Patent Grant
11701522
Disclosed embodiments enable manipulation of magnetic particles for performing actions on superficial tissues, for example, cosmetic procedures and surgery.
Conventional techniques for reducing wrinkles include the heating of tissues (for example, through application of radio-frequency energy) to stimulate synthesis of new collagen and elastic fibers in superficial tissues, e.g., skin.
Disclosed embodiments may disrupt collagen and elastic fibers and/or stimulate synthesis of new collagen and elastic fibers in superficial tissues to achieve a desired cosmetic effect.
In accordance with disclosed embodiments, an apparatus includes a controller and generator of magnetic fields coupled to one another and cooperating to apply magnetic field to one or more magnetic particles in the superficial tissue of a human or other living subject to move or activate the magnetic particles to disrupt collagen and elastic fibers and/or stimulate synthesis of new collagen and elastic fibers in the superficial tissue.
In accordance with disclosed embodiments, an apparatus may also include components configured to cooperate to image the magnetic particles in tissue to enable direction of injection, motion, guidance or activation of the one or more magnetic particles.
The detailed description particularly refers to the accompanying figures in which:
Disclosed embodiments provide and application of this principle to provide technical utility for manipulation of at least one magnetic particle for the purposes of a medical or other practitioner to perform cosmetic operations on a human or other living body to stimulate synthesis of new collagen and elastic fibers in the skin. Disclosed embodiments are directed at providing an method, apparatus and components thereof for accomplishing this and related tasks.
Thus, disclosed embodiments may be implemented in whole or in part using an apparatus that includes a controller and generator of magnetic fields coupled together and configured to cooperate to apply magnetic field for moving and activating one or more magnetic particles in superficial tissue, e.g., skin. The apparatus may also include the magnetic particle(s) being moved or activated in the tissue.
In accordance with disclosed embodiments, an apparatus may also include components configured to cooperate to image the magnetic particle(s) in tissue to enable direction of injection, motion, guidance or activation of the one or more magnetic particles. Such a capability provides technical utility in the ability to analyze and control of direction of injection, motion, guidance or activation of particles.
Such imaging may be performed with Magnetic Resonance Imaging, for example, by the controller and generator including electropermanent magnets to form a single-sided MRI, as has been described in US patent application 20170227617A1 by Irving Weinberg and Aleksandar Nacev (incorporated herein by reference). For example,
It should be understood that electropermanent magnets and other sources of magnetic fields include but are not limited to “magnetoelectric material” or “magneto-electric material” or “magnetoelectric composite” or “magneto-electric composite,” which encompass substances or combination of substances, in which changes in magnetic properties change in the presence of or application of an electric field.
Alternatively, imaging of the particle(s) and tissue could be performed with optical means, for example, provided the magnetic particles are visible optically (for example, the particles include a fluorescent material). Alternatively, imaging of the particle(s) could be accomplished with magnetic particle imaging. Alternatively, imaging of the tissue could be accomplished with ultrasound imaging.
Including imaging capability may have significant technical utility for a variety of reasons including to avoid damage to important tissue structures, for example, blood vessels or nerves resulting from transportation or other activation of particle(s), to guide the particle(s) to appropriate locations in the tissue (for example, near wrinkles), or to guide removal of the particles from the tissue following treatment of the tissue as discussed herein. Alternatively, or in addition, the particle(s) may be tethered to one another and/or to additional material or equipment to facilitate removal of the particle from tissue.
For the purposes of this disclosure, the terms “magnetic particles”, “particles” and “magnetizable particles” are defined as one or more structures that can be magnetized at least in part using magnetic fields, where the maximum dimension of the structure of the particle is one millimeter or less. The magnetization of parts of the particle structures may be in different directions, as taught by Lamar Mair in US patent application U.S. Pat. No. 10,290,404, entitled “METHOD AND APPARATUS FOR NON-CONTACT AXIAL PARTICLE ROTATION AND DECOUPLED PARTICLE PROPULSION”, incorporated herein by reference. Alternatively the magnetization of the particle structure may be uniform throughout the structure.
In accordance with disclosed embodiments, an apparatus includes a controller and generator of magnetic fields coupled to one another and cooperating to apply magnetic field to one or more magnetic particles in the superficial tissue of a human or other living subject to move or activate the magnetic particles to stimulate synthesis of new collagen and elastic fibers in the superficial tissue.
Thus,
The components of apparatus 200 may also include at least one magnetic particle 30 (and potentially a plurality of such magnetic particles 30). The magnetic particle(s) may be understood to be a structure less than a centimeter in maximum diameter in any dimension and containing at least one material that may be magnetized by an applied magnetic field. The magnetic particle may be less than a millimeter in minimal diameter.
In operations provided in accordance with disclosed embodiments, the apparatus 200 may be positioned in proximity or nearby to a superficial tissue 40 of a subject (for example a human or other animal). For the purposes of this specification, the term “proximity” and “nearby” are meant to mean less than 10 centimeters.
For the purposes of this specification, the term “superficial tissue” is meant to include tissues in which the thickness of the superficial tissue is less than 3-centimeters, and where at least some portion of the tissue is located less than 3-centimeters from the surface of the skin. The tissue may contain fibers (e.g. made of collagen and/or elastin), some of which having been stretched 50 by age or other physiological processes, and some of which having not been stretched 60. This combination of stretched and unstretched fibers may cause the appearance of indentations or wrinkles 70 in the skin.
As mentioned above, including imaging capability may have significant technical utility for a variety of reasons including to avoid damage to important tissue structures, for example, blood vessels or nerves 80 resulting from transportation or other activation of particle(s).
This insertion may have been accomplished with an injection, for example, manually via a syringe containing a solution including the particle(s). Alternatively, the insertion may have been through a skin incision made with a scalpel or other sharp instrument. Thus, in accordance with at least some embodiments, the particle(s) 30 may be injected into tissue 40. In one example, this may be accomplished with magnetic fields, using rotation, as described by the publication by Sahar Jafari et al entitled “Intra-nasal transport of particles into rodent brain by magnetic drilling”, Journal of Magnetism and Magnetic Materials (2018). 10.1016/j.jmmm.2018.08.048.
Additionally or alternatively movement and/or injection of the particles may be accomplished with magnetic propulsion, for example, as described by Irving Weinberg et al in U.S. Pat. No. 9,694,196, entitled “SYSTEM, METHOD, AND EQUIPMENT FOR IMPLEMENTING TEMPORARY DIAMAGNETIC PROPULSIVE FOCUSING EFFECT WITH TRANSIENT APPLIED MAGNETIC FIELD PULSES”, incorporated herein by reference.
Activation of the particle(s), e.g., rotation, vibration, heating or otherwise, of particle(s) (referenced as particle 30, 90 or 100) may be accomplished with magnetic torques and/or forces applied by the controller 10 and the generator of magnetic fields 20. For example, activation such as rotation may disrupt tissue fibers (referenced as 60 or 100) in order to reduce the depth of wrinkle 70, 120. The particle(s) (reference as particle 30, 90 or 100) may also reduce the depth of wrinkle 70, 120 through other means, for example, heating of the tissue via magnetic induction or other magnetic means, or as a result of a drug or other chemical agent previously loaded on or in the particle(s) and released by the particle(s). That release could be due to magnetic activation, for example, heating. Such drugs or other chemical agents may include, for example, what are known as collagen-stimulating fillers, which contain microscopic particles that prompt the superficial tissue to make new collagen, which can result in smoother skin and volume.
Accordingly,
Following completion of procedures using the particle(s) within the tissue, the particle(s) could be removed from the tissue 40 by the apparatus 200 through drilling motion, similar to the manner in which they were injected into the tissue. It should also be understood that at least some or all of the particle(s) could be eliminated from the tissue 40 via biodegradation of the particle(s). The particle(s) may be attached to a string or catheter or other tethering structure enabling or assisting withdrawal of the particle from the tissue.
Those skilled in the art will recognize, upon consideration of the above teachings, that the above exemplary embodiments may perform the above-specified operations (and those referred in the claims) under the control of at least one controller that may utilize or be based upon use of one or more programmed processors programmed with a suitable computer program. However, the disclosed embodiments could utilize one or more controllers implemented using hardware component equivalents such as special purpose hardware and/or dedicated processors. Similarly, general purpose computers, microprocessor based computers, micro-controllers, optical computers, analog computers, dedicated processors, application specific circuits and/or dedicated hard wired logic may be used to construct alternative equivalent embodiments.
Furthermore, it should be understood that control and cooperation of components of an apparatus for applying magnetic fields described herein to manipulate the one or more particles may be provided using software instructions that may be stored in a tangible, non-transitory storage device such as a non-transitory computer readable storage device storing instructions which, when executed on one or more programmed processors, carry out the above-described method operations and resulting functionality. In this case, the term non-transitory is intended to preclude transmitted signals and propagating waves, but not storage devices that are erasable or dependent upon power sources to retain information.
Those skilled in the art will appreciate, upon consideration of the above teachings, that the program operations and processes and associated data used to implement certain of the embodiments described above can be implemented using disc storage as well as other forms of storage devices including, but not limited to non-transitory storage media (where non-transitory is intended only to preclude propagating signals and not signals which are transitory in that they are erased by removal of power or explicit acts of erasure) such as for example Read Only Memory (ROM) devices, Random Access Memory (RAM) devices, network memory devices, optical storage elements, magnetic storage elements, magneto-optical storage elements, flash memory, core memory and/or other equivalent volatile and non-volatile storage technologies without departing from certain embodiments of the present invention. Such alternative storage devices should be considered equivalents.
While certain illustrative embodiments have been described, it is evident that many alternatives, modifications, permutations and variations will become apparent to those skilled in the art in light of the foregoing description. While illustrated embodiments have been outlined above, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, the various embodiments of the invention, as set forth above, are intended to be illustrative, not limiting. Various changes may be made without departing from the spirit and scope of the invention.
As a result, it will be apparent for those skilled in the art that the illustrative embodiments described are only examples and that various modifications can be made within the scope of the invention as defined in the appended claims.
This patent application claims priority to U.S. Provisional Patent Application No. 62/802,386, entitled “SKIN SCULPTING WITH MAGNETIC PARTICLES,” filed Feb. 7, 2019, the disclosure of which being incorporated herein by reference in its entirety.
| Number | Name | Date | Kind |
|---|---|---|---|
| 20050080446 | Gilson et al. | Apr 2005 | A1 |
| 20140309479 | Weinberg | Oct 2014 | A1 |
| 20170227617 | Weinberg | Aug 2017 | A1 |
| Number | Date | Country |
|---|---|---|
| 102695542 | Sep 2012 | CN |
| 201622773 | Jul 2016 | TW |
| WO-2008065652 | Jun 2008 | WO |
| Entry |
|---|
| Chinese Office Action corresponding to CN202010082741.4 dated Jan. 30, 2023. |
| Number | Date | Country | |
|---|---|---|---|
| 20200254273 A1 | Aug 2020 | US |
| Number | Date | Country | |
|---|---|---|---|
| 62802386 | Feb 2019 | US |
