Claims
- 1. A computer-implemented system for analyzing relatedness comprising:
an expandable database for storing a plurality of hierarchical trees; a first user interface for creating a plurality of data fields within at least one tree of said plurality of hierarchical trees; a second user interface for adding genetic data to at least one data field of said plurality of data fields; analytical programming for relating and alterably categorizing each data field of said plurality of data fields; executable programming for describing a genetic pattern for a first tree of said plurality of hierarchical trees; means for correlating said genetic pattern with a genetic pattern for at least a second tree of said plurality of hierarchical trees; and executable programming for predicting an antecedent genetic pattern in said first tree.
- 2. The computer-implemented system of claim 1, wherein said plurality of hierarchical trees are genealogical family trees.
- 3. The computer-implemented system of claim 1, wherein said plurality of hierarchical trees are animal pedigree charts.
- 4. The computer-implemented system of claim 1, further comprising executable programming for annotating a genetic range within statistical confidence intervals of each hierarchical tree of said plurality of hierarchical trees.
- 5. The computer-implemented system of claim 4, wherein said executable programming compare said genetic range of each said hierarchical tree with a genetic range of said at least second tree.
- 6. The computer-implemented system of claim 1, wherein said genetic data comprises a plurality of genetic markers.
- 7. The computer-implemented system of claim 6, said plurality of genetic markers comprise genetic markers in linkage disequilibrium.
- 8. The computer-implemented system of claim 1, wherein at least one data field of said plurality of data fields comprises genealogical data.
- 9. The computer-implemented system of claim 8, wherein said genealogical data is ancestral.
- 10. The computer-implemented system of claim 1, wherein each hierarchical tree of said plurality of hierarchical trees is stored in said database in association with a unique identifier.
- 11. A method of identifying a possible genetic relationship among members of a species, said method comprising:
assembling a first data set comprising genetic information from a plurality of members of a species; assembling a second data set comprising genealogical information from said plurality of members; associating said first and second data sets; analyzing said first and second data sets; and inferring at least one possible genetic relationship among said plurality of members.
- 12. The method according to claim 11, wherein associating said first and second data sets comprises identifying aplurality of chromosomal fragments in said first data set that are substantially identical by descent in said second data set.
- 13. The method according to claim 11, wherein said genetic relationship is ancestral.
- 14. The method according to claim 11, wherein said species is human.
- 15. The method according to claim 11, wherein said first data set is in genetic haplotype form.
- 16. The method according to claim 11, further comprising representing the degree of correlation between said first and second data sets statistically.
- 17. The method according to claim 11, wherein said at least one possible genetic relationship was previously unknown.
- 18. A method of determining levels of biological relatedness in members of a species, comprising:
identifying a plurality of members of a species; identifying at least one genetic marker for each of said plurality of members; identifying genealogical data for said plurality of members; creating a plurality of groups based on the at least one genetic marker; categorizing each member of said plurality of members into at least one group of said plurality of groups based on the degree of similarity of the at least one genetic marker for said plurality of members, such that each defined group of said at least one group has a representative genetic marker; and comparing the genealogical data within each defined group thereby inferring the level of biological relatedness of each said categorized member.
- 19. The method according to claim 18, wherein said at least one genetic marker is in haplotype form.
- 20. The method according to claim 18, wherein said at least one genetic marker comprises a plurality of genetic markers in linkage disequilibrium.
- 21. The method according to claim 18, further comprising limiting said at least one group's size according to said genealogical data.
- 22. The method according to claim 21, wherein said representative genetic marker is within a predetermined confidence interval.
- 23. The method according to claim 22, further comprising:
statistically correlating the representative genetic marker of each said defined group; statistically correlating each said defined group with said genealogical data; and statistically correlating the level of biological relatedness of each said defined group.
- 24. A method of determining a level of biological relatedness comprising:
identifying a plurality of family trees; identifying members of said plurality of family trees; identifying genetic markers representative of said members; identifying at least one unique genetic marker for each family tree of said plurality of family trees; obtaining a genetic sample of a subject; comparing said genetic sample with said at least one unique genetic marker; and determining the level of biological relatedness of said subject with at least one family tree of said plurality of family trees based on the degree of correlation of said subject's genetic sample to said unique genetic marker.
- 25. The method according to claim 24, further comprising:
identifying populational origin data of said members; correlating said genetic markers with said populational origin data to create genetic data; comparing said genetic sample to said genetic data; and inferring the likelihood of populational origin of said genetic sample based on the degree of correlation of said genetic sample to said genetic data.
- 26. The method according to claim 25, wherein said unique genetic identifier comprises a genetic component.
- 27. The method according to claim 26, wherein said unique genetic identifier further comprises a genealogical component.
- 28. The method according to claim 27, further comprising assigning said genetic sample a unique genetic identifier.
- 29. The method according to claim 28, further comprising amending said unique genetic identifier to reflect the level of biological relatedness of the genetic sample.
- 30. A method of correcting a genealogical family tree, comprising:
identifying genetic data for a plurality of individuals; identifying a genealogical family tree, said tree having a plurality of placeholders; identifying and comparing genetic data for each placeholder of said plurality of placeholders; placing each placeholder in a unique location within said tree based on the genetic data of each said placeholder; noting genetic discrepancies among said plurality of placeholders; designating a placeholder of said plurality of placeholders whose genetic data is outside of a genetic range as anomalous; comparing the genetic data of said plurality of individuals with the genetic data for each placeholder of said plurality of placeholders; identifying at least one individual of said plurality of individuals of said species having genetic data within said genetic range; inferring a member of said at least one individual having data within said genetic as being a potential placeholder; and resolving said anomalous placeholder.
- 31. The method according to claim 30, wherein resolving comprises deleting said anomalous placeholder from said tree.
- 32. The method according to claim 30, wherein resolving comprises replacing said anomalous placeholder with said potential placeholder.
- 33. A method of discovering populational origin, comprising:
providing a database of a plurality of family trees, each family tree of said plurality of family trees having a plurality of placeholders; supplementing said database with genetic data for at least one placeholder of said plurality of placeholders of each said family tree thereby creating a genetic genealogy for each said family tree; supplementing said database with populational origin data for at least one placeholder of said plurality of placeholders of each said family tree thereby associating said at least one placeholder's family tree with at least one populational origin; obtaining a genetic sample; comparing said genetic sample with said database; and inferring populational origin of said genetic sample.
- 34. The method according to claim 33, wherein said genetic data comprises at least one genetic marker.
- 35. The method according to claim 34, wherein said at least one genetic marker is autosomal.
- 36. The method according to claim 34, wherein said at least one genetic marker comprises a plurality of genetic markers in linkage disequilibrium.
- 37. The method according to claim 33, wherein said genetic data is in haplotype form.
- 38. The method according to claim 33, further comprising:
statistically correlating said genetic marker within a predetermined confidence interval thereby creating at least one genetically defined group; supplementing said at least one defined group with genealogical data; statistically correlating level of biological relatedness of said at least one defined group; statistically correlating said genetic sample with said at least one defined group; and identifying said genetic sample as a member of said at least one of defined group.
- 39. The method according to claim 38, further comprising supplementing said database to include the genetic sample.
- 40. A method of determining pedigree of an animal, said method comprising:
assembling a first data set comprising genetic information from a plurality of members of an animal population; assembling a second data set comprising pedigree information from said plurality of members; associating said first and second data sets; analyzing said first and second data sets; and determining at least one possible pedigreed relationship among said plurality of members.
- 41. The method according to claim 40, wherein said animal population is selected from the group consisting of primate, canine, equine, caprine, feline, fowl, bovine, ovine and suid.
- 42. The method according to claim 40, wherein associating said first and second data sets comprises identifying chromosomal fragments in said first data set that are identical by descent in said second data set.
- 43. The method according to claim 42, wherein said pedigreed relationship is ancestral.
- 44. The method according to claim 40, wherein said first data set is in genetic haplotype form.
- 45. The method according to claim 40, further comprising representing the degree of correlation between said first and second data sets statistically.
- 46. The method according to claim 40, wherein said at least one possible pedigreed relationship was previously unknown.
- 47. A method of confirming pedigree, comprising:
providing a database with a plurality of pedigree charts, each pedigree chart of said plurality of pedigree charts having a plurality of placeholders; supplementing said database with genetic data for at least one placeholder of said plurality of placeholders of each said pedigree chart thereby creating a genetic genealogy for each said pedigree chart; obtaining a genetic sample of an animal subject; comparing said genetic sample of said animal subject with said database; and confirming the pedigree of said animal subject.
- 48. The method according to claim 47, wherein said genetic data comprises at least one genetic marker.
- 49. The method according to claim 48, wherein said at least one genetic marker is autosomal.
- 50. The method according to claim 48, wherein said genetic data is in haplotype form.
- 51. The method according to claim 48, wherein said at least one genetic marker comprises a plurality of genetic markers in linkage disequilibrium.
- 52. The method according to claim 47, wherein said animal subject is selected from the group consisting of primate, human, canine, equine, caprine, feline, fowl, bovine, ovine and suid.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] Under the provisions of 35 U.S.C. §119(e), priority is claimed from Provisional Patent Application Ser. No. 60/280,226 filed Mar. 30, 2001.
Provisional Applications (1)
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Number |
Date |
Country |
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60280226 |
Mar 2001 |
US |