High frequency radiation can be used for skin care applications, such as accelerating blood circulation, strengthening lymph activity, killing bacteria and viruses, and eliminating of acne and pimples. For example, in facial treatment, applying direct or indirect high frequency radiation over the face can reduce wrinkles, tighten skin, and improve skin texture and complexion. In another example, radio frequency (RF) skin tightening is an aesthetic technique that uses RF energy to heat tissue and stimulate subdermal collagen production in order to reduce the appearance of fine lines and loose skin.
However, conventional high-frequency skin care devices are usually bulky and inconvenient to use, and the treatment area is often localized by the active device size. For example, a typical high frequency facial treatment device includes a hand-held piece having a treatment tip whose size is usually on the order of centimeters or less. Therefore, the effect of the treatment, at any given moment, is localized within the area of the skin that is in contact with the tip. In addition, to perform treatment over the entire face, the user (or an additional operator) usually holds hand-held piece and moves it around the face, which can be inconvenient and time consuming.
Embodiments of the present invention include apparatus, systems, and methods for facial treatment and strain sensing. In one example, a method of using a treatment system is disclosed. The treatment system includes a flexible film and circuitry disposed on or within the flexible film. The method includes conformally disposing the flexible film over a face of a user and applying a radio frequency (RF) wave, generated by the circuitry, onto a skin of the face.
In another example, a wearable system for facial treatment of a user includes a flexible film made of a bio-compatible material and circuitry disposed on or within the flexible film and configured to generate an RF wave. When the flexible film is conformally disposed on a face of the user, the RF wave generated by the circuitry is applied to a skin of the face.
In yet another example, a method to estimate skin tension of a user includes disposing a periodic structure in conformal contact with a skin of the user and illuminating the periodic structure with a first light beam. The method also includes measuring a wavelength of a second light beam reflected, transmitted, and/or emitted by the periodic structure in response to the first light beam and estimating the skin tension of the user based at least in part on the wavelength of the second light beam.
In yet another example, a wearable system to estimate skin tension of a user includes a light source to emit a first light beam and a periodic structure, in optical communication with the light source and configured to be conformally attached to a skin of the user during use, to generate a second light beam in response to illumination by the first light beam. The system also includes a detector, in optical communication with the periodic structure, to measure a wavelength of the second light beam. The wavelength of the second light beam is indicative of the skin tension of the user.
It should be appreciated that all combinations of the foregoing concepts and additional concepts discussed in greater detail below (provided such concepts are not mutually inconsistent) are contemplated as being part of the inventive subject matter disclosed herein. In particular, all combinations of claimed subject matter appearing at the end of this disclosure are contemplated as being part of the inventive subject matter disclosed herein. It should also be appreciated that terminology explicitly employed herein that also may appear in any disclosure incorporated by reference should be accorded a meaning most consistent with the particular concepts disclosed herein.
The skilled artisan will understand that the drawings primarily are for illustrative purposes and are not intended to limit the scope of the inventive subject matter described herein. The drawings are not necessarily to scale; in some instances, various aspects of the inventive subject matter disclosed herein may be shown exaggerated or enlarged in the drawings to facilitate an understanding of different features. In the drawings, like reference characters generally refer to like features (e.g., functionally similar and/or structurally similar elements).
Wearable Systems for High Frequency Facial Treatment
To address the inconvenience in conventional high frequency facial treatment techniques, systems and methods described herein integrated wave generation circuitry with a wearable and bio-compatible thin film that can be conformally attached to the face of a user. During operation, a user wears the thin film and the high frequency waves, such as radio frequency (RF) waves, generated by the circuitry, are applied over the user's face. In one example, a power source (e.g., a battery) can be integrated into the thin film to power the wave generation circuitry. In another example, the wave generation circuitry can be powered wirelessly via, for example, induction charging.
The high frequency wave generated by the circuitry can also be used to facilitate medicine delivery. For example, the thin film can be pre-loaded with medicine and the high frequency wave can facilitate driving the medicine into the skin of the user. In another example, the user can apply the medicine on the skin first and then wear the wearable system to drive the medicine into the skin.
The wearable approach described herein eliminates the need for a user (or a third-party operator) to hold the device and move it around the face for treatment. In addition, since the thin film can be configured as a face mask that covers substantially the entire face, the treatment can cover a large area at any given time, thereby addressing the issue of localized RF energy deposition in conventional devices. The combination with wireless energy transfer techniques further allows a user to conveniently control the operation of the circuitry and implement various types of treatment protocols. The wearable approach can also be combined with a conventional facial sheet mask to increase the efficiency of skin care or treatment.
The circuitry 120 also includes an optional antenna 128 operably coupled to the RLC circuit. In one example, the antenna 128 includes a conductive ring configured to receive wireless energy from an external power source (e.g., via inductive charging) and the received energy is used to power the RLC circuit. In another example, the antenna 128 can be configured to emit high frequency electromagnetic waves for facial treatment. The antenna 128 can also be configured to receive control signals, from an external controller (not shown), to control the operation of the circuitry 120. For example, the control signal can control the radiation power of the high frequency waves. The thickness of the antenna 128 can be, for example, greater than the skin depth at the operation frequency of the circuitry 120.
Various materials can be used to form the thin film 110. In general, the thin film 110 is bio-compatible, e.g., not harmful to the user's skin. For example, the thin film 110 can include silicone, polyethylene terephthalate (PET), poly(methyl methacrylate) (PMMA), or polydimethylsiloxane (PDMS). In some cases, the thin film 110 can also be sticky so as to facilitate the conformal contact with the user's face. Alternatively or additionally, system 100 can include an additional sticky interface (not shown in
In some cases, the thin film 110 can be configured as a face mask (also referred to as a mask or mask sheet), as illustrated in
In another example, the thin film 110 can include biocellulose, which is a fiber synthesized by specific bacteria. The fiber used herein can be very thin and therefore have good skin affinity. The fiber can also can hold up to 100 times of its dry weight in water (or serum).
In yet another example, the thin film 110 can include Tencel, which is an eco-friendly synthetic fiber obtained from, e.g., eucalyptus pulp. Tencel usually has extremely soft texture and can be very hypoallergenic. Accordingly, the thin film 110 made of Tencel can have good skin affinity and high air permeability, provides a very comfortable feeling for the user during facial treatment. In addition, the high permeability also allows quick heat dissipation when RF waves are used in the treatment.
In yet another example, the thin film 110 can include coconut gel that is made by specific bacteria during fermentation of coconut juice. Coconut gel can have a denser texture compared to hydrogel but maintain good skin affinity.
In yet another example, the thin film 110 can include cotton that is hypoallergenic and non-irritating. The cost of cotton is usually lower than that of other materials. Accordingly, a facial treatment system 100 made using cotton as the material for the thin film 110 can be a disposable treatment system.
The thickness of the thin film 110 can be substantially equal to or less than 50 μm (e.g., about 50 μm, about 45 μm, about 40 μm, about 35 μm, about 30 μm, about 25 μm, about 20 μm, or less, including any values and sub ranges in between). In use, the thin film 110 can be conformally applied over the face of the user. The conformal contact allows the thin film 110 to stay on the face of the user while the user is performing other tasks. In addition, the conformal contact also allows uniform irradiation of the face by the high frequency waves.
In one example, the circuitry 120 is disposed on the thin film 110. For example, the circuitry 120 can be fabricated on another substrate and then transferred to the thin film 110. Alternatively, the circuitry 120 can be directly fabricated on the thin film 110. In another example, the thin film 110 substantially encloses the circuitry 120. For example, the thin film 110 can include two layers disposed on opposite sides of the circuitry 120 so as to seal the circuitry 120. In one example, the two layers can be made of the same material. In another example, the two layers can be made of different materials. For example, the layer in contact with the face of the user can be made of a bio-compatible material (“first material”), while the other layer opposite the face of the user can be made of any other material (“second material”). The second material can be, for example, the original substrate (e.g., silicon, polyethylene terephthalate or PET) employed for fabricating the circuitry 120.
The frequency of the electromagnetic wave generated by the circuitry 120 can be for example, about 3 kHz to 300 MHz (e.g., about 3 kHz, about 5 kHz, about 10 kHz, about 20 kHz, about 30 kHz, about 50 kHz, about 100 kHz, about 200 kHz, about 300 kHz, about 500 kHz, about 1 MHz, about 2 MHz, about 3 MHz, about 5 MHz, about 10 MHz, about 20 MHz, about 30 MHz, about 50 MHz, about 100 MHz, about 200 MHz, or about 300 MHz, including any values and sub ranges in between). Different treatment protocols may use different frequencies. For example, skin cares may use frequencies from about 60 kHz to about 500 kHz. In another example, medical applications may use frequencies from about 3 kHz to about 300 MHz. When RLC circuit is used to generate the electromagnetic waves, the frequency ω0 of the emitted wave can be determined by ω0=1/(LC)1/2, where L is the inductance of the inductor 124 and C is the capacitance of the capacitor 126.
Although
Compared to visible light or ultra-violet (UV) light treatment, RF treatment can penetrate deeper into the skin, thereby allowing deeper treatment or care of the skin. In some cases, the penetration depth of the high frequency waves generated by the circuitry 120 can be greater than 5 μm (e.g., about 5 μm, about 10 μm, about 15 μm, about 20 μm, about 25 μm, about 30 μm, or greater, including any values and sub ranges in between). In operation, the user can adjust the radiation power to control the penetration depth.
The wearable system 100 can also be configured for medicine delivery. For example, medicine can be pre-loaded into or onto the thin film 110 and the high frequency waves generated by the circuitry 120 can facilitate the delivery of the medicine into or onto the skin of the user. In this example, the wearable system 100 can function as a treatment patch. Alternatively or additionally, the user can apply the medicine on his or her face and then wear the system 100 to increase the delivery efficiency using the high frequency waves generated by the circuitry 120.
In practice, however, the wearable system 100 can be applied to any area of the skin. In addition, other than skin area and treatment, the wearable system 100 can also be used for other treatment. For example, the wearable system 100 may be used for arthritis treatment using its heat generation and drug delivery capabilities.
Methods of Fabricating Wearable Systems for High Frequency Treatment
The wearable system 100 shown in
Out of these methods, fabrication of electronic devices and circuits by additive printing processes (e.g., screen printing) has a number of advantages over printed circuit board (PCB)-based manufacturing techniques. For example, since many components of a circuit can be made of the same material (e.g., metal material for contacts and interconnects), printing allows multiple components to be fabricated simultaneously, thereby reducing the number of processing steps and the material cost. In addition, the low temperatures used in printing are compatible with flexible and inexpensive plastic substrates, allowing fabrication of large-area electronics using high-speed roll-to-roll manufacturing processes.
In some cases, the additive printing technique can be combined with surface-mount technology (SMT) to form a hybrid approach. In this hybrid approach, some electronic components are attached or mounted at low temperature onto the substrates alongside the printed components.
The inductance and DC resistance of the inductor shown in
where μ is the permeability of the core (in this case, air), davg is the average diameter davg=(dout+din)/2, ρ is the fill ratio, i.e., ρ=(dout−din)/(dout+din), and din is the inner diameter: din=dout−2n(w+s). The DC resistance can be calculated by: Rdc=Rsheetl/w using the length l of the spiral, where l=πn[din+(w+s)(n−1)].
In practice, the outer diameter d0 of the inductor can be, for example, from about 5 mm to about 30 cm (e.g., about 5 mm, about 1 cm, about 2 cm, about 3 cm, about 5 cm, about 10 cm, about 20 cm, about 25 cm, or about 30 cm, including any values and sub ranges in between). The turn width w (i.e., the width of the metal strip forming the inductor) can be, for example, from about 50 μm to about 10 mm (e.g., about 50 μm, about 100 μm, about 200 μm, about 300 μm, about 500 μm, about 1 mm, about 2 mm, about 3 mm, about 5 mm, or about 10 mm, including any values and sub ranges in between). The turn spacing s can be, for example, comparable to the turn width, i.e., about 50 μm to about 10 mm. The number of turns n can be, for example, greater than 5 (e.g., 5 turns, 10 turns, 15 turns, 20 turns, 30 turns, or more, including any values and sub ranges in between). In general, the inductance (and the resistance) of the inductor increases as the outer diameter do and number of turns n are increased, or as the turn width w is decreased.
Generally, it can be helpful for the inductor to have low DC resistance to reduce electrical losses. For the inductor shown in
The capacitor (e.g., 126 in
The thickness of dielectric layer in the capacitor can be, for example, about 2 μm to about 200 μm (e.g., about 2 μm, about 3 μm, about 5 μm, about 10 μm, about 20 μm, about 30 μm, about 50 μm, about 100 μm, about 150 μm, or about 200 μm, including any values and sub ranges in between). The area of the capacitor can be, for example, about 0.1 cm2 to about 100 cm2 (e.g., 0.1 cm2, 0.2 cm2, 0.3 cm2, 0.5 cm2, 1 cm2, 2 cm2, 3 cm2, 5 cm2, 10 cm2, 20 cm2, 30 cm2, 50 cm2, or 100 cm2, including any values and sub ranges in between).
A number of approaches can be used to increase the capacitance. For example, a higher dielectric constant can increase the specific capacitance. This can be achieved by increasing the concentration of barium titanate particles in the ink. In another example, the thickness of the dielectric layer can be decreased to increase the capacitance. In yet another example, the capacitor can include multiple alternating layers of metal and dielectric.
The resistor (e.g., 122 in
The circuit 400 shown in
The ink for the conductive components (e.g., inductors and contacts in capacitors and resistors) can be, for example, silver micro-flake ink (e.g., Dupont 5082 or Dupont 5064H). The ink for the resistor can be carbon (e.g., Dupont 7082). For the capacitor dielectric, Conductive Compounds BT-101 barium titanate dielectric can be used. Each coat of dielectric can be produced using a double pass (wet-wet) print cycle to improve uniformity of the film.
In addition to screen printing, vacuum thermal evaporation can also be used to fabricate some components of the circuitry in a wearable system for high frequency treatment.
More information about screen printing of electronic components can be found in Aminy E. Ostfeld, et al., Screen printed passive components for flexible power electronics, Scientific Reports 5, Article number: 15959 (2015), and Jungsuek Oh, et al., Flexible Antenna Integrated with an Epitaxial Lift-Off Solar Cell Array for Flapping-Wing Robots, IEEE Transactions On Antennas and Propagation, Vol. 62, No. 8, August 2014, each of which is hereby incorporated by reference herein in its entirety.
Facial Treatment with a Wearable Treatment System
The thickness of the thin film can be substantially equal to or less than 50 μm so as to facilitate the conformal contact between the thin film and the face of the user. The material of the thin film can be any bio-compatible, such as silicone. The frequency of the RF wave can be, for example, about 3 kHz to about 300 MHz.
To generate the RF wave, the circuitry can include an RLC circuit powered by an antenna configured to receive wireless energy from an external source. The antenna can be further configured to receive control signals to operate the circuitry (e.g., controlling the power of the RF wave to be applied to the user). In some cases, the power of the RF wave can be configured to penetrate into the skin of the user for 10 μm or more.
The method 800 can also be used for medicine delivery. In this case, the method 800 can further include applying medicine over at least one of the face of the user or the flexible thin film, at 830, before conformally disposing the flexible film over the face of the user. The method 800 further includes applying the RF wave to facilitate delivering of the medicine into the skin of the user, at 840. In one example, the medicine is applied onto the face of the user. Alternatively or additionally, the medicine can be pre-loaded onto the thin film to form a treatment patch. The user can then wear the treatment patch and apply the RF wave generated by the circuitry to facilitate the delivery of the medicine into the skin.
Systems for Optical Strain Sensing
Cosmetology focuses significant efforts to promote lifestyle and products that can revitalize skin. One aspect of proper skin care and treatment is to reduce the tension in the skin to maintain a youthful complexion. While many cosmetic products offer to relieve skin tension, there are little experimental studies that can quantify the strain experienced by skin. In this application, system and methods employ an elastomeric optical nanostructure to sense skin tension by monitoring the light reflected, transmitted, or emitted by the nanostructure. The compression or tension of the skin can change the periodicity of the nanostructure, thereby changing the wavelength of the light reflected, transmitted, or emitted by the nanostructure.
This optical strain sensing approach has several advantages. First, it offers a quantifiable metric to gauge strain on skin by monitoring the change of wavelength using a spectrometer. In addition, the spatial resolution of the approach is fine and locally induced strain at micron scale can be detected using a 2-dimensional array of nanostructures with great lateral sensitivity. Accordingly, the skin tension distribution across the entire face or a portion of the face can be visually plotted. The optical nanostructure as described herein is flexible and can be conformally disposed on the face of the user. Therefore, this approach can function properly with uneven skin.
The multilayer structure 920 can use various types of materials. For example, the first material 922(1) can include a first elastomeric compound having a first refractive index and the second material 924(1) can include a second elastomeric compound having a second refractive index different from the first refractive index. The two elastomeric materials can be disposed via spin-coating. In another example, the multilayer structure 920 can include alternating layers of TiO2 and SiO2. In yet another example, the high- and low-refractive-index layers of the multilayer structure 920 can be deposited by oblique-angle deposition and include indium tin oxide (ITO) thin films with low and high porosities. In other words, the refractive index of the two materials 922(1) and 924(1) are adjusted by changing the porosity of the same material (i.e., ITO). The enclosure 930 can include an elastomeric resin and can be printed on both sides of the multilayer structure 920 so as to substantially seal the multilayer structure 920.
In contrast,
The method 1000 can have very high sensitivity due to the micro- or nano-scale changes of the DBR 1112. In practice, the method 1000 can detect a change in skin tension of less than 1% (e.g., about 1%, about 0.8%, about 0.5%, about 0.3%, about 0.2%, about 0.1%, or less, including any values and sub ranges in between).
In contrast,
In operation, the device 1500 is conformally disposed on the skin and input light is delivered to one end of the fiber core 1510 (e.g., via a coupler). As the skin strains or stretches, the DFG 1530 strains or stretches as well, thereby changing the periodicity of the DFG 1530. Accordingly, the wavelength of the light transmitted through the DFG 1530 also changes. More specifically, compression of the skin can blue shift the transmitted light, while stretching of the skin can red shift the transmitted light.
The wavelength of the emission light 1802 depends on the pitch of the nano-antenna 1820, which in turn depends on the stretching or tension of the underneath skin. For example, the compression of the skin can decrease the pitch of the nano-antenna 1820, thereby blue shifting the emission wavelength, while the stretching of the skin can increase the pitch of the nano-antenna 1820, thereby red shifting the emission wavelength.
In one example, the light emitting material 1820 includes a 2D material. In another example, the light emitting material 1820 includes a 3D material. The light emitting material 1820 can include, for example, transition metal dichalcogenide (TMD), which can be generally expressed as MX2, where M is a transition metal atom (e.g., Mo, W, etc.) and X is a chalcogen atom (e.g., S, Se, or Te). Examples of TMD include MoS2, WSe2, and MoSe2. In one example, the light emitting material 1820 can include a single layer of TMD. In another example, the light emitting material 1820 can include a heterostructure, such as a MoS2/Silicon heterostructure or a WSe2/MoS2 heterostructure. In yet another example, the light emitting material 1820 can include quantum wells, which can include one semiconductor material (e.g., gallium arsenide) sandwiched between two layers of a material having a wider bandgap (e.g., aluminium arsenide). In another example, the quantum well can include indium gallium nitride sandwiched between two layers of gallium nitride.
The systems and methods illustrated in
For example, facial rejuvenation is a procedure to restore a youthful appearance to the human face. In one example, facial rejuvenation can be performed via surgical procedures (also referred to as invasive procedures), such as a brow lift (forehead lift), eye lift (blepharoplasty), facelift (rhytidectomy), chin lift, and neck lift. In another example, facial rejuvenation can be performed with non-surgical procedures, such as chemical peels, neuromodulator (e.g., injection of botox), dermal fillers, laser resurfacing, photo-rejuvenation, radiofrequency, and ultrasound. A user (or the service provider) can measure the skin tension before and after each facial rejuvenation to evaluate the effect of the treatment. The evaluation can then be used to instruct subsequent treatment.
In another example, these systems and methods can be employed to measure the strain on one area of the skin while the medicine or treatment is applied on another area of the skin. For example, certain antioxidant product can have beneficial effects on the entire skin system and the skin tension can be monitored at locations most convenient for measurement (e.g., face, arm, hand, etc.) to evaluate the efficacy of the product.
While various inventive embodiments have been described and illustrated herein, those of ordinary skill in the art will readily envision a variety of other means and/or structures for performing the function and/or obtaining the results and/or one or more of the advantages described herein, and each of such variations and/or modifications is deemed to be within the scope of the inventive embodiments described herein. More generally, those skilled in the art will readily appreciate that all parameters, dimensions, materials, and configurations described herein are meant to be exemplary and that the actual parameters, dimensions, materials, and/or configurations will depend upon the specific application or applications for which the inventive teachings is/are used. Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific inventive embodiments described herein. It is, therefore, to be understood that the foregoing embodiments are presented by way of example only and that, within the scope of the appended claims and equivalents thereto, inventive embodiments may be practiced otherwise than as specifically described and claimed. Inventive embodiments of the present disclosure are directed to each individual feature, system, article, material, kit, and/or method described herein. In addition, any combination of two or more such features, systems, articles, materials, kits, and/or methods, if such features, systems, articles, materials, kits, and/or methods are not mutually inconsistent, is included within the inventive scope of the present disclosure.
Also, various inventive concepts may be embodied as one or more methods, of which an example has been provided. The acts performed as part of the method may be ordered in any suitable way. Accordingly, embodiments may be constructed in which acts are performed in an order different than illustrated, which may include performing some acts simultaneously, even though shown as sequential acts in illustrative embodiments.
All definitions, as defined and used herein, should be understood to control over dictionary definitions, definitions in documents incorporated by reference, and/or ordinary meanings of the defined terms.
The indefinite articles “a” and “an,” as used herein in the specification and in the claims, unless clearly indicated to the contrary, should be understood to mean “at least one.”
The phrase “and/or,” as used herein in the specification and in the claims, should be understood to mean “either or both” of the elements so conjoined, i.e., elements that are conjunctively present in some cases and disjunctively present in other cases. Multiple elements listed with “and/or” should be construed in the same fashion, i.e., “one or more” of the elements so conjoined. Other elements may optionally be present other than the elements specifically identified by the “and/or” clause, whether related or unrelated to those elements specifically identified. Thus, as a non-limiting example, a reference to “A and/or B”, when used in conjunction with open-ended language such as “comprising” can refer, in one embodiment, to A only (optionally including elements other than B); in another embodiment, to B only (optionally including elements other than A); in yet another embodiment, to both A and B (optionally including other elements); etc.
As used herein in the specification and in the claims, “or” should be understood to have the same meaning as “and/or” as defined above. For example, when separating items in a list, “or” or “and/or” shall be interpreted as being inclusive, i.e., the inclusion of at least one, but also including more than one, of a number or list of elements, and, optionally, additional unlisted items. Only terms clearly indicated to the contrary, such as “only one of” or “exactly one of,” or, when used in the claims, “consisting of,” will refer to the inclusion of exactly one element of a number or list of elements. In general, the term “or” as used herein shall only be interpreted as indicating exclusive alternatives (i.e., “one or the other but not both”) when preceded by terms of exclusivity, such as “either,” “one of,” “only one of,” or “exactly one of” “Consisting essentially of,” when used in the claims, shall have its ordinary meaning as used in the field of patent law.
As used herein in the specification and in the claims, the phrase “at least one,” in reference to a list of one or more elements, should be understood to mean at least one element selected from any one or more of the elements in the list of elements, but not necessarily including at least one of each and every element specifically listed within the list of elements and not excluding any combinations of elements in the list of elements. This definition also allows that elements may optionally be present other than the elements specifically identified within the list of elements to which the phrase “at least one” refers, whether related or unrelated to those elements specifically identified. Thus, as a non-limiting example, “at least one of A and B” (or, equivalently, “at least one of A or B,” or, equivalently “at least one of A and/or B”) can refer, in one embodiment, to at least one, optionally including more than one, A, with no B present (and optionally including elements other than B); in another embodiment, to at least one, optionally including more than one, B, with no A present (and optionally including elements other than A); in yet another embodiment, to at least one, optionally including more than one, A, and at least one, optionally including more than one, B (and optionally including other elements); etc.
In the claims, as well as in the specification above, all transitional phrases such as “comprising,” “including,” “carrying,” “having,” “containing,” “involving,” “holding,” “composed of,” and the like are to be understood to be open-ended, i.e., to mean including but not limited to. Only the transitional phrases “consisting of” and “consisting essentially of” shall be closed or semi-closed transitional phrases, respectively, as set forth in the United States Patent Office Manual of Patent Examining Procedures, Section 2111.03.
This application claims the priority benefit under 35 U.S.C. § 119(e) of U.S. Application No. 62/418,986, filed Nov. 8, 2016, entitled “WEARABLE HIGH FREQUENCY DEVICE FOR SKIN CARE AND TRANSDERMAL DRUG DELIVERY,” U.S. Application No. 62/487,201, filed Apr. 19, 2017, entitled “OPTICAL STRAIN SENSORS FOR IN SITU SKIN TENSION MEASUREMENT,” and U.S. Application No. 62/486,664, filed Apr. 18, 2017, entitled “OPTICAL SKIN TENSION SENSORS,” each of which is hereby incorporated herein by reference in its entirety.
Filing Document | Filing Date | Country | Kind |
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PCT/US2017/060577 | 11/8/2017 | WO | 00 |
Number | Date | Country | |
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62487201 | Apr 2017 | US | |
62486664 | Apr 2017 | US | |
62418986 | Nov 2016 | US |