1. Field of the Invention
The present invention relates generally to the processing of waveform data and, more particularly, to the processing of waveforms associated with medical monitoring.
2. Description of the Related Art
This section is intended to introduce the reader to various aspects of art that may be related to various aspects of the present invention, which are described and/or claimed below. This discussion is believed to be helpful in providing the reader with background information to facilitate a better understanding of the various aspects of the present invention. Accordingly, it should be understood that these statements are to be read in this light, and not as admissions of prior art.
In the field of medicine, doctors often desire to monitor certain physiological characteristics of their patients. Accordingly, a wide variety of devices have been developed for monitoring physiological characteristics. Such devices provide doctors and other healthcare personnel with the information they need to provide the best possible healthcare for their patients. As a result, such monitoring devices have become an indispensable part of modern medicine.
One technique for monitoring certain physiological characteristics of a patient is commonly referred to as pulse oximetry, and the devices built based upon pulse oximetry techniques are commonly referred to as pulse oximeters. Pulse oximetry may be used to measure various blood flow characteristics, such as the blood-oxygen saturation of hemoglobin in arterial blood, the volume of individual blood pulsations supplying the tissue, and/or the rate of blood pulsations corresponding to each heartbeat of a patient.
The quality of these measurements, however, may be adversely affected by a number of factors such as patient motion, subdermal physiological structures, poor sensor operation or fit, poor signal reception and transmission, and so forth. Such factors may result in a pulse oximetry signal which contains artifacts or noise or is otherwise of low or reduced quality. When processed, such a low or reduced quality signal may result in physiological measurements being reported which may not be as accurate or reliable as desired.
Certain aspects commensurate in scope with the originally claimed invention are set forth below. It should be understood that these aspects are presented merely to provide the reader with a brief summary of certain forms the invention might take and that these aspects are not intended to limit the scope of the invention. Indeed, the invention may encompass a variety of aspects that may not be set forth below.
There is provided a method for processing a physiological signal, the method including the acts of: performing one or more multi-resolution decompositions on a physiological signal to generate high-passed components and low-passed components; and performing one or more morphological operations on at least one of the high-passed components or the low-passed components generated by the one or more of the respective multi-resolution decompositions.
There is provided one or more machine-readable media, including: a routine configured to perform one or more multi-resolution decompositions on a physiological signal to generate high-passed components and low-passed components; and a routine configured to perform one or more morphological operations on at least one of the high-passed components or the low-passed components generated by the one or more of the respective multi-resolution decompositions.
There is provided a physiological monitoring system, including: a sensor configured to generate a physiological signal; and a monitor configured to display one or more physiological parameters derived from a modified version of the physiological signal, wherein the modified version is generated by performing one or more multi-resolution decompositions on the physiological signal to generate high-passed components and low-passed components, performing one or more morphological operations on at least one of the high-passed components or the low-passed components generated by the one or more of the respective multi-resolution decompositions, and reconstructing the modified version from one or more modified wavelet coefficients generated by the one or more morphological operations.
There is provided a physiological monitoring system, including: a sensor configured to generate a physiological signal; and a monitor configured to perform one or more multi-resolution decompositions on the physiological signal to generate high-passed components and low-passed components, and configured to perform one or more morphological operations on at least one of the high-passed components or the low-passed components generated by the one or more of the respective multi-resolution decompositions.
Advantages of the invention may become apparent upon reading the following detailed description and upon reference to the drawings in which:
One or more specific embodiments of the present invention will be described below. In an effort to provide a concise description of these embodiments, not all features of an actual implementation are described in the specification. It should be appreciated that in the development of any such actual implementation, as in any engineering or design project, numerous implementation-specific decisions must be made to achieve the developers' specific goals, such as compliance with system-related and business-related constraints, which may vary from one implementation to another. Moreover, it should be appreciated that such a development effort might be complex and time consuming, but would nevertheless be a routine undertaking of design, fabrication, and manufacture for those of ordinary skill having the benefit of this disclosure.
It is desirable to provide an output signal from a pulse oximeter (or other medical monitor) in which the artifacts and/or noise have been removed or reduced. Such a “clean” output signal may then be processed to generate accurate and reliable physiological measurements of interest, such as measurements of blood oxygen level (SpO2), pulse rate, and so forth. In accordance with some aspects of the present technique, an output signal from a medical monitor is pre-processed to remove noise and/or artifacts. The pre-processed signal may then be used to accurately derive the desired physiological measurements of interest.
Turning now to
In one embodiment, the patient monitor 12 may be a suitable pulse oximeter, such as those available from Nellcor Puritan Bennett Inc. In other embodiments, the patient monitor 12 may be a monitor suitable for measuring other physiological characteristics (such as tissue water fraction, tissue or blood carbon dioxide levels, and so forth) using spectrophotometric or other techniques. Furthermore, the monitor 12 may be a multi-purpose monitor suitable for performing pulse oximetry and/or other physiological and/or biochemical monitoring processes using data acquired via the sensor 10. Furthermore, to provide additional or enhanced functions to those performed by the monitor 12, the patient monitor 12 may be coupled to a multi-parameter patient monitor 16 via a cable 18 connected to a sensor input port and/or via a cable 20 connected to a digital communication port.
As noted above the data provided to the monitor 12 (or, alternatively, to the multi-parameter monitor 16) is generated at the sensor 10. In the example depicted in
For example, for pulse oximetry applications the oxygen saturation of the patient's arterial blood (SaO2) may be determined using two or more wavelengths of light emitted by the emitter 22, most commonly red and near infrared wavelengths. After passage through the patient's tissue, a portion of the light emitted at these wavelengths is detected by the detector 24. The detector generates one or more signals, such an electrical or optical signals, in response to the amount of each wavelength that is detected at a given time. The generated signals may be digital or, where acquired as analog signals, may be digitized in implementations where digital processing and manipulation of the signals is employed. Such digitalization may be performed at the monitor 12 or prior to reaching the monitor 12. The signals, as noted above, may be transmitted via the cable 14 to the monitor 12, where the oxygen saturation or other physiological characteristic is calculated based on the signals. The signals output received by the monitor 12 for processing may be noisy or contain artifacts due to a variety of factors, such as light modulation by subdermal anatomic structures, patient motion during data acquisition, poor sensor operation or fit, poor signal reception and transmission, and so forth. In such instances, the physiological characteristics (such as blood oxygen levels) derived based on such noisy or artifact-containing data signals may in turn be inaccurate or unreliable.
In an embodiment of the present technique, the output signals are pre-processed prior to deriving the one or more physiological characteristics. An example of such an embodiment is set forth in
In accordance with an embodiment of the present technique, the oximetry data signal 40 may, optionally, be filtered (block 42) to smooth out or remove aspects of the signal 40 which are not believed to be representative of the desired physiological data, thereby generating a filtered signal 44. For example, in one implementation the oximetry signal 40 is median filtered at block 40 to remove outlier noise that may be the result of electronic noise or other non-physiological factors. Such filtered signals 44 may then be further processed in accordance with the present technique.
The oximetry signals 40 (or filtered signals 44) may then be processed using a multi-resolution decomposition technique to decompose the signals into time-frequency or time-scale components, such as by discrete wavelet transformation (block 46) via a filter bank or other multiple or iterative decomposition implementation. Such decompositions provide time and frequency information about the decomposed signal which may be subsequently processed. Though wavelet transformation is discussed herein, those of ordinary skill in the art will appreciate that other transformation techniques capable of providing the desired time and frequency information may also be employed and are within the scope of the present technique.
As will be appreciated by those of ordinary skill in the art, each wavelet decomposition yields a low frequency or low-passed signal component 48 in the form of wavelet coefficients, which corresponds to an approximation of the signal undergoing decomposition, and a high frequency or high-passed signal component 50, which corresponds to detail components of the signal undergoing decomposition. In one implementation, each iteration, i.e., resolution level, of the decomposition decomposes the previous approximation, i.e., low-passed component 48, yielding an approximation and detail component representative of the previous approximation. In other words, the low-passed component 48 at the previous resolution level is decomposed to yield the high-passed 50 and low-passed components 48 of the current resolution level. Because the low-passed components 48 are iteratively decomposed in such an implementation, each previous resolution level may be reproduced by reintegrating the low-passed 48 and high-passed components 50 (i.e., the approximation and details) of the current resolution level. Similarly, the initial signal may be reproduced by reintegrating the current resolution level of approximation and details along with previous resolution levels of detail.
Some or all of the high-passed 50 and/or low-passed 48 filtered components generated at some or all of the decomposition resolution levels may be processed using one or more morphological operations (block 56) to generate modified wavelet coefficients 58 which may be subsequently reconstructed to generate an output waveform with reduced noise and/or artifacts. In one embodiment, the morphological operations smooth out the low-passed components 48 (i.e., approximations) and/or the high-passed components 50 (i.e., the details). For example, morphological operations performed on some or all of the filtered components at selected resolution levels may remove noise, facilitate the detection of transient edges, and/or facilitate the identification of a cutoff scale from which the processed signal will be reconstructed. In this manner, analysis at the subsequent resolution level may be facilitated.
For example, in one embodiment, the oximetry signal 40 (or filtered signal 44) undergoes a three-stage wavelet decomposition to generate the respective high-passed components 50 and low-passed components 48. In one implementation, morphological operations are applied to all three resulting scales generated by the first two rounds of wavelet decomposition. In another implementation, only the two high-pass sub-bands are processed with morphological filters after two rounds of wavelet decomposition. In general, the morphological operations performed may be selected based on the frequency of the respective components, i.e., different morphological filtering schemes may be applied to different frequency ranges or scales of the wavelet transformed signal.
Examples of morphological operations that may be performed at block 56 include dilation and erosion operations or other forms of direction, structural, and/or shape-based filtering operations. Typically in such operations, a shape or pattern is presumed to be present in the data and the filter operation is performed accordingly to emphasize or enhance portions of the data where more points are expected (i.e., a dilation) and/or to remove portions of the data where fewer points are expected (i.e., an erosion). As will be appreciated by those of ordinary skill in the art, different effects may be accomplished in the data by varying the number of erosion and/or dilation operations performed or by varying the order in which an erosion and a dilation operation are performed.
For example, in one embodiment, multiple periods or pulses of waveform data (such as 10 samples) may be analyzed prior to determine an average or underlying shape of the waveform, i.e., the expected structural elements. This average or underlying shape may then be used as a template or expected shape for the subsequent morphological operations. In this way, erosions, dilations, or other morphological operations may be performed on the data to compensate for differences between the measured data and the expected structural elements within the data, thereby compensating for artifacts which may cause deviations from the expected structural elements. As will be appreciated by those of ordinary skill in the art, the structural elements may differ at different resolutions, such as having different amplitudes, slope changes and so forth. Likewise, the artifacts being compensated may be multi-dimensional with their own wavelet components at some or all of the resolution levels. Therefore, identification of structural elements and compensation for artifacts via morphological operations may vary depending on the respective resolution level.
The decomposition and morphological filtering operations may continue until a set number of iterations have been performed or until some other threshold has been reached, as determined at block 60. For instance, in one embodiment, the decomposition process is performed until the difference threshold between successive decomposed components, such as low-passed components 48, is below a desired difference threshold. Such a threshold may be empirically determined from a database of coefficients and differences or by other means. While the present example depicts only the low-passed components 48 as being iteratively decomposed, those of ordinary skill in the art will appreciate that, in other implementations, some or all of the high-passed components 50 may also be iteratively decomposed.
The combination of morphological operations performed at block 56 on the respective high-passed 50 and/or low-passed components 48 result in modified wavelet coefficients 58 which, once pre-processing is determined to be complete at block 60, may be reconstructed (block 62) to generate the desired clean waveform 64. This clean waveform 64, in turn, may be processed to determine one or more physiological characteristics of interest, such as respiratory information, blood oxygen saturation, pulse rate, and so forth.
Referring now to
As will be appreciated by those of ordinary skill in the art, the techniques and processes discussed herein may be implemented as one or more automated routines or processes which may be stored and/or executed on suitable components of the monitor 12 or multi-parameter monitor 16. Alternatively, to the extent memory components and/or processing components may be provided on the sensor 10 and/or cable 14, 18, or 20, some or all aspects of the present technique may be stored and/or executed by these respective components. Furthermore, different aspects of the present technique may be stored and/or executed on different portions of a suitable physiological monitoring system where such divisions are desirable.
While the invention may be susceptible to various modifications and alternative forms, specific embodiments have been shown by way of example in the drawings and have been described in detail herein. However, it should be understood that the invention is not intended to be limited to the particular forms disclosed. Rather, the invention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the following appended claims. Indeed, the present techniques may not only be applied to pulse oximetry, but also to other physiological monitor outputs as well.
Number | Name | Date | Kind |
---|---|---|---|
3638640 | Shaw | Feb 1972 | A |
4714341 | Hamaguri et al. | Dec 1987 | A |
4805623 | Jöbsis | Feb 1989 | A |
4807631 | Hersh et al. | Feb 1989 | A |
4911167 | Corenman et al. | Mar 1990 | A |
4913150 | Cheung et al. | Apr 1990 | A |
4936679 | Mersch | Jun 1990 | A |
4938218 | Goodman et al. | Jul 1990 | A |
4971062 | Hasebe et al. | Nov 1990 | A |
4972331 | Chance | Nov 1990 | A |
4974591 | Awazu et al. | Dec 1990 | A |
5028787 | Rosenthal et al. | Jul 1991 | A |
5065749 | Hasebe et al. | Nov 1991 | A |
5084327 | Stengel | Jan 1992 | A |
5119815 | Chance | Jun 1992 | A |
5122974 | Chance | Jun 1992 | A |
5167230 | Chance | Dec 1992 | A |
5190038 | Polson et al. | Mar 1993 | A |
5246003 | DeLonzor | Sep 1993 | A |
5247931 | Norwood | Sep 1993 | A |
5263244 | Centa et al. | Nov 1993 | A |
5275159 | Griebel | Jan 1994 | A |
5279295 | Martens et al. | Jan 1994 | A |
5297548 | Pologe | Mar 1994 | A |
5355880 | Thomas et al. | Oct 1994 | A |
5372136 | Steuer et al. | Dec 1994 | A |
5385143 | Aoyagi | Jan 1995 | A |
5390670 | Centa et al. | Feb 1995 | A |
5413099 | Schmidt et al. | May 1995 | A |
5469845 | DeLonzor et al. | Nov 1995 | A |
5482036 | Diab et al. | Jan 1996 | A |
5483646 | Uchikoga | Jan 1996 | A |
5521851 | Wei et al. | May 1996 | A |
5553614 | Chance | Sep 1996 | A |
5564417 | Chance | Oct 1996 | A |
5575285 | Takanashi et al. | Nov 1996 | A |
5588427 | Tien | Dec 1996 | A |
5611337 | Bukta | Mar 1997 | A |
5630413 | Thomas et al. | May 1997 | A |
5645059 | Fein et al. | Jul 1997 | A |
5645060 | Yorkey | Jul 1997 | A |
5680857 | Pelikan et al. | Oct 1997 | A |
5692503 | Keunstner | Dec 1997 | A |
5730124 | Yamauchi | Mar 1998 | A |
5758644 | Diab et al. | Jun 1998 | A |
5779631 | Chance | Jul 1998 | A |
5782757 | Diab et al. | Jul 1998 | A |
5786592 | Hök | Jul 1998 | A |
5830136 | DeLonzor et al. | Nov 1998 | A |
5830139 | Abreu | Nov 1998 | A |
5831598 | Kauffert et al. | Nov 1998 | A |
5842981 | Larsen et al. | Dec 1998 | A |
5871442 | Madarasz et al. | Feb 1999 | A |
5873821 | Chance et al. | Feb 1999 | A |
5920263 | Huttenhoff et al. | Jul 1999 | A |
5921937 | Davis et al. | Jul 1999 | A |
5995855 | Kiani et al. | Nov 1999 | A |
5995856 | Mannheimer et al. | Nov 1999 | A |
5995859 | Takahashi | Nov 1999 | A |
6011985 | Athan et al. | Jan 2000 | A |
6011986 | Diab et al. | Jan 2000 | A |
6064898 | Aldrich | May 2000 | A |
6081742 | Amano et al. | Jun 2000 | A |
6088607 | Diab et al. | Jul 2000 | A |
6094592 | Yorkey et al. | Jul 2000 | A |
6120460 | Abreu | Sep 2000 | A |
6134460 | Chance | Oct 2000 | A |
6150951 | Olejniczak | Nov 2000 | A |
6154667 | Miura et al. | Nov 2000 | A |
6163715 | Larsen et al. | Dec 2000 | A |
6181958 | Steuer et al. | Jan 2001 | B1 |
6181959 | Schöllermann et al. | Jan 2001 | B1 |
6222189 | Misner et al. | Apr 2001 | B1 |
6230035 | Aoyagi et al. | May 2001 | B1 |
6266546 | Steuer et al. | Jul 2001 | B1 |
6285895 | Ristolainen et al. | Sep 2001 | B1 |
6312393 | Abreu | Nov 2001 | B1 |
6352502 | Chaiken et al. | Mar 2002 | B1 |
6353750 | Kimura et al. | Mar 2002 | B1 |
6361501 | Amano et al. | Mar 2002 | B1 |
6393311 | Edgar et al. | May 2002 | B1 |
6397091 | Diab et al. | May 2002 | B2 |
6415236 | Kobayashi et al. | Jul 2002 | B2 |
6419671 | Lemberg | Jul 2002 | B1 |
6438399 | Kurth | Aug 2002 | B1 |
6449501 | Reuss | Sep 2002 | B1 |
6461305 | Schnall | Oct 2002 | B1 |
6466809 | Riley | Oct 2002 | B1 |
6487439 | Skladnev et al. | Nov 2002 | B1 |
6496711 | Athan et al. | Dec 2002 | B1 |
6501974 | Huiku | Dec 2002 | B2 |
6501975 | Diab et al. | Dec 2002 | B2 |
6519486 | Edgar et al. | Feb 2003 | B1 |
6526301 | Larsen et al. | Feb 2003 | B2 |
6544193 | Abreu | Apr 2003 | B2 |
6546267 | Sugiura et al. | Apr 2003 | B1 |
6549795 | Chance | Apr 2003 | B1 |
6580086 | Schulz et al. | Jun 2003 | B1 |
6584336 | Ali et al. | Jun 2003 | B1 |
6587704 | Fine et al. | Jul 2003 | B1 |
6591122 | Schmitt | Jul 2003 | B2 |
6594513 | Jobsis et al. | Jul 2003 | B1 |
6606509 | Schmitt | Aug 2003 | B2 |
6606511 | Ali et al. | Aug 2003 | B1 |
6615064 | Aldrich | Sep 2003 | B1 |
6618042 | Powell | Sep 2003 | B1 |
6622095 | Kobayashi et al. | Sep 2003 | B2 |
6650918 | Terry | Nov 2003 | B2 |
6654621 | Palatnik et al. | Nov 2003 | B2 |
6654622 | Eberhard et al. | Nov 2003 | B1 |
6654623 | Kastle | Nov 2003 | B1 |
6654624 | Diab et al. | Nov 2003 | B2 |
6658276 | Kianl et al. | Dec 2003 | B2 |
6658277 | Wasserman | Dec 2003 | B2 |
6662030 | Khalil et al. | Dec 2003 | B2 |
6668183 | Hicks et al. | Dec 2003 | B2 |
6671526 | Aoyagi et al. | Dec 2003 | B1 |
6671528 | Steuer et al. | Dec 2003 | B2 |
6678543 | Diab et al. | Jan 2004 | B2 |
6684090 | Ali et al. | Jan 2004 | B2 |
6690958 | Walker et al. | Feb 2004 | B1 |
6697658 | Al-Ali | Feb 2004 | B2 |
6708048 | Chance | Mar 2004 | B1 |
6711424 | Fine et al. | Mar 2004 | B1 |
6711425 | Reuss | Mar 2004 | B1 |
6714245 | Ono | Mar 2004 | B1 |
6731274 | Powell | May 2004 | B2 |
6778923 | Norris et al. | Aug 2004 | B2 |
6785568 | Chance | Aug 2004 | B2 |
6793654 | Lemberg | Sep 2004 | B2 |
6801797 | Mannheimer et al. | Oct 2004 | B2 |
6801798 | Geddes et al. | Oct 2004 | B2 |
6801799 | Mendelson | Oct 2004 | B2 |
6810277 | Edgar et al. | Oct 2004 | B2 |
6829496 | Nagai et al. | Dec 2004 | B2 |
6850053 | Daalmans et al. | Feb 2005 | B2 |
6863652 | Huang et al. | Mar 2005 | B2 |
6873865 | Steuer et al. | Mar 2005 | B2 |
6889153 | Dietiker | May 2005 | B2 |
6898451 | Wuori | May 2005 | B2 |
6931269 | Terry | Aug 2005 | B2 |
6939307 | Dunlop | Sep 2005 | B1 |
6947780 | Scharf | Sep 2005 | B2 |
6949081 | Chance | Sep 2005 | B1 |
6961598 | Diab | Nov 2005 | B2 |
6983178 | Fine et al. | Jan 2006 | B2 |
6987994 | Mortz | Jan 2006 | B1 |
6993371 | Kiani et al. | Jan 2006 | B2 |
6996427 | Ali et al. | Feb 2006 | B2 |
7020507 | Scharf et al. | Mar 2006 | B2 |
7024235 | Melker et al. | Apr 2006 | B2 |
7027849 | Al-Ali | Apr 2006 | B2 |
7030749 | Al-Ali | Apr 2006 | B2 |
7035679 | Addison et al. | Apr 2006 | B2 |
7035697 | Brown | Apr 2006 | B1 |
7047056 | Hannula et al. | May 2006 | B2 |
7072702 | Edgar et al. | Jul 2006 | B2 |
7079880 | Stetson | Jul 2006 | B2 |
7127278 | Melker et al. | Oct 2006 | B2 |
7162306 | Caby et al. | Jan 2007 | B2 |
7209775 | Bae et al. | Apr 2007 | B2 |
7215984 | Diab et al. | May 2007 | B2 |
7215986 | Diab et al. | May 2007 | B2 |
7225013 | Geva et al. | May 2007 | B2 |
7236811 | Schmitt | Jun 2007 | B2 |
7254433 | Diab et al. | Aug 2007 | B2 |
7263395 | Chan et al. | Aug 2007 | B2 |
7272426 | Schmid | Sep 2007 | B2 |
7289835 | Mansfield et al. | Oct 2007 | B2 |
7328053 | Diab et al. | Feb 2008 | B1 |
7336982 | Yoo | Feb 2008 | B2 |
7343187 | Stetson | Mar 2008 | B2 |
7373193 | Al-Ali et al. | May 2008 | B2 |
7376453 | Diab et al. | May 2008 | B1 |
7383070 | Diab et al. | Jun 2008 | B2 |
7398115 | Lynn | Jul 2008 | B2 |
7515949 | Norris | Apr 2009 | B2 |
20010005773 | Larsen et al. | Jun 2001 | A1 |
20010020122 | Steuer et al. | Sep 2001 | A1 |
20010039376 | Steuer et al. | Nov 2001 | A1 |
20010044700 | Kobayashi et al. | Nov 2001 | A1 |
20020026106 | Khalil et al. | Feb 2002 | A1 |
20020035318 | Mannheimer et al. | Mar 2002 | A1 |
20020038079 | Steuer et al. | Mar 2002 | A1 |
20020042558 | Mendelson | Apr 2002 | A1 |
20020049389 | Abreu | Apr 2002 | A1 |
20020062071 | Diab et al. | May 2002 | A1 |
20020111748 | Kobayashi et al. | Aug 2002 | A1 |
20020133068 | Huiku | Sep 2002 | A1 |
20020156354 | Larson | Oct 2002 | A1 |
20020161287 | Schmitt | Oct 2002 | A1 |
20020161290 | Chance | Oct 2002 | A1 |
20020165439 | Schmitt | Nov 2002 | A1 |
20020198443 | Ting | Dec 2002 | A1 |
20030023140 | Chance | Jan 2003 | A1 |
20030055324 | Wasserman | Mar 2003 | A1 |
20030060693 | Monfre et al. | Mar 2003 | A1 |
20030139687 | Abreu | Jul 2003 | A1 |
20030144584 | Mendelson | Jul 2003 | A1 |
20030220548 | Schmitt | Nov 2003 | A1 |
20030220576 | Diab | Nov 2003 | A1 |
20030225337 | Scharf et al. | Dec 2003 | A1 |
20040010188 | Wasserman | Jan 2004 | A1 |
20040054270 | Pewzner et al. | Mar 2004 | A1 |
20040054281 | Adam et al. | Mar 2004 | A1 |
20040087846 | Wasserman | May 2004 | A1 |
20040107065 | Al-Ali | Jun 2004 | A1 |
20040116788 | Chernoguz et al. | Jun 2004 | A1 |
20040127779 | Steuer et al. | Jul 2004 | A1 |
20040171920 | Mannheimer et al. | Sep 2004 | A1 |
20040176670 | Takamura et al. | Sep 2004 | A1 |
20040176671 | Fine et al. | Sep 2004 | A1 |
20040193065 | Houben | Sep 2004 | A1 |
20040230106 | Schmitt et al. | Nov 2004 | A1 |
20050033129 | Edgar et al. | Feb 2005 | A1 |
20050049470 | Terry | Mar 2005 | A1 |
20050070774 | Addison et al. | Mar 2005 | A1 |
20050080323 | Kato | Apr 2005 | A1 |
20050101850 | Parker | May 2005 | A1 |
20050113651 | Wood et al. | May 2005 | A1 |
20050113656 | Chance | May 2005 | A1 |
20050131286 | Parker et al. | Jun 2005 | A1 |
20050168722 | Forstner et al. | Aug 2005 | A1 |
20050177034 | Beaumont | Aug 2005 | A1 |
20050192488 | Bryenton et al. | Sep 2005 | A1 |
20050192493 | Wuori | Sep 2005 | A1 |
20050203357 | Debreczeny et al. | Sep 2005 | A1 |
20050209517 | Diab et al. | Sep 2005 | A1 |
20050228248 | Dietiker | Oct 2005 | A1 |
20050267346 | Faber et al. | Dec 2005 | A1 |
20050283059 | Iyer et al. | Dec 2005 | A1 |
20060009688 | Lamego et al. | Jan 2006 | A1 |
20060015021 | Cheng | Jan 2006 | A1 |
20060020181 | Schmitt | Jan 2006 | A1 |
20060030763 | Mannheimer et al. | Feb 2006 | A1 |
20060052680 | Diab | Mar 2006 | A1 |
20060058683 | Chance | Mar 2006 | A1 |
20060064024 | Schnall | Mar 2006 | A1 |
20060149144 | Lynn | Jul 2006 | A1 |
20060155206 | Lynn | Jul 2006 | A1 |
20060189880 | Lynn et al. | Aug 2006 | A1 |
20060195028 | Hannula et al. | Aug 2006 | A1 |
20060200016 | Diab et al. | Sep 2006 | A1 |
20060209631 | Melese et al. | Sep 2006 | A1 |
20060211930 | Scharf et al. | Sep 2006 | A1 |
20060217609 | Diab et al. | Sep 2006 | A1 |
20060224058 | Mannheimer | Oct 2006 | A1 |
20060247501 | Ali | Nov 2006 | A1 |
20060258921 | Addison et al. | Nov 2006 | A1 |
20060258927 | Edgar et al. | Nov 2006 | A1 |
20060293574 | Norris | Dec 2006 | A1 |
20070004977 | Norris | Jan 2007 | A1 |
20070213621 | Reisfeld et al. | Sep 2007 | A1 |
20070213622 | Reisfeld | Sep 2007 | A1 |
20070225581 | Diab et al. | Sep 2007 | A1 |
20070249918 | Diab et al. | Oct 2007 | A1 |
20070291832 | Diab et al. | Dec 2007 | A1 |
20080004514 | Diab et al. | Jan 2008 | A1 |
20080033266 | Diab et al. | Feb 2008 | A1 |
20080036752 | Diab et al. | Feb 2008 | A1 |
20080045823 | Diab et al. | Feb 2008 | A1 |
20080066753 | Martin et al. | Mar 2008 | A1 |
Number | Date | Country |
---|---|---|
19640807 | Sep 1997 | DE |
0630203 | Dec 1994 | EP |
1491135 | Dec 2004 | EP |
3170866 | Jul 1991 | JP |
3238813 | Oct 1991 | JP |
4191642 | Jul 1992 | JP |
4332536 | Nov 1992 | JP |
7124138 | May 1995 | JP |
7136150 | May 1995 | JP |
10216115 | Aug 1998 | JP |
2003194714 | Jul 2003 | JP |
2003210438 | Jul 2003 | JP |
2003275192 | Sep 2003 | JP |
2003339678 | Dec 2003 | JP |
2004008572 | Jan 2004 | JP |
2004113353 | Apr 2004 | JP |
2004135854 | May 2004 | JP |
2004194908 | Jul 2004 | JP |
2004202190 | Jul 2004 | JP |
2004248819 | Sep 2004 | JP |
2004290545 | Oct 2004 | JP |
WO9101678 | Feb 1991 | WO |
WO9221281 | Dec 1992 | WO |
WO9309711 | May 1993 | WO |
WO9403102 | Feb 1994 | WO |
WO9512349 | May 1995 | WO |
WO9749330 | Dec 1997 | WO |
WO9842249 | Oct 1998 | WO |
WO9842251 | Oct 1998 | WO |
WO9843071 | Oct 1998 | WO |
WO9932030 | Jul 1999 | WO |
WO0021438 | Apr 2000 | WO |
WO0125802 | Apr 2001 | WO |
WO03000125 | Jan 2003 | WO |
WO 2004075746 | Sep 2004 | WO |
WO2004075746 | Sep 2004 | WO |
WO2005009221 | Feb 2005 | WO |
WO2006097437 | Sep 2006 | WO |
Number | Date | Country | |
---|---|---|---|
20070073120 A1 | Mar 2007 | US |