Claims
- 1. A synthetic particulate vector comprising a non-liquid hydrophilic core which comprises a matrix of polysaccharides or oligosaccharides which are naturally or chemically crosslinked, said hydrophilic core having ionic ligands grafted thereon, wherein said vector does not have an external lipid layer grafted thereon, and further comprising an active principle;wherein the vector has a diameter of between 10 nm and 5 μm and wherein the polysaccharides or oligosaccharides are cross-linked by means of bi- or tri-functional agents.
- 2. The synthetic particulate vector according to claim 1, wherein the active principle is an ionizable molecule localized into the matrix.
- 3. The synthetic particulate vector according to claim 1, wherein said active principle is selected from the group consisting of antibiotics, antiviral agents, proteins, proteoglycans, peptides, poly saccharides, lipopolysaccharides, antibodies, antigens, insecticides, fungicides, compounds which act on the cardiovascular system, anticancer agents, antimalarial agents, antiasthmatic agents, and compounds having an effect on the skin.
- 4. A synthetic particulate vector consisting essentially of a non-liquid hydrophilic matrix and an active principle wherein said hydrophilic matrix comprises polysaccharides or oligosaccharides which are naturally or chemically crosslinked, said hydrophilic matrix having ionic ligands grafted thereon;wherein the vector has a diameter of between 10 nm and 5 μm and wherein the polysaccharides or oligosaccharides are cross-linked by means of bi- or tri-functional agents.
- 5. The synthetic particulate vector according to claim 4, wherein the active principle is an ionizable molecule localized into the matrix.
- 6. The synthetic particulate vector according to claim 4, wherein said active principle is selected from the group consisting of antibiotics, antiviral agents, proteins, proteoglycans, peptides, polysaccharides, lipopolysaccharides, antibodies, antigens, insecticides, fungicides, compounds which act on the cardiovascular system, anticancer agents, antimalarial agents, antiasthmatic agents, and compounds having an effect on the skin.
- 7. A synthetic particulate vector consisting essentially of a non-liquid hydrophilic matrix and an active principle wherein said hydrophylic matrix comprises a polyhydroxylated polymer which is naturally or chemically crosslinked, said hydrophilic matrix having ionic ligands grafted thereon;wherein the vector has a diameter of between 10 nm and 5 μm and wherein the polymer is cross-linked by means of bi- or tri-functional agents.
- 8. A synthetic particulate vector comprising a non-liquid hydrophilic core which comprises a matrix of polysaccharides or oligosaccharides which are naturally or chemically cross-linked, said hydrophilic core having ionic ligands grafted thereon, and said vector further comprises an active principal, wherein said vector does not have an external lipid layer grafter thereon;wherein the vector has a diameter of between 10 nm and 5 μm and wherein the polysacchanides or oligosaccharides are cross-linked by means of bi- or tri-functional agents.
Priority Claims (1)
Number |
Date |
Country |
Kind |
93 02397 |
Mar 1993 |
FR |
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CROSS REFERENCE TO RELATED APPLICATIONS
Which application claims priority under 35 U.S.C. §§119 and/or 365 to PCT/FR94/00228 filed in WIPO on Mar. 1, 1994; and to 93 02397 filed in France on Mar. 2, 1993; the entire content of which is hereby incorporated by reference.
This application is a continuation in part of U.S. application Ser. No. 08/513,853, filed May 1, 1996 now U.S. Pat. No. 6,013,284. Application Ser. No. 08/513,853 is incorporated by reference in its entirety.
US Referenced Citations (7)
Foreign Referenced Citations (5)
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Country |
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EP |
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Non-Patent Literature Citations (1)
Entry |
N. Irving Sax and Richard J. Lewis, Sr., Hawley's Condensed Chemical Dictionary, Eleventh Edition, 1987, Van Norstrand Reinhold, New York, New York, USA. |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
08/513853 |
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US |
Child |
09/112367 |
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US |