1. Field of the Invention
The invention relates generally to the field of orthodontics and, more particularly, to computer-automated separation of a model of teeth.
2. Description of the Background Art
Tooth positioners for finishing orthodontic treatment are described by Kesling in the Am. J. Orthod. Oral. Surg. 31:297–304 (1945) and 32:285–293 (1946). The use of silicone positioners for the comprehensive orthodontic realignment of a patient's teeth is described in Warunek et al. (1989) J. Clin. Orthod. 23:694–700. Clear plastic retainers for finishing and maintaining tooth positions are commercially available from Raintree Essix, Inc., New Orleans, La. 70125, and Tru-Tain Plastics, Rochester, Minn. 55902. The manufacture of orthodontic positioners is described in U.S. Pat. Nos. 5,186,623; 5,059,118; 5,055,039; 5,035,613; 4,856,991; 4,798,534; and 4,755,139.
Other publications describing the fabrication and use of dental positioners include Kleemann and Janssen (1996) J. Clin. Orthodon. 30:673–680; Cureton (1996) J. Clin. Orthodon. 30:390–395; Chiappone (1980) J. Clin. Orthodon. 14:121–133; Shilliday (1971) Am. J. Orthodontics 59:596–599; Wells (1970) Am. J. Orthodontics 58:351–366; and Cottingham (1969) Am. J. Orthodontics 55:23–31.
Kuroda et al. (1996) Am. J. Orthodontics 110:365–369 describes a method for laser scanning a plaster dental cast to produce a digital image of the cast. See also U.S. Pat. No. 5,605,459.
U.S. Pat. Nos. 5,533,895; 5,474,448; 5,454,717; 5,447,432; 5,431,562; 5,395,238; 5,368,478; and 5,139,419, assigned to Ormco Corporation, describe methods for manipulating digital images of teeth for designing orthodontic appliances.
U.S. Pat. No. 5,011,405 describes a method for digitally imaging a tooth and determining optimum bracket positioning for orthodontic treatment. Laser scanning of a molded tooth to produce a three-dimensional model is described in U.S. Pat. No. 5,338,198. U.S. Pat. No. 5,452,219 describes a method for laser scanning a tooth model and milling a tooth mold. Digital computer manipulation of tooth contours is described in U.S. Pat. Nos. 5,607,305 and 5,587,912. Computerized digital imaging of the jaw is described in U.S. Pat. Nos. 5,342,202 and 5,340,309. Other patents of interest include U.S. Pat. Nos. 5,549,476; 5,382,164; 5,273,429; 4,936,862; 3,860,803; 3,660,900; 5,645,421; 5,055,039; 4,798,534; 4,856,991; 5,035,613; 5,059,118; 5,186,623; and 4,755,139.
In one aspect, a computer-implemented method separates a tooth from an adjacent structure, such as a gingiva, by defining a cutting surface; and applying the cutting surface between the tooth and the structure to separate the tooth in a single cut.
Implementations of the method may include one or more of the following. The cutting surface may be curved. The cutting surface may be expressed as a function, such as a spline function and a quadratic function. The quadratic function can be a parabolic function. The cutting surface can be interactively adjusted, wherein the interactive adjustment of the cutting surface modifies a function defining the cutting surface. The method can include interactively highlighting the separated portion and the border of the separated portion. The cutting surface can be defined by specifying a basis for the tooth. A gingival line separating a tooth surface and a gingiva can be determined. The method can include finding a high curvature location on the tooth surface. A spline can be fit to the gingival line. The cutting surface can be a plurality of surfaces. The root of the tooth can be modeled as a parabolic surface below a gingival line. The method can include defining an enclosing surface to enclose the crown of the tooth. The method also includes displaying the surface specified with a plurality of nodes; adjusting one or more nodes to modify the surface; and applying the surface to separate the gingiva from the tooth.
In another aspect, a system for separating a tooth from an adjacent structure, such as a gingiva, which includes means for defining a cutting surface; and means for applying the cutting surface between the tooth and the structure to separate the tooth from the structure in a single cut.
In another aspect, a computer program, residing on a tangible storage medium, for use in separating gingiva from a computer model of a tooth, the program comprising executable instructions operable to cause a computer to: define a cutting surface along the gingiva; and apply the cutting surface to the tooth to separate the gingiva from the tooth in a single cut.
In another aspect, a computer program, residing on a tangible storage medium, for use in a computer model of a tooth from a computer model of a dental structure, the program comprising executable instructions operable to cause a computer to: define a cutting surface, wherein the cutting surface is expressed as a spline function and a quadratic function; and apply the cutting surface between the computer model of the dental structure and the computer model of the tooth to separate the computer models in a single cut.
In yet another aspect, a computer has a processor, a data storage device coupled to the processor, the data storage device containing code for use in separating a computer model of a tooth from a computer model of an adjacent structure, the program comprising executable instructions operable to cause a computer to: define a cutting surface, wherein the cutting surface is expressed as a spline function and a quadratic function and wherein the cutting surface further comprises a plurality of surfaces and wherein the root of the tooth is modeled as a parabolic surface below a gingival line; and apply the cutting surface to the tooth to separate the gingiva from the tooth in a single cut.
In yet another aspect, a computer-implemented method for separating a dental structure from an adjacent tooth which includes defining a cutting surface along the gingiva; and applying the cutting surface to the tooth to separate the gingiva and reconstruct the root for the tooth in a single cut.
Advantages of the system may include one or more of the following. The system provides a flexible cutter that can be modified to follow the gingival line so user could cut off the gingiva in one single cut. The gingival line defined by user here could also be reused later for the gingival reconstruction process.
Advantages of the invention may include one or more of the following. The system separates gingiva from tooth in a single cut. The system also reconstructs the tooth to provide a root for the tooth in the same operation. The system also generates a crown surface portion of a tooth model relatively quickly by applying the computed functions. The speed in drawing the crown surface allows real time shaping by the user when the user moves the crown control points and the top control points or when the user edits the gingival line. Also it facilitates the finding of the intersection as the system can rapidly determine whether a given point, such as a vertex of the tooth mesh, is inside or outside the gingival cutting surface.
Referring now to
Referring now to
One tool for incrementally repositioning the teeth is a set of one or more adjustment appliances. Suitable appliances include any of the known positioners, retainers, or other removable appliances that are used for finishing and maintaining teeth positions in connection with conventional orthodontic treatment. As described below, a plurality of such appliances can be worn by a patient successively to achieve gradual tooth repositioning. A particularly advantageous appliance is the appliance 111, shown in
The polymeric appliance 111 of
A plaster cast of the patient's teeth is obtained by well known techniques, such as those described in Graber, Orthodontics: Principle and Practice, Second Edition, Saunders, Pa., 1969, pp. 401–415. After the tooth casting is obtained, the casting is digitally scanned by a scanner, such as a non-contact type laser or destructive scanner or a contact-type scanner, to produce the IDDS. The data set produced by the scanner may be presented in any of a variety of digital formats to ensure compatibility with the software used to manipulate images represented by the data. In addition to the 3D image data gathered by laser scanning or destructive scanning the exposed surfaces of the teeth, a user may wish to gather data about hidden features, such as the roots of the patient's teeth and the patient's jaw bones. This information is used to build a detailed model of the patient's dentition and to show with more accuracy and precision how the teeth will respond to treatment. For example, information about the roots allows modeling of all tooth surfaces, instead of just the crowns, which in turn allows simulation of the relationships between the crowns and the roots as they move during treatment. Information about the patient's jaws and gums also enables a more accurate model of tooth movement during treatment. For example, an x-ray of the patient's jaw bones can assist in identifying any close teeth, and an MRI can provide information about the density of the patient's gum tissue. Moreover, information about the relationship between the patient's teeth and other cranial features allows accurate alignment of the teeth with respect to the rest of the head at each of the treatment steps. Data about these hidden features may be gathered from many sources, including 2D and 3D x-ray systems, CT scanners, and magnetic resonance imaging (MRI) systems. Using this data to introduce visually hidden features to the tooth model is described in more detail below.
The IDDS is manipulated using a computer having a suitable graphical user interface (GUI) and software appropriate for viewing and modifying the images. More specific aspects of this process will be described in detail below.
Individual tooth and other components may be segmented or isolated in the model to permit their individual repositioning or removal from the digital model. After segmenting or isolating the components, the user will often reposition the tooth in the model by following a prescription or other written specification provided by the treating professional. Alternatively, the user may reposition one or more teeth based on a visual appearance or based on rules and algorithms programmed into the computer. Once the user is satisfied, the final teeth arrangement is incorporated into a final digital data set (FDDS) (step 204).
The FDDS is used to generate appliances that move the teeth in a specified sequence. First, the centers of each tooth model may be aligned using a number of methods. One method is a standard arch. Then, the teeth models are rotated until their roots are in the proper vertical position. Next, the teeth models are rotated around their vertical axis into the proper orientation. The teeth models are then observed from the side, and translated vertically into their proper vertical position. Finally, the two arches are placed together, and the teeth models moved slightly to ensure that the upper and lower arches properly mesh together. The meshing of the upper and lower arches together is visualized using a collision detection process to highlight the contacting points of the teeth.
In step 204, final positions for the upper and lower teeth in a masticatory system of a patient are determined by generating a computer representation of the masticatory system. An occlusion of the upper and lower teeth is computed from the computer representation; and a functional occlusion is computed based on interactions in the computer representation of the masticatory system. The occlusion may be determined by generating a set of ideal models of the teeth. Each ideal model in the set of ideal models is an abstract model of idealized teeth placement, which is customized to the patient's teeth, as discussed below. After applying the ideal model to the computer representation, the position of the teeth is optimized to fit the ideal model. The ideal model may be specified by one or more arch forms, or may be specified using various features associated with the teeth.
Based on both the IDDS and the FDDS, a plurality of intermediate digital data sets (INTDDSs) are defined to correspond to incrementally adjusted appliances (step 206). Finally, a set of incremental position adjustment appliances are produced based on the INTDDs and the FDDS (step 208).
Many types of scan data, such as that acquired by an optical scanning system, provide a 3D geometric model (e.g., a triangular surface mesh) of the teeth when acquired. Other scanning techniques, such as the destructive scanning technique described above, provide data in the form of volume elements (“voxels”) that can be converted into a digital geometric model of the tooth surfaces. In one implementation, a marching cubes algorithm is applied to convert the voxels into a mesh, which can undergo a smoothing operation to reduce the jaggedness on the surfaces of the tooth model caused by the marching cubes conversion. One smoothing operation moves individual triangle vertices to positions representing the averages of connected neighborhood vertices to reduce the angles between triangles in the mesh.
Another optional step is the application of a decimation operation to the smoothed mesh to eliminate data points, which improves processing speed. After the smoothing and decimation operation have been performed, an error value is calculated based on the differences between the resulting mesh and the original mesh or the original data, and the error is compared to an acceptable threshold value. The smoothing and decimation operations are applied to the mesh once again if the error does not exceed the acceptable value. The last set of mesh data that satisfies the threshold is stored as the tooth model.
The triangles in
The mesh model can also be simplified by removing unwanted or unnecessary sections of the model to increase data processing speed and enhance the visual display. Unnecessary sections include those not needed for creation of the tooth repositioning appliance. The removal of these unwanted sections reduces the complexity and size of the digital data set, thus accelerating manipulations of the data set and other operations. After the user positions and sizes the eraser tool and instructs the software to erase the unwanted section, all triangles within the box set by the user are removed and the border triangles are modified to leave a smooth, linear border. The software deletes all of the triangles within the box and clips all triangles that cross the border of the box. This requires generating new vertices on the border of the box. The holes created in the model at the faces of the box are retriangulated and closed using the newly created vertices.
In alternative embodiments, the computer automatically simplifies the digital model by performing the user-oriented functions described above. The computer applies knowledge of orthodontic relevance to determine which portions of the digital model are unnecessary for image manipulation.
Once a 3D model of the tooth surfaces has been constructed, models of the patient's individual teeth can be derived. In one approach, individual teeth and other components are “cut” using a cutting tool to permit individual repositioning or removal of teeth in or from the digital data. After the components are “freed,” a prescription or other written specification provided by the treating professional is followed to reposition the teeth. Alternatively, the teeth may be repositioned based on the visual appearance or based on rules and algorithms programmed into the computer. Once an acceptable final arrangement has been created, the final tooth arrangement is incorporated into a final digital data set (FDDS).
Referring now to
A saw tool is used to define the individual teeth (or possibly groups of teeth) to be moved. The tool separates the scanned image into individual geometric components enabling the software to move the tooth or other component images independent of remaining portions of the model. In one embodiment, the saw tool defines a path for cutting the graphic image by using two cubic B-spline curves lying in space, possibly constrained to parallel planes, either open or closed. A set of lines connects the two curves and shows the user the general cutting path. The user may edit the control points on the cubic B-splines, the thickness of the saw cut, and the number of erasers used, as described below.
In an alternative embodiment, the teeth are separated by using the saw as a “coring” device, cutting the tooth from above with vertical saw cuts. The crown of the tooth, as well as the gingivae tissue immediately below the crown are separated from the rest of the geometry, and treated as an individual unit, referred to as a tooth. When this model is moved, the gingivae tissue moves relative to the crown, creating a first order approximation of the way that the gingivae will reform within a patient's mouth.
Each tooth may also be separated from the original trimmed model. Additionally, a base may be created from the original trimmed model by cutting off the crowns of the teeth. The resulting model is used as a base for moving the teeth. This facilitates the eventual manufacture of a physical mold from the geometric model, as described below.
Thickness: When a cut is used to separate a tooth, the user will usually want the cut to be as thin as possible. However, the user may want to make a thicker cut, for example, when shaving down surrounding teeth, as described above. Graphically, the cut appears as a curve bounded by the thickness of the cut on one side of the curve.
Number of Erasers: A cut is comprised of multiple eraser boxes arranged next to each other as a piecewise linear approximation of the Saw Tool's curve path. The user chooses the number of erasers, which determines the sophistication of the curve created: the greater the number of segments, the more accurately the cutting will follow the curve. The number of erasers is shown graphically by the number of parallel lines connecting the two cubic B-spline curves. Once a saw cut has been completely specified the user applies the cut to the model. The cut is performed as a sequence of erasings, with a single erasing iteration of the cut as described in the algorithm for a open ended B-spline curve. For a vertical cut, the curves are closed, with PA [O] and PA [S] being the same point and PB [O] and PB [S] being the same point.
In one embodiment, the software automatically partitions the saw tool into a set of erasers based upon a smoothness measure input by the user. The saw is adaptively subdivided until an error metric measures the deviation from the ideal representation to the approximate representation to be less than a threshold specified by the smoothness setting. One error metric compares the linear length of the subdivided curve to the arclength of the ideal spline curve. When the difference is greater than a threshold computed from the smoothness setting, a subdivision point is added along the spline curve.
A preview feature may also be provided in the software. The preview feature visually displays a saw cut as the two surfaces that represent opposed sides of the cut. This allows the user to consider the final cut before applying it to the model data set.
In one embodiment, a flexible plane can be used to splice two more teeth into two groups of teeth. The process displays one or more teeth for the user to review and displays a flexible plane with a plurality of control grid nodes. The flexible plane is formed by a number of surface patches called bicubic Bézier patches. The equation of such patch is well known, and it can be described as:
where u, and v are coordinates in 3D space chosen along a straight plane between the two teeth, and S is the function along the ortho-normal direction to the straight plane,
The process accepts user adjustments to the position of various grid nodes to modify the flexible plane. The cutting curve and tooth portions associated with a flexible plane are then updated in real time. The user can repetitively perform these operations to separate all teeth into individual tooth that is ready for manipulation.
Next, the process 220 clips the gingiva from the tooth using a curved clipping algorithm (260) as described in U.S. patent application Ser. No. 09/539,185, filed on Mar. 30, 2000, entitled “System for Separating Teeth Model”; and U.S. patent application Ser. No. 09/539,021, filed on Mar. 30, 2000, entitled “Flexible Plane for Separating Teeth Model,” the contents of which are incorporated by reference.
The process 220 cuts out the gingival portion of the tooth that has been already separated in a single cut operation and at the same time reconstructs a relatively close root shape.
The cutter of
Additionally, root control points 306 are provided. The behavior of these control points differs than crown controls points 308 in that the set of control points 306 can only be moved in one direction, in and out, except for the pivot control point that can also be moved up and down, and by doing so would actually move all the root controls up and down with it. The goal of adjusting the set of root control points 306 is to define a starting root structure for the cutting tooth.
The system also provides one top control that defines the height of the upper part and one bottom control that defines the depth of the root part. Both can be moved in the up and down direction. The purpose of adjusting the top control point is so that all the crown part of tooth is enclosed within the cutter whereas the purpose of adjusting the bottom control point is to set proper root depth. Additionally, the gingival line can be visualized in a distinguishing color and can be drawn with more emphasis than other lines to enable better visualization during the editing of the gingival cut. The gingival curve created during this process can also be reused in gingival reconstruction. More details on gingival reconstruction can be found in co-pending application having Ser. No. 09/311,716 entitled “Digitally Modeling the Deformation of Gingival Tissue During Orthodontic Treatment,” filed May 14, 1999, the content of which is hereby incorporated by reference.
Next, along a preset number of angles around the z-axis of the tooth, the maximum curvature points along z-direction are found (step 238). These curvature points are found only in the area where a given tooth type could have gingival line. This eliminates finding numerous high curvature points, which are elsewhere due to noise and tooth features themselves. A filtering procedure is used to filter out the points generated by noise in the data (step 240). As the gingival line is often not quite smooth, a smoothing procedure is applied to adjust certain points and to eliminate noisy points on the curve (step 242). A smooth spline curve is fit along the final set of points that are available after filtering and smoothing procedure (step 244). This spline curve represents the gingival line for this tooth. The spline curve can optionally be edited by moving one or more control points on this curve (step 246).
The process of
i a*sqrt(z)+b*z=r
where “a” and “b” are constants. The function can be used to find radius of the point that is equidistant from z-axis for any given z value. The constants a and b are determined by the points through which the curve is passing, namely, a top point 774, a crown point 776 and the gingival point 777.
The portion of the meridian curve that lies below the gingival line 770 has two curves 772 and 773. The curve 772 is linear from the gingival point 777 to a root control point 778. The curve 773 is parabolic with vertex at a bottom control point 775. In one embodiment, this curve is represented by the function
r=d—a*(z−d—b)**2+d—c
where d_a, d_b and d_c are constants and can be computed from the conditions that the curve has to go through the the root control point 778 and the bottom control point 775.
The meridian curves 771, 772 and 773 are determined for each of the control angles that divide 360 degrees around z-axis into a preset number of intervals. Then the points on the meridian curves at uniform z-increments are found. These points at each of the elevations are used to construct a cubic periodic hermite curve 779 around z-axis. Then each of these elevation curves such as curve 779 are evaluated for uniformly distributed preset number of points around the z axis. Thus using the grid of points generated by the elevation curves, meridian curves are used to generate the whole grid for the cutter.
The crown surface part can be generated relatively quickly as it is based on functions. The speed in drawing the crown surface allows real time shaping by the user when the user moves the crown control points and the top control points or when the user edits the gingival line. Also it facilitates the intersection finding itself as the system can rapidly determine whether a given point, such as a vertex of the tooth mesh, is inside or outside the gingival cutting surface.
The initial placement of the crown control points is done using an approximate tooth shape inferred from the tooth identification information (step 256 of
In cases where the gingival line is deep, the crown surface constructed using tooth type information might cut through part of gingiva. For this purpose an “AutoCrown” procedure shown in
The user interface allows the user to turn a solids option on and off so that the surface of the gingival cutter 500 can be visualized from its wire-frame model. The root can be displayed or can remain hidden using a transparency setting and is useful for visualizing the root structure inside the tooth. Intersection geometry can be shown, and the root and crown points and root depth can be specified.
Once the intermediate and final data sets have been created, the appliances may be fabricated as illustrated in
After production, the appliances can be supplied to the treating professional all at one time. The appliances are marked in some manner, typically by sequential numbering directly on the appliances or on tags, pouches, or other items which are affixed to or which enclose each appliance, to indicate their order of use. Optionally, written instructions may accompany the system which set forth that the patient is to wear the individual appliances in the order marked on the appliances or elsewhere in the packaging. Use of the appliances in such a manner will reposition the patient's teeth progressively toward the final tooth arrangement.
Because a patient's teeth may respond differently than originally expected, the treating clinician may wish to evaluate the patient's progress during the course of treatment. The system can also do this automatically, starting from the newly-measured in-course dentition. If the patient's teeth do not progress as planned, the clinician can revise the treatment plan as necessary to bring the patient's treatment back on course or to design an alternative treatment plan. The clinician may provide comments, oral or written, for use in revising the treatment plan. The clinician also can form another set of plaster castings of the patient's teeth for digital imaging and manipulation. The clinician may wish to limit initial aligner production to only a few aligners, delaying production on subsequent aligners until the patient's progress has been evaluated.
The user interface input devices typically include a keyboard and may further include a pointing device and a scanner. The pointing device may be an indirect pointing device such as a mouse, trackball, touchpad, or graphics tablet, or a direct pointing device such as a touchscreen incorporated into the display, or a three dimensional pointing device, such as the gyroscopic pointing device described in U.S. Pat. No. 5,440,326, other types of user interface input devices, such as voice recognition systems, can also be used.
User interface output devices typically include a printer and a display subsystem, which includes a display controller and a display device coupled to the controller. The display device may be a cathode ray tube (CRT), a flat-panel device such as a liquid crystal display (LCD), or a projection device. The display subsystem may also provide non-visual display such as audio output.
Storage subsystem 806 maintains the basic required programming and data constructs. The program modules discussed above are typically stored in storage subsystem 806. Storage subsystem 806 typically comprises memory subsystem 808 and file storage subsystem 814.
Memory subsystem 808 typically includes a number of memories including a main random access memory (RAM) 810 for storage of instructions and data during program execution and a read only memory (ROM) 812 in which fixed instructions are stored. In the case of Macintosh-compatible personal computers the ROM would include portions of the operating system; in the case of IBM-compatible personal computers, this would include the BIOS (basic input/output system).
File storage subsystem 814 provides persistent (non-volatile) storage for program and data files, and typically includes at least one hard disk drive and at least one floppy disk drive (with associated removable media). There may also be other devices such as a CD-ROM drive and optical drives (all with their associated removable media). Additionally, the system may include drives of the type with removable media cartridges. The removable media cartridges may, for example be hard disk cartridges, such as those marketed by Syquest and others, and flexible disk cartridges, such as those marketed by Iomega. One or more of the drives may be located at a remote location, such as in a server on a local area network or at a site on the Internet's World Wide Web.
In this context, the term “bus subsystem” is used generically so as to include any mechanism for letting the various components and subsystems communicate with each other as intended. With the exception of the input devices and the display, the other components need not be at the same physical location. Thus, for example, portions of the file storage system could be connected via various local-area or or wide-area network media, including telephone lines. Similarly, the input devices and display need not be at the same location as the processor, although it is anticipated that personal computers and workstations typically will be used.
Bus subsystem 804 is shown schematically as a single bus, but a typical system has a number of buses such as a local bus and one or more expansion buses (e.g., ADB, SCSI, ISA, EISA, MCA, NuBus, or PCI), as well as serial and parallel ports. Network connections are usually established through a device such as a network adapter on one of these expansion buses or a modem on a serial port. The client computer may be a desktop system or a portable system.
Scanner 820 is responsible for scanning casts of the patient's teeth obtained either from the patient or from an orthodontist and providing the scanned digital data set information to data processing system 800 for further processing. In a distributed environment, scanner 820 may be located at a remote location and communicate scanned digital data set information to data processing system 800 via network interface 824.
Fabrication machine 822 fabricates dental appliances based on intermediate and final data set information received from data processing system 800. In a distributed environment, fabrication machine 822 may be located at a remote location and receive data set information from data processing system 800 via network interface 824.
The invention has been described in terms of particular embodiments. Other embodiments are within the scope of the following claims. For example, the three-dimensional scanning techniques described above may be used to analyze material characteristics, such as shrinkage and expansion, of the materials that form the tooth castings and the aligners. Also, the 3D tooth models and the graphical interface described above may be used to assist clinicians that treat patients with conventional braces or other conventional orthodontic appliances, in which case the constraints applied to tooth movement would be modified accordingly. Moreover, the tooth models may be posted on a hypertext transfer protocol (http) web site for limited access by the corresponding patients and treating clinicians.
This application is a continuation-in-part of application Ser. No. 09/640,328, filed Aug. 16, 2000 now U.S. Pat. No. 6,386,878. The full disclosure of the above application is incorporated herein by reference.
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0091876 | Oct 1983 | EP |
0299490 | Jan 1989 | EP |
0376873 | Jul 1990 | EP |
0490848 | Jun 1992 | EP |
0774933 | May 1997 | EP |
0541500 | Jun 1998 | EP |
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WO 9008512 | Aug 1990 | WO |
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WO 9410935 | May 1994 | WO |
WO 9832394 | Jul 1998 | WO |
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WO 9844865 | Oct 1998 | WO |
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Number | Date | Country | |
---|---|---|---|
20020177108 A1 | Nov 2002 | US |
Number | Date | Country | |
---|---|---|---|
Parent | 09640328 | Aug 2000 | US |
Child | 10087153 | US |