SYSTEM FOR ACCURATE DETERMINATION OF ULTRASOUND EXPOSURE

Information

  • Research Project
  • 6015029
  • ApplicationId
    6015029
  • Core Project Number
    R41RR014365
  • Full Project Number
    1R41RR014365-01
  • Serial Number
    14365
  • FOA Number
  • Sub Project Id
  • Project Start Date
    9/1/1999 - 25 years ago
  • Project End Date
    8/31/2001 - 23 years ago
  • Program Officer Name
    FILART, ROSEMARIE
  • Budget Start Date
    9/1/1999 - 25 years ago
  • Budget End Date
    8/31/2001 - 23 years ago
  • Fiscal Year
    1999
  • Support Year
    1
  • Suffix
  • Award Notice Date
    9/24/1999 - 25 years ago
Organizations

SYSTEM FOR ACCURATE DETERMINATION OF ULTRASOUND EXPOSURE

DESCRIPTION (Adapted from Applicant's Abstract): The FDA and the American Institute of Ultrasound in Medicine recommend upper limits on values of patient ultrasound exposure parameters. The current methodology used by ultrasound equipment manufacturers to determine these values involves making measurements in water and then "derating" to estimate values had the pulse propagation paths been in tissue. Deration ignores significant nonlinear propagation effects, and serious underestimation of tissue exposure parameter values can occur. A system for exposure determination will be produced in which pulse propagation occurs through a liquid TM (tissue-mimicking) material. All ultrasonic properties of the TM liquid will be close to those of representative tissues, including propagation speed, attenuation, and nonlinear propagation. The specific aims are: Produce various relevant TM liquids with long-term stability and uniformity of ultrasonic properties; Determine the transmission characteristics of a necessary membrane for containing the TM liquid; Construct and test the entire apparatus for convenient and efficient monitoring of exposure parameters; and Generate software to correct for transmission through the membrane. TM liquids will be made by condensing skim milk using reverse osmosis; added ethylene glycol and glycerol will influence nonlinear propagation. Amplitude transmission coefficients and phase shifts for the membrane will be determined experimentally from 1 through 50 MHz. PROPOSED COMMERCIAL APPLICATION: Use of the system by major ultrasound equipment manufacturers, including entire apparatus and software, could eventually be recommended or required by the FDA, the American Institute of Ultrasound in Medicine or the American College of Radiology for reporting exposure values. Though the number of systems likely produced would not be large, the societal value would be great.

IC Name
NATIONAL CENTER FOR RESEARCH RESOURCES
  • Activity
    R41
  • Administering IC
    RR
  • Application Type
    1
  • Direct Cost Amount
  • Indirect Cost Amount
  • Total Cost
  • Sub Project Total Cost
  • ARRA Funded
  • CFDA Code
    371
  • Ed Inst. Type
  • Funding ICs
  • Funding Mechanism
  • Study Section
    ZRG1
  • Study Section Name
  • Organization Name
    GAMMEX, INC.
  • Organization Department
  • Organization DUNS
  • Organization City
    MIDDLETON
  • Organization State
    WI
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    535622610
  • Organization District
    UNITED STATES