Claims
- 1. A method for detecting a thrombus in a patient in vivo, which comprises the steps of administering to the patient a radiolabelled peptide which binds in vivo to arginine-glycine-aspartic acid binding sites on activated platelets in the thrombus, allowing the labelled peptide to bind to the RGD binding sites on the activated platelets in the thrombus and for the unbound peptide to clear systemically from the patient, and detecting the accumulated peptide.
- 2. The method of claim 1, wherein the radiolabelled peptide is labelled with a radioactive substance selected from the group consisting of 99mTc, 123I and 111In.
- 3. The method of claim 1, wherein the radiolabelled peptide has 3 to 10 peptide units.
- 4. The method of claim 1, wherein the radiolabelled peptide is a synthetic peptide.
Priority Claims (2)
Number |
Date |
Country |
Kind |
8914020 |
Jun 1989 |
GB |
|
PCT GB9000933 |
Jun 1990 |
WO |
|
Parent Case Info
This application is a continuation of application Ser. No. 08/816,922, filed Mar. 12, 1997, now U.S. Pat. No. 5,843,402, which is a continuation of application Ser. No. 07/963,127, filed Oct. 19, 1992, now abandoned. This application is also a continuation of application Ser. No. 07/659,343, filed Mar. 21, 1991, now abandoned.
US Referenced Citations (3)
Non-Patent Literature Citations (5)
Entry |
Childs, 1985, Optimum Conditions for Labeling of DTPA-Coupled Antibodies with Technetium-99m, J. Nucl. Med., 26(3):293-299. |
Hnatowich, et al., 1983, Radioactive Labeling of Antibody: A Simple and Efficient Method, Science, 220:613-615. |
Paik, et al., 1985, The Labeling of High Affinity Sites of Antibodies with 99mTc, Int. J. Nucl. Med. Biol., 12(1):3-8. |
Pierschbacher and Ruoslahti, 1984, Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule, Nature, 3093):30-33. |
Rhodes et al., 1986, Technetium-99m Labeling of Murine Monoclonal Antibody Fragments, J. Nucl. Med., 27(5):685-693. |
Continuations (3)
|
Number |
Date |
Country |
Parent |
08/816922 |
Mar 1997 |
US |
Child |
09/010290 |
|
US |
Parent |
07/963127 |
Oct 1992 |
US |
Child |
08/816922 |
|
US |
Parent |
07/659343 |
Mar 1991 |
US |
Child |
07/963127 |
|
US |