Claims
- 1. A system for treating plasma after separation from whole blood comprisinga source container holding plasma after separation from whole blood, tubing adapted to be coupled the source container to convey plasma from the source container, a filter in the tubing to separate leukocytes from plasma conveyed from the source container comprising a fibrous prefilter medium to remove aggregates from the plasma by adsorption, and, in a downstream flow direction from the fibrous prefilter medium, a downstream membrane filter medium having pores sized to remove leukocytes by exclusion, and means for adding a photoactive material to the plasma.
- 2. A system for treating plasma after separation from whole blood comprisinga source container holding plasma after separation from whole blood, a transfer container, tubing adapted to be coupled the source container and the transfer container to convey plasma from the source container to the transfer container, a filter in the tubing to separate leukocytes from plasma conveyed from the source container comprising a fibrous prefilter medium to remove agregates from the plasma by adsorption and, in a downstream flow direction from the fibrous prefilter medium, a downstream membrane filter medium having pores sized to remove leukocytes by exclusion, and means for adding a photoactive material to the plasma in one of the source container and transfer container.
- 3. A system for treating plasma after separation from whole blood comprisinga transfer container, a photoactive material in the transfer container, tubing coupled to the transfer container and adapted to be coupled a source container of plasma after separation from whole blood to convey plasma from the source container into the transfer container for mixing with the photactive material, and a filter in the tubing to separate leukocytes from plasma conveyed into the transfer container comprising a fibrous prefilter medium to remove aggregates from the plasma by adsorption and, in a downstream flow direction from the fibrous prefilter medium, a downstream membrane filter medium having pores sized to remove leukocytes by exclusion.
- 4. A system according to claim 1 or 2 or 3 wherein the photoactive material is methylene blue.
- 5. A system according to claim 1 or 2 and or 3 and further including a light source emitting radiation at a selected wavelength into the plasma to activate the photoactive material.
- 6. A system for treating plasma after separation from whole blood comprisinga source container holding plasma after separation from whole blood, tubing adapted to be coupled the source container to convey plasma from the source container, a filter in the tubing to separate leukocytes from plasma conveyed from the source container comprising a fibrous prefilter medium to remove aggregates from the plasma by adsorption and, in a downstream flow direction from the fibrous prefilter medium, a downstream membrane filter medium having pores sized to remove leukocytes by exclusion, the downstream membrane filter medium including first and second membrane layers, the first membrane layer being located between the fibrous prefilter medium and the membrane second layer, the pores of the first membrane layer being larger than the pores of the second membrane layer, and means for adding a photoactive material to the plasma.
- 7. A system for treating plasma after separation from whole blood comprisingsource container holding plasma after separation from whole blood, a transfer container, tubing adapted to be coupled the source container and the transfer container to convey plasma from the source container to the transfer container, a filter in the tubing to separate leukocytes from plasma conveyed from the source container comprising a fibrous prefilter medium to remove aggregates from the plasma by adsorption and, in a downstream flow direction from the fibrous prefilter medium, a downstream membrane filter medium having pores sized to remove leukocytes by exclusion, the downstream membrane filter medium including first and second membrane layers, the first membrane layer being located between the fibrous prefilter medium and the second membrane layer, the pores of the first membrane layer being larger than the pores of the second membrane layer, and means for adding a photoactive material to the plasma in one of the source container and transfer container.
- 8. A system for treating plasma after separation from whole blood comprisingtransfer container, a photoactive material in the transfer container, tubing coupled to the transfer container and adapted to be coupled a source container of plasma after separation from whole blood to convey plasma from the source container into the transfer container for mixing with the photactive material, and a filter in the tubing to separate leukocytes from plasma conveyed into the transfer container comprising a fibrous prefilter medium to remove aggregates from the plasma by adsorption and, in a downstream flow direction from the fibrous prefilter medium, a downstream membrane filter medium having pores sized to remove leukocytes by exclusion, the downstream membrane filter medium including first and second membrane layers, the first membrane layer being located between the fibrous prefilter medium and the second membrane layer, the pores of the first membrane layer being larger than the pores of the second membrane layer.
RELATED APPLICATION
This application is a division of copending application Ser. No. 08/574,741, filed Dec. 19, 1995 (now U.S. Pat. No. 5,935,092), which is a continuation in-part of U.S. patent application Ser. No. 08/289,175, filed Aug. 11, 1994 and entitled “Systems and Methods for Simultaneously Removing Free and Entrained Contaminants in Fluids Like Blood Using Photoactive Therapy and Cellular Separation Techniques” (now U.S. Pat. No. 5,536,238), which is a continuation of U.S. patent application Ser. No. 08/215,968, filed Mar. 17, 1994 (Abandoned), which is a continuation of U.S. application Ser. No. 08/055,915, filed Apr. 29, 1993 (Abandoned), which is itself a continuation of U.S. application Ser. No. 07/630,864, filed Dec. 20, 1990 (Abandoned).
US Referenced Citations (51)
Foreign Referenced Citations (1)
Number |
Date |
Country |
0 500 472 |
Aug 1992 |
EP |
Non-Patent Literature Citations (1)
Entry |
Friedman and Stromberg, “Viral inactivation and reduction in cellular blood products”, Transfusion Hemobiology, Jan. 1993; 36(1):83-91. |
Continuations (3)
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Number |
Date |
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Parent |
08/215968 |
Mar 1994 |
US |
Child |
08/289175 |
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US |
Parent |
08/055915 |
Apr 1993 |
US |
Child |
08/215968 |
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US |
Parent |
07/630864 |
Dec 1990 |
US |
Child |
08/055915 |
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US |
Continuation in Parts (1)
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Number |
Date |
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Parent |
08/289175 |
Aug 1994 |
US |
Child |
08/574741 |
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US |