Patent Grant
11844605
The present invention relates to the field of systems and methods for detecting obstructive apnea or dyspnea, and biomarkers for obstructive apnea or dyspnea.
Airway obstruction can be a critical health emergency, leading to death within minutes. Partial obstruction is also possible.
Apnea is suspension of breathing. During apnea, the volume of the lungs initially remains unchanged. Depending on how blocked the airways are (patency), there may or may not be a flow of gas between the lungs and the environment; gas exchange within the lungs and cellular respiration is not acutely affected.
In obstructive apnea, breathing is attempted, which causes increased activation of the diaphragm and other muscles of respiration, including the intercostal muscles. After a few minutes of prolonged apnea, blood oxygen falls, and various secondary responses occur.
Epileptic seizure is associated with obstructive apnea. Seizure activity spreads to laryngeal motor neurons to cause laryngospasm. Laryngospasm results in partial or complete airway occlusion. Seizure activity changes breathing frequency, amplitude, variability, and can cause central apnea. Only obstructive apnea was associated with rapid, severe arterial oxygen desaturation, bradycardia, and death. Sudden death is the result of respiratory arrest during airway obstruction and nearly simultaneous LV dilatation and asystole. Sudden death in epilepsy can be the result of seizure induced laryngospasm sufficient to cause obstructive apnea, which leads to respiratory arrest and cardiac asystole within tens of seconds.
The recurrent laryngeal nerve (RLN) is a branch of the vagus nerve (cranial nerve X) that supplies all the intrinsic muscles of the larynx, with the exception of the cricothyroid muscles. These muscles act to open and close the vocal cords, and include the posterior cricoarytenoid muscles, the only muscle to open the vocal cords. The nerves supply muscles on the same side of the body, with the exception of the interarytenoid muscle, which is innervated from both sides. See, en.wikipedia.org/wiki/Recurrent_laryngeal_nerve. The recurrent laryngeal nerves supply sensation to the larynx below the vocal cords, gives cardiac branches to the deep cardiac plexus, and branches to the trachea, esophagus and the inferior constrictor muscles. The posterior cricoarytenoid muscles, the only muscles that can open the vocal cords, are innervated by this nerve. The nerves also carry sensory information from the mucous membranes of the larynx below the lower surface of the vocal fold, as well as sensory, secretory and motor fibers to the cervical segments of the esophagus and the trachea.
The MORTality in Epilepsy Monitoring Unit Study (MORTEMUS) identified a consistent sequence of events in epilepsy patients beginning with a generalized tonic clonic seizure and ending in death [Ryvlin et al., Lancet Neurol. 12:966, 2013]. Ten cases were used to establish that the end of the seizure was followed within minutes by terminal apnea and ultimately cardiac arrest. Most importantly, this study established a singular pattern for their SUDEP cases.
U.S. Pat. No. 5,800,470, expressly incorporated herein by reference, discloses a respiratory muscle electromyographic rate responsive implantable pacemaker. The directly detected electromyogram (EMG) signal is amplified and band passed filtered, processed to remove any electrocardiogram (ECG) or pacing impulse signal, full-wave rectified, processed to develop a moving time average signal from which the peak, the maximal slope, and the average slope of the EMG moving time average may be calculated and processed in conjunction with the inspiratory and expiratory times between successive slope detections of the moving time average EMG to develop a rate control signal representative of ventilation rate. The EMG may be selectively picked up from electrodes implanted in or near the parasternal intercostal muscles, the external intercostal muscles, the internal intercostal muscles, the diaphragm, or any other respiratory muscle such as the scalenes, or the sternocleidomastoid, and coupled to conventionally designed or special configuration pacemaker pulse generators and cardiac pace/sense lead systems.
U.S. Pat. No. 4,961,423, expressly incorporated herein by reference, proposes to employ specific electromyogram or EMG (a graph of electrical signals associated with muscle activity) signal processing circuitry in conjunction with a conventional cardiac pacing lead system to derive a control signal which reflects the patient's respiration as reflected across the electrodes in contact with the patient's heart. By use of specific filtration and signal processing, it is proposed to separate the EMG signal from the electrocardiogram (ECG) signal and pacing stimulation impulse from the aggregate signal picked up across the pacing tip and can electrode pair or across separate electrodes devoted to the detection of the EMG.
Getzel et al., “Variation of Cardiac Pacemaker Rate Relative to Respiration,” IEEE Proceedings of 32nd CEMB, 1979, p. 123, and “Variation of Cardiac Pacemaker Rate Relative to Respiration,” IEEE Trans. on Biomed. Eng., Vol. BME-26, No. 9, September 1979, p. 526., expressly incorporated orated herein by reference, describe the electronic integration of the diaphragm electromyogram to generate a control signal proportional to respiratory minute volume for use as the controlling physiological input for a pacemaker.
US 2016/0089540, expressly incorporated herein by reference, a method of treating a patient, comprising: sensing a biological parameter indicative of respiration; analyzing the biological parameter to identify a respiratory cycle; identifying an inspiratory phase of the respiratory cycle; and delivering stimulation to a hypoglossal nerve of the patient, wherein stimulation is delivered if a duration of the inspiratory phase of the respiratory cycle is greater than a predetermined portion of a duration of the entire respiratory cycle.
It is thus known that there is a respiration artifact in the ECG signal. It is also known that the intrinsic ECG signal is respiratory responsive, including R-R interval.
Nakase et al., “Laryngospasm, central and obstructive apnea during seizures: Defining pathophysiology for sudden death in a rat model, Epilepsy Research, Volume 128, 126-139 (December 2016), DOI:dx.doi.org/10.1016/j.eplepsyres.2016.08.004; www.epires-journal.com/article/S0920-1211(16)30124-3/abstract, describes the pathophysiology of sudden death in epilepsy using an animal model, and has several figures that illustrate laryngospasm, obstructive apnea, desaturation during obstructive apnea, direct measures of the forces developed during attempts to inspire against a closed airway, and evidence of artifacts in ECG records.
Seizure spread into the autonomic nervous system is thought to play an important role in sudden unexpected death in epilepsy (SUDEP; (Bermeo-Ovalle et al., 2015; Devinsky, 2011; Lathers et al., 2008; Sakamoto et al., 2008; Shorvon and Tomson, 2011; Stewart, 2011; Surges and Sander, 2012; Tolstykh and Cavazos, 2013)). Approximately 1% of the US population lives with epilepsy; depending on how one defines sudden death, 2%-17% of deaths in these patients are labeled SUDEP (e.g. (Nei and Hays, 2010)). Among adults with epilepsy, mortality rates are 2-3 times greater than among their non-epileptic counterparts (Langan, 2000; Thurman et al., 2014), and SUDEP is the single most common cause of death (Lathers et al., 1998; Wannamaker, 1985).
Seizures are known to produce significant respiratory changes (reviewed in (Massey et al., 2014; Sowers et al., 2013)). Ictal apnea (Blum, 2009) is implicated in oxygen desaturation during seizures (Bateman et al., 2008; Seyal et al., 2010). Indeed, animal research established the importance of ictal hypoxemia in seizure-induced death, as studies in sheep have shown that ictal hypoventilation leads to severe bradycardia and death (Johnston et al., 1995; Johnston et al., 1997). Similar findings have been noted in rats (Sakamoto et al., 2008; Stewart, 2011), cats (Schraeder and Lathers, 1983), and mice (Faingold et al., 2010; Uteshev et al., 2010). The physiological mechanisms, however, that link seizures to respiratory dysfunction have not been fully resolved.
One possible cause of ictal respiratory distress is laryngospasm, a tonic adduction of the vocal folds that partially or fully obstructs the upper airway. Laryngospasm has been observed during seizures or postictally, evidenced by stridor and a narrowed airway when attempting to place an endotracheal tube (Tavee and Morris, 2008) or intensive inspiratory effort with severe air hunger (Amir et al., 1983). Cats and piglets experienced hypoventilation and glottal obstruction during chemically-induced seizures (Learning et al., 1999; Terndrup et al., 1995a; Terndrup et al., 1995b). That pulmonary edema is the most common single finding at autopsy in SUDEP cases is also indirect evidence of laryngospasm (Antoniuk et al., 2001; Morentin and Alcaraz, 2002; Salmo and Connolly, 2002). Pulmonary edema can occur when “pulling” against a closed airway—the inspiratory effort increases pulmonary capillary pressure (Ead, 2003; Murray-Calderon and Connolly, 1997; Umbrain and Camu, 1993). Seizures could cause ictal laryngospasms by spreading via autonomic medullary motor regions to the laryngeal branches of the vagus nerve, the efferent innervation of the vocal folds.
A urethane/kainate rat model (reviewed in (Naggar and Stewart, 2015; Stewart, 2011)) was used to permit detailed study of laryngospasm during seizure activity. This model allows invasive monitoring during seizure activity. Recordings are obtained from the recurrent laryngeal nerve, the principal motor output to the larynx (Bartlett, 2011; Brancatisano et al., 1991; Kuna et al., 1991; Kuna et al., 1988; Kuna et al., 1990), along with simultaneous laryngoscopy (Mor et al., 2014) to define the patterns of RLN activity during seizures, the impact of seizure activity on laryngeal function, and the impact of laryngeal dysfunction on breathing. These data highlight the complexity of laryngospasm during seizures, and how changes in laryngeal function can contribute to death.
In order to monitor heart signals in an ambulatory environment, a number of options are available. Bioelectric signals may be acquired from the chest wall, limbs, and digits. Heart rate and pulse variability can also be acquired using pulse information, which can be acquired by plethysmography and optical sensors on the skin, wrist, ankle, and digits.
See: www.vitalconnect.com/upload/Documents/EngeryExpenditure2014_MobiHealth_published.pdf; www.vitalconnect.com/upload/Documents/Longterm-Remote-Monitoring_HealthInnovations_2014_published.pdf; www.vitalconnect.com/upload/Documents/AutomatedPrediction_2014_IEEE_published.pdf; www.vitalconnect.com/upload/Documents/2014-Sleep-Abstract.pdf; www.vitalconnect.com/upload/press/Chan2013EMBC_VitalConnectPatch.pdf; www.vitalconnect.com/upload/press/Selvaraj2013EMBC_OSAeventDetectionRespiratorySignals pdf; www.vitalconnect.com/upload/press/Chan2013EMBC_RespirationECGandAccelerometer.pdf; Rosenberg M., Samuel M., Thosani A, Zimetbaum P., “Use of a noninvasive continuous monitoring device in the management of atrial fibrillation: a pilot study”, Pacing Clin Electrophysiol. 2013; 36(3): 328-333.
See also, U.S. Patent and Pub. Patent App. Nos. 3942513; 3950799; 4033332; 4169462; 4197856; 4289142; 4350166; 4381788; 4387722; 4391279; 4403215; 4422458; 4446869; 4474185; 4475559; 4506626; 4558708; 4595016; 4630614; 4657026; 4686975; 4694839; 4715367; 4724844; 4732159; 4736749; 4745925; 4757824; 4757825; 4765340; 4802485; 4802486; 4803997; 4806112; 4838279; 4889116; 4895162; 4924860; 4928692; 4928703; 4958638; 4961423; 4982738; 5005234; 5005571; 5016636; 5036852; 5052400; 5095900; 5099836; 5107855; 5131387; 5133346; 5206807; 5271412; 5295490; 5307817; 5309921; 5311875; 5353793; 5360008; 5395301; 5485850; 5495242; 5603316; 5645053; 5671733; 5704345; 5765554; 5769084; 5779631; 5782240; 5792068; 5800360; 5800470; 5825293; 5853005; 5873821; 5879313; 5913826; 5928157; 5954053; 5961447; 5964720; 6017315; 6019732; 6029665; 6045514; 6062216; 6064910; 6134460; 6138675; 6150104; 6150941; 6168568; 6208897; 6223064; 6241683; 6248068; 6261238; 6267730; 6286508; 6290654; 6342039; 6342040; 6363933; 6368287; 6375621; 6390987; 6450168; 6454724; 6470888; 6477710; 6498652; 6510339; 6537228; 6544192; 6549795; 6550478; 6553242; 6553256; 6574507; 6580943; 6580944; 6621278; 6675797; 6721980; 6773404; 6785568; 6816266; 6849049; 6856141; 6881192; 6915705; 6920877; 6970737; 6984993; 6989744; 7020511; 7035432; 7039152; 7074177; 7080554; 7092755; 7117036; 7126467; 7129833; 7148797; 7166123; 7168429; 7170404; 7173525; 7179229; 7225021; 7269459; 7315760; 7320320; 7330127; 7340302; 7363086; 7391316; 7403110; 7415093; 7431700; 7435221; 7460899; 7467012; 7473227; 7477142; 7477143; 7477144; 7508307; 7515059; 7522035; 7533571; 7593764; 7597659; 7611472; 7656287; 7661426; 7667624; 7678058; 7711579; 7715905; 7716767; 7725181; 7730886; 7734335; 7794716; 7800505; 7811234; 7818058; 7827988; 7884735; 7894849; 7899521; 7909764; 7938114; 7942822; 7976470; 7988640; 8011365; 8031080; 8050765; 8106781; 8119134; 8121692; 8136521; 8142343; 8155735; 8161971; 8204580; 8219185; 8226570; 8226571; 8238996; 8255029; 8258973; 8262578; 8273053; 8301219; 8301232; 8360060; 8360983; 8381722; 8393233; 8396537; 8403861; 8417351; 8442578; 8449473; 8482418; 8483807; 8483811; 8483834; 8489182; 8509882; 8527028; 8538510; 8551010; 8554323; 8560044; 8562526; 8566115; 8568160; 8579792; 8595164; 8616203; 8630704; 8641631; 8683999; 8700137; 8718751; 8721554; 8721560; 8721573; 8731644; 8750987; 8752547; 8768731; 8790270; 8801620; 8828386; 8844525; 8862211; 8868152; 8880207; 8892194; 8923971; 8948854; 8954137; 8983587; 8985106; 9019100; 9022032; 9024781; 9026202; 9037477; 9044362; 9078577; 9089691; 9101277; 9113788; 9131892; 9132250; 9144389; 9177459; 9180270; 9192336; 9198616; 9198617; 9199053; 9202084; 9215075; 9216291; 9220459; 9220460; 9227034; 9269000; 9277867; 9302116; 9307921; 9333318; 9364180; 9370634; 9414787; 9415182; 9445736; 9445740; 9445747; 9451888; 9468835; 9477812; D284697; RE32180; 20010018557; 20010044588; 20020007126; 20020078957; 20020099300; 20020105340; 20020161290; 20020173707; 20030024528; 20030111079; 20030161436; 20030161440; 20030163059; 20030199945; 20030208130; 20030213488; 20030236548; 20040002742; 20040082874; 20040104733; 20040123866; 20040158193; 20040186523; 20040187870; 20040194220; 20040207409; 20040257233; 20050027204; 20050027206; 20050053262; 20050085736; 20050085863; 20050085865; 20050101833; 20050113656; 20050177051; 20050211248; 20050211249; 20050273361; 20050277842; 20050288572; 20060000475; 20060004245; 20060011200; 20060025696; 20060025697; 20060030894; 20060050930; 20060087325; 20060122675; 20060134106; 20060179571; 20060229489; 20060258916; 20060258921; 20060264770; 20070061393; 20070062540; 20070073177; 20070100381; 20070106536; 20070106537; 20070106750; 20070106751; 20070106752; 20070106753; 20070106754; 20070116036; 20070116037; 20070142713; 20070142741; 20070167694; 20070168461; 20070199262; 20070215146; 20070255310; 20070265539; 20070282212; 20080009755; 20080015454; 20080015457; 20080039730; 20080040151; 20080041382; 20080041383; 20080045832; 20080051845; 20080058873; 20080058892; 20080060138; 20080071185; 20080082016; 20080091082; 20080092898; 20080101532; 20080154110; 20080161708; 20080163873; 20080167567; 20080170654; 20080177789; 20080183095; 20080183239; 20080190430; 20080190436; 20080243021; 20080262360; 20080287769; 20080287770; 20080288013; 20080300499; 20080308112; 20080313816; 20080319513; 20090036790; 20090099462; 20090099469; 20090118629; 20090149778; 20090172773; 20090177050; 20090177495; 20090183312; 20090203972; 20090226861; 20090226862; 20090226863; 20090226864; 20090226865; 20090270773; 20090318820; 20090326981; 20100004549; 20100010359; 20100016783; 20100018530; 20100036209; 20100036263; 20100036268; 20100036269; 20100056850; 20100063438; 20100099963; 20100137723; 20100159426; 20100168578; 20100179396; 20100198083; 20100198289; 20100204550; 20100222685; 20100222689; 20100228120; 20100242965; 20100252037; 20100252039; 20100252040; 20100252041; 20100252042; 20100253505; 20100258123; 20100262035; 20100268093; 20100297129; 20100307500; 20100328075; 20110009722; 20110011402; 20110021970; 20110034820; 20110105921; 20110131057; 20110160601; 20110172552; 20110184298; 20110184304; 20110190651; 20110214676; 20110245706; 20110284003; 20110301435; 20110301439; 20110319777; 20120004749; 20120028504; 20120029362; 20120032778; 20120046709; 20120056746; 20120088998; 20120101690; 20120109027; 20120130204; 20120130446; 20120136231; 20120152252; 20120160243; 20120165711; 20120172689; 20120173470; 20120189632; 20120197144; 20120203491; 20120209096; 20120232398; 20120232416; 20120240934; 20120252709; 20120272429; 20120283527; 20120323104; 20120330123; 20130012827; 20130030711; 20130046151; 20130046156; 20130046157; 20130046160; 20130046161; 20130046184; 20130046185; 20130046186; 20130046187; 20130046188; 20130053674; 20130060480; 20130081479; 20130085688; 20130096447; 20130096450; 20130123654; 20130131522; 20130165809; 20130174847; 20130178719; 20130211210; 20130218030; 20130234535; 20130255683; 20130261485; 20130268030; 20130281815; 20130291060; 20130296660; 20130300575; 20130307685; 20130312752; 20130312757; 20130331663; 20130340500; 20140012145; 20140018779; 20140025141; 20140031705; 20140031709; 20140058274; 20140066741; 20140066798; 20140073969; 20140094669; 20140100628; 20140107501; 20140150793; 20140152467; 20140163343; 20140163386; 20140171783; 20140180148; 20140180154; 20140218210; 20140221859; 20140228651; 20140243934; 20140246024; 20140246025; 20140258743; 20140276287; 20140309568; 20140309943; 20140320309; 20140323946; 20140330155; 20140330540; 20140363740; 20140364706; 20150005646; 20150018660; 20150035643; 20150038867; 20150039110; 20150065891; 20150073285; 20150101609; 20150112202; 20150119739; 20150126847; 20150141766; 20150141862; 20150150500; 20150173672; 20150182132; 20150182842; 20150216448; 20150228176; 20150251016; 20150257653; 20150305634; 20150314098; 20150320588; 20150321022; 20150359964; 20150366511; 20150370320; 20150374328; 20160004820; 20160022145; 20160022204; 20160030689; 20160045134; 20160045166; 20160045167; 20160045654; 20160045695; 20160066805; 20160066809; 20160074606; 20160089540; 20160095997; 20160100798; 20160120430; 20160120431; 20160120433; 20160120434; 20160128209; 20160135706; 20160143594; 20160169930; 20160174857; 20160220197; 20160228024; 20160228060; 20160256063; 20160256644; 20160263393; 20160278658; 20160296124; 20160302726; and 20160310103.
A fingertip electrometer-based cardiac cycle sensors is disclosed in US 2012/0004523.
Seizures are known to produce significant respiratory changes and seizure spread into the autonomic nervous system can result in life-threatening cardiovascular and respiratory dysfunction. Ictal apnea and/or ictal bradycardia has been well recognized as a part of the autonomic manifestation in epileptic seizures. Prolonged peri-ictal apnea and bradycardia are both regarded as risk factors for sudden death in epilepsy (SUDEP). SUDEP is the major cause of death among persons with epilepsy. However, the physiological mechanisms of SUDEP are poorly understood and no specific indicator of SUDEP events is known. One possible cause of ictal respiratory distress is laryngospasm, a tonic adduction of the vocal folds that partially or fully obstructs the upper airway. Using a rat model, sudden death due to seizure and hypoxemia-induced conditions was studied. Based on findings of the inventors, some seizures cause laryngospasm that is sufficiently severe to produce complete airway obstruction. Once occluded, attempts to inspire against a closed airway get progressively stronger until attempts stop (the point of respiratory arrest). These attempts produce clear artifacts in recordings of electrocardiogram (ECG) and electroencephalogram (EEG) signals whose amplitudes highly correlate with the force of attempted inspiration. Late in the occlusion, the RR interval variability is dramatically increased due to an overall slower heart rate in combination with additional very short RR intervals closely associated with attempts to inspire.
Artifacts in the ECG and EEG during obstructive apnea caused by laryngospasm correspond in time and correlate in size with a direct measure of inspiratory effort in experimental animals. Likewise, these inspiration efforts cause strong electromyography (EMG) signals from muscles of respiration, including diaphragm and intercostal muscles while the resulting hypoxemia leads to bradycardia and an abrupt increase in heart rate variability with very short RR intervals at the time of each attempted inspiration.
R waves in ECG can be automatically identified through RR interval analyses and artifact detection and quantification from ECG and EEG records.
These physiological effects detected by these signals and analyzed can be used as practical biomarkers of obstructive apnea (e.g. laryngospasm). Two particular biomarkers that are specific for upper airway occlusion include:
The high frequency signal has an amplitude that corresponds to inspiratory effort, and therefore by monitoring respiration artifacts over time, an adaptive baseline may be established. When an obstructive apnea occurs, the respiratory artifacts are altered in a distinctive way. The amplitude increases on successive attempts, and the timing of these attempts differs from a normal respiratory rate. Both the high frequency signal and the variation in R-R wave intervals are responsive to obstructive apnea and indicative of an apnea activity pattern of muscles of respiration, including diaphragm and intercostal muscles.
Because these biomarkers do not require ECG analysis per se, they may be detected from electrodes in non-standard locations for cardiac monitoring, such as fingers or wrist. As such, the monitoring device may take the form of a wrist-band, ring(s), or other convenient form. Of course, traditional chest electrodes may also be employed.
The R-R interval is the basic heart rate, and therefore the rate and its variability can be determined in an alternate manner, e.g., without electrocardiographic electrodes. For example, physical or optical pulse sensors, acoustic sensors, ballistocardiographic sensors, etc.
On the other hand, the high frequency electromyographic signal from muscles of respiration, including diaphragm and intercostal muscles, superimposed on the electrocardiographic signal would generally require an electronic sensor for detection. However, other types of respiratory sensors and detection may be employed, though when directly measuring respiration, the need for a biomarker or indirect measurement for apnea is diminished.
The combination of these biomarkers clearly indicates when a person's breathing is obstructed, attempting to breathe, and generating large breathing forces in these attempts. An alarm sounded at this point to alert a caretaker will permit enough time to ensure that respiratory arrest does not occur or that, if respiratory arrest does occur, resuscitation steps can be taken to save a life. These biomarkers can also be applied to past cases and used to monitor patients to improve outcomes.
These biomarkers may have application in various types of obstructive apnea. While a preferred system and method target ictal obstructive apneas, asthmatic conditions may produce similar biomarkers. Thus, when an asthmatic attack occurs, airways are restricted, leading to reduced chest pressure and large inspiratory efforts. Asthmatic apnea tends to be an incomplete blockage, and therefore the pattern over time may differ from a laryngospasm-induced apnea, but the biomarkers are sufficiently broad to permit application in various uses.
In the case of asthma, one might seek to determine the extent of blockage, which is not always directly apparent, especially in exercise induced-asthma, where increased demand is superimposed on the airway restriction. However, the restriction will increase the efforts required, and increase the pressure differentials, and thus the asthmatic restriction may be distinguished from the mere increased respiratory rate due to exertion.
Based on these biomarkers, a system and method is provided that can detect the period of obstructive apnea and be used to sound an alarm in time to prevent respiratory arrest or in time to permit resuscitation.
A particular aspect of the system and method is the extraction of one or both of the biomarkers from ECG data, EEG data, or other bioelectric signals. The data used for biomarker extraction can thus come from multiple sources. In circumstances where ECG data or EEG data is already collected and available for analysis, e.g. any continuous ECG recording or EEG recording in a hospital setting, such as that used in Critical Care Units, Epilepsy Monitoring Units, etc., the biomarker identification algorithms can be added to the existing instrumentation. In an ambulatory or home setting, ECG can be obtained by a minimally intrusive “bracelet” such as those used for popular HR monitoring, with the exception that a telemetry component would generally be added to the bracelet and the receiving station, e.g., smartphone, would house the biomarker detection software and the hardware used for the alarm. A hat or scalp monitor with electrodes can also provide EEG data.
Of course, the data analysis can be provided within the sensor module, and an audible and/or visual alarm sounded from the module. Sensing obstruction may incur a latency, of approximately 10-30 seconds, and the time before permanent damage occurs to the patient is only a few minutes, providing only a small window of opportunity to prevent a complete laryngeal obstruction of the patients airway, and therefore a local caregiver would need to provide immediate assistance, and remote monitoring would likely be ineffective. However, within a hospital or other facility, a remote, wireless alarm may be useful. Similarly, in cases of incomplete obstruction, such as bronchial constriction, the onset and resolution of the apnea provide a larger window of opportunity for intervention.
Biomarker extraction involves taking the ECG signal and processing it in different ways for each of the two biomarkers.
Biomarker 1
The algorithm for biomarker 1 (Artifact Growth) involves the following steps applied to ECG recorded with a bandwidth of approximately 10 Hz to >1 kHz:
More generally, a bioelectric signal is obtained which includes a contribution from activity of muscles of respiration, including diaphragm and intercostal muscles activity. The bioelectric signal is processed to represent amplitude and timing of inspiratory efforts. The respiratory rate is compared with a normal pre-detection rate, and the amplitude of the bioelectric signal is compared with a pre-detection normal amplitude. The obstructive apnea is likely present if a series of inspiratory efforts are above a normal amplitude and with increasing amplitude, but at a normal rate.
Biomarker 2
The algorithm for biomarker 2 (Ultrashort RR Intervals) involves analysis of the acquired ECG signal with the following steps:
More generally, the heart rate is determined, and compared to a baseline average. A normal lower threshold is established, and if subthreshold events occur (short RR intervals), a commencement of each sequence of subthreshold events is compared for a respiratory rate-normalized window. If the number of subthreshold events exceeds a minimum for the window, obstructive apnea is likely present.
The technology may be implemented in any device that receives a bioelectric signal that includes electromygraphic signals emanating from muscles of respiration. For example, an automated external defribrillator (AED) device may be provided with program instructions that permit the ECG electrodes to read the electromygraphic signals, and provide obstructive apnea indication, in addition to the normal defribrillator functionality. As noted, the present system seeks to compare a current bioelectric signal with a baseline signal, which may not be available in an acute emergency. Likewise, the AED tends to be employed with a human user in attendance, who can observe the patient. However, the user may be untrained, and therefore automatically monitoring the patient for apnea, and to distinguish different types of apnea, may be useful, especially for differential diagnosis where a patient hooked to the AED has a normal sinus rhythm, and yet is in distress.
It is therefore an object to provide a method for detecting obstructive apnea, comprising: receiving a bioelectric signal from a mammal comprising electromyographic activity of muscles of respiration, including diaphragm and intercostal muscles; processing the bioelectric signal to isolate the electromyographic activity; determining a timing and amplitude of inspiratory efforts based on the isolated electromyographic activity; determining a baseline amplitude of inspiratory efforts; comparing an amplitude of inspiratory efforts with the determined baseline amplitude of inspiratory efforts; and determining occurrence of obstructive apnea if a series of inspiratory efforts have increasing amplitude over time, above the baseline amplitude.
The method may further comprise determining a baseline timing of inspiratory efforts, and comparing the timing of inspiratory efforts with the determined baseline timing of inspiratory efforts, wherein the occurrence of obstructive apnea is determined if a series of inspiratory efforts have increasing amplitude above the baseline amplitude over time, and a baseline timing.
The timing and amplitude of inspiratory efforts may be determined over a series of three inspiratory efforts before the occurrence of obstructive apnea is determined.
The bioelectric signal may be an electrocardiographic signal. The bioelectric signal may be an electroencephalographic signal. The bioelectric signal may be acquired from a single extremity.
The method may further comprise generating an audible alarm in response to determining the occurrence of obstructive apnea. The method may further comprise generating a wireless communication in response to determining the occurrence of obstructive apnea.
The bioelectric signal may be received from a mammal comprising electromyographic activity of muscles of respiration, including diaphragm and intercostal muscles comprises receiving at least one of an electrocardiographic signal, an electroencephalographic signal, and an electromyographic signal. The processing of the bioelectric signal may be used to isolate electromyographic activity comprises subjecting the bioelectric signal to a bandpass filter having a passband between about 300 Hz and 1 kHz. The processing of the bioelectric signal may be used to isolate electromyographic activity comprises determining a signal power within a passband over time.
The comparing of an amplitude of inspiratory efforts with the determined baseline amplitude of inspiratory efforts may comprise comparing a series of amplitudes and timings of inspiratory efforts with a baseline window representing a normal range of amplitudes and timings of inspiratory efforts.
The occurrence of obstructive apnea may be determined if a series of inspiratory efforts have increasing amplitude over time, above the baseline amplitude, comprises determining if three successive inspiratory efforts have an amplitude above a threshold with at least one of a steady amplitude and an increasing amplitude, while an interval between inspiratory efforts is within a normal range.
It is also an object to provide a method of determining obstructive apnea, comprising: determining a baseline inter-heartbeat interval and a normal range of variation for a respective respiratory rate within a respiratory interval; determining an inter-heartbeat interval and a respiratory rate of a patient; determining a commencement of a series of inter-heartbeat intervals which is outside the normal range of variation below the baseline inter-heartbeat interval for the respective respiratory rate; and determining commencement of obstructive apnea if a number of commencements of the series of at least one inter-heartbeat interval which is below the baseline inter-heartbeat interval for the respective respiratory rate within the respiratory interval is above a threshold. The threshold may be three.
The inter-heartbeat interval and the respiratory rate may be determined based on a bioelectric signal.
The bioelectric signal may be an electrocardiographic signal, an electroencephalographic signal, and/or an electromyographic signal. The bioelectric signal may be acquired from a single extremity.
The method may further comprise generating an audible alarm in response to determining the commencement of obstructive apnea. The method may further comprise generating a wireless communication in response to determining the commencement of obstructive apnea. The method may further comprise automatically generating an e911 (enhanced 911) call through a telephone network in response to determining the commencement of obstructive apnea. The inter-heartbeat interval may be determined by determining an R-R interval of an electrocardiogram.
The method may further comprise establishing a window distinguishing a normal inter-heartbeat interval from a short inter-heartbeat interval for the respective respiratory rate; and recording a time of an inter-heartbeat interval which is outside the window for the respective respiratory rate.
It is a further object to provide a system for detecting obstructive apnea, comprising: an input configured to receive a bioelectric signal from a mammal comprising electromyographic activity of muscles of respiration, including diaphragm and intercostal muscles; at least one processor configured to: process the bioelectric signal to isolate electromyographic activity; determine a timing and amplitude of inspiratory efforts based on the isolated electromyographic activity; determine a baseline amplitude of inspiratory efforts; compare an amplitude of inspiratory efforts with the determined baseline amplitude of inspiratory efforts; and determine occurrence of obstructive apnea if a series of inspiratory efforts have increasing amplitude over time, above the baseline amplitude; and an output for communicating an alarm dependent on the determined occurrence.
It is another object to provide a system for of determining obstructive apnea, comprising: an input configured to receive information defining am inter-heartbeat interval; at least one processor configured to: determine a baseline inter-heartbeat interval and a normal range of variation for a respective respiratory rate within a respiratory interval; determine an inter-heartbeat interval and a respiratory rate of a patient; determine a commencement of a series of inter-heartbeat intervals which is outside the normal range of variation below the baseline inter-heartbeat interval for the respective respiratory rate; and determine commencement of obstructive apnea if a number of commencements of the series of at least one inter-heartbeat interval which is below the baseline inter-heartbeat interval for the respective respiratory rate within the respiratory interval is above a threshold; and an output for communicating an alarm dependent on the determined commencement.
These and other objects will become apparent through a review of the description hereof.
Parenteral kainic acid was used to induce recurring seizures in urethane-anesthetized Sprague Dawley rats. EEG recordings and combinations of cardiopulmonary monitoring, including video laryngoscopy, were performed during multi-unit recordings of recurrent laryngeal nerve (RLN) activity or head-out plethysmography with or without endotracheal intubation. Controlled occlusions of a tracheal tube were used to study the kinetics of cardiac and respiratory changes after sudden obstruction. Seizure activity caused significant firing increases in the RLN that were associated with abnormal, high-frequency movements of the vocal folds. Partial airway obstruction from laryngospasm was evident in plethysmograms and was prevented by intubation. Complete glottic closure (confirmed by laryngoscopy) occurred in a subset of non-intubated animals in association with the largest increases in RLN activity, and cessation of airflow was followed in all obstructed animals within tens of seconds by ST-segment elevation, bradycardia, and death.
Periods of central apnea occurred in both intubated and non-intubated rats during seizures for periods up to 33 seconds and were associated with modestly increased RLN activity, minimal cardiac derangements, and an open airway on laryngoscopy.
For controlled airway occlusion, a T-tube was inserted into the distal trachea of urethane-anesthetized rats. EEG, ECG, and inspiratory pressure at the sidearm of the T-tube were bandpass-filtered from 1 Hz to 1 kHz. The open port of the T-tube was occluded for 100 seconds or until respiratory arrest. Inspiration artifacts in the EEG and EEG records were isolated with a digital high-pass filter (corner frequency 367 Hz, rolloff −3 dB/octave) and quantified by full-wave rectification. Inspiration artifacts matched the inspiratory pressure extrema during airway occlusion. Correlations (r) of peak inspiratory pressure to artifact amplitude in a within-animal comparison were −0.88 (ECG) and −0.75 (EEG), suggesting that artifacts extracted from ECG records may be better than those derived from EEG records. The average correlation of artifact magnitude (ECG) with peak inspiratory pressure was −0.89±0.04 (N=5 rats). The results suggest that a sudden increase in the amplitude of the inspiratory artifact in EEG and ECG recordings indicates an occluded airway, and a very high correlation of increasing inspiration artifact size with increasing inspiratory effort was observed. This artifact pattern could serve as a biomarker in two important ways: First, to review existing records for the possible contribution of obstructive apnea to documented SUDEP cases. Second, to warn about obstructive apnea in patients being monitored in real time. The specificity of the biomarker would be further enhanced by marking decreases in seizure activity and heart rate. To maximize the sensitivity of the biomarker, EEG and ECG should be recorded at the highest bandwidth possible (within the capability of the available equipment, e.g., up to 10 kHz bandwidth). The most attractive feature of this biomarker is that it can be derived from commonly-used measures in epilepsy-monitoring units and even potentially portable devices outside of the hospital.
Using a rat model that permits simultaneous autonomic, cardiovascular, and respiratory monitoring, it was demonstrated that seizure-induced laryngospasm caused obstructive apnea, which stopped the seizure and persisted until respiratory arrest, followed by cardiac arrest. The MORTEMUS study used artifacts in EEG recordings as evidence of respiration. A critical finding herein is that attempts to breathe during obstruction generated artifacts in EEG and ECG recordings that resembled artifacts associated with actual breaths.
The electrical artifacts of attempts to inspire during airway obstruction can be used as a practical biomarker of obstructive apnea. In
Bradyarrhythmia is present in most patients [Ryvlin et al.] and animals. [Nakase et al.; Hotta et al. Epilepsia 50: 923, 2009]. An abrupt change in the ECG RR interval variability (SDNN; ECG and filtered ECG) and that the normal lengthening of the RR interval during inspiration could be reversed during the late occlusion period. This pattern represents a second biomarker for airway obstruction, even with short time samples. Abnormally short RR intervals associated with inspiration occurred in no animals at baseline, 4/16 animals during early occlusion, and 15/16 during late occlusion.
The spread of seizure activity over the principal motor nerve of the larynx, RLN, was studied in one set of experiments aimed at characterizing RLN activity during normal quiet breathing (baseline) and during seizure activity induced by kainic acid. A tracheal opening or T-shaped tracheal tube that preserved RLN bilaterally was used to protect animals from laryngospasm. In animals with a tracheal tube, periods of complete glottic closure could be studied with laryngoscopy without concern about oxygen desaturation. RLN recordings were also made during other experiments with the goal of capturing RLN activity during specific events such as periods of central and obstructive apnea. EEG, multi-unit RLN activity, and ECG were recorded in all animals. Laryngoscopy was performed at intervals during experiments.
The impact of laryngospasm and seizure activity on ventilation was assessed with head-out plethysmography in a second set of experiments. One group of animals was intubated with an endotracheal tube prior to seizure induction and these animals were compared with non-intubated animals. The non-intubated animals comprised two subgroups: one with no treatment other than kainic acid to induce seizures, and a second with bilateral superior laryngeal nerve transection to prevent reflex laryngospasm performed in the pre-seizure condition.
Seizure activity was associated with increases in RLN activity and abnormal, high frequency movements of vocal folds. Within a single seizure, RLN activity progressively increased, with the highest levels of activity most commonly observed near the end of the seizure. The full pattern of an RLN activity increase during a single seizure and its decrease to baseline at the end of the seizure could be observed when the airway was protected by a tracheal tube or window (
During normal tidal breathing under urethane anesthesia, the early expiratory peak in rats resembles human breathing (Arito et al., 1997). Three of 14 non-intubated rats and 1 of 6 intubated rats had seizure activity mainly characterized by low frequency, repetitive gasping breaths and were not included in the summary data. Plethysmograph recordings were taken before and after SLN lesions in this subgroup, and before and after intubation in intubated animals. None of the measured parameters showed a difference due to SLN lesion or intubation. Pre-seizure values used for comparison with seizure values were the baseline condition for KA-only animals, the post-intubation condition for intubated animals, and the post-lesion condition for SLN lesioned animals. There were no differences between the two subgroups of non-intubated rats and their measures were pooled for statistics except when these two groups were compared with each other. Examples of flow-volume loops for non-intubated and intubated rats are shown in
Seizure activity was associated with large increases in respiratory rate in all remaining rats (11 non-intubated and 5 intubated), irrespective of treatment, from mean pre-seizure rates of 85±11 and 98±17 breaths/min for non-intubated and intubated rats, respectively to seizure associated rates of 371±54 and 295±43 breaths/min. Increases were significant (p<0.0001) after Scheffe post hoc correction of multi-variate ANOVA. Pre-seizure mean rates of 89 and 81 breaths/min were observed in the 5 KA-only rats and the 6 non-intubated SLN lesioned animals, with seizure-associated mean rates of 371 breaths/min for both groups (p<0.0001 for both comparisons).
Other details are given in Table 1, which shows a summary of first and second order plethysmography variables. The full set of plethysmography variables measured are shown with details for baseline, post manipulation (intubation or SLN lesion) and during seizure activity. The manipulations (intubation or SLN lesion) did not change baseline values significantly for any parameter, but seizure activity changed many parameters related to durations and volumes in all animals. The principal measure to discriminate between non-intubated and intubated animals was the ratio of inspiratory peak flow to expiratory peak flow. Scheffe post-hoc corrections applied to one-way ANOVAs. A p value of 0 is used to indicate p<0.0001.
Tidal volume decreased significantly in the non-intubated rats. Mean pre-seizure tidal volumes of 1.50±0.36 ml/breath decreased to 0.46±0.14 ml/breath (p<0.0001). Subgroup tidal volumes were each significantly decreased: 1.2 to 0.46, p=0.008 for KA-only rats and 1.7 to 0.46, p<0.0001 for SLN lesioned rats). The difference in pre-seizure (1.03±0.69 ml/breath) vs. seizure (0.53±0.26 ml/breath) tidal volume in intubated animals did not reach statistical significance.
Given that ventilation rates increased approximately 3-fold and tidal volumes decreased approximately 3-fold during seizure activity, the average minute ventilation during seizure activity did not differ significantly from baseline, but tended toward lower values. Mean pre-seizure values of 124.8±27.3 and 124.2±61.8 ml/min were associated with mean seizure values of 100.8±35.7 and 93.2±42.3 ml/min (NS, NS) for non-intubated and intubated rats. Only the SLN lesioned subgroup showed a significant decrease in minute ventilation from 138.8±13.2 to 106±22.4 ml/min (p<0.0001). Mean pre-seizure and seizure values for the KA-only rats were not significantly different (108.0±25.0 vs. 94.4±49.7 ml/min; NS).
The most dramatic differences were seen in the ratio of peak flow during inspiration to peak flow during expiration. This parameter is used to identify upper airway obstruction. Normally, this ratio is ≥1, and values <1 are indicative of extrathoracic (e.g. upper airway) obstruction (Blitzer and Meyer, 2006; Miller et al., 1987). Mean pre-seizure ratios were 1.04±0.25 for non-intubated rats and 1.02±0.10 for intubated rats. These values changed in opposite directions for intubated (increasing to 1.56±0.38; p=0.011) and non-intubated rats (decreasing to 0.52±0.32; p<0.001). The individual subgroups of non-intubated animals each showed decreases in the ratio of peak flows during inspiration and expiration: 0.95 to 0.60 for KA-only rats (NS) and 1.11 to 0.46 for SLN lesioned rats (p=0.001). Whereas the decrease in PF(i)/PF(e) is consistent with partial airway obstruction from laryngospasm, the increase in PF(i)/PF(e) is clearly not from one of the typical causes of variable intrathoracic obstruction. Since there was no obstruction in the intubated animals, the flow-volume characteristics of the intubated animals reflect seizure-induced disordered ventilation without contribution from airway narrowing. If this is true, the decreased PF(i)/PF(e) seen in non-intubated rats should be considered an underestimate, more properly compared with the intubated rats' seizure condition than with their own pre-seizure condition.
Values are summarized in Table 2, which shows summary statistics from plethysmography data. To compensate for multiple ANOVAs, a difference score (seizure condition minus pre-seizure condition) was computer for each animal on the 4 variables derived from the plethysmograph (respiratory rate, tidal volume, minute ventilation, and the ratio of inspiratory peak flow to expiratory peak flow). A 2-tailed Mann-Whitney test was conducted of the difference of distribution of these change-scores between intubated and pooled non-intubated study arms. Bootstrapping (20,000 replications) was used (SAS 9.4 Proc Multtest) to arrive at corrected p-values for the four measures, based on independent samples 2-tailed t-tests performed on ranked scores.
The distributions of time in quintiles of the peak-to-peak glottic opening (measured at baseline) is shown in
Whereas clear evidence of partial airway obstruction due to laryngospasm was routinely observed, the modest decreases in minute ventilation suggested that respiratory derangements during seizures were adequately compensated. However, complete glottic closure (confirmed with laryngoscopy) occurred in a subset of non-intubated animals during discrete seizures in association with the largest increases in RLN activity, and cessation of airflow was followed in all animals within tens of seconds with ST segment elevations in ECG, bradycardia, and eventually death. Complete obstructive apnea occurred in 7 of 11 non-intubated and 0 of 5 intubated rats (p=0.03, Fisher exact test, two-tailed). All 7 animals died. The start of the obstructive apneic period was taken as the time from the point at which peak-to-peak airflow reached <10% of the pre-apneic peak-to-peak airflow, and the endpoint was the time at which the recording was stopped and the animal removed from the plethysmography chamber with evidence of severe bradycardia on ECG that, upon removal from the plethysmography chamber, was associated with apparent cardiopulmonary arrest. Only when an artificial airway was present was a period of complete glottic closure due to laryngospasm seen to terminate on its own with a reversion to the normal pattern of opening and closing with each breath.
On plethysmography records, airflow declined rapidly to zero or near zero flow (
Table 3 shows contrasts between obstructive apnea and central apnea. Details of obstructive and central apneic periods captured in non-intubated and intubated rats. Obstructive apnea appeared only in non-intubated rats, a difference that was significant (p=0.034). Central apneic periods averaged durations <10 seconds, but some periods exceeded 30 seconds in duration. To compare the impact of apnea of either type on cardiac activity, HR and the presence or absence of ST segment elevation were compared over equivalent 10 second periods from the onset of apnea based on plethysmography records. ST segment changes were only seen during obstructive apnea periods. Taking the minimum HR over this period in comparison with baseline, both obstructive and central apneic periods were associated with significant bradycardia, but the changes associated with obstructive apnea were greater. All comparisons were two-tailed unpaired t-tests.
As further evidence that the glottic closure was active and not passive (e.g. resembling vocal fold paralysis (Mor et al., 2014)), plethysmography was performed, and recorded vocal fold motion in an animal whose right vocal fold was paralyzed by RLN damage (
The lethality of obstructive apnea periods is contrasted with the minimal impact of central apnea periods in the same animals. That these transient periods of central apnea are separate from the central apnea that characterizes respiratory arrest. Periods of central apnea were defined by an abrupt cessation of breathing for periods ≥1 second as evidenced in plethysmography records. These were recorded during seizure activity in animals of all groups with no differences in the frequency or duration of central apneic periods between groups. No central apneic periods were ever seen in baseline, pre-seizure/post-intubation, or pre-seizure/post-SLN transection conditions. Three of 6 KA-only animals showed central apneic periods, compared with 3/5 SLN-lesioned animals, and 5/5 intubated animals. Central apneic periods as long as 33 seconds were recorded. The mean durations and counts of central apneic periods ≥1 s, and the subset of periods whose durations were ≥5 s are detailed in Table 3.
Two findings highlight the contrast between obstructive and central apnea. First, on laryngoscopy during central apneic periods, the vocal folds were abducted and immobile and held the glottis in a completely open configuration for the entirety of the apneic period (
A series of experiments were conducted in which a controlled complete occlusion of the airway was used to study response kinetics without the uncertainty of when complete obstruction would occur during seizure activity. A T-shaped tracheal tube was implanted after dissecting the RLN free bilaterally. This enabled securing the tracheal tube in place without disturbing normal laryngeal function. A pressure transducer on the tracheal tube sidearm recorded forces developed during either normal breathing with the tracheal tube open to the atmosphere or during complete closure of the open port with an airtight cap. Complete obstruction of the airway was performed for 100 seconds or until 20 s after respiratory arrest occurred, whichever was earlier. In addition to tracheal sidearm pressures, ECG and pulse oximetry were recorded continuously. In subsets of animals, echocardiography and/or continuous arterial blood pressure monitoring were performed.
During occlusion, respiratory effort to inspire progressively increased, then ceased, usually in less than 1 minute (60.4±24.0 s; median=54.4 s; n=16). Respiratory arrest was associated with cardiac dilatation and asystole, an increase of systemic blood pressure (which collapsed without resuscitation), and laryngospasm sufficient for complete glottic closure. This is a type of central apnea that differs from the central apneic episodes reported earlier that were associated with an actively open airway. The LV diastolic cavity size became dilated by about 40% (0.47±0.07 at baseline to 0.64±0.22 cm 10 sec after respiratory arrest) and the end systolic LV cavity size became dilated by nearly 300% (0.12±0.03 at baseline and 0.44±0.23 cm 10 seconds after respiratory arrest). The LV ejection fraction fell from 94±2 to 49±23 percent.
An example experiment is illustrated in
This demonstrates that biomarker 1 has utility in any condition where EMG associated with inspiratory effort can be increased.
In
Multiple Comparisons:
Tracheal tubes were placed in four rats, and strong seizure activity induced with kainic acid. In three rats, systemic variables to describe the sequence of events leading to death were monitored. During the period continuous seizure activity (status epilepticus), shallow, irregular breathing was mixed with gasping breaths that occurred at a rate of 1/s, but dropped abruptly to 1/15 s before apparently stopping completely. Although the airway was completely open, oxygen saturations of 54 or 77% (no data for 3rd rat) preceded the transition to very slow or arrested breathing. The rate of change of oxygen saturation over time was well fitted with a straight line (slope=−0.07±0.05 pulse oximetry percentage points per second, R2 v=0.93±0.04). From these values, an average 10% drop in oxygen saturation took 135 seconds (2.25 minutes)—compared with times of <10 seconds after onset of laryngospasm-induced obstructive apnea or controlled occlusion. Whereas these animals demonstrated that, during periods of sustained seizure activity, very low oxygen saturations and death could occur with an intact airway, the times for desaturation were so long that this mechanism is unlikely to be the principal mechanism for desaturation during discrete seizures. Rather, this mechanism is likely a distinct feature of status epilepticus.
Unlike laryngospasm-mediated obstruction where the vocal folds were continuously adducted, during the period of obstruction, each attempted inspiration was associated with an opening and closing of the airway by vocal fold movements such that the degree of opening increased as the inspiratory effort increased. Each glottic opening was followed by a complete closure of the airway due to fully apposed arytenoid cartilages and vocal folds. The maximal opening angle during the last breath attempt was 56.7±5.3° compared to baseline values of 27.6±4.6° (p<0.00001). After the last breath attempt, the airway stayed in this closed position for an additional 20-60 seconds before normal breathing and vocal fold motion resumed after resuscitation or a small glottic opening became evident when the vocal folds appeared to relax in animals that were not resuscitated.
From the point of the last apparent breath, a minimum in heart rate was reached in 30, 70, or 140 seconds. In two animals, laryngospasm was recorded only after the appearance of bradycardia because the larynx was not being continuously monitored. For the third rat, first evidence of laryngospasm was captured on video. This showed that breathing appeared to stop 18 seconds before laryngospasm and cessation of seizure activity as evidenced by flattening of the EEG. Whereas hypoxia-induced laryngospasm such as that described in the controlled occlusion experiments might account for the laryngospasm observed in the first two rats, laryngospasm in the third rat was uncoupled from the respiratory pattern and apparently still driven by seizure activity.
The key findings of these studies are that: 1) seizure activity causes large increases in RLN activity; 2) seizure activity changes breathing frequency, amplitude, variability, and can cause central apnea; 3) seizure activity causes laryngospasm that can result in partial or complete airway occlusion (obstructive apnea); 4) only obstructive apnea was associated with rapid, severe arterial oxygen desaturation, bradycardia, respiratory arrest, and death; 5) hypoxemia itself can cause laryngospasm, significantly prolonging complete airway closure; and 6) sudden death is the result of respiratory arrest during airway obstruction and nearly simultaneous left-ventricle dilatation and asystole. From this set of findings, it is concluded that sudden death in any animal or person experiencing a seizure can be the result of seizure-induced laryngospasm sufficient to cause obstructive apnea, which leads to respiratory arrest and cardiac asystole within tens of seconds, and which can only be reversed by cardiopulmonary resuscitation (i.e. spontaneous recovery is highly unlikely).
Seizures clearly disrupt normal breathing. Respiratory frequency, tidal volume, and cycle variability were all changed by seizure activity. More severe outcomes were marked by periods of no airflow at all, either because the drive to breathe ceased while the glottis was fully open (central apnea) or because the glottis was closed due to laryngospasm (obstructive apnea). The most significant impact on oxygen status and cardiac and respiratory function was from obstructive apnea secondary to seizure-induced laryngospasm. A straightforward interpretation of these observations is a spread of seizure activity along the pathway from subiculum to paraventricular nucleus (PVN) of the hypothalamus (Canteras and Swanson, 1992) and from PVN to medullary regions (e.g. (Geerling et al., 2010)), where it impacts medullary autonomic nuclei, respiratory centers, and laryngeal motor neurons.
What is it about seizure-induced obstructive apnea that resulted in such rapid and severe cardiopulmonary dysfunction? The lack of airflow could not have been the problem since the periods of central apnea did not cause the same deterioration. The remarkable feature of the obstructive apneas was that the airway was completely shut. The forces of vocal fold contractions during seizure-induced laryngospasm were illustrated by the fact that an active vocal fold actually crossed the midline when it was not opposed by a paralyzed vocal fold and the fact that the usual opening of the vocal folds during attempts to gasp did not occur. By contrast, the vocal folds were always in a completely open position during periods of central apnea. It is conceivable that the occurrence of laryngospasm merely reflected a level of seizure activity that caused cardiopulmonary dysfunction by a mechanism independent of obstructive apnea. However, when the airway was manually occluded by closing a tracheal tube in rats that had not been treated with kainate and were not undergoing seizures, the same sequence and time course of events was observed: oxygen desaturation, bradycardia, and ST-segment elevation within seconds, respiratory arrest and serious cardiac mechanical failure within about one minute, and cardiac arrest within several minutes. The combination of these findings indicates that it is the airway occlusion that triggers cardiopulmonary collapse and death.
A major difference between central and obstructive apnea relates to the intense autonomic response that comes during attempts to breathe against a closed airway or during asphyxiation (e.g. (Brostrom et al., 2007; Hotta et al., 2009; Weiss et al., 2015)), but does not occur in the absence of a drive to breathe. Breath holding can last for long times without detriment; the current world record in humans exceeds 11 minutes, or over 22 minutes after hyperventilation with pure oxygen (Association Internationale pour le Développement de l'Apnée; www.aidainternational.org/). It involves a voluntary reduction of the drive to breath, but does not require closing the glottis (Donzelli and Brady, 2004; Mendelsohn and Martin, 1993) and does not significantly activate the autonomic nervous system. Seizure-induced central apneas are generally harmless because they induce only a minimal autonomic and systemic response in the absence of a drive to breathe. Seizure-induced obstructive apneas, in contrast, are deadly because the attempt to breathe against a closed airway triggers a strong autonomic co-activation, on top of an already raised autonomic tone due to the seizures themselves, that ultimately results in cardiopulmonary collapse.
Given the complexity and interdependence of the cardiac, respiratory, and nervous systems, the question arises whether laryngospasm is both necessary and sufficient for sudden death. First, seizure-induced laryngospasm is not reflex-driven by salivation or other pharyngeal stimuli because a subgroup of non-intubated rats had bilateral superior-laryngeal-nerve lesions that would abolish the afferent limb of a reflex to drive laryngospasm. All of the deaths observed during the plethysmography experiments occurred with a sequence of seizure-induced laryngospasm followed by respiratory and then cardiac arrest with exactly the same temporal profile observed during the controlled occlusion of tracheal implants. Therefore, closing the airway by itself crosses a critical threshold and that seizure-induced laryngospasm is sufficient for sudden death.
The MORTEMUS heart rate data show that 9/10 patients experienced the largest drop in heart rate during the period of apparent respiration at the end of the seizure (FIG. 3 of Ryvlin et al., 2013) and before the onset of terminal apnea. The timing of the sharp drop in heart rate in the present rat experiments corresponds to a point late in the period of obstruction, after the seizure would have been terminated (Stewart, 2008), but before the point of respiratory arrest, which are believed to correspond to the onset of terminal apnea in the MORTEMUS study (Ryvlin et al., 2013). It is not only possible, but probable that the SUDEP cases of the MORTEMUS study experienced obstructive apnea as evidenced by the same terminal sequence of events leading to respiratory arrest and death as found for rats.
Laryngospasm may contribute to sudden death even in cases when it is not the initial trigger. In the manual airway occlusion experiments, laryngospasm was observed after respiratory arrest. This complicates the interpretation of clinical case reports since the presence of laryngospasm postictally may indicate either laryngospasm-mediated hypoxia or hypoxia-mediated laryngospasm. More ominously, whether laryngospasm starts the desaturation or occurs after desaturation, it guarantees that death occurs unless cardiopulmonary resuscitation is initiated shortly after respiratory arrest (when there is no effort to breathe and the heart is severely dilated).
A sequence of events is defined that links seizures to sudden death. In particular, seizure-induced laryngospasm resulted in cessation of airflow, followed within tens of seconds by ST-segment elevation, bradycardia, and respiratory arrest. These data were obtained in an established animal model for seizure experiments (urethane-anesthetized rats treated with kainic acid), not in humans, but demonstrate the utility of this rat model for studying laryngospasm and obstructive apnea.
The block diagram of a proposed ECG monitoring system combined a wearable ECG acquisition sensor with a smartphone is shown in
The block diagram of traditional implementation of ECG acquisition device is presented in
Miao et al. propose an architecture using a fully custom, fully integrated, low power AFE, with all the function circuits integrated, as shown in
US 2016/0128209, expressly incorporated herein by reference in its entirety, discloses an exemplary hardware platform that can be used to implement the present technology, as shown in
Referring to FIG. 17 of US 2016/0128209, the electronic device 100 can constitute at least one of: at least one AP (application processor) 910, a communication module 920, a SIM (subscriber identification module) card 924, a memory 930, a sensor module 940, an input device 950, a display 960 (e.g. the display device 13), an interface 970, an audio module 980, a camera module 991, a power management module 995, a battery 996, an indicator 997, and a motor 998. The AP 910 controls a plurality of hardware or software components connected to the AP 910 by driving an operating system or an application program, process various data including multimedia data, and perform calculations. The AP 910 can be embodied as, for example, a System on Chip (SoC). According to an embodiment, the AP 910 further includes a Graphic Processing Unit (GPU). The communication module 920 (e.g. the communication interface 160) can perform data transmission/reception in connection with communication with other electronic devices connected to the electronic device 100 via a network. According to one embodiment, the communication module 920 includes at least one of: a cellular module 921, a Wi-Fi module 923, a BT module 925, a GPS module 927, an NFC module 928, and a Radio Frequency (RF) module 929. The cellular module 921 provides a voice call, a video call, a text message service, or an Internet service through a communication network (for example, LTE, LTE-A, CDMA, WCDMA, UMTS, WiMax, GSM, 3G, 4G, 5G, or the like). Further, the cellular module 921 distinguishes and authenticates electronic devices within a communication network by using a subscriber identification module (for example, the SIM card 924). According to an embodiment, the cellular module 921 performs at least some of functions that the AP 910 provides. For example, the cellular module 921 can perform at least a part of a multimedia control function.
The cellular module 921 may include a Communication Processor (CP). Further, the cellular module 921 can be implemented by, for example, an SoC. Although components such as the cellular module 921 (e.g., the communication processor), the memory 930, or the power management module 995 are illustrated to be separate from the AP 910 in
Each of the Wi-Fi module 923, the BT module 925, the GPS module 927, and the NFC module 928 can include, for example, a processor for processing data transmitted/received through the corresponding module. In
The RF module 929 transmits and receives data, for example, an RF signal. Although not illustrated, the RF module 929 includes, for example, a transceiver, a Power Amplifier Module (PAM), a frequency filter, a Low Noise Amplifier (LNA), or the like. Further, the RF module 929 further includes a component for transmitting/receiving an electromagnetic wave in a free space during a radio communication, such as a conductor or a conducting wire. Although the cellular module 921, the Wi-Fi module 923, the BT module 925, the GPS module 927, and the NFC module 928 are illustrated to share one RF module 929 in
The SIM card 924 is a card including a subscriber identification module, and can be inserted into a slot formed in a particular portion of the electronic device. The SIM card 924 includes unique identification information (for example, Integrated Circuit Card Identifier (ICCID)) or subscriber information (for example, International Mobile Subscriber Identity (IMSI)).
The memory 930 (for example, memory 130) includes an internal memory 932 or an external memory 934. The internal memory 932 includes at least one of a volatile memory (for example, a Dynamic RAM (DRAM), a Static RAM (SRAM), a Synchronous Dynamic RAM (SDRAM), and the like) and a non-volatile memory (for example, a One Time Programmable ROM (OTPROM), a Programmable ROM (PROM), an Erasable and Programmable ROM (EPROM), an Electrically Erasable and Programmable ROM (EEPROM), a mask ROM, a flash ROM, a NAND flash memory, a NOR flash memory, and the like).
According to an embodiment, the internal memory 932 is a Solid State Drive (SSD). The external memory 934 can further include a flash drive, for example, a Compact Flash (CF), a Secure Digital (SD), a Micro Secure Digital (Micro-SD), a Mini Secure Digital (Mini-SD), an extreme Digital (xD), a memory stick or the like. The external memory 934 can be functionally connected to the electronic device 100 through various interfaces. According to an embodiment, the electronic device 100 further includes a storage device (or storage medium) such as a hard drive.
The sensor module 940 measures a physical quantity or detects an operation state of the electronic device 100, and converts the measured or detected information to an electronic signal. The sensor module 940 includes, for example, at least one of a gesture sensor 940A, a gyro sensor 940B, an atmospheric pressure sensor 940C, a magnetic sensor 940D, an acceleration sensor 940E, a grip sensor 940F, a proximity sensor 940G, a color sensor 940H (for example, red, green, and blue (RGB) sensor), a biometric sensor 940I, a temperature/humidity sensor 940J, a luminance sensor 940K, and an Ultra Violet (UV) sensor 940M. Additionally or alternatively, the sensor module 940 includes, for example, an E-nose sensor (not illustrated), an ElectroMyoGraphy (EMG) sensor (not illustrated), an ElectroEncephaloGram (EEG) sensor (not illustrated), an ElectroCardioGram (ECG) sensor (not illustrated), an InfraRed (IR) sensor, an iris sensor (not illustrated), a fingerprint sensor (not illustrated) and the like. The sensor module 940 further includes a control circuit for controlling one or more sensors included therein.
The input device 950 includes a touch panel 952, a (digital) pen sensor 954, a key 956, or an ultrasonic input device 958. The touch panel 952 recognizes a touch input through at least one of, for example, a capacitive scheme, a resistive scheme, an infrared scheme, and an ultrasonic scheme. The touch panel 952 further includes a control circuit. The capacitive scheme touch panel recognizes physical contact or proximity. The touch panel 952 further includes a tactile layer. In this case, the touch panel 952 provides a tactile reaction to a user.
The (digital) pen sensor 954 can be embodied, for example, using a method identical or similar to a method of receiving a touch input of a user, or using a separate recognition sheet. The key 956 includes, for example, a physical button, an optical key or a keypad. The ultrasonic input device 958 has an input tool, which generates ultrasonic signals, so that the electronic device 100 senses sound waves using the microphone 988 and identifies data, and is capable of wireless recognition. According to an embodiment, the electronic device 100 receives a user input from an external device (for example, computer or server) connected thereto by using the communication module 920.
The display 960 (e.g. the display device 13) includes a panel 962, a hologram device 964, or a projector 966. The panel 962 can be, for example, a Liquid Crystal Display (LCD), Active-Matrix Organic Light Emitting Diode (AM-OLED), or the like. The panel 962 can be embodied to be, for example, flexible, transparent, or wearable. The panel 962 can be also configured as one module together with the touch panel 952. The hologram 964 can show a stereoscopic image in the air by using interference of light. The projector 966 can project light onto a screen to display an image. For example, the screen can be located inside or outside the electronic device 100. According to one embodiment, the display 960 can further include a control circuit for controlling the panel 962, the hologram device 964, or the projector 966.
The interface 970 includes, for example, a High-Definition Multimedia Interface (HDMI) 972, a Universal Serial Bus (USB) 974, an optical interface 976, or a D-subminiature (D-sub) 978. Additionally or alternatively, the interface 970 includes, for example, a Mobile High-definition Link (MHL) interface, a Secure Digital (SD) card/Multi-Media Card (MMC) interface, or an Infrared Data Association (IrDA) standard interface.
The audio module 980 bi-directionally converts a sound and an electronic signal. At least some of the components of the audio module 980 can be included in the input/output interface. The audio module 980 processes voice information input or output through, for example, a speaker 982, a receiver 984, earphones 986, the microphone 988 or the like.
The camera module 991 is a device which can photograph an image and a dynamic image. According to an embodiment, the camera module 291 includes one or more image sensors (for example, a front sensor or a back sensor), a lens (not shown), an Image Signal Processor (ISP) (not shown) or a flash (not shown) (for example, LED or xenon lamp).
The power management module 995 manages power of the electronic device 100. Although not illustrated, the power management module 995 includes, for example, a Power Management Integrated Circuit (PMIC), a charger Integrated Circuit (IC), or a battery or fuel gauge. The PMIC can be mounted to, for example, an integrated circuit or an SoC semiconductor. Charging methods can be classified into a wired charging method and a wireless charging method. The charger IC charges a battery and prevents over voltage or over current from being flowed from a charger. According to an embodiment, the charger IC includes a charger IC for at least one of the wired charging method and the wireless charging method. A magnetic resonance scheme, a magnetic induction scheme, or an electromagnetic scheme can be exemplified as the wireless charging method, and an additional circuit for wireless charging, such as a coil loop circuit, a resonance circuit, a rectifier circuit, and the like can be added. The battery fuel gauge measures, for example, a remaining quantity of the battery 996, or a voltage, a current, or a temperature during the charging. The battery 996 stores or generates electricity, and supplies power to the electronic device 100 using the stored or generated electricity. The battery 996 can include, for example, a rechargeable battery or a solar battery.
The indicator 997 indicates particular states (e.g., a booting state, a message state, a charging state, etc.) of the electronic device 100 or a part (e.g., the AP 910) of the electronic device 900. The motor 998 converts an electrical signal to a mechanical vibration. Although not illustrated, the electronic device 100 includes a processing unit (for example, GPU) for mobile TV support. The processing unit for supporting the mobile TV processes media data according to a standard of Digital Multimedia Broadcasting (DMB), Digital Video Broadcasting (DVB), media flow or the like.
The above described components of the electronic device according to various embodiments of the present disclosure can be formed of one or more components, and a name of a corresponding component element may be changed based on the type of electronic device. The electronic device according to the present disclosure may include one or more of the aforementioned components or may further include other additional components, or some of the aforementioned components may be omitted. Further, some of the components of the electronic device according to the various embodiments of the present disclosure may be combined to form a single entity, and thus, may equivalently execute functions of the corresponding elements prior to the combination.
The “module” used in various embodiments of the present disclosure may refer to, for example, a “unit” including one of hardware, software, and firmware, or a combination of two or more of the hardware, software, and firmware. The “module” may be interchangeable with a term, such as a unit, a set of logic, e.g., embodied in a non-transitory computer readable medium, a logical block, a component, or a circuit. The “module” may be a minimum unit of an integrated component element or a part thereof. The “module” may be a minimum unit for performing one or more functions or a part thereof. The “module” may be mechanically or electronically implemented. For example, the “module” according to various embodiments of the present disclosure may include at least one of an Application-Specific Integrated Circuit (ASIC) chip, a Field-Programmable Gate Arrays (FPGAs), and a programmable-logic device for performing operations which have been known or are to be developed hereafter.
FIG. 18 of US 2016/0128209 is a diagram illustrating a network environment including an electronic device 100 which includes a bus 110, a processor 120, a memory 130, an input/output interface 140, a display 150, a communication interface 160, and an application operation module 170. The bus 110 is a circuit that connects the above-described components with each other and to transfer communication (for example, control messages) between the above-described components. For example, the processor 120 can receive instructions from the aforementioned other elements (e.g., the memory 130, the input/output interface 140, the display 150, the communication interface 160, and the application operation module 170) through the bus 110, decipher the received instructions, and perform calculation or data processing according to the deciphered instructions.
The memory 130 stores instructions or data received from the processor 120 or other elements (e.g., the input/output interface 140, the display 150, the communication interface 160, the application operation module 170, or the like) or generated by the processor 120 or other elements. The memory 130 includes programming modules, such as a kernel 130a, middleware 130b, API (application programming interface) 130c, or an application 130d. Each of the programming modules described above can be formed of software, firmware, and hardware, or a combination thereof.
The kernel 130a controls or manage system resources (for example, the bus 110, the processor 120, the memory 130 or the like) which are used for performing operations or functions implemented by other programming modules, for example, the middleware 130b, the API 130c or the application 130d. Further, the kernel 130a provides an interface through which the middleware 130b, the API 130c, or the application 130d can access and control or manage individual components of the electronic device 100.
The middleware 130b serves as an intermediator that allows the API 130c or the application 130d to communicate with and exchange data with the kernel 130a. Further, in relation to requests for an operation received from the application 130d, the middleware 130b controls (for example, scheduling or load-balancing) the requests for the operation by using, for example, a method of determining sequence for using system resources (for example, the bus 110, the processor 120, the memory 130, or the like) of the electronic device 100 with respect to at least one application among the applications 130d.
The API 130c is an interface by which the application 130d controls functions provided from the kernel 130a or the middleware 130b, and includes, for example, at least one interface or function (for example, instructions) for file control, window control, image processing, or text control.
According to various embodiments, the application 130d includes a Short Message Service (SMS)/Multimedia Message Service (MMS) application, an e-mail application, a calendar application, an alarm application, a health care application (for example, an application for measuring the amount of exercise or blood sugar), an environmental information application (for example, an application for providing atmospheric pressure, humidity, or temperature), or the like. Additionally or alternatively, the application 130d can be an application related to information exchange between the electronic device 100 and an external electronic device 104. The application related to the information exchange can include, for example, a notification relay application for transmitting specific information to the external electronic device, or a device management application for managing the external electronic device.
For example, the notification relay application can include a function of transferring notification information generated in other applications (for example, the SMS/MMS application, the e-mail application, the health care application, or the environmental information application) of the electronic device 100 to the external electronic device 104. Additionally or alternatively, the notification relay application can receive the notification information from, for example, the external electronic device 104, and can provide the received notification information to a user. The device management application manages (for example, install, delete, or update), for example, at least some functions (for example, turning external electronic device (or some elements) on or off, or adjusting the brightness (or resolution) of a display) of the external electronic device 104 that communicates with the electronic device 100, applications performed in the external electronic device, or services (for example, a phone call service, or a messaging service) provided by the external electronic device.
According to various embodiments, the application 130d includes applications, which are designated according to the attribute (e.g., device type) of the external electronic device 104. For example, in a case where the external electronic device is an MP3 player, the application 130d includes an application related to the reproduction of music. Similarly, when the external electronic device is a mobile medical device, the application 130d includes an application related to health care. According to an embodiment, the application 130d includes at least one of an application designated for the electronic device 100 or an application received from a different electronic device (for example, a server 106, or an external electronic device 104).
The input/output interface 140 transmits a command or data input from the user through an input/output device (for example, sensor, keyboard, or touch screen) to the processor 120, the memory 130, the communication interface 160, or the application operation module 170 through, for example, the bus 110. For example, the input/output interface 140 provides, to the processor 120, data for a user's touch which is input through the touch screen. Further, through the input/output device (for example, a speaker or a display), the input/output interface 140 outputs commands or data received from the processor 120, the memory 130, the communication interface 160, or the application operation module 170 through the bus 110. For example, the input/output interface 140 outputs voice data processed by the processor 120 to the user through the speaker.
The display 150 displays various pieces of information (for example, multimedia data or text data) for the user.
The communication interface 160 makes a communication connection between the electronic device 100 and a different electronic device (for example, the external electronic device 104 or the server 106). For example, the communication interface 160 connects to a network 162 through wireless or wired communication to communicate with the external electronic device. The wireless communication includes, for example, at least one of Wi-Fi, Wi-Fi Direct, Bluetooth (BT), Near Field Communication (NFC), a Global Positioning System (GPS), or cellular communication (for example, LTE, LTE-A, CDMA, WCDMA, UMTS, WiMax, GSM, 3G, 4G, 5G, etc.). The wired communication includes at least one of, for example, a Universal Serial Bus (USB, USB 2.0, USB 3.0, USB 3.1, etc.), a High Definition Multimedia Interface (HDMI), Ethernet (802.3, etc.), Recommended Standard 232 (RS-232), and a Plain Old Telephone Service (POTS) port/interface.
According to an embodiment, the network 162 can be a telecommunications network. The communication network can include at least one of a computer network, the Internet, the Internet of things, and a telephone network. According to an embodiment, protocols (for example, a transport layer protocol, a data link layer protocol, or a physical layer protocol) for communication between the electronic device 100 and external electronic devices can be supported by at least one of the application 130d, the API 130c, the middleware 130b, the kernel 130a, and the communication interface 160.
According to an embodiment, the application operation module 170 supports driving of the electronic device 100 by performing at least one of the operations (or functions) implemented by the electronic device 100. For example, the server 106 can include a communication control server module 108 capable of supporting the application operation module 170 implemented in the electronic device 100. For example, the communication control server module 108 can include at least one component of the application operation module 170, and can perform (e.g., perform as a proxy) at least one of the operations performed by the application operation module 170.
The application operation module 170 processes at least some of the information obtained from other components (for example, the processor 120, the memory 130, the input/output interface 140, or the communication interface 160) and utilize the same in various manners. For example, the application operation module 170 controls at least some functions of the electronic device 100 by using the processor 120 or independently thereof so that the electronic device 100 can interwork with a different electronic device (e.g., the external electronic device 104 or the server 106). The connection control module 170 can be integrated into the processor 120. According to an embodiment, at least one component of the application operation module 170 can be included in the server 106 (for example, the communication control server module 108) and can have at least one operation, which is performed by the application operation module 170, supported by the server 106.
Although the present disclosure has been described with an exemplary embodiment, various changes and modifications may be suggested to one skilled in the art. It is intended that the present disclosure encompass such changes and modifications as fall within the scope of the appended claims.
What is claimed is:
Each reference cited herein (including those aforementioned) is expressly incorporated herein by reference in its entirety.
| Filing Document | Filing Date | Country | Kind |
|---|---|---|---|
| PCT/US2017/061099 | 11/10/2017 | WO |
| Publishing Document | Publishing Date | Country | Kind |
|---|---|---|---|
| WO2018/089789 | 5/17/2018 | WO | A |
| Number | Name | Date | Kind |
|---|---|---|---|
| 3942513 | Frank | Mar 1976 | A |
| 3950799 | Frank | Apr 1976 | A |
| 4033332 | Hardway, Jr. et al. | Jul 1977 | A |
| 4169462 | Strube | Oct 1979 | A |
| 4197856 | Northrop | Apr 1980 | A |
| 4289142 | Kearns | Sep 1981 | A |
| 4308872 | Watson et al. | Jan 1982 | A |
| 4350166 | Mobarry | Sep 1982 | A |
| 4381788 | Douglas | May 1983 | A |
| 4387722 | Kearns | Jun 1983 | A |
| 4391279 | Stein | Jul 1983 | A |
| 4403215 | Hofmann et al. | Sep 1983 | A |
| 4422458 | Kravath | Dec 1983 | A |
| 4446869 | Knodle | May 1984 | A |
| 4474185 | Diamond | Oct 1984 | A |
| 4475559 | Horn | Oct 1984 | A |
| 4506626 | Schurman et al. | Mar 1985 | A |
| 4506666 | Durkan | Mar 1985 | A |
| 4558708 | Labuda et al. | Dec 1985 | A |
| RE32180 | Lewiner et al. | Jun 1986 | E |
| 4595016 | Fertig et al. | Jun 1986 | A |
| D284697 | Brefka | Jul 1986 | S |
| 4617525 | Lloyd | Oct 1986 | A |
| 4630614 | Atlas | Dec 1986 | A |
| 4648407 | Sackner | Mar 1987 | A |
| 4657026 | Tagg | Apr 1987 | A |
| 4686975 | Naimon et al. | Aug 1987 | A |
| 4686999 | Snyder et al. | Aug 1987 | A |
| 4694839 | Timme | Sep 1987 | A |
| 4715367 | Crossley | Dec 1987 | A |
| 4724844 | Rafelson | Feb 1988 | A |
| 4732159 | Kraman | Mar 1988 | A |
| 4736749 | Lundback | Apr 1988 | A |
| 4745925 | Dietz | May 1988 | A |
| 4757824 | Chaumet | Jul 1988 | A |
| 4757825 | Diamond | Jul 1988 | A |
| 4765340 | Sakai et al. | Aug 1988 | A |
| 4777962 | Watson et al. | Oct 1988 | A |
| 4802485 | Bowers et al. | Feb 1989 | A |
| 4802486 | Goodman et al. | Feb 1989 | A |
| 4803997 | Bowman | Feb 1989 | A |
| 4806112 | Roberts et al. | Feb 1989 | A |
| 4807616 | Adahan | Feb 1989 | A |
| 4815473 | Watson et al. | Mar 1989 | A |
| 4838279 | Fore | Jun 1989 | A |
| 4860766 | Sackner | Aug 1989 | A |
| 4889116 | Taube | Dec 1989 | A |
| 4895162 | Dolliver | Jan 1990 | A |
| 4924860 | Larsen et al. | May 1990 | A |
| 4928692 | Goodman et al. | May 1990 | A |
| 4928703 | Wong | May 1990 | A |
| 4941469 | Adahan | Jul 1990 | A |
| 4958638 | Sharpe et al. | Sep 1990 | A |
| 4961423 | Canducci | Oct 1990 | A |
| 4982738 | Griebel | Jan 1991 | A |
| 5005234 | Kelleher et al. | Apr 1991 | A |
| 5005571 | Dietz | Apr 1991 | A |
| 5016636 | Kulakowski | May 1991 | A |
| 5036852 | Leishman | Aug 1991 | A |
| 5052400 | Dietz | Oct 1991 | A |
| 5095900 | Fertig et al. | Mar 1992 | A |
| 5099836 | Rowland et al. | Mar 1992 | A |
| 5105354 | Nishimura | Apr 1992 | A |
| 5107855 | Harrington et al. | Apr 1992 | A |
| 5131387 | French et al. | Jul 1992 | A |
| 5131399 | Sciarra | Jul 1992 | A |
| 5133346 | Kulkarni | Jul 1992 | A |
| 5134995 | Gruenke et al. | Aug 1992 | A |
| 5146918 | Kallok et al. | Sep 1992 | A |
| 5174287 | Kallok et al. | Dec 1992 | A |
| 5191893 | Reiten | Mar 1993 | A |
| 5199424 | Sullivan et al. | Apr 1993 | A |
| 5206807 | Hatke et al. | Apr 1993 | A |
| 5211173 | Kallok et al. | May 1993 | A |
| 5215082 | Kallok et al. | Jun 1993 | A |
| 5233983 | Markowitz | Aug 1993 | A |
| 5245995 | Sullivan et al. | Sep 1993 | A |
| 5259373 | Gruenke et al. | Nov 1993 | A |
| 5271412 | Shtalryd et al. | Dec 1993 | A |
| 5275159 | Griebel | Jan 1994 | A |
| 5277194 | Hosterman et al. | Jan 1994 | A |
| 5278190 | Askanazi et al. | Jan 1994 | A |
| 5294642 | Askanazi et al. | Mar 1994 | A |
| 5295490 | Dodakian | Mar 1994 | A |
| 5300094 | Kallok et al. | Apr 1994 | A |
| 5307817 | Guggenbuhl et al. | May 1994 | A |
| 5309921 | Kisner et al. | May 1994 | A |
| 5311875 | Stasz | May 1994 | A |
| 5348008 | Bornn et al. | Sep 1994 | A |
| 5353793 | Bornn | Oct 1994 | A |
| 5360008 | Campbell, Jr. | Nov 1994 | A |
| 5373859 | Forney | Dec 1994 | A |
| 5385144 | Yamanishi et al. | Jan 1995 | A |
| 5395301 | Russek | Mar 1995 | A |
| 5398682 | Lynn | Mar 1995 | A |
| 5458137 | Axe et al. | Oct 1995 | A |
| 5483969 | Testerman et al. | Jan 1996 | A |
| 5485850 | Dietz | Jan 1996 | A |
| 5485851 | Erickson | Jan 1996 | A |
| 5492113 | Estes et al. | Feb 1996 | A |
| 5495242 | Kick et al. | Feb 1996 | A |
| 5513631 | McWilliams | May 1996 | A |
| 5513646 | Lehrman et al. | May 1996 | A |
| 5522382 | Sullivan et al. | Jun 1996 | A |
| 5522862 | Testerman et al. | Jun 1996 | A |
| 5535738 | Estes et al. | Jul 1996 | A |
| 5537997 | Mechlenburg et al. | Jul 1996 | A |
| 5540219 | Mechlenburg et al. | Jul 1996 | A |
| 5540731 | Testerman | Jul 1996 | A |
| 5540732 | Testerman | Jul 1996 | A |
| 5540733 | Testerman et al. | Jul 1996 | A |
| 5546952 | Erickson | Aug 1996 | A |
| 5549106 | Gruenke et al. | Aug 1996 | A |
| 5549655 | Erickson | Aug 1996 | A |
| 5551418 | Estes et al. | Sep 1996 | A |
| 5555891 | Eisenfeld | Sep 1996 | A |
| 5564429 | Bornn et al. | Oct 1996 | A |
| 5591216 | Testerman et al. | Jan 1997 | A |
| 5603316 | Coufal et al. | Feb 1997 | A |
| 5605151 | Lynn | Feb 1997 | A |
| 5611349 | Halleck et al. | Mar 1997 | A |
| 5632269 | Zdrojkowski | May 1997 | A |
| 5645053 | Remmers et al. | Jul 1997 | A |
| 5655522 | Mechlenburg et al. | Aug 1997 | A |
| 5671733 | Raviv et al. | Sep 1997 | A |
| 5704345 | Berthon-Jones | Jan 1998 | A |
| 5765554 | Somerson et al. | Jun 1998 | A |
| 5769084 | Katz et al. | Jun 1998 | A |
| 5779631 | Chance | Jul 1998 | A |
| 5782240 | Raviv et al. | Jul 1998 | A |
| 5792068 | Bowman et al. | Aug 1998 | A |
| 5794614 | Gruenke et al. | Aug 1998 | A |
| 5794615 | Estes | Aug 1998 | A |
| 5800360 | Kisner et al. | Sep 1998 | A |
| 5800470 | Stein et al. | Sep 1998 | A |
| 5803065 | Zdrojkowski et al. | Sep 1998 | A |
| 5803066 | Rapoport et al. | Sep 1998 | A |
| 5823187 | Estes et al. | Oct 1998 | A |
| 5825293 | Ahmed et al. | Oct 1998 | A |
| 5845636 | Gruenke et al. | Dec 1998 | A |
| 5853005 | Scanlon | Dec 1998 | A |
| 5862803 | Besson et al. | Jan 1999 | A |
| 5873821 | Chance et al. | Feb 1999 | A |
| 5879313 | Raviv et al. | Mar 1999 | A |
| 5891023 | Lynn | Apr 1999 | A |
| 5895360 | Christopherson et al. | Apr 1999 | A |
| 5901704 | Estes et al. | May 1999 | A |
| 5902250 | Verrier | May 1999 | A |
| 5904141 | Estes et al. | May 1999 | A |
| 5913826 | Blank | Jun 1999 | A |
| 5921942 | Remmers et al. | Jul 1999 | A |
| 5928157 | O'Dwyer | Jul 1999 | A |
| 5944680 | Christopherson et al. | Aug 1999 | A |
| 5947115 | Lordo et al. | Sep 1999 | A |
| 5953713 | Behbehani et al. | Sep 1999 | A |
| 5954050 | Christopher | Sep 1999 | A |
| 5954053 | Chance et al. | Sep 1999 | A |
| 5957854 | Besson et al. | Sep 1999 | A |
| 5961447 | Raviv et al. | Oct 1999 | A |
| 5964720 | Pelz | Oct 1999 | A |
| 5970975 | Estes et al. | Oct 1999 | A |
| 5989193 | Sullivan | Nov 1999 | A |
| 6015388 | Sackner et al. | Jan 2000 | A |
| 6017315 | Starr et al. | Jan 2000 | A |
| 6019732 | Volgyesi | Feb 2000 | A |
| 6021352 | Christopherson et al. | Feb 2000 | A |
| 6029664 | Zdrojkowski et al. | Feb 2000 | A |
| 6029665 | Berthon-Jones | Feb 2000 | A |
| 6032072 | Greenwald | Feb 2000 | A |
| 6045514 | Raviv et al. | Apr 2000 | A |
| 6062216 | Corn | May 2000 | A |
| 6064910 | Andersson et al. | May 2000 | A |
| 6085747 | Axe et al. | Jul 2000 | A |
| 6099479 | Christopherson et al. | Aug 2000 | A |
| 6105575 | Estes et al. | Aug 2000 | A |
| 6120441 | Griebel | Sep 2000 | A |
| 6126611 | Bourgeois et al. | Oct 2000 | A |
| 6132384 | Christopherson et al. | Oct 2000 | A |
| 6134460 | Chance | Oct 2000 | A |
| 6138675 | Berthon-Jones | Oct 2000 | A |
| 6142950 | Allen et al. | Nov 2000 | A |
| 6142952 | Behbehani et al. | Nov 2000 | A |
| 6150104 | Splawski et al. | Nov 2000 | A |
| 6150941 | Geiger et al. | Nov 2000 | A |
| 6159158 | Lowe | Dec 2000 | A |
| 6165133 | Rapoport et al. | Dec 2000 | A |
| 6168568 | Gavriely | Jan 2001 | B1 |
| 6190328 | Ruton et al. | Feb 2001 | B1 |
| 6208897 | Jorgenson et al. | Mar 2001 | B1 |
| 6223064 | Lynn et al. | Apr 2001 | B1 |
| 6241683 | Macklem et al. | Jun 2001 | B1 |
| 6248068 | Seabron | Jun 2001 | B1 |
| 6251126 | Ottenhoff et al. | Jun 2001 | B1 |
| 6261238 | Gavriely | Jul 2001 | B1 |
| 6267730 | Pacunas | Jul 2001 | B1 |
| 6269269 | Ottenhoff et al. | Jul 2001 | B1 |
| 6273859 | Remmers et al. | Aug 2001 | B1 |
| 6286508 | Remmers et al. | Sep 2001 | B1 |
| 6289238 | Besson et al. | Sep 2001 | B1 |
| 6290654 | Karakasoglu | Sep 2001 | B1 |
| 6305374 | Zdrojkowski et al. | Oct 2001 | B1 |
| 6306088 | Krausman et al. | Oct 2001 | B1 |
| 6331536 | Radulovacki et al. | Dec 2001 | B1 |
| 6342039 | Lynn et al. | Jan 2002 | B1 |
| 6342040 | Starr et al. | Jan 2002 | B1 |
| 6359449 | Reining et al. | Mar 2002 | B1 |
| 6363933 | Berthon-Jones | Apr 2002 | B1 |
| 6368287 | Hadas | Apr 2002 | B1 |
| 6375621 | Sullivan | Apr 2002 | B1 |
| 6390987 | Graham | May 2002 | B1 |
| 6397845 | Burton | Jun 2002 | B1 |
| 6398739 | Sullivan et al. | Jun 2002 | B1 |
| 6409676 | Ruton et al. | Jun 2002 | B2 |
| 6411843 | Zarychta | Jun 2002 | B1 |
| 6450168 | Nguyen | Sep 2002 | B1 |
| 6450957 | Yoshimi et al. | Sep 2002 | B1 |
| 6454724 | Greene | Sep 2002 | B1 |
| 6470888 | Matter | Oct 2002 | B1 |
| 6477710 | Ojoyeyi | Nov 2002 | B1 |
| 6491647 | Bridger et al. | Dec 2002 | B1 |
| 6498652 | Varshneya et al. | Dec 2002 | B1 |
| 6510339 | Kovtun et al. | Jan 2003 | B2 |
| 6517497 | Rymut et al. | Feb 2003 | B2 |
| 6529752 | Krausman et al. | Mar 2003 | B2 |
| 6537228 | Lambert | Mar 2003 | B1 |
| 6539940 | Zdrojkowski et al. | Apr 2003 | B2 |
| 6544192 | Starr et al. | Apr 2003 | B2 |
| 6547743 | Brydon | Apr 2003 | B2 |
| 6549795 | Chance | Apr 2003 | B1 |
| 6550478 | Remmers et al. | Apr 2003 | B2 |
| 6551252 | Sackner et al. | Apr 2003 | B2 |
| 6553242 | Sarussi | Apr 2003 | B1 |
| 6553256 | Jorgenson et al. | Apr 2003 | B1 |
| 6555564 | Radulovacki et al. | Apr 2003 | B1 |
| 6572543 | Christopherson et al. | Jun 2003 | B1 |
| 6574507 | Bonnet | Jun 2003 | B1 |
| 6577893 | Besson et al. | Jun 2003 | B1 |
| 6580943 | Nissila | Jun 2003 | B2 |
| 6580944 | Katz et al. | Jun 2003 | B1 |
| 6595215 | Wood | Jul 2003 | B2 |
| 6609517 | Estes et al. | Aug 2003 | B1 |
| 6621278 | Ariav | Sep 2003 | B2 |
| 6629527 | Estes et al. | Oct 2003 | B1 |
| 6635021 | Sullivan et al. | Oct 2003 | B1 |
| 6637434 | Noble | Oct 2003 | B2 |
| 6675797 | Berthon-Jones | Jan 2004 | B1 |
| 6705315 | Sullivan et al. | Mar 2004 | B2 |
| 6721980 | Price et al. | Apr 2004 | B1 |
| 6727242 | Radulovacki et al. | Apr 2004 | B2 |
| 6739335 | Rapport et al. | May 2004 | B1 |
| 6748252 | Lynn et al. | Jun 2004 | B2 |
| 6760608 | Lynn | Jul 2004 | B2 |
| 6770037 | Sullivan et al. | Aug 2004 | B2 |
| 6773404 | Poezevera et al. | Aug 2004 | B2 |
| 6776162 | Wood | Aug 2004 | B2 |
| 6785568 | Chance | Aug 2004 | B2 |
| 6807967 | Wood | Oct 2004 | B2 |
| 6811538 | Westbrook et al. | Nov 2004 | B2 |
| 6814073 | Wickham | Nov 2004 | B2 |
| 6816266 | Varshneya et al. | Nov 2004 | B2 |
| 6832609 | Wright et al. | Dec 2004 | B2 |
| 6840907 | Brydon | Jan 2005 | B1 |
| 6848446 | Noble | Feb 2005 | B2 |
| 6849049 | Starr et al. | Feb 2005 | B2 |
| 6856141 | Ariav | Feb 2005 | B2 |
| 6881192 | Park | Apr 2005 | B1 |
| 6889691 | Eklund et al. | May 2005 | B2 |
| 6890306 | Poezevera | May 2005 | B2 |
| 6904320 | Park et al. | Jun 2005 | B2 |
| 6915705 | Truitt et al. | Jul 2005 | B1 |
| 6918878 | Brodnick | Jul 2005 | B2 |
| 6920877 | Remmers et al. | Jul 2005 | B2 |
| 6928324 | Park et al. | Aug 2005 | B2 |
| 6932084 | Estes et al. | Aug 2005 | B2 |
| 6935335 | Lehrman et al. | Aug 2005 | B1 |
| 6948497 | Zdrojkowski et al. | Sep 2005 | B2 |
| 6964641 | Cho et al. | Nov 2005 | B2 |
| 6970737 | Brodnick et al. | Nov 2005 | B1 |
| 6974814 | Radulovacki et al. | Dec 2005 | B2 |
| 6984993 | Ariav | Jan 2006 | B2 |
| 6988994 | Rapoport et al. | Jan 2006 | B2 |
| 6989744 | Proebsting | Jan 2006 | B2 |
| 6997177 | Wood | Feb 2006 | B2 |
| 6999817 | Park et al. | Feb 2006 | B2 |
| 7004908 | Sullivan et al. | Feb 2006 | B2 |
| 7013892 | Estes et al. | Mar 2006 | B2 |
| 7013893 | Wickham et al. | Mar 2006 | B2 |
| 7018341 | Wright et al. | Mar 2006 | B2 |
| 7020511 | Boyd et al. | Mar 2006 | B2 |
| 7025730 | Cho et al. | Apr 2006 | B2 |
| 7035432 | Szuba | Apr 2006 | B2 |
| 7039152 | Bruder et al. | May 2006 | B2 |
| 7047969 | Noble | May 2006 | B2 |
| 7059328 | Wood | Jun 2006 | B2 |
| 7074177 | Pickett et al. | Jul 2006 | B2 |
| 7080554 | Ariav et al. | Jul 2006 | B2 |
| 7081095 | Lynn et al. | Jul 2006 | B2 |
| 7089936 | Madaus et al. | Aug 2006 | B2 |
| 7092755 | Florio | Aug 2006 | B2 |
| 7100607 | Zdrojkowski et al. | Sep 2006 | B2 |
| 7117036 | Florio | Oct 2006 | B2 |
| 7126467 | Albert et al. | Oct 2006 | B2 |
| 7128717 | Thach et al. | Oct 2006 | B1 |
| 7129833 | Albert | Oct 2006 | B2 |
| 7130687 | Cho et al. | Oct 2006 | B2 |
| 7141021 | Sullivan et al. | Nov 2006 | B2 |
| 7148797 | Albert | Dec 2006 | B2 |
| 7153271 | Aylsworth | Dec 2006 | B2 |
| 7159588 | Wickham | Jan 2007 | B2 |
| 7160898 | Radulovacki et al. | Jan 2007 | B2 |
| 7166123 | Hovanes et al. | Jan 2007 | B2 |
| 7168429 | Matthews et al. | Jan 2007 | B2 |
| 7170404 | Albert et al. | Jan 2007 | B2 |
| 7173525 | Albert | Feb 2007 | B2 |
| 7178524 | Noble | Feb 2007 | B2 |
| 7179229 | Koh | Feb 2007 | B1 |
| 7186221 | Rapoport et al. | Mar 2007 | B2 |
| 7188624 | Wood | Mar 2007 | B2 |
| 7190995 | Chervin et al. | Mar 2007 | B2 |
| 7212862 | Park et al. | May 2007 | B2 |
| 7215991 | Besson et al. | May 2007 | B2 |
| 7225013 | Geva et al. | May 2007 | B2 |
| 7225021 | Park et al. | May 2007 | B1 |
| 7269459 | Koh | Sep 2007 | B1 |
| 7296573 | Estes et al. | Nov 2007 | B2 |
| 7297119 | Westbrook et al. | Nov 2007 | B2 |
| 7306564 | Nakatani et al. | Dec 2007 | B2 |
| 7314046 | Schroeder et al. | Jan 2008 | B2 |
| 7314451 | Halperin et al. | Jan 2008 | B2 |
| 7315759 | Markowitz et al. | Jan 2008 | B2 |
| 7315760 | Brodnick et al. | Jan 2008 | B2 |
| 7320320 | Berthon-Jones | Jan 2008 | B2 |
| 7324845 | Mietus et al. | Jan 2008 | B2 |
| 7330127 | Price et al. | Feb 2008 | B2 |
| 7336996 | Hartley et al. | Feb 2008 | B2 |
| 7340302 | Falkenberg et al. | Mar 2008 | B1 |
| 7361146 | Bharmi et al. | Apr 2008 | B1 |
| 7363086 | Koh et al. | Apr 2008 | B1 |
| 7364547 | Stahmann et al. | Apr 2008 | B2 |
| 7371220 | Koh et al. | May 2008 | B1 |
| 7391316 | Albert et al. | Jun 2008 | B2 |
| 7396333 | Stahmann et al. | Jul 2008 | B2 |
| 7398115 | Lynn | Jul 2008 | B2 |
| 7403110 | Albert et al. | Jul 2008 | B2 |
| 7415093 | Tkaczyk et al. | Aug 2008 | B2 |
| 7431700 | Aoki et al. | Oct 2008 | B2 |
| 7435221 | Bharmi et al. | Oct 2008 | B1 |
| 7438686 | Cho et al. | Oct 2008 | B2 |
| 7440795 | Poezevara | Oct 2008 | B2 |
| 7460899 | Almen | Dec 2008 | B2 |
| 7467012 | Park et al. | Dec 2008 | B1 |
| 7468040 | Hartley et al. | Dec 2008 | B2 |
| 7469697 | Lee et al. | Dec 2008 | B2 |
| 7473227 | Hsu et al. | Jan 2009 | B2 |
| 7477142 | Albert et al. | Jan 2009 | B2 |
| 7477143 | Albert | Jan 2009 | B2 |
| 7477144 | Albert | Jan 2009 | B2 |
| 7479114 | Hartley et al. | Jan 2009 | B2 |
| 7508307 | Albert | Mar 2009 | B2 |
| 7509164 | Jensen et al. | Mar 2009 | B2 |
| 7510531 | Lee et al. | Mar 2009 | B2 |
| 7515059 | Price et al. | Apr 2009 | B2 |
| 7519425 | Benser et al. | Apr 2009 | B2 |
| 7520279 | Berthon-Jones | Apr 2009 | B2 |
| 7522035 | Albert | Apr 2009 | B2 |
| 7532934 | Lee et al. | May 2009 | B2 |
| 7533571 | Ariav et al. | May 2009 | B2 |
| 7545279 | Sato et al. | Jun 2009 | B2 |
| 7572225 | Stahmann et al. | Aug 2009 | B2 |
| 7591265 | Lee et al. | Sep 2009 | B2 |
| 7593764 | Kohls et al. | Sep 2009 | B2 |
| 7593767 | Modarres | Sep 2009 | B1 |
| 7596413 | Libbus et al. | Sep 2009 | B2 |
| 7597659 | Pickett et al. | Oct 2009 | B2 |
| 7611472 | Lu | Nov 2009 | B2 |
| 7623912 | Akselrod et al. | Nov 2009 | B2 |
| 7636600 | Koh | Dec 2009 | B1 |
| 7650189 | Park et al. | Jan 2010 | B1 |
| 7656287 | Albert et al. | Feb 2010 | B2 |
| 7661426 | Lauk et al. | Feb 2010 | B2 |
| 7662101 | Lee et al. | Feb 2010 | B2 |
| 7667624 | Stoval | Feb 2010 | B2 |
| 7668579 | Lynn | Feb 2010 | B2 |
| 7668591 | Lee et al. | Feb 2010 | B2 |
| 7670295 | Sackner et al. | Mar 2010 | B2 |
| 7674230 | Reisfeld | Mar 2010 | B2 |
| 7678058 | Patangay et al. | Mar 2010 | B2 |
| 7678061 | Lee et al. | Mar 2010 | B2 |
| 7680537 | Stahmann et al. | Mar 2010 | B2 |
| 7691067 | Westbrook et al. | Apr 2010 | B2 |
| 7697990 | Ujhazy et al. | Apr 2010 | B2 |
| 7705039 | Carley et al. | Apr 2010 | B2 |
| 7706852 | Baker, Jr. | Apr 2010 | B2 |
| 7708697 | Wilkinson et al. | May 2010 | B2 |
| 7711579 | Lancaster et al. | May 2010 | B2 |
| 7715905 | Kurzweil et al. | May 2010 | B2 |
| 7716767 | Bohm et al. | May 2010 | B2 |
| 7720541 | Stahmann et al. | May 2010 | B2 |
| 7725181 | Bornzin et al. | May 2010 | B1 |
| 7730886 | Berthon-Jones | Jun 2010 | B2 |
| 7734334 | Mietus et al. | Jun 2010 | B2 |
| 7734335 | Kontothanassis et al. | Jun 2010 | B2 |
| 7734340 | De Ridder | Jun 2010 | B2 |
| 7734350 | Dubnov et al. | Jun 2010 | B2 |
| 7735491 | Doshi et al. | Jun 2010 | B2 |
| 7735492 | Doshi et al. | Jun 2010 | B2 |
| 7740591 | Starr et al. | Jun 2010 | B1 |
| 7747323 | Libbus et al. | Jun 2010 | B2 |
| 7748493 | Moses et al. | Jul 2010 | B2 |
| 7757690 | Stahmann et al. | Jul 2010 | B2 |
| 7758503 | Lynn et al. | Jul 2010 | B2 |
| 7766840 | Kwok et al. | Aug 2010 | B2 |
| 7766841 | Yamamoto et al. | Aug 2010 | B2 |
| 7770578 | Estes et al. | Aug 2010 | B2 |
| 7787946 | Stahmann et al. | Aug 2010 | B2 |
| 7788343 | Haselhurst et al. | Aug 2010 | B2 |
| 7789837 | Lehrman et al. | Sep 2010 | B2 |
| 7794406 | Reisfeld et al. | Sep 2010 | B2 |
| 7794716 | Adair | Sep 2010 | B2 |
| 7798148 | Doshi et al. | Sep 2010 | B2 |
| 7800505 | Pietersen | Sep 2010 | B2 |
| 7803118 | Reisfeld et al. | Sep 2010 | B2 |
| 7803119 | Reisfeld | Sep 2010 | B2 |
| 7806120 | Loomas et al. | Oct 2010 | B2 |
| 7810496 | Estes et al. | Oct 2010 | B2 |
| 7810497 | Pittman et al. | Oct 2010 | B2 |
| 7811234 | McGrath | Oct 2010 | B2 |
| 7818058 | Mentelos | Oct 2010 | B2 |
| 7819816 | Pu et al. | Oct 2010 | B2 |
| 7827988 | Matthews et al. | Nov 2010 | B2 |
| 7828739 | Arnold | Nov 2010 | B2 |
| 7848792 | Vitali et al. | Dec 2010 | B2 |
| 7856979 | Doshi et al. | Dec 2010 | B2 |
| 7884735 | Newkirk | Feb 2011 | B2 |
| 7887493 | Stahmann et al. | Feb 2011 | B2 |
| 7894849 | Kass et al. | Feb 2011 | B2 |
| 7896812 | Rapoport et al. | Mar 2011 | B2 |
| 7899519 | Carlson et al. | Mar 2011 | B2 |
| 7899521 | Demharter et al. | Mar 2011 | B2 |
| 7900626 | Daly | Mar 2011 | B2 |
| 7909764 | Wenzel et al. | Mar 2011 | B1 |
| 7934500 | Madaus et al. | May 2011 | B2 |
| 7938114 | Matthews et al. | May 2011 | B2 |
| 7938782 | Stahmann et al. | May 2011 | B2 |
| 7942822 | Koh | May 2011 | B1 |
| 7942823 | Wright et al. | May 2011 | B2 |
| 7942824 | Kayyali et al. | May 2011 | B1 |
| 7970470 | Hartley et al. | Jun 2011 | B2 |
| 7976470 | Patangay et al. | Jul 2011 | B2 |
| 7981042 | Stahmann et al. | Jul 2011 | B2 |
| 7988640 | Berthon-Jones et al. | Aug 2011 | B2 |
| 7993279 | Hartley et al. | Aug 2011 | B2 |
| 7994218 | Jandeleit et al. | Aug 2011 | B2 |
| 8002553 | Hatlestad et al. | Aug 2011 | B2 |
| 8011365 | Douglas et al. | Sep 2011 | B2 |
| 8021309 | Zilberg | Sep 2011 | B2 |
| 8031080 | Price et al. | Oct 2011 | B2 |
| 8043225 | Poezevara | Oct 2011 | B2 |
| 8050765 | Lee et al. | Nov 2011 | B2 |
| 8053413 | Carley et al. | Nov 2011 | B2 |
| 8069852 | Burton et al. | Dec 2011 | B2 |
| 8074646 | Daly | Dec 2011 | B2 |
| 8076315 | Carley et al. | Dec 2011 | B2 |
| 8104470 | Lee et al. | Jan 2012 | B2 |
| 8106781 | Pietersen | Jan 2012 | B2 |
| 8119134 | Adair | Feb 2012 | B2 |
| 8121692 | Haefner et al. | Feb 2012 | B2 |
| 8136521 | Matthews et al. | Mar 2012 | B2 |
| 8140164 | Tehrani et al. | Mar 2012 | B2 |
| 8142343 | Pickett et al. | Mar 2012 | B2 |
| 8152732 | Lynn et al. | Apr 2012 | B2 |
| 8155735 | Bashour et al. | Apr 2012 | B2 |
| 8161971 | Jaffe et al. | Apr 2012 | B2 |
| 8167812 | Scholler et al. | May 2012 | B2 |
| 8168617 | Jandeleit et al. | May 2012 | B2 |
| 8187200 | Jensen et al. | May 2012 | B2 |
| 8187201 | Lynn | May 2012 | B2 |
| 8192376 | Lovett et al. | Jun 2012 | B2 |
| 8200336 | Tehrani et al. | Jun 2012 | B2 |
| 8203330 | Ansay et al. | Jun 2012 | B2 |
| 8204580 | Kurzweil et al. | Jun 2012 | B2 |
| 8207230 | Carley et al. | Jun 2012 | B2 |
| 8219185 | Lin et al. | Jul 2012 | B2 |
| 8221327 | Lee et al. | Jul 2012 | B2 |
| 8225789 | Berthon-Jones | Jul 2012 | B2 |
| 8226569 | Sotos et al. | Jul 2012 | B2 |
| 8226570 | Pu et al. | Jul 2012 | B2 |
| 8226571 | Landesberg et al. | Jul 2012 | B2 |
| 8233987 | Gelfand et al. | Jul 2012 | B2 |
| 8238996 | Burnes et al. | Aug 2012 | B2 |
| 8241213 | Lynn et al. | Aug 2012 | B2 |
| 8251061 | Lee et al. | Aug 2012 | B2 |
| 8255029 | Addison et al. | Aug 2012 | B2 |
| 8255056 | Tehrani | Aug 2012 | B2 |
| 8258973 | Newkirk | Sep 2012 | B2 |
| 8261742 | Strothmann et al. | Sep 2012 | B2 |
| 8262578 | Bharmi et al. | Sep 2012 | B1 |
| 8265759 | Tehrani et al. | Sep 2012 | B2 |
| 8273053 | Saltzstein | Sep 2012 | B2 |
| 8275553 | Ochs et al. | Sep 2012 | B2 |
| 8280513 | Tehrani et al. | Oct 2012 | B2 |
| 8301219 | Chen et al. | Oct 2012 | B2 |
| 8301232 | Albert et al. | Oct 2012 | B2 |
| 8321022 | Stahmann et al. | Nov 2012 | B2 |
| 8323204 | Stahmann et al. | Dec 2012 | B2 |
| 8333708 | Rapoport et al. | Dec 2012 | B2 |
| 8343057 | Starr et al. | Jan 2013 | B2 |
| 8348840 | Heit et al. | Jan 2013 | B2 |
| 8348941 | Tehrani | Jan 2013 | B2 |
| 8356594 | Ujhazy et al. | Jan 2013 | B2 |
| 8360060 | Berthon-Jones | Jan 2013 | B2 |
| 8360983 | Patangay et al. | Jan 2013 | B2 |
| 8365729 | Alder et al. | Feb 2013 | B2 |
| 8365730 | Baker, Jr. et al. | Feb 2013 | B2 |
| 8380296 | Lee et al. | Feb 2013 | B2 |
| 8381722 | Berthon-Jones | Feb 2013 | B2 |
| 8393233 | Lu | Mar 2013 | B2 |
| 8396537 | Balji et al. | Mar 2013 | B2 |
| 8398555 | Ochs et al. | Mar 2013 | B2 |
| 8401626 | Mietus et al. | Mar 2013 | B2 |
| 8401655 | De Ridder | Mar 2013 | B2 |
| 8403848 | Mietus et al. | Mar 2013 | B2 |
| 8403861 | Williams et al. | Mar 2013 | B2 |
| 8403865 | Halperin et al. | Mar 2013 | B2 |
| 8408205 | Madaus et al. | Apr 2013 | B2 |
| 8417351 | Kilger | Apr 2013 | B2 |
| 8442578 | Kass et al. | May 2013 | B2 |
| 8442638 | Libbus et al. | May 2013 | B2 |
| 8449473 | Varney et al. | May 2013 | B2 |
| 8454528 | Yuen et al. | Jun 2013 | B2 |
| 8460159 | Mikhailenok et al. | Jun 2013 | B2 |
| 8467876 | Tehrani | Jun 2013 | B2 |
| 8482418 | Harman | Jul 2013 | B1 |
| 8483807 | Kurzweil et al. | Jul 2013 | B2 |
| 8483811 | Ueda | Jul 2013 | B2 |
| 8483834 | Lee et al. | Jul 2013 | B2 |
| 8485181 | Daly | Jul 2013 | B2 |
| 8489182 | Duckert et al. | Jul 2013 | B2 |
| 8491490 | Ozaki et al. | Jul 2013 | B2 |
| 8509882 | Albert et al. | Aug 2013 | B2 |
| 8509901 | Tehrani | Aug 2013 | B2 |
| 8515529 | Pu et al. | Aug 2013 | B2 |
| 8522779 | Lee et al. | Sep 2013 | B2 |
| 8527028 | Kurzweil et al. | Sep 2013 | B2 |
| 8532737 | Cervantes | Sep 2013 | B2 |
| 8538510 | Toledo et al. | Sep 2013 | B2 |
| 8545416 | Kayyali et al. | Oct 2013 | B1 |
| 8551010 | Pu et al. | Oct 2013 | B2 |
| 8554323 | Haefner et al. | Oct 2013 | B2 |
| 8560044 | Kurzweil et al. | Oct 2013 | B2 |
| 8562526 | Heneghan et al. | Oct 2013 | B2 |
| 8565846 | Ono et al. | Oct 2013 | B2 |
| 8566115 | Moore | Oct 2013 | B2 |
| 8568160 | Coggins et al. | Oct 2013 | B2 |
| 8569374 | Veasey | Oct 2013 | B2 |
| 8579792 | Pickett et al. | Nov 2013 | B2 |
| 8595164 | Dong et al. | Nov 2013 | B2 |
| 8600502 | Lovett et al. | Dec 2013 | B2 |
| 8603010 | Lange et al. | Dec 2013 | B2 |
| 8604066 | Baud et al. | Dec 2013 | B2 |
| 8606356 | Lee et al. | Dec 2013 | B2 |
| 8607793 | Armitstead et al. | Dec 2013 | B2 |
| 8616203 | Jaffe et al. | Dec 2013 | B2 |
| 8620448 | Delia | Dec 2013 | B1 |
| 8630704 | Pu et al. | Jan 2014 | B2 |
| 8630712 | Moses et al. | Jan 2014 | B2 |
| 8641631 | Sierra et al. | Feb 2014 | B2 |
| 8644921 | Wilson | Feb 2014 | B2 |
| 8646447 | Martin et al. | Feb 2014 | B2 |
| 8657756 | Stahmann et al. | Feb 2014 | B2 |
| 8666467 | Lynn et al. | Mar 2014 | B2 |
| 8679034 | Halperin et al. | Mar 2014 | B2 |
| 8683999 | Douglas et al. | Apr 2014 | B2 |
| 8684000 | Berthon-Jones et al. | Apr 2014 | B2 |
| 8688219 | Ransom | Apr 2014 | B2 |
| 8696589 | Kwok et al. | Apr 2014 | B2 |
| 8700137 | Albert | Apr 2014 | B2 |
| 8707953 | Wickham | Apr 2014 | B2 |
| 8708920 | Delos et al. | Apr 2014 | B2 |
| 8718751 | Hastings et al. | May 2014 | B2 |
| 8721554 | Lin et al. | May 2014 | B2 |
| 8721555 | Westbrook et al. | May 2014 | B2 |
| 8721560 | Koh | May 2014 | B2 |
| 8721573 | Hoffmann | May 2014 | B2 |
| 8728001 | Lynn | May 2014 | B2 |
| 8731644 | Mehrotra et al. | May 2014 | B2 |
| 8731646 | Halperin et al. | May 2014 | B2 |
| 8739789 | Wickham | Jun 2014 | B2 |
| 8740806 | Parfenova et al. | Jun 2014 | B2 |
| 8740808 | Curti et al. | Jun 2014 | B2 |
| 8750987 | Pu et al. | Jun 2014 | B2 |
| 8752547 | Berthon-Jones | Jun 2014 | B2 |
| 8755854 | Addison et al. | Jun 2014 | B2 |
| 8758243 | Wang et al. | Jun 2014 | B2 |
| 8764667 | Avidor et al. | Jul 2014 | B2 |
| 8768731 | Moore | Jul 2014 | B2 |
| 8771184 | Besson et al. | Jul 2014 | B2 |
| 8781753 | Ochs et al. | Jul 2014 | B2 |
| 8790270 | Landesberg et al. | Jul 2014 | B2 |
| 8794235 | Garde et al. | Aug 2014 | B2 |
| 8794236 | Phuah et al. | Aug 2014 | B2 |
| 8801620 | Melker et al. | Aug 2014 | B2 |
| 8828386 | Adair | Sep 2014 | B2 |
| 8844525 | Schindhelm et al. | Sep 2014 | B2 |
| 8862196 | Lynn | Oct 2014 | B2 |
| 8862211 | Toledo et al. | Oct 2014 | B2 |
| 8868152 | Burnes et al. | Oct 2014 | B2 |
| 8880207 | Abeyratne et al. | Nov 2014 | B2 |
| 8892194 | Balji et al. | Nov 2014 | B2 |
| 8897870 | De Ridder | Nov 2014 | B2 |
| 8905928 | Hayes et al. | Dec 2014 | B2 |
| 8915741 | Hatlestad et al. | Dec 2014 | B2 |
| 8923971 | Haefner et al. | Dec 2014 | B2 |
| 8932227 | Lynn | Jan 2015 | B2 |
| 8938299 | Christopherson et al. | Jan 2015 | B2 |
| 8948854 | Friedman et al. | Feb 2015 | B2 |
| 8954137 | Kurzweil et al. | Feb 2015 | B2 |
| 8971936 | Derchak | Mar 2015 | B2 |
| 8983587 | Kurzweil et al. | Mar 2015 | B2 |
| 8983611 | Mokelke et al. | Mar 2015 | B2 |
| 8985106 | Armitstead | Mar 2015 | B2 |
| 8992434 | Halperin et al. | Mar 2015 | B2 |
| 8992436 | Pu et al. | Mar 2015 | B2 |
| 8999658 | Gozal et al. | Apr 2015 | B2 |
| 9011341 | Jensen et al. | Apr 2015 | B2 |
| 9011347 | Addison et al. | Apr 2015 | B2 |
| 9014819 | Lee et al. | Apr 2015 | B2 |
| 9019100 | Sholder | Apr 2015 | B2 |
| 9022032 | Holzrichter | May 2015 | B2 |
| 9024781 | Zhang et al. | May 2015 | B2 |
| 9026202 | Albert | May 2015 | B2 |
| 9031793 | Lynn et al. | May 2015 | B2 |
| 9037477 | Bardy et al. | May 2015 | B2 |
| 9042952 | Lynn et al. | May 2015 | B2 |
| 9044362 | Gozelski, Jr. et al. | Jun 2015 | B2 |
| 9044558 | Baker, Jr. et al. | Jun 2015 | B2 |
| 9044565 | Colman et al. | Jun 2015 | B2 |
| 9050024 | Ujhazy et al. | Jun 2015 | B2 |
| 9053222 | Lynn et al. | Jun 2015 | B2 |
| 9078577 | He et al. | Jul 2015 | B2 |
| 9084859 | Connor | Jul 2015 | B2 |
| 9089691 | Libbus et al. | Jul 2015 | B2 |
| 9095307 | Parfenova et al. | Aug 2015 | B2 |
| 9095471 | Iyer et al. | Aug 2015 | B2 |
| 9101277 | Doerr | Aug 2015 | B2 |
| 9108009 | Rapoport et al. | Aug 2015 | B2 |
| 9113788 | Balji et al. | Aug 2015 | B2 |
| 9131892 | Markel | Sep 2015 | B2 |
| 9131902 | Halperin et al. | Sep 2015 | B2 |
| 9132250 | Allum et al. | Sep 2015 | B2 |
| 9138553 | Wood | Sep 2015 | B2 |
| 9144389 | Srinivasan et al. | Sep 2015 | B2 |
| 9155493 | Addison et al. | Oct 2015 | B2 |
| 9168344 | Rapoport et al. | Oct 2015 | B2 |
| 9177459 | Sholder | Nov 2015 | B2 |
| 9180270 | Kapust et al. | Nov 2015 | B2 |
| 9192336 | Addison et al. | Nov 2015 | B2 |
| 9198616 | Addison et al. | Dec 2015 | B2 |
| 9198617 | Kurzweil et al. | Dec 2015 | B2 |
| 9199053 | Allum et al. | Dec 2015 | B1 |
| 9202084 | Moore | Dec 2015 | B2 |
| 9215075 | Poltorak | Dec 2015 | B1 |
| 9216291 | Lee et al. | Dec 2015 | B2 |
| 9220459 | Addison et al. | Dec 2015 | B2 |
| 9220460 | Addison et al. | Dec 2015 | B2 |
| 9220856 | Martin et al. | Dec 2015 | B2 |
| 9227034 | Kapust et al. | Jan 2016 | B2 |
| 9238113 | Loomas et al. | Jan 2016 | B2 |
| 9247885 | Kirchner et al. | Feb 2016 | B2 |
| 9259544 | Kane et al. | Feb 2016 | B2 |
| 9259573 | Tehrani et al. | Feb 2016 | B2 |
| 9269000 | Korhonen et al. | Feb 2016 | B2 |
| 9277867 | Kurzweil et al. | Mar 2016 | B2 |
| 9283341 | Ujhazy et al. | Mar 2016 | B2 |
| 9284333 | Bialy et al. | Mar 2016 | B2 |
| 9295797 | Shissler et al. | Mar 2016 | B2 |
| 9302066 | Bertinetti et al. | Apr 2016 | B2 |
| 9302116 | Vo-Dinh et al. | Apr 2016 | B2 |
| 9307921 | Friedman et al. | Apr 2016 | B2 |
| 9314168 | Watson et al. | Apr 2016 | B2 |
| 9333318 | Cragg et al. | May 2016 | B2 |
| 9364180 | Armitstead | Jun 2016 | B2 |
| 9370634 | Melker et al. | Jun 2016 | B2 |
| 9386952 | Younes | Jul 2016 | B2 |
| 9392950 | Milpied | Jul 2016 | B2 |
| 9402563 | Thakur et al. | Aug 2016 | B2 |
| 9414787 | Montambeau et al. | Aug 2016 | B2 |
| 9415182 | Schneider et al. | Aug 2016 | B2 |
| 9427539 | Rapoport et al. | Aug 2016 | B2 |
| 9433356 | Olde et al. | Sep 2016 | B2 |
| 9435814 | Gozal et al. | Sep 2016 | B2 |
| 9445736 | Kurzweil et al. | Sep 2016 | B2 |
| 9445740 | Crone et al. | Sep 2016 | B1 |
| 9445747 | Rahamim et al. | Sep 2016 | B2 |
| 9449493 | Shinar et al. | Sep 2016 | B2 |
| 9451888 | Bernstein | Sep 2016 | B1 |
| 9462975 | Sackner et al. | Oct 2016 | B2 |
| 9468378 | Lynn et al. | Oct 2016 | B2 |
| 9468835 | Martikka et al. | Oct 2016 | B2 |
| 9477812 | Lin et al. | Oct 2016 | B2 |
| 9492106 | Haveri | Nov 2016 | B2 |
| 9521971 | Lynn et al. | Dec 2016 | B2 |
| 9526429 | Heneghan et al. | Dec 2016 | B2 |
| 9533114 | Kayyali et al. | Jan 2017 | B1 |
| 9533115 | Rapoport et al. | Jan 2017 | B2 |
| 9538954 | Patangay et al. | Jan 2017 | B2 |
| 9586048 | Ternes et al. | Mar 2017 | B2 |
| 9629970 | Matthews et al. | Apr 2017 | B2 |
| 9669172 | Cullen et al. | Jun 2017 | B2 |
| 9675264 | Acquista et al. | Jun 2017 | B2 |
| 9682208 | Ramanan et al. | Jun 2017 | B2 |
| 9687177 | Ramanan et al. | Jun 2017 | B2 |
| 9706934 | Wilson | Jul 2017 | B2 |
| 9724020 | Bowman et al. | Aug 2017 | B2 |
| 9726390 | Miller | Aug 2017 | B2 |
| 9730632 | Kayyali et al. | Aug 2017 | B1 |
| 9737258 | Poon et al. | Aug 2017 | B2 |
| 9743841 | Pittman et al. | Aug 2017 | B2 |
| 9750429 | Sackner et al. | Sep 2017 | B1 |
| 9764135 | De Ridder | Sep 2017 | B2 |
| 9782133 | Wickham | Oct 2017 | B2 |
| 9788782 | Thakur et al. | Oct 2017 | B2 |
| 9814429 | Lee et al. | Nov 2017 | B2 |
| 9826903 | Derchak | Nov 2017 | B2 |
| 9833354 | Loomas et al. | Dec 2017 | B2 |
| 9839756 | Klasek | Dec 2017 | B2 |
| 9848820 | Chen et al. | Dec 2017 | B2 |
| 9848831 | Nonaka et al. | Dec 2017 | B2 |
| 9867955 | Rapoport et al. | Jan 2018 | B2 |
| 9872987 | Libbus et al. | Jan 2018 | B2 |
| 9878114 | Daly | Jan 2018 | B2 |
| 9884159 | Daly | Feb 2018 | B2 |
| 9884860 | Bialy et al. | Feb 2018 | B2 |
| 9889267 | Wells et al. | Feb 2018 | B2 |
| 9919121 | Wood | Mar 2018 | B2 |
| 9925086 | Sanders et al. | Mar 2018 | B2 |
| 9931074 | Ni et al. | Apr 2018 | B2 |
| 9931483 | Knepper et al. | Apr 2018 | B2 |
| 9932565 | Vitalis et al. | Apr 2018 | B2 |
| 9950112 | Melker et al. | Apr 2018 | B2 |
| 9980664 | Fernando et al. | May 2018 | B2 |
| 9987488 | Gelfand et al. | Jun 2018 | B1 |
| 9999768 | Gelfand et al. | Jun 2018 | B2 |
| 20010018557 | Lynn et al. | Aug 2001 | A1 |
| 20010044588 | Mault | Nov 2001 | A1 |
| 20020007126 | Nissila | Jan 2002 | A1 |
| 20020007127 | Sullivan et al. | Jan 2002 | A1 |
| 20020023645 | Zdrojkowski et al. | Feb 2002 | A1 |
| 20020032386 | Sackner et al. | Mar 2002 | A1 |
| 20020043264 | Wickham | Apr 2002 | A1 |
| 20020049479 | Pitts | Apr 2002 | A1 |
| 20020059935 | Wood | May 2002 | A1 |
| 20020072685 | Rymut et al. | Jun 2002 | A1 |
| 20020078957 | Remmers et al. | Jun 2002 | A1 |
| 20020086870 | Radulovacki et al. | Jul 2002 | A1 |
| 20020092527 | Wood | Jul 2002 | A1 |
| 20020095076 | Krausman et al. | Jul 2002 | A1 |
| 20020099300 | Kovtun et al. | Jul 2002 | A1 |
| 20020100477 | Sullivan et al. | Aug 2002 | A1 |
| 20020105340 | Ariav | Aug 2002 | A1 |
| 20020124848 | Sullivan et al. | Sep 2002 | A1 |
| 20020161290 | Chance | Oct 2002 | A1 |
| 20020162558 | Noble | Nov 2002 | A1 |
| 20020165462 | Westbrook et al. | Nov 2002 | A1 |
| 20020173707 | Lynn et al. | Nov 2002 | A1 |
| 20020185130 | Wright et al. | Dec 2002 | A1 |
| 20020185131 | Madaus et al. | Dec 2002 | A1 |
| 20030000522 | Lynn et al. | Jan 2003 | A1 |
| 20030023175 | Arzbaecher | Jan 2003 | A1 |
| 20030024528 | Graham | Feb 2003 | A1 |
| 20030045806 | Brydon | Mar 2003 | A1 |
| 20030095263 | Varshneya et al. | May 2003 | A1 |
| 20030111079 | Matthews et al. | Jun 2003 | A1 |
| 20030121519 | Estes et al. | Jul 2003 | A1 |
| 20030130266 | Radulovacki et al. | Jul 2003 | A1 |
| 20030130589 | Poezevera | Jul 2003 | A1 |
| 20030135127 | Sackner et al. | Jul 2003 | A1 |
| 20030145856 | Zdrojkowski et al. | Aug 2003 | A1 |
| 20030153953 | Park et al. | Aug 2003 | A1 |
| 20030153954 | Park et al. | Aug 2003 | A1 |
| 20030153955 | Park et al. | Aug 2003 | A1 |
| 20030153956 | Park et al. | Aug 2003 | A1 |
| 20030158466 | Lynn et al. | Aug 2003 | A1 |
| 20030161436 | Boyd et al. | Aug 2003 | A1 |
| 20030161440 | Boyd et al. | Aug 2003 | A1 |
| 20030163059 | Poezevera et al. | Aug 2003 | A1 |
| 20030195571 | Burnes et al. | Oct 2003 | A1 |
| 20030199945 | Ciulla | Oct 2003 | A1 |
| 20030204213 | Jensen et al. | Oct 2003 | A1 |
| 20030208130 | Yotam et al. | Nov 2003 | A1 |
| 20030208465 | Yurko et al. | Nov 2003 | A1 |
| 20030209246 | Schroeder et al. | Nov 2003 | A1 |
| 20030213488 | Remmers et al. | Nov 2003 | A1 |
| 20030221689 | Berthon-Jones | Dec 2003 | A1 |
| 20030236228 | Radulovacki et al. | Dec 2003 | A1 |
| 20030236548 | Hovanes et al. | Dec 2003 | A1 |
| 20040002742 | Florio | Jan 2004 | A1 |
| 20040015058 | Besson et al. | Jan 2004 | A1 |
| 20040016433 | Estes et al. | Jan 2004 | A1 |
| 20040020493 | Wood | Feb 2004 | A1 |
| 20040082874 | Aoki et al. | Apr 2004 | A1 |
| 20040103899 | Noble | Jun 2004 | A1 |
| 20040104733 | Ariav | Jun 2004 | A1 |
| 20040123866 | Berthon-Jones | Jul 2004 | A1 |
| 20040127572 | Carley et al. | Jul 2004 | A1 |
| 20040138576 | Wright et al. | Jul 2004 | A1 |
| 20040138719 | Cho et al. | Jul 2004 | A1 |
| 20040158193 | Bui et al. | Aug 2004 | A1 |
| 20040162499 | Nagai et al. | Aug 2004 | A1 |
| 20040176695 | Poezevara | Sep 2004 | A1 |
| 20040186523 | Florio | Sep 2004 | A1 |
| 20040187870 | Matthews et al. | Sep 2004 | A1 |
| 20040194220 | Price et al. | Oct 2004 | A1 |
| 20040207409 | Ariav et al. | Oct 2004 | A1 |
| 20040230105 | Geva et al. | Nov 2004 | A1 |
| 20040254481 | Brodnick | Dec 2004 | A1 |
| 20040254493 | Chervin et al. | Dec 2004 | A1 |
| 20040257233 | Proebsting | Dec 2004 | A1 |
| 20050027204 | Kligfield et al. | Feb 2005 | A1 |
| 20050027206 | Ariav | Feb 2005 | A1 |
| 20050027207 | Westbrook et al. | Feb 2005 | A1 |
| 20050034730 | Wood | Feb 2005 | A1 |
| 20050038353 | Rapoport et al. | Feb 2005 | A1 |
| 20050039745 | Stahmann et al. | Feb 2005 | A1 |
| 20050039750 | Wickham et al. | Feb 2005 | A1 |
| 20050039757 | Wood | Feb 2005 | A1 |
| 20050042589 | Hatlestad et al. | Feb 2005 | A1 |
| 20050043644 | Stahmann et al. | Feb 2005 | A1 |
| 20050043652 | Lovett et al. | Feb 2005 | A1 |
| 20050043772 | Stahmann et al. | Feb 2005 | A1 |
| 20050053262 | Szuba | Mar 2005 | A1 |
| 20050055060 | Koh et al. | Mar 2005 | A1 |
| 20050061315 | Lee et al. | Mar 2005 | A1 |
| 20050061319 | Hartley et al. | Mar 2005 | A1 |
| 20050061320 | Lee et al. | Mar 2005 | A1 |
| 20050061323 | Lee et al. | Mar 2005 | A1 |
| 20050065447 | Lee et al. | Mar 2005 | A1 |
| 20050065560 | Lee et al. | Mar 2005 | A1 |
| 20050065566 | Hartley et al. | Mar 2005 | A1 |
| 20050065567 | Lee et al. | Mar 2005 | A1 |
| 20050065572 | Hartley et al. | Mar 2005 | A1 |
| 20050074741 | Lee et al. | Apr 2005 | A1 |
| 20050076905 | Stahmann et al. | Apr 2005 | A1 |
| 20050076908 | Lee et al. | Apr 2005 | A1 |
| 20050080348 | Stahmann et al. | Apr 2005 | A1 |
| 20050080461 | Stahmann et al. | Apr 2005 | A1 |
| 20050081847 | Lee et al. | Apr 2005 | A1 |
| 20050085736 | Ambrose et al. | Apr 2005 | A1 |
| 20050085738 | Stahmann et al. | Apr 2005 | A1 |
| 20050085863 | Brodnick et al. | Apr 2005 | A1 |
| 20050085865 | Tehrani | Apr 2005 | A1 |
| 20050085866 | Tehrani | Apr 2005 | A1 |
| 20050085867 | Tehrani et al. | Apr 2005 | A1 |
| 20050090871 | Cho et al. | Apr 2005 | A1 |
| 20050096559 | Yanai | May 2005 | A1 |
| 20050101833 | Hsu et al. | May 2005 | A1 |
| 20050103346 | Noble | May 2005 | A1 |
| 20050107838 | Lovett et al. | May 2005 | A1 |
| 20050113656 | Chance | May 2005 | A1 |
| 20050113710 | Stahmann et al. | May 2005 | A1 |
| 20050113711 | Nakatani et al. | May 2005 | A1 |
| 20050115561 | Stahmann et al. | Jun 2005 | A1 |
| 20050119711 | Cho et al. | Jun 2005 | A1 |
| 20050126574 | Wood | Jun 2005 | A1 |
| 20050148897 | Cho et al. | Jul 2005 | A1 |
| 20050165457 | Benser et al. | Jul 2005 | A1 |
| 20050177051 | Almen | Aug 2005 | A1 |
| 20050197588 | Freeberg | Sep 2005 | A1 |
| 20050211248 | Lauk et al. | Sep 2005 | A1 |
| 20050211249 | Wagner et al. | Sep 2005 | A1 |
| 20050217674 | Burton | Oct 2005 | A1 |
| 20050224078 | Zdrojkowski et al. | Oct 2005 | A1 |
| 20050241639 | Zilberg | Nov 2005 | A1 |
| 20050247315 | Estes et al. | Nov 2005 | A1 |
| 20050251218 | Markowitz et al. | Nov 2005 | A1 |
| 20050261600 | Aylsworth | Nov 2005 | A1 |
| 20050267362 | Mietus et al. | Dec 2005 | A1 |
| 20050267380 | Poezevara | Dec 2005 | A1 |
| 20050273361 | Busch | Dec 2005 | A1 |
| 20050277842 | Silva | Dec 2005 | A1 |
| 20050283089 | Sullivan et al. | Dec 2005 | A1 |
| 20050288572 | Graw | Dec 2005 | A1 |
| 20050288728 | Libbus et al. | Dec 2005 | A1 |
| 20050288729 | Libbus et al. | Dec 2005 | A1 |
| 20060000475 | Matthews et al. | Jan 2006 | A1 |
| 20060004245 | Pickett et al. | Jan 2006 | A1 |
| 20060009708 | Rapoport et al. | Jan 2006 | A1 |
| 20060011200 | Remmers et al. | Jan 2006 | A1 |
| 20060025696 | Kurzweil et al. | Feb 2006 | A1 |
| 20060025697 | Kurzweil et al. | Feb 2006 | A1 |
| 20060030894 | Tehrani | Feb 2006 | A1 |
| 20060036294 | Tehrani | Feb 2006 | A1 |
| 20060037615 | Wilkinson et al. | Feb 2006 | A1 |
| 20060039866 | Rao et al. | Feb 2006 | A1 |
| 20060039867 | Rao et al. | Feb 2006 | A1 |
| 20060047217 | Mirtalebi et al. | Mar 2006 | A1 |
| 20060050930 | Szuba | Mar 2006 | A1 |
| 20060079802 | Jensen et al. | Apr 2006 | A1 |
| 20060084877 | Ujhazy et al. | Apr 2006 | A1 |
| 20060087325 | Ariav et al. | Apr 2006 | A1 |
| 20060095088 | De Ridder | May 2006 | A1 |
| 20060102179 | Rapoport et al. | May 2006 | A1 |
| 20060112960 | Wickham | Jun 2006 | A1 |
| 20060118112 | Cattano et al. | Jun 2006 | A1 |
| 20060122127 | Rao et al. | Jun 2006 | A1 |
| 20060122675 | Libbus et al. | Jun 2006 | A1 |
| 20060128605 | Shibahara et al. | Jun 2006 | A1 |
| 20060134106 | Adair | Jun 2006 | A1 |
| 20060135878 | Wright et al. | Jun 2006 | A1 |
| 20060145878 | Lehrman et al. | Jul 2006 | A1 |
| 20060149144 | Lynn et al. | Jul 2006 | A1 |
| 20060154856 | Veasey | Jul 2006 | A1 |
| 20060155206 | Lynn | Jul 2006 | A1 |
| 20060155207 | Lynn et al. | Jul 2006 | A1 |
| 20060161071 | Lynn et al. | Jul 2006 | A1 |
| 20060174889 | Noble | Aug 2006 | A1 |
| 20060179571 | Newkirk | Aug 2006 | A1 |
| 20060189872 | Arnold | Aug 2006 | A1 |
| 20060189880 | Lynn et al. | Aug 2006 | A1 |
| 20060195041 | Lynn et al. | Aug 2006 | A1 |
| 20060212081 | Suga et al. | Sep 2006 | A1 |
| 20060228775 | Collier et al. | Oct 2006 | A1 |
| 20060229489 | Pickett et al. | Oct 2006 | A1 |
| 20060235315 | Akselrod et al. | Oct 2006 | A1 |
| 20060235324 | Lynn | Oct 2006 | A1 |
| 20060241164 | Radulovacki et al. | Oct 2006 | A1 |
| 20060241510 | Halperin et al. | Oct 2006 | A1 |
| 20060258916 | Pietersen | Nov 2006 | A1 |
| 20060258921 | Addison et al. | Nov 2006 | A1 |
| 20060258948 | Linville | Nov 2006 | A1 |
| 20060264770 | Wellens et al. | Nov 2006 | A1 |
| 20060272641 | Madaus et al. | Dec 2006 | A1 |
| 20060275313 | Clark et al. | Dec 2006 | A1 |
| 20060276695 | Lynn et al. | Dec 2006 | A9 |
| 20060276701 | Ray | Dec 2006 | A1 |
| 20060279428 | Sato et al. | Dec 2006 | A1 |
| 20060293604 | Carlson et al. | Dec 2006 | A1 |
| 20070021589 | Collier et al. | Jan 2007 | A1 |
| 20070021795 | Tehrani | Jan 2007 | A1 |
| 20070032733 | Burton | Feb 2007 | A1 |
| 20070044796 | Zdrojkowski et al. | Mar 2007 | A1 |
| 20070051371 | Sullivan et al. | Mar 2007 | A1 |
| 20070055115 | Kwok et al. | Mar 2007 | A1 |
| 20070055168 | Rapoport et al. | Mar 2007 | A1 |
| 20070061393 | Moore | Mar 2007 | A1 |
| 20070062540 | Murray-Harris | Mar 2007 | A1 |
| 20070073177 | Kontothanassis et al. | Mar 2007 | A1 |
| 20070073181 | Pu et al. | Mar 2007 | A1 |
| 20070084464 | Wickham et al. | Apr 2007 | A1 |
| 20070093721 | Lynn et al. | Apr 2007 | A1 |
| 20070100381 | Snyder et al. | May 2007 | A1 |
| 20070106536 | Moore | May 2007 | A1 |
| 20070106537 | Moore | May 2007 | A1 |
| 20070106750 | Moore | May 2007 | A1 |
| 20070106751 | Moore | May 2007 | A1 |
| 20070106752 | Moore | May 2007 | A1 |
| 20070106753 | Moore | May 2007 | A1 |
| 20070106754 | Moore | May 2007 | A1 |
| 20070116036 | Moore | May 2007 | A1 |
| 20070116037 | Moore | May 2007 | A1 |
| 20070118180 | Ni et al. | May 2007 | A1 |
| 20070123517 | Radulovacki et al. | May 2007 | A1 |
| 20070129643 | Kwok et al. | Jun 2007 | A1 |
| 20070129645 | Hartley et al. | Jun 2007 | A1 |
| 20070129647 | Lynn | Jun 2007 | A1 |
| 20070135335 | Collier et al. | Jun 2007 | A1 |
| 20070135724 | Ujhazy et al. | Jun 2007 | A1 |
| 20070137653 | Wood | Jun 2007 | A1 |
| 20070142713 | Lancaster et al. | Jun 2007 | A1 |
| 20070142741 | Berthon-Jones et al. | Jun 2007 | A1 |
| 20070149860 | Lynn et al. | Jun 2007 | A1 |
| 20070150022 | Ujhazy et al. | Jun 2007 | A1 |
| 20070156059 | Vitali et al. | Jul 2007 | A1 |
| 20070156060 | Cervantes | Jul 2007 | A1 |
| 20070161917 | Ozaki et al. | Jul 2007 | A1 |
| 20070167694 | Causevic et al. | Jul 2007 | A1 |
| 20070168461 | Moore | Jul 2007 | A1 |
| 20070173728 | Pu et al. | Jul 2007 | A1 |
| 20070173893 | Pitts | Jul 2007 | A1 |
| 20070191688 | Lynn | Aug 2007 | A1 |
| 20070191697 | Lynn et al. | Aug 2007 | A1 |
| 20070199262 | Kern et al. | Aug 2007 | A1 |
| 20070208235 | Besson et al. | Sep 2007 | A1 |
| 20070213620 | Reisfeld | Sep 2007 | A1 |
| 20070213621 | Reisfeld et al. | Sep 2007 | A1 |
| 20070213622 | Reisfeld | Sep 2007 | A1 |
| 20070213624 | Reisfeld et al. | Sep 2007 | A1 |
| 20070215146 | Douglas et al. | Sep 2007 | A1 |
| 20070221224 | Pittman et al. | Sep 2007 | A1 |
| 20070227539 | Schwaibold et al. | Oct 2007 | A1 |
| 20070239057 | Pu et al. | Oct 2007 | A1 |
| 20070240718 | Daly | Oct 2007 | A1 |
| 20070251527 | Sleeper | Nov 2007 | A1 |
| 20070255160 | Daly | Nov 2007 | A1 |
| 20070255310 | Hovanes et al. | Nov 2007 | A1 |
| 20070265539 | Hastings et al. | Nov 2007 | A1 |
| 20070273366 | Ansay et al. | Nov 2007 | A1 |
| 20070277832 | Doshi et al. | Dec 2007 | A1 |
| 20070282212 | Sierra et al. | Dec 2007 | A1 |
| 20070293907 | Dubnov et al. | Dec 2007 | A1 |
| 20070295338 | Loomas et al. | Dec 2007 | A1 |
| 20080009755 | Patangay et al. | Jan 2008 | A1 |
| 20080015454 | Gal | Jan 2008 | A1 |
| 20080015457 | Silva | Jan 2008 | A1 |
| 20080027502 | Ransom | Jan 2008 | A1 |
| 20080039730 | Pu et al. | Feb 2008 | A1 |
| 20080039904 | Bulkes et al. | Feb 2008 | A1 |
| 20080040151 | Moore | Feb 2008 | A1 |
| 20080041382 | Matthews et al. | Feb 2008 | A1 |
| 20080041383 | Matthews et al. | Feb 2008 | A1 |
| 20080045813 | Phuah et al. | Feb 2008 | A1 |
| 20080045832 | McGrath | Feb 2008 | A1 |
| 20080051845 | Mentelos | Feb 2008 | A1 |
| 20080053442 | Estes et al. | Mar 2008 | A1 |
| 20080053443 | Estes et al. | Mar 2008 | A1 |
| 20080053444 | Estes et al. | Mar 2008 | A1 |
| 20080058665 | Scholler et al. | Mar 2008 | A1 |
| 20080058873 | Lee et al. | Mar 2008 | A1 |
| 20080058892 | Haefner et al. | Mar 2008 | A1 |
| 20080060138 | Price et al. | Mar 2008 | A1 |
| 20080066753 | Martin et al. | Mar 2008 | A1 |
| 20080071185 | Beck et al. | Mar 2008 | A1 |
| 20080081961 | Westbrook et al. | Apr 2008 | A1 |
| 20080082016 | Kohls et al. | Apr 2008 | A1 |
| 20080082659 | Haslehurst et al. | Apr 2008 | A1 |
| 20080091082 | Lu | Apr 2008 | A1 |
| 20080092898 | Schneider et al. | Apr 2008 | A1 |
| 20080101532 | Tkaczyk et al. | May 2008 | A1 |
| 20080139948 | Stahmann et al. | Jun 2008 | A1 |
| 20080142011 | Aylsworth et al. | Jun 2008 | A1 |
| 20080142013 | Hallett et al. | Jun 2008 | A1 |
| 20080153159 | Clark et al. | Jun 2008 | A1 |
| 20080154110 | Burnes et al. | Jun 2008 | A1 |
| 20080154330 | Tehrani et al. | Jun 2008 | A1 |
| 20080161708 | Kenigsberg et al. | Jul 2008 | A1 |
| 20080161878 | Tehrani | Jul 2008 | A1 |
| 20080163873 | Berthon-Jones | Jul 2008 | A1 |
| 20080167567 | Bashour et al. | Jul 2008 | A1 |
| 20080167695 | Tehrani et al. | Jul 2008 | A1 |
| 20080170654 | Tkaczyk et al. | Jul 2008 | A1 |
| 20080177347 | Tehrani et al. | Jul 2008 | A1 |
| 20080177789 | Stoval | Jul 2008 | A1 |
| 20080183095 | Austin et al. | Jul 2008 | A1 |
| 20080183239 | Tehrani et al. | Jul 2008 | A1 |
| 20080183240 | Tehrani et al. | Jul 2008 | A1 |
| 20080188904 | Tehrani et al. | Aug 2008 | A1 |
| 20080190430 | Melker et al. | Aug 2008 | A1 |
| 20080190436 | Jaffe et al. | Aug 2008 | A1 |
| 20080200367 | Carley et al. | Aug 2008 | A1 |
| 20080215106 | Lee et al. | Sep 2008 | A1 |
| 20080221468 | Stahmann et al. | Sep 2008 | A1 |
| 20080243021 | Causevic et al. | Oct 2008 | A1 |
| 20080257349 | Hedner et al. | Oct 2008 | A1 |
| 20080261922 | Carley et al. | Oct 2008 | A1 |
| 20080262360 | Dalal et al. | Oct 2008 | A1 |
| 20080264426 | Walker | Oct 2008 | A1 |
| 20080269583 | Reisfeld | Oct 2008 | A1 |
| 20080269625 | Halperin et al. | Oct 2008 | A1 |
| 20080287769 | Kurzweil et al. | Nov 2008 | A1 |
| 20080287770 | Kurzweil et al. | Nov 2008 | A1 |
| 20080288010 | Tehrani et al. | Nov 2008 | A1 |
| 20080288013 | Schecter | Nov 2008 | A1 |
| 20080288015 | Tehrani et al. | Nov 2008 | A1 |
| 20080289631 | Schroeder et al. | Nov 2008 | A1 |
| 20080300499 | Strube | Dec 2008 | A1 |
| 20080300500 | Reisfeld | Dec 2008 | A1 |
| 20080302364 | Garde et al. | Dec 2008 | A1 |
| 20080308105 | Alder et al. | Dec 2008 | A1 |
| 20080308112 | Aarts | Dec 2008 | A1 |
| 20080312548 | Hartley et al. | Dec 2008 | A1 |
| 20080313816 | Bohm et al. | Dec 2008 | A1 |
| 20080319513 | Pu et al. | Dec 2008 | A1 |
| 20090005357 | Radulovacki et al. | Jan 2009 | A1 |
| 20090030335 | Kuchler | Jan 2009 | A1 |
| 20090036790 | Landesberg et al. | Feb 2009 | A1 |
| 20090038617 | Berthon-Jones et al. | Feb 2009 | A1 |
| 20090050154 | Strothmann et al. | Feb 2009 | A1 |
| 20090062628 | Yamamoto et al. | Mar 2009 | A1 |
| 20090062675 | Weigand et al. | Mar 2009 | A1 |
| 20090069419 | Jandeleit et al. | Mar 2009 | A1 |
| 20090076147 | Jandeleit et al. | Mar 2009 | A1 |
| 20090076364 | Libbus | Mar 2009 | A1 |
| 20090078256 | Armitstead et al. | Mar 2009 | A1 |
| 20090082440 | Jandeleit et al. | Mar 2009 | A1 |
| 20090082464 | Jandeleit et al. | Mar 2009 | A1 |
| 20090082639 | Pittman et al. | Mar 2009 | A1 |
| 20090099253 | Li et al. | Apr 2009 | A1 |
| 20090099462 | Almen | Apr 2009 | A1 |
| 20090099469 | Flores | Apr 2009 | A1 |
| 20090107498 | Plattner et al. | Apr 2009 | A1 |
| 20090112116 | Lee et al. | Apr 2009 | A1 |
| 20090118629 | Lin et al. | May 2009 | A1 |
| 20090136444 | Priest et al. | May 2009 | A1 |
| 20090142294 | Priest et al. | Jun 2009 | A1 |
| 20090149496 | Brendel et al. | Jun 2009 | A1 |
| 20090149778 | Naujokat et al. | Jun 2009 | A1 |
| 20090155267 | Priest et al. | Jun 2009 | A1 |
| 20090156650 | Baud et al. | Jun 2009 | A1 |
| 20090172773 | Moore | Jul 2009 | A1 |
| 20090173347 | Berthon-Jones | Jul 2009 | A1 |
| 20090175819 | Priest et al. | Jul 2009 | A1 |
| 20090177050 | Griffiths et al. | Jul 2009 | A1 |
| 20090177495 | Abousy et al. | Jul 2009 | A1 |
| 20090177702 | Stahmann et al. | Jul 2009 | A1 |
| 20090183312 | Price et al. | Jul 2009 | A1 |
| 20090202472 | Priest et al. | Aug 2009 | A1 |
| 20090203972 | Heneghan et al. | Aug 2009 | A1 |
| 20090209880 | Jensen et al. | Aug 2009 | A1 |
| 20090221658 | Radulovacki et al. | Sep 2009 | A1 |
| 20090226861 | Thieberger Ben-Haom et al. | Sep 2009 | A1 |
| 20090226862 | Thieberger Ben-Haom et al. | Sep 2009 | A1 |
| 20090226863 | Thieberger Ben-Haim et al. | Sep 2009 | A1 |
| 20090226864 | Thieberger Ben-Haim et al. | Sep 2009 | A1 |
| 20090226865 | Thieberger Ben-Haim et al. | Sep 2009 | A1 |
| 20090232808 | Priest et al. | Sep 2009 | A1 |
| 20090238819 | Clark et al. | Sep 2009 | A1 |
| 20090240126 | Baker, Jr. et al. | Sep 2009 | A1 |
| 20090270773 | Hoffmann | Oct 2009 | A1 |
| 20090306528 | Curti et al. | Dec 2009 | A1 |
| 20090306529 | Curti et al. | Dec 2009 | A1 |
| 20090308395 | Lee et al. | Dec 2009 | A1 |
| 20090311247 | Priest et al. | Dec 2009 | A1 |
| 20090318820 | Toledo et al. | Dec 2009 | A1 |
| 20090326402 | Addison et al. | Dec 2009 | A1 |
| 20090326981 | Karkanias et al. | Dec 2009 | A1 |
| 20100004549 | Kohls et al. | Jan 2010 | A1 |
| 20100010359 | Kenigsberg et al. | Jan 2010 | A1 |
| 20100016694 | Martin et al. | Jan 2010 | A1 |
| 20100016783 | Bourke, Jr. et al. | Jan 2010 | A1 |
| 20100018530 | Schindhelm et al. | Jan 2010 | A1 |
| 20100030085 | Rojas Ojeda et al. | Feb 2010 | A1 |
| 20100031959 | Avidor et al. | Feb 2010 | A1 |
| 20100036209 | Ferren et al. | Feb 2010 | A1 |
| 20100036263 | Ferren et al. | Feb 2010 | A1 |
| 20100036268 | Ferren et al. | Feb 2010 | A1 |
| 20100036269 | Ferren et al. | Feb 2010 | A1 |
| 20100043795 | Ujhazy et al. | Feb 2010 | A1 |
| 20100056850 | Pickett et al. | Mar 2010 | A1 |
| 20100063438 | Bengtsson | Mar 2010 | A1 |
| 20100069762 | Mietus et al. | Mar 2010 | A1 |
| 20100079292 | Lynn et al. | Apr 2010 | A1 |
| 20100081943 | Watson et al. | Apr 2010 | A1 |
| 20100095959 | Farrell | Apr 2010 | A1 |
| 20100099963 | Kilger | Apr 2010 | A1 |
| 20100106211 | Lee et al. | Apr 2010 | A1 |
| 20100113955 | Colman et al. | May 2010 | A1 |
| 20100113956 | Curti et al. | May 2010 | A1 |
| 20100121207 | Moersdorf et al. | May 2010 | A1 |
| 20100130873 | Yuen et al. | May 2010 | A1 |
| 20100137251 | Carley et al. | Jun 2010 | A1 |
| 20100137723 | Patangay et al. | Jun 2010 | A1 |
| 20100145201 | Westbrook et al. | Jun 2010 | A1 |
| 20100152553 | Ujhazy et al. | Jun 2010 | A1 |
| 20100152600 | Droitcour et al. | Jun 2010 | A1 |
| 20100159426 | Thieberger Ben-Haim et al. | Jun 2010 | A1 |
| 20100168578 | Garson, Jr. et al. | Jul 2010 | A1 |
| 20100168600 | Adriance et al. | Jul 2010 | A1 |
| 20100168601 | Adriance et al. | Jul 2010 | A1 |
| 20100174154 | Lee et al. | Jul 2010 | A1 |
| 20100174161 | Lynn | Jul 2010 | A1 |
| 20100174207 | Lee et al. | Jul 2010 | A1 |
| 20100174335 | Stahmann et al. | Jul 2010 | A1 |
| 20100179396 | Lin et al. | Jul 2010 | A1 |
| 20100179613 | Stahmann et al. | Jul 2010 | A1 |
| 20100198083 | Lin et al. | Aug 2010 | A1 |
| 20100198289 | Kameli et al. | Aug 2010 | A1 |
| 20100204550 | Heneghan et al. | Aug 2010 | A1 |
| 20100204586 | Pu et al. | Aug 2010 | A1 |
| 20100222655 | Starr et al. | Sep 2010 | A1 |
| 20100222685 | Berthon-Jones et al. | Sep 2010 | A1 |
| 20100222689 | Kurzweil et al. | Sep 2010 | A1 |
| 20100228120 | Thijs et al. | Sep 2010 | A1 |
| 20100228317 | Libbus et al. | Sep 2010 | A1 |
| 20100234705 | Lynn | Sep 2010 | A1 |
| 20100234750 | Ariav et al. | Sep 2010 | A1 |
| 20100240999 | Droitcour et al. | Sep 2010 | A1 |
| 20100242965 | Berthon-Jones | Sep 2010 | A1 |
| 20100249630 | Droitcour et al. | Sep 2010 | A1 |
| 20100249633 | Droitcour et al. | Sep 2010 | A1 |
| 20100252037 | Wondka et al. | Oct 2010 | A1 |
| 20100252039 | Cipollone et al. | Oct 2010 | A1 |
| 20100252040 | Kapust et al. | Oct 2010 | A1 |
| 20100252041 | Kapust et al. | Oct 2010 | A1 |
| 20100252042 | Kapust et al. | Oct 2010 | A1 |
| 20100253505 | Chou | Oct 2010 | A1 |
| 20100256460 | Haveri et al. | Oct 2010 | A1 |
| 20100256512 | Sullivan | Oct 2010 | A1 |
| 20100258123 | Somaiya et al. | Oct 2010 | A1 |
| 20100258126 | Ujhazy et al. | Oct 2010 | A1 |
| 20100262035 | Subramanian | Oct 2010 | A1 |
| 20100262205 | De Ridder | Oct 2010 | A1 |
| 20100268093 | Balji et al. | Oct 2010 | A1 |
| 20100292568 | Droitcour et al. | Nov 2010 | A1 |
| 20100297129 | Adair | Nov 2010 | A1 |
| 20100298733 | Kwok et al. | Nov 2010 | A1 |
| 20100307500 | Armitstead | Dec 2010 | A1 |
| 20100319709 | Goncalves | Dec 2010 | A1 |
| 20100326447 | Loomas et al. | Dec 2010 | A1 |
| 20100328075 | Rahamim et al. | Dec 2010 | A1 |
| 20100331715 | Addison et al. | Dec 2010 | A1 |
| 20100331716 | Watson et al. | Dec 2010 | A1 |
| 20110004081 | Addison et al. | Jan 2011 | A1 |
| 20110009722 | Amundson et al. | Jan 2011 | A1 |
| 20110011402 | Berthon-Jones | Jan 2011 | A1 |
| 20110015501 | Lynn et al. | Jan 2011 | A1 |
| 20110021928 | Giovangrandi et al. | Jan 2011 | A1 |
| 20110021970 | Vo-Dinh et al. | Jan 2011 | A1 |
| 20110028802 | Addison et al. | Feb 2011 | A1 |
| 20110034820 | Pietersen | Feb 2011 | A1 |
| 20110036352 | Estes et al. | Feb 2011 | A1 |
| 20110040201 | Pu et al. | Feb 2011 | A1 |
| 20110046462 | Ono et al. | Feb 2011 | A1 |
| 20110046500 | Haveri | Feb 2011 | A1 |
| 20110054270 | Derchak | Mar 2011 | A1 |
| 20110054279 | Reisfeld et al. | Mar 2011 | A1 |
| 20110054290 | Derchak | Mar 2011 | A1 |
| 20110060380 | Gelfand et al. | Mar 2011 | A1 |
| 20110061647 | Stahmann et al. | Mar 2011 | A1 |
| 20110067709 | Doshi et al. | Mar 2011 | A1 |
| 20110087115 | Sackner et al. | Apr 2011 | A1 |
| 20110097333 | Clark et al. | Apr 2011 | A1 |
| 20110105869 | Wilson et al. | May 2011 | A1 |
| 20110105921 | Wang | May 2011 | A1 |
| 20110130249 | Mikhailenok et al. | Jun 2011 | A1 |
| 20110131057 | Newkirk | Jun 2011 | A1 |
| 20110137197 | Stahmann et al. | Jun 2011 | A1 |
| 20110137367 | Carlson et al. | Jun 2011 | A1 |
| 20110152706 | Christopherson et al. | Jun 2011 | A1 |
| 20110160601 | Wang et al. | Jun 2011 | A1 |
| 20110166470 | Rapoport et al. | Jul 2011 | A1 |
| 20110172552 | Rothman et al. | Jul 2011 | A1 |
| 20110184298 | De Marchena et al. | Jul 2011 | A1 |
| 20110184304 | Koh | Jul 2011 | A1 |
| 20110186050 | Daly | Aug 2011 | A1 |
| 20110190594 | Heit et al. | Aug 2011 | A1 |
| 20110190651 | Ota et al. | Aug 2011 | A1 |
| 20110192400 | Burton et al. | Aug 2011 | A9 |
| 20110208082 | Madaus et al. | Aug 2011 | A1 |
| 20110208539 | Lynn | Aug 2011 | A1 |
| 20110214676 | Allum et al. | Sep 2011 | A1 |
| 20110217719 | Gozal et al. | Sep 2011 | A1 |
| 20110230727 | Sanders et al. | Sep 2011 | A1 |
| 20110230932 | Tehrani et al. | Sep 2011 | A1 |
| 20110245628 | Baker, Jr. et al. | Oct 2011 | A1 |
| 20110245706 | Lu | Oct 2011 | A1 |
| 20110264164 | Christopherson et al. | Oct 2011 | A1 |
| 20110270114 | Addison et al. | Nov 2011 | A1 |
| 20110284003 | Douglas et al. | Nov 2011 | A1 |
| 20110288609 | Tehrani et al. | Nov 2011 | A1 |
| 20110297156 | Shelly et al. | Dec 2011 | A1 |
| 20110301435 | Albert et al. | Dec 2011 | A1 |
| 20110301439 | Albert et al. | Dec 2011 | A1 |
| 20110301484 | Curti et al. | Dec 2011 | A1 |
| 20110301487 | Abeyratne et al. | Dec 2011 | A1 |
| 20110303223 | Kane et al. | Dec 2011 | A1 |
| 20110306850 | Hatlestad et al. | Dec 2011 | A1 |
| 20110313689 | Holley et al. | Dec 2011 | A1 |
| 20110319777 | Mehrotra et al. | Dec 2011 | A1 |
| 20120004523 | Richter et al. | Jan 2012 | A1 |
| 20120004749 | Abeyratne et al. | Jan 2012 | A1 |
| 20120010198 | Carley et al. | Jan 2012 | A1 |
| 20120017904 | Ratto et al. | Jan 2012 | A1 |
| 20120022348 | Droitcour et al. | Jan 2012 | A1 |
| 20120028504 | Coggins et al. | Feb 2012 | A1 |
| 20120029362 | Patangay et al. | Feb 2012 | A1 |
| 20120032778 | Nakano et al. | Feb 2012 | A1 |
| 20120035436 | Kirchner et al. | Feb 2012 | A1 |
| 20120041037 | Baud et al. | Feb 2012 | A1 |
| 20120046709 | Lee et al. | Feb 2012 | A1 |
| 20120053480 | Ueda | Mar 2012 | A1 |
| 20120056746 | Kaigler et al. | Mar 2012 | A1 |
| 20120065533 | Carrillo, Jr. et al. | Mar 2012 | A1 |
| 20120078319 | De Ridder | Mar 2012 | A1 |
| 20120088998 | Bardy et al. | Apr 2012 | A1 |
| 20120101690 | Srinivasan et al. | Apr 2012 | A1 |
| 20120108570 | Radulovacki et al. | May 2012 | A1 |
| 20120109027 | Gozelski, Jr. et al. | May 2012 | A1 |
| 20120116187 | Hayes et al. | May 2012 | A1 |
| 20120125337 | Asanoi | May 2012 | A1 |
| 20120130204 | Basta et al. | May 2012 | A1 |
| 20120130205 | Burton et al. | May 2012 | A1 |
| 20120130445 | Lee et al. | May 2012 | A1 |
| 20120130446 | Haefner et al. | May 2012 | A1 |
| 20120132202 | Burton et al. | May 2012 | A1 |
| 20120136231 | Markel | May 2012 | A1 |
| 20120136405 | Burton et al. | May 2012 | A1 |
| 20120145153 | Bassin et al. | Jun 2012 | A1 |
| 20120152252 | Matthews et al. | Jun 2012 | A1 |
| 20120157900 | Iyer et al. | Jun 2012 | A1 |
| 20120158091 | Tehrani et al. | Jun 2012 | A1 |
| 20120160243 | Berthon-Jones et al. | Jun 2012 | A1 |
| 20120165711 | Pickett et al. | Jun 2012 | A1 |
| 20120172689 | Albert et al. | Jul 2012 | A1 |
| 20120172730 | Delos et al. | Jul 2012 | A1 |
| 20120173470 | Bashour et al. | Jul 2012 | A1 |
| 20120179061 | Ramanan et al. | Jul 2012 | A1 |
| 20120189632 | Adair | Jul 2012 | A1 |
| 20120190998 | Armitstead et al. | Jul 2012 | A1 |
| 20120197144 | Christ et al. | Aug 2012 | A1 |
| 20120203491 | Sun et al. | Aug 2012 | A1 |
| 20120209096 | Jaffe et al. | Aug 2012 | A1 |
| 20120209127 | Jensen et al. | Aug 2012 | A1 |
| 20120227740 | Berthon-Jones et al. | Sep 2012 | A1 |
| 20120232398 | Roham et al. | Sep 2012 | A1 |
| 20120232416 | Gilham et al. | Sep 2012 | A1 |
| 20120234323 | Connor | Sep 2012 | A1 |
| 20120240934 | Holzrichter | Sep 2012 | A1 |
| 20120245437 | Lovett et al. | Sep 2012 | A1 |
| 20120252709 | Felts et al. | Oct 2012 | A1 |
| 20120253249 | Wilson | Oct 2012 | A1 |
| 20120255553 | Wood | Oct 2012 | A1 |
| 20120272429 | Porporino et al. | Nov 2012 | A1 |
| 20120283527 | Pu et al. | Nov 2012 | A1 |
| 20120283581 | Olde et al. | Nov 2012 | A1 |
| 20120291785 | Ramanan et al. | Nov 2012 | A1 |
| 20120302845 | Lynn et al. | Nov 2012 | A1 |
| 20120304998 | Wickham et al. | Dec 2012 | A1 |
| 20120323104 | Burnes et al. | Dec 2012 | A1 |
| 20120323293 | Tehrani et al. | Dec 2012 | A1 |
| 20120330118 | Lynn et al. | Dec 2012 | A1 |
| 20120330123 | Doerr | Dec 2012 | A1 |
| 20130012827 | Kurzweil et al. | Jan 2013 | A1 |
| 20130012830 | Leininger | Jan 2013 | A1 |
| 20130019870 | Collazo et al. | Jan 2013 | A1 |
| 20130030257 | Nakata et al. | Jan 2013 | A1 |
| 20130030711 | Korhonen | Jan 2013 | A1 |
| 20130046151 | Bsoul et al. | Feb 2013 | A1 |
| 20130046156 | Addison et al. | Feb 2013 | A1 |
| 20130046157 | Addison et al. | Feb 2013 | A1 |
| 20130046160 | Addison et al. | Feb 2013 | A1 |
| 20130046161 | Addison et al. | Feb 2013 | A1 |
| 20130046184 | Addison et al. | Feb 2013 | A1 |
| 20130046185 | Addison et al. | Feb 2013 | A1 |
| 20130046186 | Addison et al. | Feb 2013 | A1 |
| 20130046187 | Addison et al. | Feb 2013 | A1 |
| 20130046188 | Addison et al. | Feb 2013 | A1 |
| 20130053674 | Volker | Feb 2013 | A1 |
| 20130060110 | Lynn et al. | Mar 2013 | A1 |
| 20130060149 | Song et al. | Mar 2013 | A1 |
| 20130060150 | Song et al. | Mar 2013 | A1 |
| 20130060480 | Korhonen et al. | Mar 2013 | A1 |
| 20130079842 | Mokelke et al. | Mar 2013 | A1 |
| 20130081479 | Miller et al. | Apr 2013 | A1 |
| 20130085688 | Miller et al. | Apr 2013 | A1 |
| 20130096442 | Stahmann et al. | Apr 2013 | A1 |
| 20130096447 | Dhawan et al. | Apr 2013 | A1 |
| 20130096450 | Duckert et al. | Apr 2013 | A1 |
| 20130104898 | Berthon-Jones | May 2013 | A1 |
| 20130118494 | Ujhazy et al. | May 2013 | A1 |
| 20130123654 | Rahamim et al. | May 2013 | A1 |
| 20130131028 | Snyder et al. | May 2013 | A1 |
| 20130131522 | Patangay et al. | May 2013 | A1 |
| 20130137998 | Lange et al. | May 2013 | A1 |
| 20130144178 | Halperin et al. | Jun 2013 | A1 |
| 20130146056 | Baker, Jr. et al. | Jun 2013 | A1 |
| 20130158625 | Gelfand et al. | Jun 2013 | A1 |
| 20130165809 | Abir | Jun 2013 | A1 |
| 20130172720 | Yamamori et al. | Jul 2013 | A1 |
| 20130172759 | Melker et al. | Jul 2013 | A1 |
| 20130174847 | Berthon-Jones | Jul 2013 | A1 |
| 20130178719 | Balji et al. | Jul 2013 | A1 |
| 20130178761 | Alder et al. | Jul 2013 | A1 |
| 20130197321 | Wilson | Aug 2013 | A1 |
| 20130197601 | Tehrani et al. | Aug 2013 | A1 |
| 20130199532 | Shissler et al. | Aug 2013 | A1 |
| 20130211210 | Freeman | Aug 2013 | A1 |
| 20130218030 | Barroso et al. | Aug 2013 | A1 |
| 20130231713 | De Ridder | Sep 2013 | A1 |
| 20130234535 | Sako et al. | Sep 2013 | A1 |
| 20130238052 | Libbus et al. | Sep 2013 | A1 |
| 20130239960 | Bertinetti et al. | Sep 2013 | A1 |
| 20130255683 | Kapust et al. | Oct 2013 | A2 |
| 20130261485 | Ishikawa et al. | Oct 2013 | A1 |
| 20130268030 | Lee et al. | Oct 2013 | A1 |
| 20130276785 | Melker et al. | Oct 2013 | A1 |
| 20130281815 | Varadan | Oct 2013 | A1 |
| 20130281874 | Nishida | Oct 2013 | A1 |
| 20130281883 | Nishida | Oct 2013 | A1 |
| 20130291060 | Moore | Oct 2013 | A1 |
| 20130291869 | Daly | Nov 2013 | A1 |
| 20130296660 | Tsien et al. | Nov 2013 | A1 |
| 20130296823 | Melker et al. | Nov 2013 | A1 |
| 20130296964 | Tehrani | Nov 2013 | A1 |
| 20130300575 | Kurzweil et al. | Nov 2013 | A1 |
| 20130307685 | Sholder | Nov 2013 | A1 |
| 20130310657 | Sullivan et al. | Nov 2013 | A1 |
| 20130312752 | Kapust et al. | Nov 2013 | A2 |
| 20130312757 | Cragg et al. | Nov 2013 | A1 |
| 20130324877 | Nonaka et al. | Dec 2013 | A1 |
| 20130331663 | Albert et al. | Dec 2013 | A1 |
| 20130331722 | Rodriguez-Villegas et al. | Dec 2013 | A1 |
| 20130333696 | Lee et al. | Dec 2013 | A1 |
| 20130338459 | Lynn et al. | Dec 2013 | A1 |
| 20130340500 | Miller et al. | Dec 2013 | A1 |
| 20140012099 | Halperin et al. | Jan 2014 | A1 |
| 20140012145 | Kurzweil et al. | Jan 2014 | A1 |
| 20140018779 | Worrell et al. | Jan 2014 | A1 |
| 20140020687 | Cullen et al. | Jan 2014 | A1 |
| 20140025141 | Haefner et al. | Jan 2014 | A1 |
| 20140031705 | Kurzweil et al. | Jan 2014 | A1 |
| 20140031709 | Toledo et al. | Jan 2014 | A1 |
| 20140045755 | Carley et al. | Feb 2014 | A1 |
| 20140051938 | Goldstein et al. | Feb 2014 | A1 |
| 20140053846 | Wood | Feb 2014 | A1 |
| 20140058274 | Landesberg et al. | Feb 2014 | A1 |
| 20140066741 | Peterson et al. | Mar 2014 | A1 |
| 20140066798 | Albert | Mar 2014 | A1 |
| 20140069428 | Sears et al. | Mar 2014 | A1 |
| 20140073969 | Zou et al. | Mar 2014 | A1 |
| 20140094669 | Jaffe et al. | Apr 2014 | A1 |
| 20140100628 | Pu et al. | Apr 2014 | A1 |
| 20140107501 | Komanduri et al. | Apr 2014 | A1 |
| 20140107506 | Lee et al. | Apr 2014 | A1 |
| 20140109909 | Shelly et al. | Apr 2014 | A1 |
| 20140116442 | Martin et al. | May 2014 | A1 |
| 20140128697 | Parfenova et al. | May 2014 | A1 |
| 20140128761 | Cline et al. | May 2014 | A1 |
| 20140142457 | Armitstead et al. | May 2014 | A1 |
| 20140144438 | Klasek | May 2014 | A1 |
| 20140148720 | Younes | May 2014 | A1 |
| 20140150793 | Douglas et al. | Jun 2014 | A1 |
| 20140152467 | Spencer et al. | Jun 2014 | A1 |
| 20140152673 | Lynn et al. | Jun 2014 | A1 |
| 20140158124 | L'her et al. | Jun 2014 | A1 |
| 20140163343 | Heneghan et al. | Jun 2014 | A1 |
| 20140163386 | He et al. | Jun 2014 | A1 |
| 20140163897 | Lynn et al. | Jun 2014 | A1 |
| 20140171769 | Ochs et al. | Jun 2014 | A1 |
| 20140171783 | Schmidt et al. | Jun 2014 | A1 |
| 20140178350 | Vitalis et al. | Jun 2014 | A1 |
| 20140180148 | Coggins et al. | Jun 2014 | A1 |
| 20140180154 | Sierra et al. | Jun 2014 | A1 |
| 20140194705 | Kwok et al. | Jul 2014 | A1 |
| 20140194793 | Nakata et al. | Jul 2014 | A1 |
| 20140200476 | Wickham | Jul 2014 | A1 |
| 20140207204 | Halperin et al. | Jul 2014 | A1 |
| 20140213913 | Parfenova et al. | Jul 2014 | A1 |
| 20140213919 | Poon et al. | Jul 2014 | A1 |
| 20140218210 | De Jong et al. | Aug 2014 | A1 |
| 20140221859 | Albert | Aug 2014 | A1 |
| 20140228651 | Causevic et al. | Aug 2014 | A1 |
| 20140238399 | Daly | Aug 2014 | A1 |
| 20140243934 | Vo-Dinh et al. | Aug 2014 | A1 |
| 20140246024 | Cragg et al. | Sep 2014 | A1 |
| 20140246025 | Cragg et al. | Sep 2014 | A1 |
| 20140258743 | Nool et al. | Sep 2014 | A1 |
| 20140261425 | Connor | Sep 2014 | A1 |
| 20140275928 | Acquista et al. | Sep 2014 | A1 |
| 20140276120 | Starr et al. | Sep 2014 | A1 |
| 20140276287 | Pickett et al. | Sep 2014 | A1 |
| 20140283831 | Foote et al. | Sep 2014 | A1 |
| 20140288953 | Lynn et al. | Sep 2014 | A1 |
| 20140309540 | Morikawa et al. | Oct 2014 | A1 |
| 20140309568 | Pickett et al. | Oct 2014 | A1 |
| 20140309943 | Grundlehner et al. | Oct 2014 | A1 |
| 20140320309 | Zhang et al. | Oct 2014 | A1 |
| 20140323946 | Bourke, Jr. et al. | Oct 2014 | A1 |
| 20140326253 | Baratier et al. | Nov 2014 | A1 |
| 20140330155 | Brewer et al. | Nov 2014 | A1 |
| 20140330156 | Bowman et al. | Nov 2014 | A1 |
| 20140330540 | Lin et al. | Nov 2014 | A1 |
| 20140345060 | Ribble et al. | Nov 2014 | A1 |
| 20140363740 | Holme et al. | Dec 2014 | A1 |
| 20140364706 | Schindhelm et al. | Dec 2014 | A1 |
| 20140371635 | Shinar et al. | Dec 2014 | A1 |
| 20150005646 | Balakrishnan et al. | Jan 2015 | A1 |
| 20150005658 | Nonaka et al. | Jan 2015 | A1 |
| 20150018342 | Bialy et al. | Jan 2015 | A1 |
| 20150018660 | Thomson et al. | Jan 2015 | A1 |
| 20150034081 | Tehrani et al. | Feb 2015 | A1 |
| 20150035643 | Kursun | Feb 2015 | A1 |
| 20150038867 | Armitstead et al. | Feb 2015 | A1 |
| 20150039110 | Abeyratne et al. | Feb 2015 | A1 |
| 20150045686 | Lynn | Feb 2015 | A1 |
| 20150057555 | Milpied | Feb 2015 | A1 |
| 20150059755 | Bassin | Mar 2015 | A1 |
| 20150065891 | Wiesel | Mar 2015 | A1 |
| 20150073240 | Huang et al. | Mar 2015 | A1 |
| 20150073285 | Albert et al. | Mar 2015 | A1 |
| 20150088212 | De Ridder | Mar 2015 | A1 |
| 20150101609 | Melker et al. | Apr 2015 | A1 |
| 20150105632 | Melker et al. | Apr 2015 | A1 |
| 20150107594 | Rapoport et al. | Apr 2015 | A1 |
| 20150112202 | Abir | Apr 2015 | A1 |
| 20150114396 | Ramanan et al. | Apr 2015 | A1 |
| 20150115483 | Miller | Apr 2015 | A1 |
| 20150119739 | Kurzweil et al. | Apr 2015 | A1 |
| 20150119740 | Hernandez et al. | Apr 2015 | A1 |
| 20150120067 | Wing et al. | Apr 2015 | A1 |
| 20150122260 | Daly | May 2015 | A1 |
| 20150122685 | Wakeham et al. | May 2015 | A1 |
| 20150126847 | Balji et al. | May 2015 | A1 |
| 20150126879 | Hoskuldsson et al. | May 2015 | A1 |
| 20150128941 | Holley et al. | May 2015 | A1 |
| 20150136146 | Hood et al. | May 2015 | A1 |
| 20150139935 | Braley et al. | May 2015 | A1 |
| 20150141766 | Fine | May 2015 | A1 |
| 20150141862 | Montambeau et al. | May 2015 | A1 |
| 20150141879 | Harper et al. | May 2015 | A1 |
| 20150150485 | Fernando et al. | Jun 2015 | A1 |
| 20150150500 | Armitstead | Jun 2015 | A1 |
| 20150151094 | Lewer | Jun 2015 | A1 |
| 20150164322 | Derchak | Jun 2015 | A1 |
| 20150164375 | Schindhelm et al. | Jun 2015 | A1 |
| 20150164433 | Halperin et al. | Jun 2015 | A1 |
| 20150164682 | Remmers et al. | Jun 2015 | A1 |
| 20150165140 | Cappelli et al. | Jun 2015 | A1 |
| 20150165147 | Rapoport et al. | Jun 2015 | A1 |
| 20150173672 | Goldstein | Jun 2015 | A1 |
| 20150177264 | Gozal et al. | Jun 2015 | A1 |
| 20150182132 | Harris et al. | Jul 2015 | A1 |
| 20150182713 | Phuah et al. | Jul 2015 | A1 |
| 20150182842 | Martikka et al. | Jul 2015 | A1 |
| 20150190088 | Chen et al. | Jul 2015 | A1 |
| 20150190089 | Christopherson et al. | Jul 2015 | A1 |
| 20150199479 | Semen et al. | Jul 2015 | A1 |
| 20150216448 | Lotan et al. | Aug 2015 | A1 |
| 20150217074 | Wells et al. | Aug 2015 | A1 |
| 20150228176 | Sholder | Aug 2015 | A1 |
| 20150230750 | McDarby et al. | Aug 2015 | A1 |
| 20150238107 | Acquista et al. | Aug 2015 | A1 |
| 20150246195 | Baker, Jr. et al. | Sep 2015 | A1 |
| 20150250963 | Ramanan et al. | Sep 2015 | A1 |
| 20150251016 | Vo-Dinh et al. | Sep 2015 | A1 |
| 20150257653 | Hyde et al. | Sep 2015 | A1 |
| 20150265796 | Miller et al. | Sep 2015 | A1 |
| 20150272934 | Stein et al. | Oct 2015 | A1 |
| 20150282738 | Thakur et al. | Oct 2015 | A1 |
| 20150283383 | Ternes et al. | Oct 2015 | A1 |
| 20150290415 | Dunn | Oct 2015 | A1 |
| 20150290416 | Klasek | Oct 2015 | A1 |
| 20150305634 | Stergiou | Oct 2015 | A1 |
| 20150314098 | Allum et al. | Nov 2015 | A1 |
| 20150320588 | Connor | Nov 2015 | A1 |
| 20150321022 | Sullivan et al. | Nov 2015 | A1 |
| 20150335507 | Emmons et al. | Nov 2015 | A1 |
| 20150335851 | Cullen et al. | Nov 2015 | A1 |
| 20150343161 | Knepper et al. | Dec 2015 | A1 |
| 20150352306 | Scheiner et al. | Dec 2015 | A1 |
| 20150352308 | Cullen et al. | Dec 2015 | A1 |
| 20150352312 | Wood | Dec 2015 | A1 |
| 20150359964 | Walker et al. | Dec 2015 | A1 |
| 20150366468 | Levy | Dec 2015 | A1 |
| 20150366511 | Addison et al. | Dec 2015 | A1 |
| 20150370320 | Connor | Dec 2015 | A1 |
| 20150374328 | Ginestet et al. | Dec 2015 | A1 |
| 20160004820 | Moore | Jan 2016 | A1 |
| 20160008565 | Wood | Jan 2016 | A1 |
| 20160022145 | Mostov | Jan 2016 | A1 |
| 20160022204 | Mostov | Jan 2016 | A1 |
| 20160029949 | Landesberg et al. | Feb 2016 | A1 |
| 20160029971 | Sachdev et al. | Feb 2016 | A1 |
| 20160030689 | Landesberg et al. | Feb 2016 | A1 |
| 20160045134 | Jensen et al. | Feb 2016 | A1 |
| 20160045166 | Gheeraert et al. | Feb 2016 | A1 |
| 20160045167 | Gheeraert et al. | Feb 2016 | A1 |
| 20160045654 | Connor | Feb 2016 | A1 |
| 20160045695 | Kapust et al. | Feb 2016 | A1 |
| 20160058964 | Doemer et al. | Mar 2016 | A1 |
| 20160066805 | Scherf et al. | Mar 2016 | A1 |
| 20160066809 | Luo et al. | Mar 2016 | A1 |
| 20160067433 | Martin et al. | Mar 2016 | A1 |
| 20160074606 | Whiting et al. | Mar 2016 | A1 |
| 20160089540 | Bolea | Mar 2016 | A1 |
| 20160093196 | Shinar et al. | Mar 2016 | A1 |
| 20160095997 | Kapust et al. | Apr 2016 | A1 |
| 20160100798 | Markel | Apr 2016 | A1 |
| 20160120430 | Bayasi et al. | May 2016 | A1 |
| 20160120431 | Habte et al. | May 2016 | A1 |
| 20160120433 | Hughes et al. | May 2016 | A1 |
| 20160120434 | Park et al. | May 2016 | A1 |
| 20160120465 | Parfenova et al. | May 2016 | A1 |
| 20160120716 | Ribble et al. | May 2016 | A1 |
| 20160128209 | Yoon et al. | May 2016 | A1 |
| 20160128863 | Loomas et al. | May 2016 | A1 |
| 20160135706 | Sullivan et al. | May 2016 | A1 |
| 20160135734 | Schindhelm | May 2016 | A1 |
| 20160143594 | Moorman et al. | May 2016 | A1 |
| 20160144144 | Smith et al. | May 2016 | A1 |
| 20160151014 | Ujhazy et al. | Jun 2016 | A1 |
| 20160151593 | Rapoport et al. | Jun 2016 | A1 |
| 20160151595 | Rapoport et al. | Jun 2016 | A1 |
| 20160158091 | Amblard et al. | Jun 2016 | A1 |
| 20160158092 | Amblard et al. | Jun 2016 | A1 |
| 20160158478 | Bertinetti et al. | Jun 2016 | A1 |
| 20160159793 | Bialy et al. | Jun 2016 | A1 |
| 20160166796 | Orr | Jun 2016 | A1 |
| 20160166797 | Orr | Jun 2016 | A1 |
| 20160169930 | Korhonen et al. | Jun 2016 | A1 |
| 20160174857 | Eggers et al. | Jun 2016 | A1 |
| 20160175552 | Harrington | Jun 2016 | A1 |
| 20160193437 | Bao et al. | Jul 2016 | A1 |
| 20160210747 | Hay et al. | Jul 2016 | A1 |
| 20160220197 | Rantala | Aug 2016 | A1 |
| 20160228024 | Batzer et al. | Aug 2016 | A1 |
| 20160228060 | Mazar et al. | Aug 2016 | A1 |
| 20160232321 | Silverman | Aug 2016 | A1 |
| 20160256063 | Friedman et al. | Sep 2016 | A1 |
| 20160256644 | Armitstead | Sep 2016 | A1 |
| 20160256655 | Mah et al. | Sep 2016 | A1 |
| 20160263376 | Yoo et al. | Sep 2016 | A1 |
| 20160263393 | Vo-Dinh et al. | Sep 2016 | A1 |
| 20160270718 | Heneghan et al. | Sep 2016 | A1 |
| 20160270719 | Liu et al. | Sep 2016 | A1 |
| 20160278658 | Bardy et al. | Sep 2016 | A1 |
| 20160287122 | Heneghan | Oct 2016 | A1 |
| 20160296124 | Wegerich et al. | Oct 2016 | A1 |
| 20160296165 | Moore et al. | Oct 2016 | A1 |
| 20160296720 | Henry et al. | Oct 2016 | A1 |
| 20160302704 | Lynn et al. | Oct 2016 | A9 |
| 20160302726 | Chang | Oct 2016 | A1 |
| 20160310046 | Heinrich et al. | Oct 2016 | A1 |
| 20160310085 | Delia | Oct 2016 | A1 |
| 20160310103 | Liu et al. | Oct 2016 | A1 |
| 20160324467 | Thakur et al. | Nov 2016 | A1 |
| 20160336841 | Nagorny et al. | Nov 2016 | A1 |
| 20160338597 | Melker et al. | Nov 2016 | A1 |
| 20160345897 | Ni et al. | Dec 2016 | A1 |
| 20160354063 | Ward et al. | Dec 2016 | A1 |
| 20160361067 | Cline et al. | Dec 2016 | A9 |
| 20160375209 | Shadie et al. | Dec 2016 | A1 |
| 20170007798 | Salmon et al. | Jan 2017 | A1 |
| 20170014587 | Whiting et al. | Jan 2017 | A1 |
| 20170020919 | Theus | Jan 2017 | A1 |
| 20170035303 | Sullivan et al. | Feb 2017 | A1 |
| 20170035304 | Shiau | Feb 2017 | A1 |
| 20170035978 | Holley et al. | Feb 2017 | A1 |
| 20170128002 | Christopherson et al. | May 2017 | A1 |
| 20170135604 | Kent et al. | May 2017 | A1 |
| 20170135629 | Kent et al. | May 2017 | A1 |
| 20170143257 | Kent et al. | May 2017 | A1 |
| 20170143259 | Kent et al. | May 2017 | A1 |
| 20170143280 | Kent et al. | May 2017 | A1 |
| 20170143960 | Kent et al. | May 2017 | A1 |
| 20170143973 | Tehrani | May 2017 | A1 |
| 20170164871 | Ramanan | Jun 2017 | A1 |
| 20170164906 | Ramanan | Jun 2017 | A1 |
| 20170172459 | Bernstein et al. | Jun 2017 | A1 |
| 20170181663 | Hansen et al. | Jun 2017 | A1 |
| 20170182358 | Zavrel | Jun 2017 | A1 |
| 20170188940 | Goldstein | Jul 2017 | A9 |
| 20170204386 | Vitalis et al. | Jul 2017 | A1 |
| 20170209657 | Levings et al. | Jul 2017 | A1 |
| 20170224943 | Creusot et al. | Aug 2017 | A1 |
| 20170231504 | Heneghan et al. | Aug 2017 | A1 |
| 20170238812 | Atlas | Aug 2017 | A1 |
| 20170238867 | Javed et al. | Aug 2017 | A1 |
| 20170239433 | Martin et al. | Aug 2017 | A1 |
| 20170258365 | Ramanan et al. | Sep 2017 | A1 |
| 20170274165 | Ramanan et al. | Sep 2017 | A1 |
| 20170311879 | Armitstead et al. | Nov 2017 | A1 |
| 20170321914 | Miller | Nov 2017 | A1 |
| 20170326025 | Hernandez | Nov 2017 | A1 |
| 20170326316 | Rapoport et al. | Nov 2017 | A1 |
| 20170326320 | Baigent et al. | Nov 2017 | A1 |
| 20170347904 | Wilson | Dec 2017 | A1 |
| 20170347951 | Gollakota et al. | Dec 2017 | A1 |
| 20170361041 | Scheerer et al. | Dec 2017 | A1 |
| 20170361044 | Armitstead et al. | Dec 2017 | A1 |
| 20170361045 | Fu et al. | Dec 2017 | A1 |
| 20170361103 | Hadjiyski | Dec 2017 | A1 |
| 20170363096 | Fleming et al. | Dec 2017 | A1 |
| 20170367619 | Zhan | Dec 2017 | A1 |
| 20170368339 | De Ridder | Dec 2017 | A1 |
| 20180000427 | Wickham | Jan 2018 | A1 |
| 20180003723 | Rai et al. | Jan 2018 | A1 |
| 20180015282 | Waner et al. | Jan 2018 | A1 |
| 20180028770 | Parrish | Feb 2018 | A1 |
| 20180036533 | Yoo et al. | Feb 2018 | A1 |
| 20180043125 | Bencke et al. | Feb 2018 | A1 |
| 20180049678 | Hoskuldsson et al. | Feb 2018 | A1 |
| 20180064390 | Thakur et al. | Mar 2018 | A1 |
| 20180070890 | Bradley et al. | Mar 2018 | A1 |
| 20180071471 | Kirollos | Mar 2018 | A1 |
| 20180085246 | Loomas et al. | Mar 2018 | A1 |
| 20180103860 | Christopherson et al. | Apr 2018 | A1 |
| 20180103896 | Shin et al. | Apr 2018 | A1 |
| 20180106897 | Shouldice et al. | Apr 2018 | A1 |
| 20180116588 | Wang | May 2018 | A1 |
| 20180117270 | Bassin | May 2018 | A1 |
| 20180133430 | Orr | May 2018 | A1 |
| 20180140795 | Wells et al. | May 2018 | A1 |
| 20180153427 | Al-Jumaily et al. | Jun 2018 | A1 |
| 20180168502 | Cho et al. | Jun 2018 | A1 |
| 20180168852 | Sanders et al. | Jun 2018 | A1 |
| 20180169361 | Dennis et al. | Jun 2018 | A1 |
| 20180185599 | Wood | Jul 2018 | A1 |
| 20180200467 | Finch | Jul 2018 | A1 |
| 20180206762 | Huang | Jul 2018 | A1 |
| 20180228399 | Orr et al. | Aug 2018 | A1 |
| 20180236191 | Martin et al. | Aug 2018 | A1 |
| 20180236200 | Goldspink et al. | Aug 2018 | A1 |
| 20180242903 | Zhuang | Aug 2018 | A1 |
| 20180250486 | Amarasinghe et al. | Sep 2018 | A1 |
| 20180256069 | McMahon | Sep 2018 | A1 |
| 20180256096 | Galeev et al. | Sep 2018 | A1 |
| 20180256843 | Eves et al. | Sep 2018 | A1 |
| Number | Date | Country |
|---|---|---|
| WO-2005018737 | Mar 2005 | WO |
| Entry |
|---|
| “A. Bartolo, et al. Analysis of diaphragm EMG signals: comparison of gating vs. subtraction for removal of ECG contamination. Jun. 1996. Journal of Applied Physiology. vol. 80, Issue 6. pp. 1898-1900” (Year: 1996). |
| U.S. Appl. No. 10/004,438, filed Jun. 26, 2018, Huang et al. |
| U.S. Appl. No. 10/004,862, filed Jun. 26, 2018, Armitstead et al. |
| U.S. Appl. No. 10/022,084, filed Jul. 17, 2018, Nonaka et al. |
| U.S. Appl. No. 10/029,058, filed Jul. 24, 2018, Foote et al. |
| U.S. Appl. No. 10/032,526, filed Jul. 24, 2018, Lynn et al. |
| U.S. Appl. No. 10/045,907, filed Aug. 14, 2018, Harper et al. |
| U.S. Appl. No. 10/046,127, filed Aug. 14, 2018, Berthon-Jones. |
| U.S. Appl. No. 10/047,964, filed Aug. 14, 2018, Miller. |
| U.S. Appl. No. 10/052,449, filed Aug. 21, 2018, Miller et al. |
| U.S. Appl. No. 10/058,269, filed Aug. 28, 2018, Lynn. |
| U.S. Appl. No. 10/058,272, filed Aug. 28, 2018, Heinrich et al. |
| U.S. Appl. No. 10/065,008, filed Sep. 4, 2018, Cullen et al. |
| PCT/US2017/061099 IPER. |
| PCT/US2017/061099 ISR. |
| Number | Date | Country | |
|---|---|---|---|
| 20200405184 A1 | Dec 2020 | US |
| Number | Date | Country | |
|---|---|---|---|
| 62420308 | Nov 2016 | US |
