an oligosaccharide to a carrier, such as a carrier protein are conventional, and a skilled practitioner can create conjugates in accordance with the present invention using conventional methods. Guidance is also available in various disclosures, including, for example, U.S. Pat. Nos. 4,356,170; 4,619,828; 5,153,312; 5,422,427; and 5,445,817; and in various print and online Pierce protein cross-linking guides and catalogs (Thermo Fisher, Rockford, Ill.).


In one embodiment, the carbohydrate antigens of the present invention are conjugated to CRM 197, a commercially available protein carrier used in a number of FDA approved vaccines. CRM-conjugates have the advantage of being easier to synthesize, purify and characterize than other FDA approved carriers such as OMPC. Carbohydrate antigens may be conjugated to CRM via thiol-bromoacetyl conjugation chemistry. CRM activation may be achieved by reacting the lysine side chains with the NHS ester of bromoacetic acid using standard conditions as previously described in U.S. Pat. Appl. Publ. 2007-0134762, the disclosures of which are incorporated by reference herein. CRM may be functionalized with 10-20 bromoacetyl groups per protein (n=10-20) prior to conjugation. Conjugation may be performed at pH=9 to avoid aggregation of CRM. Careful monitoring of pH must be employed to ensure complete CRM reaction with NHS-bromoacetate while minimizing background hydrolysis of CRM. Activated CRM may be purified by size exclusion chromatography prior to conjugation. Antigen-CRM conjugates may be synthesized by reacting thiol-terminated carbohydrate antigens with bromoacetamide-activated CRM.


CRM conjugates may be purified via size exclusion chromatography to remove and recover any unreacted carbohydrate. MBTH (specific for GlcNAc residues) and Bradford assays may be used to determine carbohydrate:protein ratio and protein content, respectively, as previously described (Manzi et al., Curr. Prot. Mol. Biol., section 17.9.1 (Suppl. 32), 1995. In preferred embodiments, a minimum carbohydrate content of about 15% by weight for each conjugate may be generated. Typically, a conjugate may include about 3-20 antigens per protein carrier.


In another embodiment, oligosaccharide antigens may be conjugated to one or more carriers suitable for development of diagnostic assays, including ELISAs and microarrays. Exemplary carriers for use in such assays include bovine serum albumin (BSA), keyhole limpet hemocyanine (KLH), biotin, a label, a glass slide or a gold surface. By way of example, synthetic oligosaccharide antigens may be conjugated to BSA by a thiol-maleimide coupling procedure (FIG. 5B). Maleimide-BSA contains 15-20 maleimide groups per protein (n=15-20). Accordingly, oligosaccharide antigens may be conjugated to maleimide functionalized BSA, whereby a 20-fold molar excess of the antigen is reacted with commercially available Imject maleimide BSA (Pierce) in maleimide conjugation buffer (Pierce). Conjugation may be performed at pH=7.2 to avoid hydrolysis of the maleimide group during conjugation.


BSA conjugates may be purified via size exclusion chromatography to remove and recover any unreacted carbohydrate. Characterization via MBTH and Bradford assays may be performed along with MALDI-MS to provide information on the carbohydrate content and valency of the conjugates. In preferred embodiments, conjugates will contain a minimum carbohydrate content of about 10% by weight per BSA conjugate and >8 antigen copies per conjugate.


Methods for Synthesizing Oligo-β-(1-6)-Glucosamine Structures


In another aspect, the invention provides a method for assembling mixed sequence oligo-β-(1→6)-glucosamine structures 1.


The synthetic oligosaccharides 3 according to the present invention can be synthesized by selective coupling of the donor building blocks 3a with acceptor building blocks 3b.


The structure of the donor building block 3a is shown below:




embedded image


wherein the each PG1 is independently selected from the group consisting of NPhth, NHTroc, NHTFA, NHTCA, NHCbz, and N3;.


The oxygen protecting group(s) PGox may be independently selected from the group consisting of acetyl (Ac), benzoate, trifluoro benzoate, 4-chlorobenzoate, benzyl, and 4-halobenzyl


The protecting group PG2 is independently selected from the group consisting of tertbutyl dimethylsilyl (TBS), triethylsilyl (TES), tert-butyldiphenylsilyl (TBDPS), monochloracetate, trifluoroacetate, levulinoyl, 4-O-acetyl, 2,2-dimethylbutanoate, trityl, dimethoxytrityl, 9-fluoreneylmethoxycarbonyl (Fmoc), allyloxycarbonyl (AllOC) and naphthyl. Tertbutyl dimethylsilyl (TBS) and tert-butyldiphenylsilyl (TBDPS) are preferred.


The activating group L is selected from the group consisting of trichloroacetimidate (TCl), N-phenyl-trifluoroacetimidate, thioethyl, thiophenyl, thiotolyl, thioadamantyl, thioisopropyl, dibutyl phosphate, dibenzyl phosphate, and diphenylphosphate. Trichloroacetimidate (TCl) and N-phenyl-trifluoroacetimidate are preferred.


The donor building block has a defined number of monosaccharide units m. In one embodiment, m is equal or greater than 1. In another embodiment, the number of units m is between 1 and 17. In another embodiment, the number of units m is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17. In another embodiment the number of monomeric units m is preferably 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11.


The structure of the acceptor building block 3b is shown below:




embedded image


wherein in the acceptor building block 3b, each PG1 is independently selected from the group consisting of NPhth, NHTroc, NHTFA, NHTCA, NHCbz, and N3.


The oxygen protective groups PGox are independently selected from the group consisting of acetate, benzoate, trifluorobenzoate, 4-chlorobenzoate, benzyl, or 4-halobenzyl, 9-fluoreneylmethoxycarbonyl (Fmoc), and allyloxycarbonyl (AllOC)


The protective group PG3 is selected from the group consisting of (C2-C10)alkenyl, or (C2-C10)alkynyl. —CH2CH═CH2, —CH2CCH (propargyl), and —CH2CH2CH2CH═CH2 (pent-4-enyl) are preferred.


The acceptor building block has a defined number of monosaccharide units o. In one embodiment, m is equal or greater than 1. In another embodiment, the number of units o is between 1 and 17. In another embodiment, the number of units is 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, or 17. In another embodiment the number of monomeric units o is preferably 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or 11.


In one embodiment m+o≧4.


To allow for the introduction of two different R1 and/or R2 groups for oligosaccharides of the present invention 1a, at least two different PG1 groups, namely PG1a and PG1b, are present in the coupled oligosaccharide 3:




embedded image


In case the coupled oligosaccharide 3 does not provide for the final number of monosaccharide units, the coupled oligomer can be converted into a corresponding acceptor block by removal of the PG2 group, as shown below:




embedded image


The methods for removal of the protecting group PG2 are know to those skilled in the art. For example, if PG2 is TBS, the TBS may be removed by treatment with a Lewis acid such as Sc(OTf)3, and if PG2 is Fmoc, the Fmoc may be removed by treatment under basic conditions such as 2,6-lutidine/triethylamine.


Alternatively, the coupled product can also be converted into a new donor building block by removal of the protecting group PG3 and introduction of the activating group L, as shown below:




embedded image


The methods for removal of the protecting group PG3 are known to those skilled in the art. For example, if PG3 is allyl, the allyl group may be removed by treatment with a catalyst such as Ir[COD(PMePh2)]PF6,


If the final number of monosaccharide units is not yet achieved in the product 3, the converted oligosaccharides 4a/b can be used as donor or acceptor building blocks for a further coupling reaction to build up larger oligosaccharides of the present invention.


The coupled oligosaccharide 3 can be further reacted to the oligosaccharide 1a by removal of the respective protecting groups PG1a/b, PG2, pGox and/or PG3.


The protecting group PG2 can be removed by methods known in the art, such as the procedure outlined in SOP1 for the removal of the preferred protecting group TBS.


The coupled product 3 contains at least two different protecting groups PG1, PG1a and PG1b, at least one of which is selectively removed and thus allows for a selective reaction of the deprotected group(s) while the other protecting groups may still be in place. In one embodiment, in a first step, the protecting group PG1a is removed. In a preferred embodiment, the protecting group PG1a is NHTroc. In one embodiment the second protecting group PG1b remains in place when the first protecting group PG1a is selectively removed.


In one embodiment, the deprotected N-groups are converted into a N-acetyl group. In another embodiment, the N-acetylation is performed in situ. In another embodiment, the acetylation of the deprotected N-groups is done in a separate reaction step.


The reaction conditions used for the selective removal of the protective group PG1a have to be carefully chosen such that any damage of the further protecting groups in the oligosaccharide is avoided. In particular, any removal or damage of the second N-protecting group PG1b has to be avoided in order to allow for a selective introduction of a substituent at the first unprotected nitrogen such as an acetyl group.


In a preferred embodiment PG1a is NHTroc and PG1b is NPhth. The selective removal of the Troc-protecting group is achieved by a reaction in the presence of Zinc. In a preferred embodiment the Zn is activated. Activation of the Zn can be done for example by treatment with HCl.


In case, the removal of the NHTroc group is done in situ with the N-acetylation, a mixture of Ac2O:AcOH is present. Preferably the mixture of Ac2O:AcOH is present in a ratio (v:v) from 10:1 to 1:10, more preferably from 5:1 to 1:5, and most preferably from 3:1 to 1:3. Typically, the reaction is performed in an ether solvent such as Et2O, Dioxane, or THF, and preferably THF.


In one embodiment the presence of other metals than Zn is excluded in this reaction.


The protecting group PG1b is removed by methods known to the person skilled in the art. In a preferred embodiment, the protecting group PG1b is NPhth.


The protecting group PGox is removed by methods known to the person skilled in the art. In a preferred embodiment the protecting groups PGox are selected from the group consisting of acetate and benzoate and more preferably is acetate.


In embodiments, wherein the linker X is a bond, removal of the protecting group PG3 is sufficient. The carrier group Y may be bond to the oligosaccharide directly.


The protecting group PG3 may optionally be converted into a linker group or a precursor thereof. Alternatively, after removal of the protecting group PG3 by methods known to the person skilled in the art, a linker group may be introduced.


Suitable linker groups are substituted or unsubstituted heteroalkylene, arylalkylene, alkylene, alkenylene, or (oligo)alkylene glycol groups. Linker groups preferably comprise substituted or unsubstituted (C1-C10) alkylene moieties or an substituted or unsubstituted (C2-C10) alkenylene moieties.


In one embodiment the PG3 group is —CH2CH═CH2. This group may be converted into a linker-CH2CH2CH2—S— by addition of thiol acetic acid under suitable conditions and optionally subsequent removal of the acetate group. Suitable reaction conditions are known to the person skilled in the art such as for example described in SOP6 (Example 7).


In a further embodiment the linker group is —(CH2)pS—, where p is an integer selected from the group consisting of 3, 4, 5, 6, 7, 8, 9, 10.


In one embodiment the removal of the protecting groups PG1b, PGox and optionally PG3 is done in subsequent steps, In another embodiment, the removal of the protecting groups PG1b, PGo and optionally PG3 is done is performed in a single step reaction. Suitable reaction conditions for the removal of the protective groups are known to the person skilled in the art, such as exemplified in SOP7 (Example 8).


Suitable conditions for the removal of the protective groups are known to the person skilled in the art (see for example T. W. Greene, P. G. M. Wuts “Protective Groups in Organic Synthesis”, Wiley & Sons, 3rd edition, 1999 herein incorporated by reference in its entirety). In Table 10 below, standard reaction conditions are listed, which may be applied to remove the respective protecting groups. However, it should be noted that in the present invention, the one N-protecting group PG1a is selectively removed while at least one further N-protecting group PG1b is still present in the oligosaccharide.









TABLE 10







Protecting groups and suitable removal conditions









Abbre-




viation
Full name
Removal conditions










N-protecting groups (PG1) -


stable to conditions used to remove PG2









N-Phth
Phthaloyl
Hydrazine, ethylene diamine


NH-Troc
2,2,2-trichloro-
Zn, THF, H2O



ethoxycarbonyl



NH-TFA
Trifluoroacetyl
Strong base


NH-TCA
Trichloroacetyl
NH3, EtOH, CHCl3;




Bu3SnH, AlBN


NH-Cbz
Benzyloxycarbonyl
H2, Pd on Carbon


N3
Azide
H2, Pd on Carbon







O-protecting groups (PGox independently) -


stable to conditions used to remove PG2









Ac
Acetyl
Hydrazine; Mild Base;




AcCl, MeOH


Bz
Benzoyl
Hydrazine; Mild Base



Trifluorobenzoate
Hydrazine; Mild Base



4-chlorobenzoate
Hydrazine; Mild Base


Bn
Benzyl
H2, Pd on Carbon



4-halobenzyl
H2, Pd on Carbon; Pd,




amine, Lewis acid relay







O-protecting groups (PG2)









TBS
tert-
Sc(OTf)3, CH3CN, H2O;



butyldimethylsilyl
TBAF, AcOH; HF


TES
Triethylsilyl
TBAF, AcOH; HF


TBDPS
tert-
TBAF, AcOH; HF



butyldiphenylsilyl



MCA
Monochloracetate
NH3, MeOH, THF


TFA
Trifluoroacetate
NH3, MeOH, THF


Lev
Levulinoyl
Hydrazine


ADMB
4-O-acety l2,2-
DBU, MeOH



dimethylbutanoate



Tr
Triphenylmethyl
Mild Acid


DMT
Dimethoxytrityl
Mild Acid


FMOC
9-fluorenylmethyl
DBU; lutidine; Et3N,



carbonate
Pyridine; Mild base


Alloc
Allyl oxycarbonyl
Rh(PPh3)3Cl;




PdCl2(PPh3)2; Pd(PPh3)4


Nap
Napthyl
DDQ; Cerium




ammonium nitrate







Activating group (L)









TCI or
Trichloroacetimidate
TMSOTf, TBSOTf, BF3—OEt2


TCA





N-phenyl-
TMSOTf, TBSOTf,



trifluoroacetimidate
BF3—OEt2, TfOH


SEt
Thioethyl
NIS, TfOH


SPh
Thiophenyl
NIS, TfOH


STol
Thiotolyl
NIS, TfOH


SAdm
Thioadamantyl
NIS, TfOH


S(iPr)
Thioisopropyl
NIS, TfOH



dibutyl phosphate
TMSOTf, TBSOTf,




BF3—OEt2



dibenzyl phosphate
TMSOTf, TBSOTf,




BF3—OEt2



Diphenylphosphate
TMSOTf, TBSOTf,




BF3—OEt2







Protecting Group PG3









Allyl
—OCH2CH═CH2
[Ir(COD)(PMePh2)2]PF6,




OsO4; PdCl2, acetate buffer


Propargyl
—OCH2CCH
Co(CO)8, H2O


Pentenyl
—OCH2CH2CH2CH═CH2
NBS, TfOH; NBS, H2O









The deprotected oligosaccharide may be further attached to a carrier group. Suitable carrier groups are described above.


In a further aspect the present invention is directed to a method of selectively converting an N-Troc group in an N-Troc protected aminosugar in the presence of at least a further protecting group into an N-acetyl group, the method comprising reacting an N-Troc protected aminosugar with a mixture of Ac2O and AcOH in the presence of Zn.


In one embodiment, the aminosugar is selected from the group consisting of glucosamine, galactosamine, mannosamine, and fucosamine.


In one embodiment the Zn is activated. Activation of the Zn can be done for example by treatment with HCl.


In one embodiment the removal of the N-Troc group is done in situ with the N-acetylation. In this case, a mixture of Ac2O:AcOH is present. Preferably the mixture of Ac2O:AcOH is present in a ratio (v:v) from 10:1 to 1:10, more preferably from 5:1 to 1:5, and most preferably from 3:1 to 1:3.


Typically, the reaction is performed in an ether solvent such as Et2O, Dioxane, or THF, and preferably THF.


In one embodiment the reaction is performed at ambient temperatures.


Building Blocks for Synthesizing Oligo-β-(1-6) Glucosamine Structures


Preferred Building blocks for the synthesis of the oligosaccharides of the present invention are described below including the four monosaccharide building blocks 6, 8, 14, and 47. The four building blocks include donor building blocks 8 and 14, and acceptor building blocks 6 and 47 below.




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Building blocks 6 and 8 further contain an —NPhth group for selective amine group protection of individual monosaccharide units. Building blocks 14 and 47 contain a protective —NHTroc group for selective protection and subsequent acetylation of individual monosaccharide units.


Acceptor building blocks 6 and 47 have a linker precursor incorporated at the reducing end, which may be reacted with thioacetic acid and deblocked to form a conjugation-ready thiol for conjugation to a carrier as further described above. For example, when incorporated into an oligosaccharide of the present invention, the —O—CH2—CH═CH2 group at the reducing end may be converted into a linker comprising the sequence, —O—(CH2)3—SH as further described in FIGS. 5B, 6B, and 7.


The four monosaccharide building blocks 6, 8, 14, and 47 may be synthesized from a single monosaccharide 1 as shown in FIG. 3.


In a further aspect, the invention provides mixed disaccharide building blocks which can be used in combination with other monosaccharide- or disaccharide building blocks to form higher-order dPNAG/PNAG structures. In FIG. 4A, monosaccharide donor 14 is reacted with monosaccharide acceptor 6 to form a mixed disaccharide building block 15 in which the first monosaccharide unit is protected for selective acetylation and the amine in the second monosaccharide unit is selectively protected. In FIG. 4B, monosaccharide donor 8 is reacted with monosaccharide acceptor 47 to form a mixed disaccharide building block 49 in which the amine in the first monosaccharide unit is selectively protected and the second monosaccharide unit position is protected for selective acetylation.


In FIG. 4A, disaccharide building block 15 can be converted into a disaccharide donor 17 or a disaccharide acceptor 48 for further couplings to other acceptors or donors, respectively. Likewise, in FIG. 4B, disaccharide building block 49 can be converted into a disaccharide donor 51 or a disaccharide acceptor 52 for further couplings to other acceptors or donors, as well. For example, disaccharide donors 17 and 51 can be coupled with either of the monosaccharide acceptors 6 and 47 to form trisaccharides, or they can be coupled with disaccharide acceptors 48 and 52 to form tetrasaccharides.


In another aspect, the present invention provides disaccharide blocks for forming consecutive acetylated residues or consecutive non-acetylated resides. In FIG. 4C, monosaccharide donor 14 is reacted with monosaccharide acceptor 47 to form a disaccharide building block 53 in which each of the two monosaccharide units is protected for selective acetylation. In FIG. 4D, monosaccharide donor 8 is reacted with monosaccharide acceptor 6 to from a disaccharide building block 18 in which each of the 2-position amines in the two monosaccharide units is protected.


In FIG. 4C, disaccharide building block 53 can be converted into a disaccharide donor 55 or a disaccharide acceptor 56 for further couplings to other acceptors or donors, respectively. Likewise, in FIG. 4D, disaccharide building block 18 can be converted into a disaccharide donor 20 or a disaccharide acceptor 57 for further couplings to other acceptors or donors, as well. For example, disaccharide donors 20 and 55 can be coupled with either of the monosaccharide acceptors 6 and 47 to form trisaccharides or they can be coupled with any of the above-described disaccharide acceptors 48, 52, 56, or 57 to form tetrasaccharides.


Any of the above-described donors can be coupled to any complementary acceptor according to the method of the present invention. Accordingly, by coupling the monosaccharide-, disaccharide-, or other higher order donor modules of higher length with complementary monosaccharide-, disaccharide-, or other higher order acceptor modules of higher length, any mixed sequence oligosaccharide of the present invention can be formed in which the individual acetylation positions and oligosaccharide length are engineered into a given synthesis process in a pre-determined fashion.


Exemplary donor and acceptor building blocks for the synthesis of the oligosaccharides of the present invention are shown below:


Suitable Trisaccharide donor building blocks are




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Suitable tetrasaccharide donor building blocks are




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Suitable trisaccharide acceptor building blocks are:




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Exemplary tetramer acceptor building blocks are:




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Compositions and methods for synthesizing exemplary oligosaccharides are described in the Examples below.


In FIGS. 3-10, syntheses of various oligosaccharides of the present invention proceed by a number of standard operating procedures (SOPs). In another aspect, the present invention provides a number of SOPs (or reaction steps) for synthesizing dPNAG/PNAG oligosaccharides, including SOP 1, removal of 1° TBS group(s); SOP 2, removal of allyl group(s); SOP 3, trichloroacetimidate formation; SOP 4, glycosylation using trichloroacetimidate donors; SOP 5, removal of N-Troc group and in situ N-acetylation; SOP 6, thiol addition to olefin; and SOP 7, removal of O-acetate, N-phthaloyl and S-acetate groups. SOPs 1-7 are further detailed in the Examples below.


In some cases, the above-described protecting groups may be substituted with other protecting groups customarily considered in carbohydrate chemistry, including those mentioned in “Protective Groups in Organic Synthesis”, 3.sup.rd edition, T. W. Greene and P. G. M. Wuts (Ed.), John Wiley and Sons, New York, 1999. By way of example, O-acetate groups may be replaced with O-benzoate groups for producing the antigens.


Compositions


In another aspect, the present invention provides compositions containing dPNAG/PNAG oligosaccharides 1a and a pharmaceutically acceptable vehicle. The compositions are preferably immunogenic and immunoprotective.


The present invention contemplates the use of single- and multi-valent vaccines comprising any of the synthetic oligosaccharides described herein. The identification of a single oligosaccharide antigen eliciting a protective immune response can facilitate development of a single-antigen vaccine candidate against one or more bacterial target(s) expressing dPNAG/PNAG. Thus, in one embodiment, the compositions may contain a single oligosaccharide 1a.


The present invention further contemplates multi-antigen vaccine candidates and vaccines thereof. In one embodiment, the invention provides a composition containing two, three, four or more different oligosaccharides 1a.


In another embodiment, the invention provides a composition containing two, three, four or more different oligosaccharides, including at least one oligosaccharide 1a and at least one oligosaccharide 1c:




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where R1 is always H or always COCH3; n is at least 3, X is a bond or a linker, and Y is H or a carrier (i.e., oligosaccharides 1c are fully acetylated or fully non-acetylated). When two or more oligosaccharides are used in a composition, the oligosaccharides are preferably formed separately and combined (either prior to conjugation to the carrier or after conjugation), so that the ratio of each can be controlled.


Suitable vehicles and their formulation, inclusive of other human proteins, e.g., human serum albumin, are described, for example, in Remington's Pharmaceutical Sciences (18th ed., Mack Easton Pa. (1990)). Pharmaceutically acceptable vehicles may include any vehicle that does not itself induce the production of antibodies harmful to the individual receiving the composition. Suitable vehicles may include large, slowly metabolized macromolecules such as proteins, polysaccharides, polylactic acids, polyglycolic acids, polymeric amino acids, amino acid copolymers; inactive virus particles, insoluble aluminum compounds, calcium phosphate, liposomes, virosomes, ISCOMS, microparticles, emulsions, and VLPs.


The compositions of the present invention may further include one or more adjuvants. An oligosaccharide-protein conjugate composition may further include one or more immunogenic adjuvant(s). An immunogenic adjuvant is a compound that, when combined with an antigen, increases the immune response to the antigen as compared to the response induced by the antigen alone so that less antigen can be used to achieve a similar response. For example, an adjuvant may augment humoral immune responses, cell-mediated immune responses, or both.


Those of skill in the art will appreciate that the terms “adjuvant,” and “carrier,” can overlap to a significant extent. For example, a substance which acts as an “adjuvant” may also be a “carrier,” and certain other substances normally thought of as “carriers,” for example, may also function as an “adjuvant.” Accordingly, a substance which may increase the immunogenicity of the synthetic oligosaccharide or carrier associated therewith is a potential adjuvant. As used herein, a carrier is generally used in the context of a more directed site-specific conjugation to an oligosaccharide of the present invention, whereby an adjuvant is generally used in a less specific or more generalized structural association therewith.


Exemplary adjuvants and/or adjuvant combinations may be selected from the group consisting of mineral salts, including aluminum salts, such as aluminum phosphate and aluminum hydroxide (alum) (e.g., Alhydrogel™, Superfos, Denmark) and calcium phosphate; RIBI, which contains three components extracted from bacteria, monophosphoryl lipid A, trehalose dimycolate, and cell wall skeleton (MPL+TDM+CWS) in a 2% squalene/Tween 80 emulsion, whereby any of the 3 components MPL, TDM or CWS may also be used alone or combined 2 by 2; toll-like receptor (TLR) agonists, including, for example, agonists of TLR-1 (e.g. tri-acyl lipopeptides); agonists of TLR-2 [e.g. peptidoglycan of gram-positive bacteria like streptococci and staphylococci; lipoteichoic acid]; agonists of TLR-3 (e.g. double-stranded RNA and their analogs such as poly 1:C); agonists of TLR-4 (e.g. lipopolysaccharide (endotoxin) of gram-negative bacteria like Salmonella and E. coli); agonists of TLR-5 (e.g. flagellin of motile bacteria like Listeria); agonists of TLR-6 (e.g. with TLR-2 peptidoglycan and certain lipids (diacyl lipopeptides)); agonists of TLR-7 (e.g. single-stranded RNA (ssRNA) genomes of such viruses as influenza, measles, and mumps; and small synthetic guanosine-base antiviral molecules like loxoribine and ssRNA and their analogs); agonists of TLR-8 (e.g. binds ssRNA); agonists of TLR-9 (e.g. unmethylated CpG of the DNA of the pathogen and their analogs; agonists of TLR-10 (function not defined) and TLR-11- (e.g. binds proteins expressed by several infectious protozoans (Apicomplexa), specific toll-like receptor agonists include monophosphoryl lipid A (MPL®), 3 De-β-acylated monophosphoryl lipid A (3 D-MPL), OM-174 (E. coli lipid A derivative); OM triacyl lipid A derivative, and other MPL®- or lipid A-based formulations and combinations thereof, including MPL®-SE, RC-529 (Dynavax Technologies), AS01 (liposomes+MPL+QS21), AS02 (oil-in-water PL+QS-21), and AS04 (Alum+MPL) (GlaxoSmith Kline, Pa.), CpG-oligodeoxynucleotides (ODNs) containing immunostimulatory CpG motifs, double-stranded RNA, polyinosinic:polycytidylic acid (poly I:C), and other oligonucleotides or polynucleotides optionally encapsulated in liposomes; oil-in-water emulsions, including AS03 (GlaxoSmith Kline, Pa.), MF-59 (microfluidized detergent stabilized squalene oil-in-water emulsion; Novartis), and Montanide ISA-51 VG (stabilized water-in-oil emulsion) and Montanide ISA-720 (stabilized water/squalene; Seppic Pharmaceuticals, Fairfield, N.J.); cholera toxin B subunit; saponins, such as Quil A or QS21, an HPLC purified non-toxic fraction derived from the bark of Quillaja Saponaria Molina (STIMULON™ (Antigenics, Inc., Lexington, Mass.) and saponin-based adjuvants, including immunostimulating complexes (ISCOMs; structured complex of saponins and lipids) and other ISCOM-based adjuvants, such as ISCOMATRIX™ and AbISCO®-100 and -300 series adjuvants (Isconova AB, Uppsala, Sweden); QS21 and 3 D-MPL together with an oil in water emulsion as disclosed in U.S. Pat. Appl. No. 2006/0073171; stearyl tyrosine (ST) and amide analogs thereof; virus-like particles (VLPs) and reconstituted influenza virosomes (IRIVs); complete Freund's adjuvant (CFA); incomplete Freund's adjuvant (IFA); E. coli heat-labile enterotoxin (LT); immune-adjuvants, including cytokines, such as IL-2, IL-12, GM-CSF, Flt3, accessory molecules, such as B7.1, and mast cell (MC) activators, such as mast cell activator compound 48/80 (C48/80); water-insoluble inorganic salts; liposomes, including those made from DNPC/Chol and DC Chol; micelles; squalene; squalane; muramyl dipeptides, such as N-acetyl-muramyl-L-threonyl-D-isoglutamine (thr-MDP) as found in U.S. Pat. No. 4,606,918, N-acetyl-normuramyl-L-alanyl-D-isoglutamine (nor-MDP), and N-acetylmuramyl-L-alanyl-D-isoglutaminyl-L-alanine-2-(1′2′-dipalmitoyl-n-glycero-3-hydroxyphosphoryl; SAF-1 (Syntex); AS05 (GlaxoSmith Kline, Pa.); and combinations thereof.


In preferred embodiments, adjuvant potency may be enhanced by combining multiple adjuvants as described above, including combining various delivery systems with immunopotentiating substances to form multi-component adjuvants with the potential to act synergistically to enhance antigen-specific immune responses in vivo. Exemplary immunopotentiating substances include the above-described adjuvants, including, for example, MPL and synthetic derivatives, MDP and derivatives, oligonucleotides (CpG etc), ds RNAs, alternative pathogen-associated molecular patterns (PAMPs) (E. coli heat labile enterotoxin; flagellin, saponins (QS-21 etc), small molecule immune potentiators (SMIPs, e.g., resiquimod [R848]), cytokines, and chemokines.


Methods of Treating or Preventing Staphyloccus Infections


Oligosaccharide Compositions


In one embodiment, the present invention provides pharmaceutically acceptable immunogenic or immunoprotective oligosaccharide compositions and their use in methods for preventing Staphylococcus infection in a patient in need thereof. In one embodiment, comprising administering an effective amount of an oligosaccharide of the present invention. An immunogenic or immunoprotective composition will include a “sufficient amount” or “an immunologically effective amount” of a dPNAG/PNAG-protein conjugate according to the present invention, as well as any of the above mentioned components, for purposes of generating an immune response or providing protective immunity, as further defined herein.


Administration of the oligosaccharide- or oligosaccharide conjugate compositions or antibodies, as described herein may be carried out by any suitable means, including by parenteral administration (e.g., intravenously, subcutaneously, intradermally, or intramuscularly); by topical administration, of for example, antibodies to an airway surface; by oral administration; by in ovo injection in birds, for example, and the like. Preferably, they are administered intramuscularly.


Typically, the compositions may be prepared as injectables, either as liquid solutions or suspensions; solid forms suitable for solution in, or suspension in, liquid vehicles prior to injection. An aqueous composition for parenteral administration, for example, may include a solution of the immunogenic component(s) dissolved or suspended in a pharmaceutically acceptable vehicle or diluent, preferably a primarily aqueous vehicle. An aqueous composition may be formulated as a sterile, pyrogen-free buffered saline or phosphate-containing solution, which may include a preservative or may be preservative free. Suitable preservatives include benzyl alcohol, parabens, thimerosal, chlorobutanol, and benzalkonium chloride, for example. Aqueous solutions are preferably approximately isotonic, and its tonicity may be adjusted with agents such as sodium tartrate, sodium chloride, propylene glycol, and sodium phosphate. Additionally, auxiliary substances required to approximate physiological conditions, including pH adjusting and buffering agents, tonicity adjusting agents, wetting or emulsifying agents, pH buffering substances, and the like, including sodium acetate, sodium lactate, sodium chloride, potassium chloride, calcium chloride, sorbitan monolaurate, triethanolamine oleate, etc. may be included with the vehicles described herein.


Compositions may be formulated in a solid or liquid form for oral delivery. For solid compositions, nontoxic and/or pharmaceutically acceptable solid vehicles may include, for example, pharmaceutical grades of mannitol, lactose, starch, magnesium stearate, sodium saccharin, talcum, cellulose, glucose, sucrose, magnesium carbonate, and the like. For oral administration, a pharmaceutically acceptable nontoxic composition may be formed by incorporating any of the normally employed excipients, including those vehicles previously listed, and a unit dosage of an active ingredient, that is, one or more compounds of the invention, whether conjugated to a carrier or not. Topical application of antibodies to an airway surface can be carried out by intranasal administration (e.g., by use of dropper, swab, or inhaler which deposits a pharmaceutical formulation intranasally). Topical application of the antibodies to an airway surface can also be carried out by inhalation administration, such as by creating respirable particles of a pharmaceutical formulation (including both solid particles and liquid particles) containing the antibodies as an aerosol suspension, and then causing the subject to inhale the respirable particles. Methods and apparatuses for administering respirable particles of pharmaceutical formulations are well known, and any conventional technique can be employed. Oral administration may be in the form of an ingestible liquid or solid formulation.


The preparation of such pharmaceutical compositions is within the ordinary skill in the art, and may be guided by standard reference books such as Remington the Science and Practice of Pharmacy, Lippincott Williams & Wilkins; 21 ed., May 1, 2005, which is incorporated herein by reference.


The concentration of the oligosaccharides of the invention in the pharmaceutical formulations can vary widely, i.e., from less than about 0.1%, usually at or at least about 0.1% to as much as 20% to 50% or more by weight, and may be selected on the basis of fluid volumes, viscosities, stability, etc., and/or in accordance with the particular mode of administration selected. A human unit dose form of the compounds and composition is typically included in a pharmaceutical composition that comprises a human unit dose of an acceptable vehicle, preferably an aqueous vehicle, and is administered in a volume of fluid that is known by those of skill in the art to be used for administration of such compositions to humans, and is adjusted according to commonly understood principles for a particular subject to be treated. Thus in one embodiment, the invention provides a unit dosage of the vaccine components of the invention in a suitable amount of an aqueous solution, such as 0.1-3 ml, preferably 0.2-2 mL.


The compositions of the present invention may be administered to any animal species at risk for developing an infection by a microbial species expressing a PNAG and/or PNAG antigen.


The present invention can also be used to treat or prevent other bacteria infections where the bacterium is known or suspected to express PNAG or dPNAG. Suitable bacteria that can be treated with the present invention include Staphylococcus species, such as S. aureus and S. epidermidis; Escherichia coli; Yersinia species (spp.), such as Y. pestis, Y. pseudotuberculosis, and Y. entercolitica; Bordetella spp., including B. pertussis, B. bronchiseptica, and B. parapertussis; Aggregatibacter actinomycetemcomitans, Actinobacillus pleuropneumoniae; Acinetobacter spp.; Burkholderia spp.; Stenatrophomonas maltophilia, Klebsiella spp., and Shigella spp. Accordingly, specific dPNAG/PNAG oligosaccharides may be modified, depending on the specific compositional makeup, including acetylation profiles of these antigens in their respective bacterial species.


The treatment may be given in a single dose schedule, or preferably a multiple dose schedule in which a primary course of treatment may be with 1-10 separate doses, followed by other doses given at subsequent time intervals required to maintain and or reinforce the response, for example, at 1-4 months for a second dose, and if needed, a subsequent dose(s) after several months. Examples of suitable treatment schedules include: (i) 0, 1 month and 6 months, (ii) 0, 7 days and 1 month, (iii) 0 and 1 month, (iv) 0 and 6 months, or other schedules sufficient to elicit the desired responses expected to reduce disease symptoms, or reduce severity of disease.


The amounts effective for inducing an immune response or providing protective immunity will depend on a variety of factors, including the oligosaccharide composition, conjugation to a carrier, inclusion and nature of adjuvant(s), the manner of administration, the weight and general state of health of the patient, and the judgment of the prescribing physician. By way of example, the amounts may generally range for the initial immunization (that is for a prophylactic administration) from about 1.0 μg to about 5,000 μg of oligosaccharide for a 70 kg patient, (e.g., 1.0 μg, 2.0 μg, 2.5 μg, 3.0 μg, 3.5 μg, 4.0 μg, 4.5 μg, 5.0 μg, 7.5 μg, 10 μg, 12.5 μg, 15 μg, 17.5 μg, 20 μg, 25 μg, 30 μg, 35 μg, 40 μg, 45 μg, 50 μg, 75 μg, 100 μg, 250 μg, 500 μg, 750 μg, 1,000 μg, 1,500 μg, 2,000 μg, 2,500 μg, 3,000 μg, 3,500 μg, 4,000 μg, 4,500 μg or 5,000 μg). The actual dose administered to a subject is often, but not necessarily, determined according to an appropriate amount per kg of the subject's body weight. For example, an effective amount may be about 0.1 μg to 5 μg/kg body weight.


A primary dose may optionally be followed by boosting dosages of from about 1.0 to about 1,000 of peptide (e.g., 1.0 μg, 2.0 μg, 2.5 μg, 3.0 μg, 3.5 μg, 4.0 μg, 4.5 μg, 5.0 μg, 7.5 μg, 10 μg, 12.5 μg, 15 μg, 17.5 μg, 20 μg, 25 μg, 30 μg, 35 μg, 40 μg, 45 μg, 50 μg, 75 μg, 100 μg, 250 μg, 500 μg, 750 μg, 1,000 μg, 1,500 μg, 2,000 μg, 2,500 μg, 3,000 μg, 3,500 μg, 4,000 μg, 4,500 μg or 5,000 μg) pursuant to a boosting regimen over weeks to months depending upon the patient's response and condition by measuring specific T cell activity in the patient's blood.


The immunogenic compositions comprising a compound of the invention may be suitable for use in adult humans or in children, including young children or others at risk for contracting an infection caused by a dPNAG/PNAG-expressing bacterial species. Optionally such a composition may be administered in combination with other pharmaceutically active substances, and frequently it will be administered in combination with other vaccines as part of a childhood vaccination program.


Antibody Compositions


In another embodiment, the invention provides an antibody preparation against one or more oligo-β-(1→6)-glucosamine 1a in accordance with the present invention. The antibody preparation may include any member from the group consisting of polyclonal antibody, monoclonal antibody, mouse monoclonal IgG antibody, humanized antibody, chimeric antibody, fragment thereof, or combination thereof.


Pharmaceutical antibody compositions may be used in a method for providing passive immunity against a bacterial target species of interest, including S. aureus and other dPNAG/PNAG-expressing bacteria. A pharmaceutical antibody composition may be administered to an animal subject, preferably a human, in an amount sufficient to prevent or attenuate the severity, extent of duration of the infection by the bacterial target species of interest.


The administration of the antibody may be either prophylactic (prior to anticipated exposure to a bacterial infection) or therapeutic (after the initiation of the infection, at or shortly after the onset of the symptoms). The dosage of the antibodies will vary depending upon factors as the subject's age, weight and species. In general, the dosage of the antibody may be in a range from about 1-10 mg/kg body weight. In a preferred embodiment, the antibody is a humanized antibody of the IgG or the IgA class. The route of administration of the antibody may be oral or systemic, for example, subcutaneous, intramuscular or intravenous.


Antibodies in Diagnostic Assays


In a further aspect, the present invention provides compositions and methods for inducing production of antibodies for diagnosing, treating, and/or preventing one or more infections caused by dPNAG/PNAG expressing bacteria.


Antisera to dPNAG/PNAG conjugates may be generated in New Zealand white rabbits by 3-4 subcutaneous injections over 13 weeks. A pre-immune bleed may generate about 5 mL of baseline serum from each rabbit. A prime injection (10 μg antigen equivalent) may be administered as an emulsion in complete Freund's adjuvant (CFA). Subsequent injections (5 μg antigen equivalent) may be given at three week intervals in incomplete Freund's adjuvant (IFA). Rabbits may be bled every two weeks commencing one week after the third immunization. Approximately 25-30 mL of serum per rabbit may be generated from each bleeding event and frozen at −80° C. Serum may be analyzed by ELISA against the corresponding dPNAG/PNAG conjugate as described below. In addition, antisera from later bleeds may be affinity purified as further described below.


The oligosaccharides and antibodies generated therefrom can be used as diagnostic reagents for detecting dPNAG-PNAG structures or antibodies thereagainst, which are present in biological samples. The detection reagents may be used in a variety of immunodiagnostic techniques, known to those of skill in the art, including ELISA- and microarray-related technologies. In addition, these reagents may be used to evaluate antibody responses, including serum antibody levels, to immunogenic oligosaccharide conjugates. The assay methodologies of the invention typically involve the use of labels such as fluorescent, chemiluminescent, radioactive, enzymatic labels or dye molecules, and/or secondary immunologic reagents for direct or indirect detection of a complex between an antigen or antibody in a biological sample and a corresponding antibody or antigen bound to a solid support.


Such assays typically involve separation of unbound antibody in a liquid phase from a solid phase support to which antibody-antigen complexes are bound. Solid supports which can be used in the practice of the invention include substrates such as nitrocellulose (e.g., in membrane or microtiter well form); polyvinylchloride (e.g., sheets or microtiter wells); polystyrene latex (e.g., beads or microtiter plates); polyvinylidine fluoride; diazotized paper; nylon membranes; activated beads, magnetically responsive beads, and the like.


Typically, a solid support is first reacted with a first binding component (e.g., an anti-dPNAG-PNAG antibody or dPNAG-PNAG oligosaccharide) under suitable binding conditions such that the first binding component is sufficiently immobilized to the support. In some cases, mobilization to the support can be enhanced by first coupling the antibody or oligosaccharide to a protein with better binding properties, or that provides for immobilization of the antibody or antigen on the support without significant loss of antibody binding activity or specificity. Suitable coupling proteins include, but are not limited to, macromolecules such as serum albumins including bovine serum albumin (BSA), keyhole limpet hemocyanin (KLH), immunoglobulin molecules, thyroglobulin, ovalbumin, and other proteins well known to those skilled in the art. Other molecules that can be used to bind antibodies the support include polysaccharides, polylactic acids, polyglycolic acids, polymeric amino acids, amino acid copolymers, and the like. Such molecules and methods of coupling these molecules are well known to those of ordinary skill in the art and are described in, for example, U.S. Pat. No. 7,595,307, U.S. Pat. Appl. No. US 2009/0155299, the disclosures and cited references therein of which are incorporated by reference herein.


The following examples are included for purposes of illustration and are not intended to limit the scope of the invention.


EXAMPLES
Example 1
Generation of dPNAG/PNAG Test Libraries

The above-described monosaccharide- and disaccharide building blocks were used in higher antigen assembly to initially provide a route for forming three large, defined poly-glucosamine structures. Thus, an initial library was generated from three basic hexamer units or “analog cores” (FIG. 2B) corresponding to: (1) a fully acetylated N-acetyl PNAG (ANC-PNAG; exemplified by thiol oligosaccharide 58), (2) a partially acetylated (16.7%) PNAG (ANC-dPNAG exemplified by thiol oligosaccharide 37) and (3) a fully non-acetylated PNAG (ANC-PNG; exemplified by thiol oligosaccharide 61).


Molecules generated with the first analog core in the initial PNAG library represented by 58, 59, 60 can serve as a control group and to mimic functionally the major secreted component of staphylococcal biofilm.


The second analog core containing a partially acetylated PNAG molecule exemplified by oligosaccharides 37, 40, 34, and conjugates thereof (see FIG. 2B) represents one possible product of chemical or ica B-mediated deacetylation (16.7% N-acetyl), which was shown by the semi-synthetically prepared version to confer opsonic and immunoprotective capability. The synthetic antigens herein are structurally defined molecules wherein the N-acetyl groups are regularly spaced every 6 glucosamine units. A significant portion of the multiple free amine groups in these antigens are likely to be protonated at physiologic pH and will have a major impact on the physical properties, such as tertiary structure and solubility.


The third analog core exemplifying a fully deacetylated PNAG molecule as represented by 61, 62, 63 in FIG. 2B. The third analog core presents a three-dimensional structure or tertiary structure distinguished from naturally derived deacetylated PNG structures and is similar to synthetic PNAGs recently described (Gening et al., Infect. Immun., 78:764, 2010, epub Nov. 30, 2009).


Key building blocks were divided into two batches; in each case, one was converted into an acceptor, the other into a donor. Coupling of the donor and acceptor units provided a key monosaccharide or disaccharide units for use in higher antigen assembly so as to provide an efficient route to large, defined poly-glucosamine structures. To produce the mixed-N-acetyl sequences (Ag 3, 6, and 9), an N-Troc protective group was employed to facilitate selective replacement with an N-acetyl. This chemistry was highly selective and produced a set of three mixed N-acetyl sequences (6, 12, and 18-mer) with one, two and three N-acetyl groups respectively. This corresponds to 16.7% incorporation of N-acetyl, similar to the average degree of N-acetylation found in the most active naturally-derived heterogeneous materials (Maira-Litran et al., Infect. Immun., 73:6752, 2005).


Each protected antigen was reacted with thioacetic acid to install a thioacetate at the reducing end as a conjugation site (See Scheme 2 of Buskas et al., J. Org. Chem., 65:958, 2000). Removal of the protecting groups provided two sets of compounds, the 100% poly-NH2 sequences (by 61, 62, 63) and the 16.7% N-acetyl substituted structures (thiol oligosaccharides 37, 40, 34). Reaction of a portion of the 100% poly-NH2 sequences with acetic anhydride under aqueous conditions provided the 100% poly-N-acetyl sequences (58, 59, 60). All synthetic antigens were purified via size exclusion chromatography (BioGel P2 or P4) and fully characterized by 1H-NMR, 13C-NMR and mass spectroscopy.


The PNAG-based library set contains 9 structures comprised of molecules varying by the 3 core unit analogs used and by 3 different molecule lengths (FIG. 2B). Complete analytical characterization (NMR, MS, HPLC, elemental analysis) demonstrated that each molecule was over 98% pure compound.


Example 2
Standard Operating Procedure (SOP) 1: Removal of 1° TBS Group

To a solution of the starting tert-butyldimethylsilyl (TBS) containing material (35 mmol) in CH3CN (500 mL) were added H2O (50 mL) over 10 minutes. Scandium trifluoromethanesulfonate trihydrate (Sc(OTf)3, 400 mg, 0.8 mmol) were added and the reaction mixture was stirred at room temperature for 24 hours. The reaction mixture was then diluted with EtOAc (500 mL) and washed with saturated aqueous NaHCO3 and brine. The organic solution was dried over Na2SO4, filtered and concentrated. Purification via silica gel chromatography (EtOAc/Heptanes; 50-100% EtOAc gradient) afforded the desired deprotected product. Typical isolated yields for the product formation varied between 60-92%.


Example 3
SOP 2: Removal of Allyl Group

A solution of 1,5-cyclooctadienebis(methyldiphenylphosphine)iridium(I) hexafluorophosphate (Ir cat.; 0.3 mmol) in THF (50 mL) was purged with hydrogen bubbling until a clear yellow solution remained (˜15 minutes). The activated Ir catalyst solution was then purged with nitrogen bubbling for 15 minutes. A solution of the allyl glycoside (10 mmol) in THF (20 mL) was added in one portion to the Ir catalyst solution and the resulting reaction mixture was stirred for 30 minutes. The inert atmosphere was removed and a solution of N-methylmorpholine N-oxide (NMO, 50% aqueous, 20 mL) was added followed by osmium tetroxide (0.03 mmol). The resulting biphasic reaction mixture was stirred in the dark for 2 h, then quenched with 20 mL 1M aqueous Na2S2O4. After vigorous stirring for 1 h, the organic phase was partitioned, diluted with EtOAc (400 mL) and washed with 1M HCl (aq.), H2O and brine. The organics were dried over Na2SO4, filtered and concentrated. Purification via silica gel chromatography (EtOAc/Heptanes; 50-100% EtOAc gradient) afforded the desired hydroxyl product. Typical isolated yields for the product formation varied between 80-95%.


Example 4
SOP 3: Tricholoracetimidate Formation

Formation with DBU.


A solution of the starting sugar (4 mmol) in CH2Cl2 (20 mL) was treated with trichloroacetonitrile (5 mL). To the reaction mixture were added 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU, 0.1 mL, 0.6 mmol) dropwise. The reaction mixture was stirred at room temperature for 1 h, then concentrated to a viscous oil. Purification via filtration through a silica gel plug pre-treated with EtOAc containing 0.1% TEA afforded the desired trichloroacetimidate product. Typical isolated yields for the product formation varied between 80-95%.


Formation with K2CO3.


A solution of the starting sugar (4 mmol) in CH2Cl2 (20 mL) was treated with trichloroacetonitrile (5 mL). K2CO3 (5 g) was added to the reaction mixture and the heterogeneous solution was stirred for 12 h. The reaction mixture was filtered through celite, rinsed with CH2Cl2 and concentrated in vacuo. Purification via filtration through a silica gel plug pre-treated with EtOAc containing 0.1% TEA afforded the desired trichloroacetimidate product. Typical isolated yields for the product formation varied between 80-95%.


Example 5
SOP 4: Glycoslyation Using Trichloroacetimidate Donors

Glycosyl trichloroacetimidate (12.0 mmol) and glycosyl acceptor (10.0 mmol) were combined, co-evaporated with toluene (3×20 mL) and dried in vacuo for 1 h. The resulting mixture was dissolved in dry CH2Cl2 (50 mL) under nitrogen and the reaction mixture was cooled to −20° C. A solution of trimethylsilyl trifluoromethanesulfonate (TMSOTf, 0.10 M in CH2Cl2, 0.12 mL, 1.2 mmol) was added dropwise over 10 minutes and the reaction stirred for an additional 30 minutes. The reaction mixture was diluted with CH2Cl2 (50 mL) and washed with saturated aqueous NaHCO3 and brine. The organic solution was dried over Na2SO4, filtered and concentrated. Purification via silica gel chromatography (EtOAc/Heptanes; 50-100% EtOAc gradient) afforded the desired coupling product. Typical isolated yields for the product formation varied between 60-97%.


Example 6
SOP 5: Removal of N-Troc Group and In Situ N-Acetylation

Starting N-Troc oligosaccharide (0.22 mmol) was dissolved in THF:Ac2O:AcOH (8:3:1, v:v:v; 20 mL). The reaction mixture was treated with activated Zn (15 mmol) and stirred at room temperature for 1 h. The reaction mixture was diluted with EtOAc, filtered through celite and washed with saturated aqueous NaHCO3 and brine. Purification via silica gel chromatography (EtOAc/Heptanes; 100% EtOAc gradient) afforded the desired N-Acetate product. Typical isolated yields for the product formation varied between 60-90%.


Zinc activation: Zinc (50 g, powdered) was washed with 200 mL each: 2M HCl (aqueous), H2O, EtOH and THF. The solids were dried in vacuo overnight to a constant weight.


Example 7
SOP 6: Thiol Addition to Olefin

Starting allyl glycoside (0.22 mmol) was dissolved in 1,4-dioxane (5 mL). The solution was degassed with nitrogen. Thiol acetic acid (2.2 mmol) and 2,2′-azobis(isobutyronitrile) (0.088 mmol) were added and the reaction mixture was degassed a second time. The reaction was heated to 75° C. for 3 h, then cooled to room temperature and quenched with cyclohexene (0.2 mL). After concentration, the crude reaction mixture was purified via silica gel chromatography (EtOAc/Heptanes; 50-100% EtOAc gradient) to provide the thiolated reaction product. Typical isolated yields for the product formation varied between 70-95%.


Example 8
SOP7: Removal of O-Acetate, N-Phthaloyl, and S-Acetate Groups

Starting protected oligosaccharide (0.06 mmol) was dissolved in MeOH (10 mL). Hydrazine hydrate (1 mL) was added and the reaction mixture was heated to 65° C. for 3 h. White precipitates formed upon heating. After 3 h at 65° C., H2O (5 mL) was added and the reaction mixture was stirred at 65° C. for an additional 12 h. The reaction mixture was concentrated in vacuo and co-evaporated with H2O (3×5 mL). Purification via size exclusion chromatography (Biogel P-2 Media, 1″×24″ column, gravity pressure, H2O eluent) afforded the desired fully deprotected oligosaccharides as a mixture of thiol-disulfide products. Typical isolated yields for the product formation varied between 60-85%.


Example 9
Synthesis of Monosaccharide Building Blocks


FIG. 3 outlines the reaction scheme for synthesizing the monosaccharide building blocks, which proceeds according to the following steps.


Synthesis of Building Blocks 6 and 8 for Selective Amine Group Protection of Individual Monosaccharide Units


Glucosamine 1 (90 g, 0.23 mol), (prepared as described in Tetrahedron 1997, 53, 12, 4159) was dissolved in pyridine (405 mL) and triethylamine (36.5 mL). The solution was stirred for 15 minutes followed by the addition of phthalic anhydride (22 g, 0.15 mmol). The reaction mixture was maintained at room temperature in a water bath for 30 minutes. Triethylamine (40.5 mL) and phthalic anhydride (22 g, 0.15 mmol) were added and stirred at room temperature for an additional 45 minutes. The reaction mixture was heated to 90° C. and acetic anhydride (121.5 mL) was added. The reaction mixture was maintained at 90-95° C. for 10 minutes followed by concentration in vacuo to a thick, yellow syrup. The crude product was dissolved in CH2Cl2 (1.0 L) and washed with H2O (3×500 mL). The organic solution was dried over Na2SO4, filtered and concentrated to a syrup. The product was recovered via recrystallization from ethanol (300 mL, 190 proof, 0.1% MeOH). Recovered 103 g product 2, 93% yield. To a solution of 2 (103 g, 0.21 mol) in CH2Cl2 (700 mL) were added allyl alcohol (62 mL). The reaction mixture was purged with N2 and cooled to 0° C. SnCl4 (62 mL) was added dropwise over 1 h. The reaction mixture was kept at 0° C. for 6 h then warmed to room temperature and stirred for 48 h. The solution was poured into ice water (1 L), separated and the organics were washed with 3×500 mL H2O, dried over Na2SO4, filtered and concentrated to a syrup. Recovered 3 (100 g) as a yellow oil. A solution of 3 (1.0 g, 2.1 mmol) was dissolved in MeOH (10 mL) and cooled to 0° C. Acetyl chloride (0.75 mL) was added dropwise over 5 minutes. The solution was allowed to warm to room temperature over 2 h and stirred for an additional 48 h. The reaction mixture was concentrated in vacuo to afford 4 (0.7 g) as a white solid. Starting monomer 4 (49.2 g, 0.141 mol) was dissolved in pyridine (160 mL) and cooled to 0° C. under N2. A solution of tert-butyldimethylsilyl chloride (TBSCl, 21.3 g, 0.141 mol) in CH2Cl2 (70 mL) was added over 1 h and the temperature was maintained at <1° C. The reaction mixture was stirred for an additional 1 h at 0° C., then a second portion of TBSCl (2.0 g, 0.014 mol) in CH2Cl2 (7 mL) was added and stirred at 0° C. for 1 h. The reaction mixture was warmed to room temperature for 2 h and then re-cooled to 0° C. Acetic anhydride (80 mL) was added over 1 h at 0° C. and the solution was warmed to room temperature overnight. After 12 h at rt, the reaction mixture was poured onto ice water (1 L) and stirred for 1 h. The biphasic solution was extracted with EtOAc in 3 portions (1 L, then 2×250 mL). The combined organics were concentrated and the product recrystallized from hot ethanol (300 mL) to give 5 (66 g, 86% yield) as a white solid. TBS removal was performed as described in SOP 1 using 5 (32 g, 59 mmol) and Sc(OTf)3 (400 mg, 0.8 mmol). Product 6 was formed in 88% yield (22.5 g). Allyl removal was performed as described in SOP 2 using Ir catalyst (1.0 g, 1.2 mmol), 5 (70 g, 127 mmol), 50% aqueous NMO (100 mL) and OsO4 (20 mg, 0.08 mmol). Product 7 was formed in 94% yield (61 g). Glycosyl trichloroacetimidate 8 was formed as described in SOP 3a using 7 (61 g, 120 mmol), trichloroacetonitrile (30 mL) and DBU (1 mL). Product 8 was formed in 96% yield (75.9 g).


Synthesis of Monosaccharide Building Blocks 14 and 47 for Selective Protection and Subsequent Acetylation of Individual Monosaccharide Units


Starting sugar 1 (50 g, 130 mmol; see FIG. 3) was dissolved in THF (350 mL). With constant stirring, a solution of NaHCO3 (22 g in 170 mL H2O) was added slowly over 20 minutes. The reaction mixture was stirred for an additional 20 minutes. Troc-Cl (18.5 mL, 60 mmol) was added over 10 minutes followed by a second portion (18.5 mL, 60 mmol). After 1 hour, the reaction mixture was diluted with H2O (500 mL) and EtOAc (1 L). The organics were partitioned and washed with 2×250 mL brine, dried over Na2SO4, filtered and concentrated. Product 9 was recovered in quantitative yield (69 g). To a solution of 9 (78 g, 0.15 mol) in CH2Cl2 (350 mL) were added allyl alcohol (43 mL). The reaction mixture was purged with N2 and cooled to 0° C. SnCl4 (43 mL) was added dropwise over 1 h. The reaction mixture was kept at 0° C. for 6 h then warmed to room temperature and stirred for 24 h. The solution was poured into ice water (1 L), separated and the organics were washed with 3×500 mL H2O, dried over Na2SO4, filtered and concentrated to a syrup. Recovered 10 (72 g) as a yellow oil in 92% yield. A solution of 10 (72 g, 138 mmol) was dissolved in MeOH (300 mL) and cooled to 0° C. Acetyl chloride (30 mL) was added dropwise over 5 minutes. The solution was allowed to warm to room temperature over 2 h and stirred for an additional 48 h. The reaction mixture Was concentrated in vacuo to afford 11 (54 g) as a yellow syrup that was used in the next step without further purification. Starting monomer 11 (54 g, 0.138 mol) was dissolved in pyridine (180 mL) and cooled to 0° C. under N2. A solution of tert-butyldimethylsilyl chloride (TBSCl, 23.7 g, 0.157 mol) in CH2Cl2 (75 mL) was added over 1 h and the temperature was maintained at <1° C. The reaction mixture was stirred for an additional 1 h at 0° C., then a second portion of TBSCl (4.0 g, 0.028 mol) in CH2Cl2 (10 mL) was added and stirred at 0° C. for 1 h. The reaction mixture was warmed to room temperature for 2 h and then re-cooled to 0° C. Acetic anhydride (80 mL) was added over 1 h at 0° C. and the solution was warmed to room temperature overnight. After 12 h at rt, the reaction mixture was poured onto ice water (1 L) and stirred for 1 h. The biphasic solution was extracted with EtOAc in 3 portions (1 L, then 2×250 mL). The combined organics were concentrated and the product recrystallized from hot ethanol (300 mL) to give 12 (65 g, 80% yield) as a white solid. Allyl removal was performed as described in SOP 2 using Ir catalyst (0.6 g, 0.7 mmol), 12 (32 g, 54 mmol), 50% aqueous NMO (50 mL) and OsO4 (10 mg, 0.04 mmol). Product 13 was formed in 70% yield (21 g, 38 mmol). Glycosyl trichloroacetimidate 14 was formed as described in SOP 3 using 13 (21 g, 38 mmol), trichloroacetonitrile (30 mL) and K2CO3 (20 g). Product 14 was formed in 97% yield (25.5 g).


Example 10
Synthesis of Disaccharide Building Blocks


FIG. 4A-4D outline reaction schemes for synthesizing various disaccharide building blocks, including those depicted in FIG. 4A which proceeds according to the following steps. In FIG. 4A, coupling was performed as described in SOP 4 using trichloroacetimidate 14 (13.2 g, 19.1 mmol), acceptor 6 (6.34 g, 14.7 mmol) and TMSOTf (2.94 mL, 0.5 M in CH2Cl2, 1.47 mmol). Product 15 was formed in 80% yield (11.04 g). Allyl removal was performed as described in SOP 2 using Ir catalyst (0.25 g, 0.3 mmol), 15 (10 g, 10 mmol), 50% aqueous NMO (25 mL) and OsO4 (5 mg, 0.02 mmol). Product 16 was formed in 90% yield (9 g, 9 mmol). Glycosyl trichloroacetimidate 17 was formed as described in SOP 3 using 16 (9 g, 9 mmol), trichloroacetonitrile (20 mL) and K2CO3 (10 g). Product 17 was formed in quantitative yield (10 g).


The reaction schemes depicted in FIGS. 4B-4D employ monosaccharide building block starting materials (as shown), but essentially the same steps and SOPs (-1, -2, -3, and -4) as described above. For example, in FIG. 4C, coupling was performed as described in SOP 4 using: trichloroacetimidate 14 (12 g, 17.2 mmol), acceptor 47 (6.86 g, 14.3 mmol) and TMSOTf (1.43 mL, 1.0 M in CH2Cl2, 1.43 mmol). Product 48 was formed in 98% yield (14.2 g, 14 mmol).


Example 11
Synthesis of Mixed-N-acetyl oligo-β-(1→6)-glucosamine Structures


FIG. 5A-5B depict a reaction scheme for synthesizing a mixed-N-acetyl oligo-β-(1→6)-glucosamine 6-mer (37 in FIG. 2B), which proceeds according to the following steps. Utilization of monosaccharide and disaccharide building blocks described in FIGS. 3 and 4A-4D in conjunction with the indicated SOPs additionally described in Examples 2-8 exemplify the methodologies and reagents for synthesizing mixed-N-acetyl oligo-β-(1→6)-glucosamine structures, including oligosaccharides 37, 40, and 34 in FIG. 2B, the syntheses of which are outlined in FIGS. 5A, 5B (6-mer, 37), FIGS. 6A, 6B (12-mer, 40), and FIGS. 7A, 7B (18-mer, 34) and further described below.


Synthesis of Mixed-N-acetyl oligo-β-(1→6)-glucosamine 6-mer thiol 37


Referring to FIG. 5A, coupling was performed as described in SOP 4 using trichloroacetimidate 8 (65 g, 101 mmol), acceptor 6 (36.3 g, 84 mmol) and TMSOTf (8.4 mL, 1.0 M in CH2Cl2, 8.4 mmol). Product 18 was formed in 96% yield (75 g). TBS removal was performed as described in SOP 1 using 18 (35 g, 38 mmol) and Sc(OTf)3 (400 mg, 0.8 mmol). Product 21 was formed in 84% yield (26 g, 32 mmol). Allyl removal was performed as described in SOP 2 using Ir catalyst (0.50 g, 0.6 mmol), 18 (50 g, 55 mmol), 50% aqueous NMO (50 mL) and OsO4 (10 mg, 0.04 mmol). Product 19 was formed in 77% yield (37.5 g, 42.5 mmol). Glycosyl trichloroacetimidate 20 was formed as described in SOP 3 using 19 (37 g, 42 mmol), trichloroacetonitrile (20 mL) and DBU (0.6 mL). Product 20 was formed in quantitative yield (44 g). Coupling was performed as described in SOP 4 using trichloroacetimidate 20 (35 g, 34 mmol), acceptor 21 (23 g, 28 mmol) and TMSOTf (2.8 mL, 1.0 M in CH2Cl2, 2.8 mmol). Product 22 was formed in 82% yield (38 g). TBS removal was performed as described in SOP 1 using 22 (37 g, 22 mmol) and Sc(OTf)3 (400 mg, 0.8 mmol). Product 23 was formed in 68% yield (24 g, 15 mmol).


Referring now to FIG. 5B, coupling was performed as described in SOP 4 using trichloroacetimidate 17 (9.9 g, 9.2 mmol), acceptor 23 (12 g, 7.7 mmol) and TMSOTf (0.77 mL, 1.0 M in CH2Cl2, 0.77 mmol). Product 24 was formed in 83% yield (15.7 g, 6.4 mmol). TBS removal was performed as described in SOP 1 using 24 (4.55 g, 1.8 mmol) and Sc(OTf)3 (60 mg, 0.12 mmol). Product 27 was formed in 83% yield (3.6 g, 1.5 mmol). Exchange of N-Troc for N-Acetate groups was performed as described in SOP 5 using 27 (0.50 g, 0.23 mmol) and Zn (1 g) in THF:Ac2O:AcOH (20 mL). Product 35 was formed in 51% yield (0.25 g, 0.12 mmol). Thiol addition was performed as described in SOP 6 using 35 (0.20 g, 0.09 mmol), HSAc (0.5 mL) and AIBN (50 mg). Product 36 was formed in 78% yield (0.16 g, 0.07 mmol). Deprotection was performed as described in SOP 7 using 36 (0.15 g, 0.06 mmol) and hydrazine (1 mL). Product 37 was formed in 90% yield (0.07 g, 0.054 mmol).


Synthesis of Mixed-N-acetyl oligo-β-(16)-glucosamine 12-mer thiol


As depicted in FIGS. 6A and 6B, synthesis of the mixed-N-acetyl oligo-β-(1→6)-glucosamine 12-mer thiol proceeded according to the following steps. With reference to FIG. 6A, allyl removal in 24 was performed as described in SOP 2 using Ir catalyst (0.25 g, 0.3 mmol), 24 (7.5 g, 3.0 mmol), 50% aqueous NMO (25 mL) and OsO4 (5 mg, 0.04 mmol). Product 25 was formed in 93% yield (7.0 g, 2.8 mmol). Glycosyl trichloroacetimidate 26 was formed from 25 as described in SOP 3b using 25 (7.0 g, 2.8 mmol), trichloroacetonitrile (10 mL) and K2CO3 (7 g). Product 26 was formed in 86% yield (6.3 g, 2.4 mmol). TBS removal of was performed as described in SOP 1 using 24 (4.55 g, 1.8 mmol) and Sc(OTf)3 (60 mg, 0.12 mmol). Product 27 was formed in 83% yield (3.6 g, 1.5 mmol). Coupling of 26 and 27 was performed as described in SOP 4 using trichloroacetimidate 26 (4.2 g, 1.6 mmol), acceptor 27 (3.2 g, 1.36 mmol) and TMSOTf (1.36 mL, 0.1 M in CH2Cl2, 0.136 mmol). Product 28 was formed in 65% yield (4.2 g, 0.88 mmol). TBS removal in 28 was performed as described in SOP 1 using 28 (4.0 g, 0.84 mmol) and Sc(OTf)3 (60 mg, 0.12 mmol). Product 29 was formed in 63% yield (2.6 g, 0.55 mmol);


Referring now to FIG. 6B, (6) exchange of N-Troc for N-Acetate groups in 29 was performed as described in SOP 5 using 29 (0.47 g, 0.10 mmol) and Zn (1 g) in THF:Ac2O:AcOH (20 mL). Product 38 was formed in 90% yield (0.4 g, 0.09 mmol). Thiol addition to 38 was performed as described in SOP 6 using 38 (0.40 g, 0.09 mmol), HSAc (0.5 mL) and AIBN (50 mg). Product 39 was formed in 57% yield (0.23 g, 0.51 mmol). Deprotection of 39 and formation of 40 was performed as described in SOP 7 using 39 (0.22 g, 0.065 mmol) and hydrazine (3 mL). Product 40 was formed in 73% yield (0.10 g, 0.047 mmol).


Synthesis of Mixed-N-acetyl oligo-β-(1→6)-glucosamine 18-mer thiol


As depicted in FIG. 7, synthesis of the mixed-N-acetyl oligo-(3-(1→6)-glucosamine 18-mer thiol proceeded according to the following steps. Coupling of 26 and 29 was performed as described in SOP 4 using trichloroacetimidate 26 (1.17 g, 0.455 mmol), acceptor 29 (1.41 g, 0.303 mmol) and TMSOTf (0.3 mL, 0.1 M in CH2Cl2, 0.03 mmol). Product 30 was formed in 67% yield (1.4 g, 0.20 mmol). TBS removal in 30 was performed as described in SOP 1 using 30 (2 g, 0.29 mmol) and Sc(OTf)3 (40 mg, 0.08 mmol). Product 31 was formed in 90% yield (0.18 g, 0.26 mmol). Exchange of N-Troc for N-Acetate groups in 31 was performed as described in SOP 5 using 31 (0.73 g, 0.10 mmol) and Zn (1 g) in THF:Ac2O:AcOH (20 mL). Product 32 was formed in 92% yield (0.6 g, 0.092 mmol). Thiol addition to 32 was performed as described in SOP 6 using 32 (0.6 g, 0.092 mmol), HSAc (0.5 mL) and AIBN (50 mg). Product 33 was formed in 83% yield (0.5 g, 0.076 mmol). Deprotection of 33 and formation of 34 was performed as described in SOP 7 using 33 (0.5 g, 0.076 mmol) and hydrazine (3 mL). Product 34 was formed in 79% yield (0.19 g, 0.06 mmol).


Table 1 provides supporting characterization data for selected antigens and intermediates described in Example 11.













TABLE 1









Molecule
NMR
Mass Spec














Series
Description
#

1H


13C

Theo.
ESI (Pos. Mode)
MALDI





6-mer
Troc/Phth
27


2355
2376 (M + Na+)




NHAc/Phth
35


2221
2277 (M+ + HOAc)



NHAc/Phth/SAc
36


2340
2353 (M+)



NHAc/NH2
37


1101
1101 (M+)


12-mer
Troc/Phth
29


4652

4674 (M + Na+)



NHAc/Phth
38


4386

4409 (M + Na+)



NHAc/Phth/SAc
39


4459
4482 (M + Na+)



NHAc/NH2
40


2109

2110 (M + H+)


18-mer
Troc/Phth
31


6949

6973 (M + Na+)



NHAc/Phth
32


6549

6572 (M + Na+)



NHAc/Phth/SAc
33


6622

6668 (M+ + HOAc)



NHAc/NH2
34


3117
1039 (M+3)
3140 (M + Na+)









In Table 1, protein assays were performed according to the method of Bradford, M. Anal. Biochem. 1976, 72, 248. Maldi analysis was performed using 2,5-dihydroxybenzoid acid as a matrix. Copy numbers were determined by the formula: copy number=[Maldi(observed)−76,000(Maldi of BSA alone)]/antigen MW. Carbohydrate content in KLH sample was extrapolated from BSA using the formula: KLH carbohydrate content=BSA carbohydrate content/2.65.


Example 12
Conjugation of Mixed-N-acetyl oligo-β-(1→6)-glucosamine thiols to BSA and KLH

Conjugation of Mixed-N-acetyl oligo-β-(1→6)-glucosamine 6-mer thiol 34 to BSA and KLH



FIGS. 8A and 8B depict reaction schemes for conjugating a mixed-N-acetyl oligo-β-(1→6)-glucosamine 6-mer thiol 37 to BSA and KLH as follows. First, a conjugation stock solution of hexamer thiol 37 was prepared by dissolving the hexamer thiol 37 (4.2 mg, 3.81 μmol) in water (0.300 mL). A solution of tris(2-carboxyethyl)phosphine (TCEP) in water (40 μL, 0.05 M, 1.95 μmol) was added and stirred for 1 hour. Imject® Conjugation Buffer (Pierce, 300 μL) was added to provide a stock solution for conjugation to BSA (FIG. 8A) and KLH (FIG. 8B).


With reference to FIG. 8A, the conjugation stock solution of hexamer thiol 37 (500 μL, 3.0 μmol) was added to a solution of maleimide-activated bovine serum albumin (Imject® BSA, Pierce, Rockford, Ill.) (5 mg, —1.5 μmol maleimide) in Imject® Conjugation Buffer (Pierce, 250 μL diluted with 250 μL water) and the resulting solution stirred for 18 hours at room temperature. The reaction mixture was purified by de-salting on D-Salt P-6000 10 mL column (Pierce, Rockford, Ill.). The column was pre-equilibrated with 30 mL of purification buffer (Pierce, Prod. No. 77159), the crude material loaded onto the column and eluted with purification buffer. 1-mL fractions were collected and analyzed for protein content by absorbance at 280 nm (A280). Fractions containing protein were combined and lyophilized to give the desired hexamer-BSA conjugate 41.


Turning now to FIG. 8B, the conjugation stock solution of hexamer thiol 37 (140 μL, 0.86 μmol) was added to a solution of maleimide-activated keyhole limpet hemocyanin (Imject® KLH, Pierce, Rockford, Ill.) (5 mg, ˜0.43 μmol maleimide) in water (0.5 mL) was added and the resulting solution stirred overnight at room temperature. The reaction mixture was purified by de-salting on D-Salt P-6000 10 mL column (Pierce, Rockford, Ill.). The column was pre-equilibrated with 30 mL of purification buffer (Pierce, Prod. No. 77159), the crude material loaded onto the column and eluted with purification buffer. 1-mL fractions were collected and analyzed for protein content by absorbance at 280 nm (A280). Fractions containing protein were combined and lyophilized to give the desired hexamer-KLH conjugate 42.


Conjugation of Mixed-N-acetyl oligo-β-(1→6)-glucosamine 12-mer thiol 40 to BSA and KLH



FIGS. 9A and 9B depict reaction schemes for conjugating mixed-N-acetyl oligo-β-(1→6)-glucosamine 12-mers (Ag 9 in FIG. 2B) to BSA and KLH as follows. First, a conjugation stock solution of 12-per thiol 40 was prepared by dissolving the 12-mer 40 (8.1 mg, 3.84 μmol) in water (300 μL). A solution of tris(2-carboxyethyl)phosphine (TCEP) in water (30 μL, 0.05 M, 1. 5 μmol) was added and stirred for 1 hour. Imject® Conjugation Buffer (Pierce, 300 μL) was added to provide a stock solution for conjugation to BSA (FIG. 9A) and KLH (FIG. 9B).


With reference to FIG. 9A, the conjugation stock solution of 12-mer thiol 40 (500 μL, 3.0 μmol) was added to a solution of maleimide-activated bovine serum albumin (Imject® BSA, Pierce, Rockford, Ill.) (5 mg, ˜1.5 μmol maleimide) in Imject® Conjugation Buffer (Pierce, 250 μL diluted with water, 250 μL) and the resulting solution stirred for 18 hours at room temperature. The reaction mixture was purified by de-salting on D-Salt P-6000 10 mL column (Pierce, Rockford, Ill.). The column was pre-equilibrated with 30 mL of purification buffer (Pierce, Prod. No. 77159), the crude material loaded onto the column and eluted with purification buffer. 1-mL fractions were collected and analyzed for protein content by absorbance at 280 nm (A280). Fractions containing protein were combined and lyophilized to give the desired 12-mer-BSA conjugate 43.


Turning now to FIG. 9B, the conjugation stock solution of 12-mer thiol 40 (140 μL, 0.86 μmol) was added to a solution of maleimide-activated keyhole limpet hemocyanin (Imject® KLH, Pierce, Rockford, Ill.) (5 mg, ˜0.43 μmol maleimide) in water (0.5 mL) was added and the resulting solution stirred overnight at room temperature. The reaction mixture was purified by de-salting on D-Salt P-6000 10 mL column (Pierce, Rockford, Ill.). The column was pre-equilibrated with 30 mL of purification buffer (Pierce, Prod. No. 77159), the crude material loaded onto the column and eluted with purification buffer. 1-mL fractions were collected and analyzed for protein content by absorbance at 280 nm (A280). Fractions containing protein were combined and lyophilized to give the desired 12-mer-KLH conjugate 44.


Conjugation of Mixed-N-acetyl oligo-β-(1→6)-glucosamine 18-mer thiol 34 to BSA and KLH



FIGS. 10A and 10B depict reaction schemes for conjugating mixed-N-acetyl oligo-β-(1→6)-glucosamine 18-mers (Ag 3 in FIG. 2B) to BSA and KLH as follows. First, a conjugation stock solution of 18-mer thiol 34 was prepared by dissolving the 18-mer 34 (12 mg, 3.8 μmol) in water (0.3 mL). A suspension of tris(2-carboxyethyl)phosphine (TCEP)-bound agarose resin in water (200 μL, ˜1 μmol) was added and stirred for 1 hour. The TCEP-resin was filtered and to the filtrate was added Imject® Conjugation Buffer (Pierce, 300 μL) to provide a stock solution for conjugation to KLH (FIG. 10A) and BSA (FIG. 10B).


With reference to FIG. 10A, the conjugation stock solution of 18-mer thiol 34 (0.5 mL, 3.0 μmol) was added to a solution of maleimide-activated bovine serum albumin (Imject® BSA, Pierce, Rockford, Ill.) (5 mg, ˜1.5 mol maleimide) in Imject® Conjugation Buffer (Pierce, 250 μL diluted with water, 2500 μL) and the resulting solution stirred for 18 hours at room temperature. The reaction mixture was purified by de-salting on D-Salt P-6000 10 mL column (Pierce, Rockford, Ill.). The column was pre-equilibrated with 30 mL of purification buffer (Pierce, Prod. No. 77159), the crude material loaded onto the column and eluted with purification buffer. 1-mL fractions were collected and analyzed for protein content by absorbance at 280 nm (A280). Fractions containing protein were combined and lyophilized to give the desired 18-mer-BSA conjugate 45.


Turning now to FIG. 10B, the conjugation stock solution of 18-mer thiol 34 (0.14 mL, 0.86 μmol) was added to a solution of keyhole limpet hemocyanin (Imject® KLH, Pierce, Rockford, Ill.) (5 mg, ˜0.43 μmol maleimide) in water (500 μL) and the resulting solution stirred for 18 hours at room temperature. The reaction mixture was purified by de-salting on D-Salt P-6000 10 mL column (Pierce, Rockford, Ill.). The column was pre-equilibrated with 30 mL of purification buffer (Pierce, Prod. No. 77159), the crude material loaded onto the column and eluted with purification buffer. 1-mL fractions were collected and analyzed for protein content by absorbance at 280 nm (A280). Fractions containing protein were combined and lyophilized to give the desired 18-mer-KLH conjugate 46.


Table 2 provides supporting characterization data for the antigen conjugates described in Example 12.













TABLE 2









Protein Assay

% Carbohydrate















Conjugate

BSA
KLH

Antigen
Ave Copy




#
Description
(mg/mL)
(mg/mL)
MALDI
MW
Number
MALDI
Sample





41
S-6Mix-BSA
1.62

100,900
1101
23
23%



42
S-6Mix-KLH

0.85

1101


 9%


43
S-12Mix-BSA
0.98

112,100
2109
17
30%


44
S-12Mix-KLH

1.32

2109


11%


45
S-18Mix-BSA
1.33

126,251
3117
16
38%


46
S-18Mix-KLH

1.21

3117


14%









In Table 2, protein assays, Maldi analysis, copy numbers, and carbohydrate content were determined as described above with reference to Table 1.


Example 13
Serum Antibody Production and Purification

Antisera to antigen-KLH conjugates were raised in New Zealand white rabbits by four subcutaneous injections of antigen-KLH conjugate over 13 weeks. A pre-immune bleed generated 5 mL of baseline serum from each rabbit. The prime injection (10 μg antigen equivalent) was given as an emulsion in complete Freund's adjuvant (CFA). Subsequent injections (5 μg antigen equivalent) were given at three week intervals in incomplete Freund's adjuvant (IFA). Rabbits were bled every two weeks commencing one week after the third immunization. Approximately 25-30 mL of serum per rabbit was generated for each bleeding event, and was aliquoted into 1-mL aliquots and frozen at −80° C. Serum was analyzed by ELISA against the corresponding antigen-BSA conjugate as described in Example 3 below.


Affinity purification of antisera was conducted with serum from the third bleed from each rabbit. Affinity purification was carried out by coupling of antigen-BSA conjugates to CNBr-activated Sepharose 4B. Briefly, CNBr-activated Sepharose 4B (0.8 g, 2.5 ml of final gel volume) was washed and re-swelled on a sintered glass filter with 1 mM HCl, then coupling buffer (0.1 M NaHCO3, 0.25M NaCl, pH 8.5). Antigen-BSA conjugate (1 mg) was dissolved in coupling buffer, mixed with the gel suspension and incubated overnight at 40° C. Unreacted active groups were capped with glycine buffer (0.2M, pH 8.1) and excess adsorbed conjugated was washed away with coupling buffer, then acetate buffer (0.1 M containing 0.5M NaCl, pH 4.3). The column was equilibrated with phosphate buffered saline (PBS), pH 7.7.


Antisera were affinity purified by diluting clear antiserum (5 mL) 1:1 with PBS pH 7.7 and applying the diluted antisera to the affinity column at the rate of 0.3 ml/min and absorbance of eluate was monitored at 280 nm. Unbound material (flow through) was collected and analyzed by ELISA using the general ELISA procedure. The column was washed with PBS until A280 reached baseline. Bound antibodies were eluted with 0.2M glycine (pH 1.85) into one fraction until the A280 returned to baseline. Fractions were neutralized with 1M Tris-HCl, pH 8.5 immediately after collection and the OD at 280 nm was determined. ELISA analysis was conducted using the corresponding antigen-BSA conjugate according to the general ELISA protocol to confirm the recovered antibody and the removal of all the antibodies from the original serum. Antibody quantification was determined by A280 reading of the antibody (a small amount was diluted to give an OD value of about 1.0) and this value was divided by the extinction coefficient of IgG, 1.4, to give mg/mL. The solutions were concentrated to ˜1-2 mg/mL, dialyzed against PBS with 0.02% sodium azide, aliquoted and frozen at −80° C.


Example 14
ELISA Plate Preparation and Use

An oligosaccharide-BSA conjugate solution was prepared by dissolving the conjugate in carbonate buffer (1.59 g Na2CO3, 2.93 g NaHCO3, 0.20 g NaN3, dissolved and diluted to 1 L in H2O, final pH 9.5) at a concentration of 5-10 μg/mL. COSTAR flat bottom EIA 8-well strips were incubated with oligosaccharide-BSA conjugate solution (100 μL per well) for 24 hours in a humidity chamber to coat the well surfaces. Coating solution was removed, each well was rinsed twice with water, and dried on a paper towel. Blocking solution (0.1% BSA in PBS with 0.02% thimerosal, 200 μL) was added to each well and incubated for 2 hours in a humidity chamber. Blocking solution was removed; each well was rinsed with water and dried on a paper towel.


Serum samples were prepared by 1:5 serial dilutions starting from a 1:1,000 dilution of serum in 0.1% BSA in PBS with 0.02% thimerosal. Diluted serum (100 μL) was added to each well and incubated for 2 hours at room temperature in a humidity chamber. The serum solution was removed, the wells were rinsed twice with water and dried on a paper towel. Goat anti-rabbit-HRP conjugate solution (100 μL/well) was added and incubated for 2 hours at room temperature in a humidity chamber. The HRP-conjugate solution was removed, and wells were washed three times with PBS/0.02% thimerosal/0.05% tween-20, twice with water, and dried on a paper towel. TMB solution (100 μL/well) was added and developed at room temperature. The reaction was stopped by the addition of 1N HCl (100 μL/well) and the wells were read immediately at A450 (absorbance at 450 nm). The titer of the test serum was designated as the dilution which gave an optical density (OD450) reading of 0.1 above background.


Example 15
Rabbit Immunogenicity and ELISA Results

Immunogenicity of Synthetic Antigen-KLH Conjugates in Rabbits (ELISA).



FIGS. 11A-11C depict IgG antibody titers as a function of antibody-antigen complex absorption (OD450) at 3 serum dilutions of immune sera obtained from 3 successive bleeds (pre-immune, 1st bleed, and final bleed) in rabbits (n=2) immunized with antigen-KLH conjugates corresponding to (A) 6-Mix-KLH 42; (B) 12-Mix-KLH 44; and (C) 18-Mix-KLH 46. In each case, the antisera were incubated on ELISA plates adsorbed with their corresponding BSA conjugate, specifically, (A) 6-Mix-BSA 41; (B) 12-Mix-BSA 43; and (C) 18-Mix-BSA 45 as described the ELISA protocol above (Example 14).



FIGS. 11D-11F depict antigen-specific IgG antibody titers from antigen-KLH conjugate-derived antibodies recovered at three successive stages of purification, including the pre-affinity purification fraction (3rd bleed), the flow-through fraction, and the antibody-enriched (purified) fraction. Results are shown as a function of antibody-antigen complex absorption (OD450) at the indicated serum dilutions obtained from the above-described antibody-enriched fractions generated against antigen-KLH conjugates corresponding to (A) 6-Mix-KLH 42; (B) 12-Mix-KLH 44; and (C) 18-Mix-KLH 46. In each case, the antisera were incubated on ELISA plates adsorbed with their corresponding BSA conjugate, specifically, (A) 6-Mix-BSA 41; (B) 12-Mix-BSA 43; and (C) 18-Mix-BSA 45.


Affinity purification of 10 mL of 3rd bleed sera (in each case) yielded: 5.5 mL of a purified 6-Mix Ab solution at 2.3 mg/mL (12.7 mg purified Ab total); 5.4 mL of a purified 12-Mix Ab solution at 5.5 mg/mL (29.7 mg purified Ab total); and 5.4 mL of purified 18-Mix Ab solution at 1.7 mg/mL (9.2 mg purified Ab total).


Example 16
Specificity and Cross-Reactivity of Antisera to Different Antigens


FIGS. 12A-12G depict the results of a cross-ELISA assay examining the specificity and cross-reactivity between fully non-acetylated (6-NH2 61, 12-NH2 62, 18-NH2 63;); mixed (6-Mix 37, 12-Mix 40, 18-Mix 34) and fully acetylated (6-NHAc 58, 12-NHAc 59, 18-NHAc 60;) oligo-β-(1→6)-glucosamines and antibodies derived therefrom. In FIGS. 12A-12G, antisera from rabbits immunized with the indicated antigen-KLH conjugates corresponding to (left to right) 6-NH2, 6-Mix 42, 6-NHAc, 12-NH2 44, 12-Mix, 12-NHAc, 18-NH2, 18-Mix 46, and 18-NHAc were incubated in each case with an ELISA plate adsorbed with a different antigen-BSA conjugate, specifically (A) 6-NH2-BSA 64; (B) 6-Mix-BSA 41; (C) 6-NHAc-BSA 65; (D) 12-NH2-BSA 66; (E) 12-Mix-BSA 43; (F) 12-NHAc-BSA;. (G) 18-Mix-BSA 45. Results are shown as a function of antibody-antigen complex absorption (OD450) representing the averages from of antisera from two rabbits in each case at the indicated serum dilutions, whereby total OD450 is measured by subtracting away the background OD450 from KLH antibodies alone. The results surprisingly showed that antibodies against the 12-Mix-KLH conjugate 44 antigen (16.7% acetylation) cross-reacted strongly with all of the antigens screened, including fully non-acetylated, mixed, and fully acetylated antigens, and typically to a greater extent than antibodies against the fully acetylated or fully aminylated oligosaccharides.


Example 17
Whole-Cell ELISA Experiment


FIGS. 13A-13D depict the results of a whole-cell ELISA assay examining the binding of pre-immune sera (A, C) or immune sera (B, D) generated from rabbits immunized against (left to right) KLH control, fully non-acetylated antigen (12-NH2) 62; mixed antigen (12-Mix) 44 and fully acetylated antigen (12-NHAc) 59 and Staphylococcus epidermidis coated onto ELISA fixed with methanol (A, B) or formalin (C, D). Results are shown as a function of antibody-antigen complex absorption (OD450) at the indicated serum dilutions. The results surprisingly showed that at the higher dilutions, antibodies against the poorly acetylated 12-Mix-KLH conjugate 44 antigen (16.7% acetylation) reacted more strongly to S. epidermidis than antibodies against the fully non-acetylated (12-NH2) or fully acetylated (12-NHAc) antigens even though the PNAG/dPNAG from natural S. epidermidis isolates are highly acetylated.


Example 18
Opsonophaoocytic Assay

The opsonophagocytic (bacterial killing) activity of serum samples was determined in an assay using S. aureus ATCC strain 25904 in the presence of phagocytic cells and complement.


Freshly isolated human PMN's were used as the effector cells in this assay. PMN's were isolated according to standard protocols known in the art. Briefly, approximately 60 mL of whole human blood was collected into 8×10-mL EDTA Vacutainer tubes. The blood from each tube was removed and carefully layered over approximately 15-mL of PMN separation medium in each of 4×50-mL conical tubes. The mixture was centrifuged at 450×g for 35 minutes at room temperature. The PNM layers from each tube were withdrawn and combined in a single tube, diluted with one volume of 0.5× sterile saline and mixed gently. The suspension was centrifuged at 450×g for 10 minutes at room temperature, and the supernatant was removed and discarded. The PMN pellet was resuspended in 5 mL of sterile saline and centrifuged again at 400-450×g for 10 minutes at room temperature. The PMN pellet was resuspended in a volume of SMEM medium to give 5×107 PMN's per mL (PMN's were counted using a hemocytometer using standard protocols).


Approximately 50 ul of a stock solution of target bacteria were grown on tryptic soy agar plates with 5% sheep red blood cells (blood agar plates) and incubated overnight at 36-38° C. The bacterial lawn was transferred to a sterile 50 ml conical containing 30 mls of tryptic soy broth with 1% (w/v) glucose. The bacteria were grown in a shaking water batch set for 40 strokes per minute at 36-38° C. for 2-3 hours. The bacterial suspension was adjusted to a % T of 72-75% (1 cm light path) and 2.7-3.0 ul of this suspension was mixed with 1.4 mls of TSB for a final concentration of approximately 5-6×104 cfu/ml.


Antisera raised to the antigen-carrier conjugates or antibody control solutions were serially diluted and 40 ul of each dilution of each antiserum or control antibody were added to each well of a 96-well round bottom plate (Nunc 163320 or equivalent). Antibody dilutions were made in DMEM/F12 medium buffered with 10 mM HEPES to maintain a pH of 7.2-7.6.


Forty ul of the PMN cell suspension was added to each well of the 96-well assay plate followed by addition of 10 ul of complement (at different dilutions) per well. The complement was derived from human serum treated with protein A and protein L to extract inherent antibodies reactive with the target bacteria.


The OP reaction was initiated with the addition of 10 ul of the bacterial suspension to each well and the plate was incubated at 36-37° C. in a shaking incubator at ˜100 rpm for 30-40 minutes.


Following addition of the bacteria to the assay plate, the reagents were mixed by rapid pipetting up and down 20-25 times using a multichannel pipettor set at 10 ul. After mixing a sample was removed from each well, diluted 20-fold in water containing 0.1% BSA and 0.01% Tween20. These samples were designated the T0 samples and 100 ul of each T0 sample was transferred to a blood agar plate, allowed to dry, inverted and incubated overnight at 36-37° C.


After transfer of the T0 samples the assay plate was incubated at 36-37° C. in an orbital shaking incubator at 250-300 rpm for an additional 90 minutes. At the end of this incubation period samples were taken from each well, diluted and plated as described above (T90 samples).


Assay controls included PMN's alone, PMN's with complement and reference antibody. The percentage of bacterial killing was calculated using the formula:








(


Number





of





colonies






T
0


-

Number





of





colonies






T
90



)


(

Number





of





Colonies






T
0


)


*
100




The results are shown below:









TABLE







C′ mediated killing of S. epidermidis


(ATCC 25984)(Anti-serum @ 1:40)










Bacterial Death (%)











Pre-immune
3rd bleed














Positive control
0
5



Carrier
50
70



Antiserum 1 (Ag8-Carrier)
30
80



Antiserum 2 (Ag9-Carrier)
0
70
















TABLE







C′ mediated killing of S. aureus Newman (Anti-serum @ 1:100)










Bacterial Death (%)











Pre-immune
3rd bleed














Ag8
30
70



Ag9
0
50



Ag10
20
60



Ag10
10
80









Example 19
In Vivo Challenge Protocol

Five week old female Crl:CD-1° Swiss outbred mice were acclimated for 7 days prior to study start. Mice were randomized into study groups (n=10 per group) the day before initial immunization. Test articles were reconstituted using sterile saline to the appropriate dosing concentration (10 μg glycan equivalent of test article/1004 solution). Each dose was mixed with an equal volume (1004) of CFA or IFA to form a stable emulsion. On Day 0, mice were administered a single subcutaneous (SC) treatment of the appropriate test or control article at a volume of 100 μL. Prime immunizations were followed by two boost immunizations on Days 11 and 22. A separate group of untreated mice (untreated control) were not be vaccinated.


On Day 29, each mouse was challenged via intravenous tail injection (IV) route with Staphylococcus aureus Newman strain at a concentration of approximately 4×109 CFU/mL in a dose volume of 0.2 mL. Bacteria inoculation suspensions were prepared by harvesting isolated colonies seeding 50-mL of fresh Trypticase Soy Broth (TSB). The culture was incubated (37° C.) with shaking for approximately 3-5 hours, washed and resuspended. The concentration in the final culture was adjusted to 4.0×109 CFU/mL dose using a spectrophotometer (Target OD620=3.0). The concentration was verified using the dilution plate count method.


On Days −3, 10, 21 and 28 mice were bled via retro-orbital sinus (approx. 0.2 mL) into serum separator tubes for processing of sera (stored frozen at −20° C.). On Days 30, 31 and 32, mice were bled in the sub-mandibular region (approx. 0.1 mL) onto solid media for bacteremia analysis. All surviving animals will be euthanized via CO2 asphyxiation on Day 36. The percentage of survival and mortality for each group was determined and microbiological analyses of blood were expressed as ±bacteremia.


The results are shown below:









TABLE







Day 7 Survival









% survival














Vaccine group
dPNAG1-carrier (Ag8-Carrier)
88




dPNAG2-carrier (Ag9-Carrier)
78




PNAG-carrier (Ag10-Carrier)
60



Control group
Carrier alone
60




untreated
50









It is intended that the foregoing detailed description be regarded as illustrative rather than limiting, and that it be understood that it is the following claims, including all equivalents, that are intended to define the spirit and scope of this invention.

Claims
  • 1. A homogenous composition consisting essentially of a synthetic oligosaccharide 1a
  • 2-113. (canceled)
PCT Information
Filing Document Filing Date Country Kind 371c Date
PCT/US11/00723 4/22/2011 WO 00 1/11/2013
Provisional Applications (1)
Number Date Country
61327626 Apr 2010 US