Claims
- 1. A probe for measuring tissue, comprising:
a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less; a delivery optical fiber in the probe coupled at the proximal end to a light source and having a first filter at the distal end; a collection optical fiber in the probe that collects Raman scattered radiation from tissue, the collection optical fiber being coupled at the proximal end to a detector and having a second filter at the distal end; and an optical lens system at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and one of a reflective and refractive optical element.
- 2. The probe of claim 1 wherein the delivery waveguide comprises a rod and the collection waveguide comprises a cylindrical tube, the tube being concentric about the rod.
- 3. The probe of claim 1 wherein the lens comprises a ball lens optically coupled to the delivery fiber and the collection fiber.
- 4. The probe of claim 1 further comprising a sleeve that optically isolates the delivery waveguide from the collection waveguide.
- 5. The probe of claim 1 further comprising a first plurality of collection fibers arranged concentrically about the delivery fiber at a first radius, and a second plurality of collection fibers arranged concentrically about the delivery fiber at a second radius that is larger than the first radius.
- 6. The probe of claim 1 further comprising a controller that gates a collection time, the collection time being less than 2 seconds.
- 7. The probe of claim 1 wherein the optical lens system has a length less than 10 mm.
- 8. The probe of claim 1 wherein the optical lens system has a length of less than 4 mm.
- 9. The probe of claim 1 wherein the light source has a wavelength longer than 750 nm.
- 10. The probe of claim 1 wherein the optical lens systems delivers and collects radiation in a radial direction.
- 11. The probe of claim 1 wherein the probe measures spectral features of cardiac tissue.
- 12. A spectroscopic diagnostic system for measuring tissue comprising:
a fiber optic probe having a proximal end, a distal end; a delivery optical fiber in the probe coupled at the proximal end to a light source to deliver radiation to the distal end, the delivery optical fiber having a first filter at the distal end; a collection optical fiber in the probe that collects Raman scattered radiation from tissue, the collection optical fiber being coupled at the proximal end to a detector system, the collection optical fiber having a second filter at the distal end; and an optical lens system at the distal end of the probe including a delivery waveguide coupled to the delivery optical fiber and a collection waveguide coupled to the collection optical fiber and lens system.
- 13. The spectroscopic diagnostic system of claim 12 wherein the delivery waveguide comprises a rod and the collection waveguide comprises a cylindrical tube, the tube being concentric about the rod.
- 14. The spectroscopic diagnostic system of claim 12 wherein the delivery waveguide comprises a first cylindrical tube and the collection waveguide comprises a second cylindrical tube, the second cylindrical tube being concentric about the first cylindrical tube.
- 15. The spectroscopic diagnostic system of claim 12 wherein the lens system comprises an elliptical axicon optically coupled to the delivery optical fiber and the collection optical fiber.
- 16. The spectroscopic diagnostic system of claim 12 further comprising a sleeve that optically isolates the delivery waveguide from the collection waveguide.
- 17. The spectroscopic diagnostic system of claim 12 further comprising a first plurality of collection fibers arranged concentrically about the delivery fiber at a first radius, and a second plurality of collection fibers arranged concentrically about the delivery fiber at a second radius that is larger than the first radius.
- 18. The spectroscopic diagnostic system of claim 12 wherein the spectroscopic diagnostic system generates a circumferential image.
- 19. The spectroscopic diagnostic system of claim 12 further comprising a controller that gates a collection time, the collection time being less than 2 seconds.
- 20. The spectroscopic diagnostic system of claim 12 wherein the optical lens system has a length less than 10 mm.
- 21. The spectroscopic diagnostic system of claim 12 wherein the optical lens system has a length of less than 4 mm.
- 22. The spectroscopic diagnostic system of claim 12 wherein the light source has a wavelength longer than 750 nm.
- 23. The spectroscopic diagnostic system of claim 12 wherein the optical lens systems delivers and collects radiation in a radial direction.
- 24. A spectroscopic catheter system for measuring system, comprising:
a fiber optic probe having a proximal end and a distal end; at least one delivery optical fiber in the probe coupled at the proximal end to a light source and having a first filter at the distal end; at least one collection optical fiber in the probe that collects Raman scattered radiation from tissue, the collection optical fiber being coupled at the proximal end to a detector and having a second filter at the distal end; and an optical system at the distal end of the probe including a delivery waveguide coupled to the delivery optical fiber, a collection waveguide coupled to the collection optical fiber and one of a reflective and refractive optical element.
- 25. The spectroscopic catheter system of claim 24 further comprising an inflatable balloon disposed around the fiber optic probe.
- 26. The spectroscopic catheter system of claim 25 further comprising a channel for inflating the balloon.
- 27. The spectroscopic catheter system of claim 24 wherein the delivery waveguide comprises a rod and the collection waveguide comprises a cylindrical tube, the tube being concentric about the rod.
- 28. The spectroscopic catheter system of claim 24 wherein the delivery waveguide comprises a first cylindrical tube and the collection waveguide comprises a second cylindrical tube, the second cylindrical tube being concentric about the first cylindrical tube.
- 29. The spectroscopic catheter system of claim 24 wherein the optical element comprises an elliptical axicon optically coupled to the delivery optical fiber and the collection optical fiber.
- 30. The spectroscopic catheter system of claim 24 further comprising a sleeve that optically isolates the delivery waveguide from the collection waveguide.
- 31. The spectroscopic catheter system of claim 24 further comprising a first plurality of collection fibers arranged concentrically about the delivery fiber at a first radius, and a second plurality of collection fibers arranged concentrically about the delivery fiber at a second radius that is larger than the first radius.
- 32. The spectroscopic catheter system of claim 24 wherein the spectroscopic catheter system generates a circumferential image.
- 33. The spectroscopic catheter system of claim 24 wherein the optical element comprises a ball lens optically coupled to the delivery optical fiber and the collection optical fiber.
- 34. The spectroscopic catheter system of claim 24 further comprising a controller that gates a collection time, the collection time being less than 2 seconds.
CROSS REFERENCES TO RELATED APPLICATIONS
[0001] The present application claims the benefit of the U.S. Provisional Patent Application No. 60/370,197, filed Apr. 5, 2002. The entire contents of the above application is incorporated herein by reference in its entirety.
GOVERNMENT SUPPORT
[0002] This invention was supported, in whole or in part, by grants P41-RR-02594 and NIH-HL-64675 from the National Institute of Health. The Government has certain rights in the invention.
Provisional Applications (1)
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Number |
Date |
Country |
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60370197 |
Apr 2002 |
US |