Patent Application
20100094449
The present invention relates to a system for rejection of tablets produced in a rotary tablet press, comprising an ejection nozzle for direction of a gas jet at a tablet to be rejected, so that the tablet is redirected and thereby sorted out from the remaining tablets leaving the tablet press during production, the ejection nozzle being supplied with compressed gas through a supply line having an inlet end for connection with a source of compressed gas and an outlet end communicating with the ejection nozzle, the supply line being provided with a control valve controlled by a control unit in order to open the supply line when a tablet to be sorted out has been detected by the control unit, and the supply line being provided with a sensor adapted to detect a variable indicative of a gas flow through the control valve in order for the control unit to generate an error signal in the case of malfunction of the control valve.
EP 1 247 640 B1 describes a device for sorting out tablets from a rotary tablet press, whereby a nozzle via a line and a controllable valve disposed in the line is adapted to be connected to a pressure source in order to route a tablet into a reject duct. Between the orifice of the nozzle and the valve is arranged a pressure sensor that delivers a sensor signal if the valve is opened or a predetermined minimum pressure prevails in the line. An error signal is produced, if no sensor signal is detected, when the valve is controlled to open. In this way, the opening of the valve may be monitored. However, if the orifice of the nozzle is choked up, the pressure sensor will also deliver a sensor signal, when the valve is opened, and consequently this malfunction will not be detected by the device.
The object of the present invention is to provide a system for rejection of tablets, whereby the system has improved performance.
In view of this object, the sensor is arranged in the supply line between the control valve and the inlet end of the supply line.
In this way, it is possible to arrange the control valve closer to the ejection nozzle and thereby obtain a better and faster reaction time of the gas jet by means of which the tablet is rejected. Thereby a more precise rejection of the tablet may be achieved. Also a faster rejection can be achieved, which is important, because the production speed, that is the rotary speed of the turret, of modern rotary tablet presses is ever increasing. At the same time, no sensor signal will be detected in the case that the control valve opens and the ejection nozzle is blocked, because there is no gas flow through the control valve. In this case, an error signal may be generated both if the control valve should not function properly and if the nozzle should be clogged up. Consequently, a good monitoring of the rejection of tablets may be obtained, and thereby a better performance of the system may be achieved.
In an embodiment, the control valve is arranged next to the ejection nozzle. Thereby, an even more precise control of the ejection time may be obtained due to the short flow distance between the control valve and the ejection nozzle, and consequently, an even better performance of the system may be achieved. Specifically, this execution makes it possible to reject a single tablet. Without this feature, in prior art systems, typically three or four tablets are rejected at a time, although only one of these needs to be rejected. The advantage is that there are fewer tablets rejected, and consequently there is less scrap, and the tabletting yield is higher. Furthermore, this execution makes it possible to use the reject system to perform a single sampling, that is sampling of a single tablet during production. In prior art presses, it is not possible to use the system of rejection for sampling of single tablets due to the fact that more than one tablet are rejected at a time.
To assess, investigate, validate or trouble-shoot the tabletting process, it is an advantage to be able the reject and sample the tablets pressed by specific punches of the tablet press. Furthermore, for instance, the tablet pressed by a specific punch could be rejected and sampled during a number of revolutions, if the control system indicates that this tablet is slightly off the mean target value.
In a structurally advantageous embodiment, the system comprises an ejection finger adapted to guide tablets from a die table of the tablet press into a first channel of a tablet chute, and the ejection nozzle is arranged in the ejection finger in order to direct tablets into a second channel of the tablet chute.
In a structurally advantageous embodiment, the ejection finger has a fixed end adapted to be mounted beside the die table and a free end to be located above the die table, and the control valve is located at the free end of the ejection finger. Thereby, it is an advantage that the valve can be located closer to the nozzle.
In a structurally advantageous embodiment, the control valve is integrated in the ejection finger. Thereby, it is an advantage that the valve can be located closer to the nozzle.
In an embodiment, the sensor is arranged at the fixed end of the ejection finger. This is advantageous, because it is possible to choose every kind of sensor, regardless of the size of it.
In an embodiment, the fixed end of the ejection finger is mounted on the top of a pole mounted on a dividing wall of a tablet press, and wherein the sensor is arranged below the dividing wall and under the pole. This is advantageous, because it is possible to choose every kind of sensor, regardless of the size of it.
In an embodiment, the supply line is integrated into the pole and the ejection finger. Thereby, the unit is easier to clean, which is an advantage in the pharmaceutical industry.
In an embodiment, the sensor is a pressure sensor, and the control unit is adapted to generate an error signal, if a predetermined drop of the pressure measured by the pressure sensor is not detected by the control unit, when the control valve is opened. When the sensor is a pressure sensor, and it is positioned in the supply line before the control valve, no sensor signal will be detected in the case that the control valve opens and the ejection nozzle is blocked, because there is no gas flow through the control valve, and consequently no pressure drop before the control valve. This is an advantage, because as a result, an error signal will not only be generated, if the control valve does not open, but also if the ejection nozzle is blocked.
In an embodiment, the predetermined drop of pressure is at least 2 percent, and preferably at least 3 percent.
In an embodiment, the control unit is adapted to monitor the pressure measured by the pressure sensor, when the control valve is closed, and to generate an error signal in case that the pressure goes under a minimum pressure. Thereby, the correct performance of the system may be even better secured.
In an embodiment, the sensor is a flowmeter, such as a differential pressure flowmeter, an ultrasonic flowmeter, a target flowmeter, a coriolis mass flowmeter or any kind of suitable flowmeter. Also in this case, no sensor signal will be detected, in the case that the control valve opens and the ejection nozzle is blocked, and an error signal may be generated.
In an embodiment, a rotary tablet press comprises the system for rejection of tablets.
The invention furthermore relates to a method of rejection of tablets produced in a rotary tablet press, whereby a gas jet is directed at a tablet to be rejected, so that the tablet is redirected and thereby sorted out from the remaining tablets leaving the tablet press during production, whereby the compressed gas is supplied to the ejection nozzle through a supply line from a source of compressed gas, whereby a control valve arranged in the supply line opens for the supply of gas when it receives a control signal from a control unit, the control unit sending the control signal to the control valve when it has detected a tablet to be sorted out, whereby a sensor arranged in the supply line detects a variable indicative of a gas flow through the control valve, and whereby the system generates an error signal in the case of malfunction of the control valve.
The method is characterized by that the variable is detected by the sensor in the supply line from the source of compressed gas to the control valve. Thereby, the above-mentioned advantages may be obtained.
In an embodiment, the control valve opens for the gas flow next to the ejection nozzle. Thereby, the above-mentioned advantages may be obtained.
In an embodiment, successful tablets are guided by means of an ejection finger from a die table of the tablet press into a first channel of a tablet chute, and defective tablets are directed into a second channel of the tablet chute by means of a gas jet ejected through an ejection nozzle arranged in the ejection finger. Thereby, the above-mentioned advantages may be obtained.
In an embodiment, the control valve is opened inside the ejection finger. Thereby, the above-mentioned advantages may be obtained.
In an embodiment, the variable detected by the sensor is a pressure signal, whereby the control unit generates an error signal, if a predetermined drop of the pressure measured by the pressure sensor is not detected by the control unit, when the control valve is opened. Thereby, the above-mentioned advantages may be obtained.
In an embodiment, the predetermined drop of pressure is at least 2 percent, and preferably at least 3 percent.
In an embodiment, the pressure measured by the pressure sensor is monitored by the control unit, when the control valve is closed, and an error signal is generated in case that the pressure goes under a minimum pressure. Thereby, the above-mentioned advantages may be obtained.
In an embodiment, the variable detected by the sensor is flow signal, and the flow signal is measured by means of a differential pressure flowmeter, an ultrasonic flowmeter, a target flowmeter, a coriolis mass flowmeter or any kind of suitable flowmeter.
In an embodiment, a method of tabletting comprises the method of rejection of tablets. Thereby, the above-mentioned advantages may be obtained.
The invention will now be explained in more detail below by means of examples of embodiments with reference to the very schematic drawing, in which
The rotary turret 1 comprises a die table 2 having a number of dies 3 arranged evenly distributed along its circumference, each die having the form of a bore arranged with its axis parallel to the vertical rotational axis of the turret. On either side of the die table are arranged top and bottom punches, respectively, of which only the bottom punches 4 are shown, in corresponding guides accommodated in the turret so that a first end of each punch is able to enter a corresponding die by displacement of the punch in its guide in order to compress material in the die.
A second end of each punch is in a well-known manner co-operating with not shown top and bottom cams, respectively, arranged stationary in relation to the press housing in order to effect axial displacement of the punches by rotation of the turret 1. The turret is located in a central section, designated the compression section 5, of a not shown press housing is composed of three sections, which are located on top of each other and are separated by means of partition walls. The lower section, designated the drive section 6, is separated from the compression 5 section by a lower partition wall 7, and the compression section 5 is separated from a not shown upper section, designated the accessory section, by a not shown upper partition wall.
The tablet press is provided with a tablet chute 8 protruding from the periphery of the die table 2 for conducting away compressed material in the form of tablets from the dies. The tablet chute 8 comprises a tablet discharge device in the form of a so-called ejection finger 9 in order to collect and guide the tablets from the dies 3 and lead them out through the tablet chute 8. The ejection finger 9 projects above the die table 2 and has a fixed end 10 fastened to an upper end of a pole 11, the lower end of which is fastened on the upper side of the lower partition wall 7. The ejection finger 9 further has a free end 12 located right above the die table 2.
A curved guide plate 13 of the ejection finger 9 is adapted to lead the properly pressed tablets to a first channel 14 of the tablet chute 8. Furthermore, the ejection finger 9 is provided with a sorting apparatus in the form of a ejection nozzle 15 adapted to lead defective tablets to a second channel 16 of the tablet chute 8 by blowing the tablets away from their normal path that follows the guide plate 13 and leads them into the first channel 14.
Tablets led into the first channel 14 of the tablet chute 8 may by means of a pivotal guide flap 17 be directed either into a middle outlet 19 dedicated to properly pressed tablets made in automatic mode of the tablet press or into a right outlet 20 dedicated to sampled tablets made either in automatic or manual mode. In
The pivotal guide flap 21 is used to switch from its right position in manual mode, whereby the operator sets the press, the control system is inactive, and tablets made are defective tablets, to its straight position in automatic mode, whereby the control system is active and tablets made are properly pressed tablets. The pivotal guide flap 17 deviates tablets either in manual mode or automatic mode to the sampling outlet, the right outlet 20.
The outlets 18, 19, 20 may lead the tablets directly into containers and may be provided with a closing mechanism, or they may be connected to a further system of channels by means of couplings.
The opening of the ejection nozzle 15 is formed as a hole 22 in the curved guide plate 13 of the ejection finger 9. The ejection nozzle is supplied with compressed gas through a supply line 23 having an inlet end 24 for connection with a not shown source of compressed gas and having an outlet end 25 communicating with the ejection nozzle. The supply line 23 is provided with a control valve 26 controlled by a control unit 27 in order to open the supply line 23 when a tablet to be sorted out has been detected by the control unit 27. The control valve 26 is integrated into the free end 12 of the ejection finger 9 right beside the ejection nozzle 15 so that the reaction time from the opening of the control valve to the ejection of gas out through the opening 22 of the ejection nozzle 15 is very short. The control unit 27 decides whether a tablet is defective and should be sorted out on the basis of a monitoring of operational parameters of the tablet press, such as compression force or displacement of a punch during compression, for instance, among others. The monitored parameters may by indicative of qualities of the compressed tablets such as weight, hardness, thickness, dissolution and active dose, among others. This monitoring is well-known in the art and not indicated on the drawing.
Furthermore, the supply line 23 is provided with a sensor in the form of a pressure meter 28 arranged between the inlet end 24 of the supply line 23 and the control valve 26. The pressure meter 28 is located under the lower partition wall 7, below the pole 11, on which the ejection finger 9 is mounted, see
The pressure measured by the pressure meter 28 is indicative of a gas flow through the supply line 23 and consequently also through the control valve 26. When the control valve 26 is closed, the static pressure in the supply line 23 generated by means of the not shown source of compressed gas is monitored by means of the control unit 27 on the basis of a pressure signal supplied from the pressure meter 28 to the control unit 27 through the electric line 29. The control unit 27 generates an error signal, in the case that this static pressure goes under a predetermined minimum pressure, for instance 6 barg. In this case, the supply pressure is not correct. When the control valve 26 is controlled to open by means of an electrical signal from the control unit 27 to the control valve 26 through an electric line 30, the pressure measured by the pressure meter 28 is also monitored, and in case that a predetermined pressure drop occurs after a predetermined reaction time, it is assumed that the control valve 26 has been opened properly, and that the ejection nozzle 15 functions properly; especially that the ejection nozzle is not clogged up. The predetermined pressure drop could, for instance, be a drop from 6.0 barg to 5.8 barg and is a result of the flow resistance in the supply line according to Poiseuille's law. In the opposite case, whereby said predetermined pressure drop does not occur, after said predetermined reaction time, it is assumed that either the control valve 26 has not been opened properly or that the ejection nozzle 15 does not function properly, for instance because it is clogged up. In that case, the control unit generates an error signal indicating that proper measured must be taken by the operator of the tablet press.
Instead of the pressure meter 28 other kinds of suitable sensors may also be applied in order to detect a variable indicative of a gas flow through the control valve 27. Especially, different kinds of standard flowmeter may by applied, such as a differential pressure flowmeter, an ultrasonic flowmeter, a target flowmeter, or a coriolis mass flowmeter.
15
| Filing Document | Filing Date | Country | Kind | 371c Date |
|---|---|---|---|---|
| PCT/IB06/53567 | 9/29/2006 | WO | 00 | 3/27/2009 |
