The present invention pertains generally to systems and methods for performing ophthalmic laser surgery. More particularly, the present invention pertains to systems and methods for performing an ophthalmic laser surgical procedure that accounts for optical distortions introduced by the anatomy of the eye and by the system components that are required for performing laser surgery. The present invention is particularly, but not exclusively, useful as a system and method for establishing precise locations for a focal point within a predetermined tolerance that is established for a scanning range which is required to conduct a particular ophthalmic laser procedure.
Femtosecond laser technology has been adapted for use with various ophthalmic laser surgical procedures. Until recently, the use of femtosecond lasers on the eye has focused primarily on the cornea. As the use of femtosecond lasers becomes more advanced, other areas of the eye that lie beyond the cornea are now being targeted by procedures that use femtosecond lasers. As appreciated by skilled artisans, often laser systems such as picosecond and UV lasers can be similarly employed. In the event when areas beyond the cornea are targeted, establishing precise locations for the focal point of the laser becomes less precise due to deviations in focal point location caused by: (1) the location in the eye where the procedure is being conducted; (2) system components required for the procedure; and (3) the interaction of the system with the eye during the procedure. Furthermore, these deviations in focal point location can cause the laser procedure to be less effective, or cause damage to areas of the eye that are not being targeted by the procedure.
For any laser surgical procedure, attention must be paid to deviations in focal point location. Different surgical procedures target different areas of the eye, and targeted areas of the eye may be more prone to deviations because of factors like depth within the eye or the anatomical structure of the targeted area. Deviations can also occur based on distortions of the eye that occur due to contact of the eye by the laser unit during the procedure.
System components required for a laser surgical procedure can also produce deviations in focal point location. One important component required by a laser system for positioning a laser beam focal point is an algorithm that is used by a computer to produce a reference datum. Such a reference datum is needed for accurate movement and placement of the focal point during the procedure. Typically, each algorithm will introduce a deviation because of the level of detail it provides for the reference datum. This will vary depending on the algorithm that is selected. Another component that can produce deviations is the lens or lenses in the optical unit. In particular, during a procedure, the lens or lenses must follow a very precise path to accurately focus the laser to a focal point. Further, imprecise or inaccurate mechanical responses of the laser system (e.g. inaccurate lens movement) will also introduce deviations in focal point location. Other deviations in focal point location can be caused by distortions in the eye which are caused when a patient interface is used to facilitate a connection between the laser unit and the eye.
One way to account for the deviations that may be caused by the factors discussed above is to establish a tolerance. In the context of the present invention, the tolerance is an acceptable margin for error in the location of the focal point during a procedure. This tolerance is selected to allow for slight deviations to occur that will not affect the quality of the laser procedure being performed or damage non-targeted areas of the eye.
In light of the above, it is an object of the present invention to provide systems and methods for establishing precise locations for a focal point of a laser. Another object of the present invention is to provide systems and methods for establishing precise locations for a focal point that accounts for deviations caused by the interaction of a laser system with the eye. Still another object of the present invention is to provide systems and methods establishing precise locations for a focal point of a laser beam within a predetermined scanning range that are easy to use and comparatively cost effective.
In accordance with the present invention, a system and method are provided for precisely positioning the focal point of a laser beam during laser ophthalmic surgery. Initially, the particular surgical procedure to be performed is selected and identified. For the present invention it is envisioned that such a procedure may be performed anywhere in an eye where a laser beam can be effectively focused (examples include, but are not limited to, the cornea, the crystalline lens, the trabecular meshwork, and the retina). Based on the requirements of the selected procedure, a tolerance for deviation of the laser beam's focal point from the laser beam path during the procedure is determined and established. For instance, it may be necessary to keep the laser beam's focal point beyond a certain distance from an identified tissue interface. Specifically, this restriction may be necessary in order to prevent unwanted collateral damage to a non-targeted tissue, or because the application demands high precision. In each case, as implied above, such considerations go to establishing the tolerance for the particular procedure.
It is understood by the present invention that various factors can affect the operation of a laser system and, consequently the placement of its laser beam's focal point. Of particular concern here is the extent to which these factors, individually and collectively, will cause the focal point to deviate from an intended beam path during an operational procedure. In the event, whatever deviations in focal point placement may be introduced, their cumulative effect must not exceed the limitations of the predetermined tolerance. For the present invention, the factors which can create focal point deviations that are of particular interest include: 1) the mechanical response of the optical components in a laser system during the focusing and placement of a laser beam's focal point; 2) the accuracy of the algorithm that is to be used by a laser system for operational guidance and control of a laser beam's focal point; and 3) distortions of the eye that may be caused when a patient interface is used to bring a laser unit into contact alignment with an eye.
Structurally, the system of the present invention includes a laser unit for generating a laser beam, and it includes a moveable lens that is mounted on a rail for focusing the laser beam to a focal point. Also included is a computer for defining a path for movement of the focal point in an x-y-z space during surgery. Specifically, movement of the focal point will be within the scanning range that is required by the surgical procedures and, most importantly, the position of the focal point will be confined to within an established tolerance.
In order to minimize deviations in out-of-tolerance focal point movements that may be introduced by the laser unit itself, an arrestor is selectively positioned on the rail to fix a start position for the lens. An actuator then moves the lens along the rail from the start position in response to instructions from the controller. In particular, the start position is selected to keep required lens movements close to the start position. This is done to thereby minimize out-of-tolerance deviations that may otherwise be caused when lens movements are farther from the start position and less controllable. As envisioned for the present invention, additional arrestors can be positioned along the rail, as desired, to minimize focal point deviations in selected areas of the scanning range.
Another structural component of interest for the present invention is an optical imaging device that can be used to produce an image of the x-y-z space required by the ophthalmic procedure. Once created, the image is inputted into an algorithm to establish a reference datum for movement of the focal point along a defined path in the x-y-z space. As is well known, different types of imaging devices, and different algorithms have different levels of accuracy and precision. With this in mind, the present invention requires selection of an algorithm that establishes a reference datum which will effectively maintain precise locations for the focal point within the predetermined tolerance. Preferably, the ophthalmic imaging device for the present invention will be an Optical Coherence Tomography (OCT) scanner or a Hartmann-Shack sensor. In addition to an OCT scanner and a Hartmann-Shack sensor, other types of imaging devices appropriate for use with the present invention include: a topographic imaging unit, a Scheimpflug imaging unit, a confocal imaging unit, a two-photon imaging unit, a laser range finding imaging unit, and a non-optical imaging unit.
Still another structural component that is often used in a laser system which may cause a laser focal point to deviate from its intended focal point is a patient interface. Specifically, patient interfaces are sometimes used to establish an interaction between the laser unit and an eye of a patient that will stabilize the eye during a surgical procedure. In use, however, patient interfaces can distort the eye and thereby introduce deviations in focal point placements. Typical patient interfaces, in order of improving operational effect (i.e. less distortion), include an applanation lens, a concave lens, and a water-filled lens. Like the other structural components mentioned above, the patient interface needs to be selected to maintain the focal point within the predetermined tolerance.
In an alternate embodiment, instead of using a single lens for positioning the focal point of the laser beam along the z-axis, two lenses are used. More specifically, the system can include two lenses mounted for movement on the rail, with a first (proximal) lens mounted on the rail nearer to the laser unit and a second (distal) lens mounted on the rail further from the laser unit. For this embodiment, the distal lens can be selectively positioned at one of a plurality of distal start points. Specifically, each of these distal start points corresponds to a particular ophthalmic procedure. For example, when the distal lens is positioned at a selected start point, the system will be configured for moving the laser beam's focal point to treat tissue in a specific portion of the eye (e.g. cornea, crystalline lens or retina). Preferably, throughout the procedure, the distal lens remains stationary and the proximal lens moves along the rail. This structural cooperation moves the focal point of the laser beam in the manner required for the present invention.
The novel features of this invention, as well as the invention itself, both as to its structure and its operation, will be best understood from the accompanying drawings, taken in conjunction with the accompanying description, in which similar reference characters refer to similar parts, and in which:
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Continuing the procedure after an optical path has been determined to be within the tolerance 44, an algorithm is selected at action block 72. This algorithm is used to produce a reference datum that is used to guide the focal point 26 during the procedure. It will be appreciated that, if two or three positions on a corneal surface are measured, only second-order Zernike polynomial coefficients can be accurately calculated. That is, the spherical shape or the cylindrical shape can be determined. If ten points on a corneal surface are measured, then third-order Zernike polynomial coefficients can be calculated. If fifteen points on a corneal surface are measured, then fourth-order Zernike polynomial coefficients can be calculated. That is, defocus, spherical aberration, second order astigmatism, coma, and trefoil can be calculated. After the algorithm is selected, the computer 12 then determines whether the focal point 26 is within the tolerance 44 due to deviations induced by the algorithm at inquiry block 84. It should be noted that the computer 12 in inquiry block 84 also must account for deviations caused by the optical path (See action block 68). If the focal point is within the tolerance 44, the planning of the procedure continues. If it is not, the computer 12 again determines whether the focal point 26 can be brought into tolerance 44, and if it can be brought into tolerance 44 at inquiry block 86, the algorithm is modified at action block 88. The decision to either restart or stop the procedure is the same as described earlier with inquiry block 78 and action blocks 80 and 82.
Once it has been determined that the focal point is in tolerance at inquiry block 84, a patient interface 40 is selected or detected at action block 90. Once the patient interface 40 is selected or detected, the computer 12 determines whether the focal point 26 remains within the tolerance 44 due to deviations caused by the patient interface 40 at inquiry block 92. At inquiry block 92, the computer 12 is still accounting for deviations caused by the optical path and the algorithm (See blocks 68 and 84). If the focal point 26 is within the tolerance 44, then the procedure is conducted as depicted in action block 94. If the focal point 26 is not within the tolerance 44, the computer 12 again determines whether it can be brought within the tolerance 44 at inquiry block 96. If the focal point 26 can be brought within the tolerance 44, then a new patient interface 40 is selected at action block 98. If the focal point 26 cannot be brought into tolerance 44 at inquiry block 96, a decision is again made at block 78 to restart or stop the procedure. The follow-on steps to inquiry block 78 are the same as disclosed previously.
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For each of the above described scenarios (i.e. respective scanning ranges 114, 116 and 118) it will be appreciated that either the proximal lens 22, or the distal lens 102, can be moved from their respectively selected start points to move focal point 26 within a selected scanning range 114, 116 or 118. In each case, the respective start points for lenses 22 and 102 will be established by an arrestor. Specifically, lens 22 will operate relative to the arrestor 34, and lens 102 will operate relative to whichever arrestor 108, 110 or 112 is to be used for a selected procedure. During an operation of the system 100, however, only one of the lenses, lens 22 or lens 102 will be moved to vary the location of the focal point 26 within the particularly selected scanning range 114, 116 or 118.
While the particular System and Method for Controlling the Focal Point Locations of a Laser Beam as herein shown and disclosed in detail is fully capable of obtaining the objects and providing the advantages herein before stated, it is to be understood that it is merely illustrative of the presently preferred embodiments of the invention and that no limitations are intended to the details of construction or design herein shown other than as described in the appended claims.