The present disclosure relates to methods and systems for conveying articles. The present disclosure more particularly relates to methods and systems for conveying articles comprising a displaceable wall portion configured to adjust the width of the conveyor. More particularly, the present disclosure relates to methods and systems for conveying articles in aseptic environments.
In order to bring down production costs of products that need to be treated under aseptic conditions, such as drugs and medicines, it is often necessary to automate processes related to the handling of containers comprising the same.
An aseptic environment is a necessary condition for the development and manufacturing of biotechnology and pharmaceutical products. An aseptic environment, and any task carried out inside dealing with corresponding products, must comply with standards of Good Manufacturing Practices (GMP). These GMP standards involve the manufacturing, processing, packaging or holding of a drug product. In this respect, there are several standards applicable to equipment in aseptic environments, see for example, EU GMP Part 1, annex1 and annex 15 or 21 CFR part 211 subpart D, in force in March 2022. There are also several design guidelines for equipment such as ASME BPE where comprehensive rules are summarized.
These standards and regulations require that said aseptic environments should be provided with equipment for adequate control over inter alia air pressure, micro-organisms, dust, humidity, and temperature. Further, these standards also state that air filtration systems must be used on air supplies to production areas. It is also generally required to take measures to control recirculation of particulate matter, i.e. dust and/or micro-organisms. Thus, adequate systems to control contaminants such as particulate matter from moving components or from lubricating systems must be provided.
A common approach to automatize the transport of vials and other containers aimed at storing drugs and medicines inside aseptic environments is by using automatic conveying systems. However, conveyors that operate in such aseptic environments must satisfy certain requirements that may not be relevant in other manufacturing environments.
Known conveying systems for aseptic environments generally comprise sidewalls that guide the product along the conveying direction and which limit the transverse motion of the products. The distance between the sidewalls is generally chosen such as to substantially match the width of the product and to only leave a small margin on each side of the product. Therefore, products may be transported along a conveyor in a single line, and the position of the product in a direction across the conveyor may at least be partially controlled. An example of such a conveying system may be arranged between a vial filling station and a freeze-drying station, or between a freeze-drying station and a capping station.
In some cases, the operators of an aseptic environment may require conveying a new product with different dimensions. With reference to the aforementioned example, after a batch of vials with first dimensions has been prepared and transported, a filling station may start to fill a batch of larger vials with a higher amount of content. When this occurs, in order to be able to transport the vials from the vial filling station to e.g. the freeze-drying station, the conveying system needs to be adapted so that the sidewalls substantially match the width of the new product.
To do so, the operators of the cleanroom generally stop the conveyor line, remove the sidewalls of the conveyor system, and install other sidewalls that leave a clearance between them that substantially corresponds to the width of the new product. These new elements evidently have to be sanitized in order to be used in that environment. This results in a tedious and time-consuming task that requires manual labor and can even propagate the contamination of the aseptic environment by the introduction of additional components, i.e. sidewalls, and operators moving in and out of the aseptic environment.
The present disclosure provides systems and methods that at least partially overcome some of the aforementioned drawbacks.
In a first aspect of the present disclosure, a system for conveying articles in an aseptic environment is provided. The system for conveying articles comprises a conveyor belt, a first sidewall portion, a second sidewall portion and an actuator. The conveyor belt, and the first and second sidewall portions define a conveyor path portion. Further, at least one of the first and second sidewall portions is a displaceable wall portion. Thus, the at least one displaceable wall portion is configured to adjust a width of the conveyor path portion to a width of the conveyed article. The actuator is configured to move the displaceable wall portion such that the displaceable wall portion is maintained parallel to a displaceable wall portion that it faces. Additionally, the displaceable wall portion comprises a guided portion configured to be displaced along a guide.
In accordance with this aspect, the system for conveying articles allows to safely convey articles of different sizes using the same sidewall portions. The operators of the conveyor are not required to swap components, i.e. sidewall portions, of the system do adapt the width of the conveyor path portion in case e.g. another batch of articles is to be conveyed.
This can provide a considerable reduction in waiting times during production or handling of receptacles and products of different dimensions and can also reduce the aforementioned contamination related to operators replacing sidewall portions.
The conveyor path portion maintains a constant width, for practical purposes, along its length according to this aspect, i.e. the wall portion is maintained in parallel with a wall portion that it faces (which may or may not be displaceable as well). The displaceable wall portions may in particular be moved in a straight path.
In examples, the guided portion and the guide are configured to be sanitized according to GMP standards.
Further, the system disclosed is suitable for use in an aseptic environment. More precisely, the guided portion of the displaceable wall and the corresponding guide are configured to be cleaned and sanitized according to GMP standards. Thus, both the guided portion and the guide are configured to limit the deposition of debris, and are easy to clean and sanitize. These components substantially avoid difficult to reach areas, and may not include porous or reticulated materials. More precisely, the guided portion and the guide are configured in such a way that they may be effectively cleaned using a cloth containing a sanitizing solution such as distilled water or a solution comprising alcohol.
In the present disclosure, an actuator may be regarded as a component that is responsible for moving and controlling a mechanism or system. I.e. in the present disclosure, the actuator is the element that moves (directly or indirectly) a sidewall portion of the conveyor system. The actuator is powered or forced to move by a drive.
In the present disclosure, a drive may be regarded as a source of energy or power that is supplied to the actuator to move and control the movement of a mechanism. A drive may be e.g. an electric motor.
Throughout the present disclosure, “aseptic” may be understood to mean that an environment is free from contamination caused by particles and/or harmful bacteria, viruses, or other microorganisms and may in specific cases mean that an environment is surgically sterile or sterilized.
Throughout the present disclosure, “sanitizing” may be understood to refer to make something clean and free from bacteria and may include disinfecting.
In a second aspect, a method to adjust a width of a conveyor system in an aseptic environment is provided. The conveyor system comprises a conveyor belt, a first sidewall portion and a second sidewall portion. The method provided comprises displacing at least one of the first and second sidewall portions so that a distance between the first and second sidewall portions is modified. Further, the step of displacing at least one of the sidewall portions is carried out by an actuator that moves the sidewall portion. In addition, the at least one sidewall portion comprises a guided portion configured to be displaced along a guide. Additionally, the guided portion and the guide are configured to be cleaned and sanitized according to GMP standards.
Throughout the present disclosure, aseptic environments should be understood as those environments which comply with the Good Manufacturing Practices (GMP) for aseptic pharmaceutical products. The GMP for aseptic pharmaceutical products include standards for cleaning, sterilization, air filtration, clean air monitoring, microbiological and particulate cleanliness of air and surfaces, etc.,
Throughout the present disclosure, cleaning according to “GMP standards” should be understood as general regulations regarding aseptic environments, as may be found for example in EU GMP Part 1, annex1 and annex 15 or 21 CFR part 211 subpart D, in force in March 2022. More precisely, a component configured to be cleaned according to GMP standards should be understood as a component made of suitable materials and with certain geometric conditions that allow an effective cleaning and sanitization. In this context, a suitable material may be understood as a material that allows reaching sufficiently low levels of surface particle concentration, i.e. low number of individual particles per unit of surface area. This parameter may also depend on surface finish, capacity to be loaded electrostatically and others. Further, suitable materials may be highly resistant to chemical reactions, such as stainless steel, polytetrafluoroethylene (Teflon™), polyvinylidene, polypropylene, polyether ether ketone or perfluoroalkoxy alkane. Further, components configured to be cleaned according to GMP standards may not include shapes and surfaces that may tend to accumulate contaminants on the surface of the component, such as e.g. blind holes.
In this particular context therefore, the guide(s) and guided portion(s) of the sidewall may be made of one of the suitable materials mentioned above. Similarly, the sidewalls on either side of the conveyor belt(s) may be made of such materials as well. And generally, all components that are used in the aseptic environment may be made of such materials.
Additional objects, advantages and features of embodiments of the present disclosure will become apparent to those skilled in the art upon examination of the description, or may be learned by practice.
Non-limiting examples of the present disclosure will be described in the following, with reference to the appended figures, in which:
Reference now will be made in detail to embodiments of the disclosure, one or more examples of which are illustrated in the drawings. Each example is provided by way of explanation, not as a limitation. In fact, it will be apparent to those skilled in the art that various modifications and variations can be made in the present disclosure without departing from the scope or spirit of the teaching. For instance, features illustrated or described as part of one embodiment can be used with another embodiment to yield a still further embodiment. Thus, it is intended that the present disclosure covers such modifications and variations as come within the scope of the appended claims and their equivalents. In general, the same reference signs have been used to denote the same or similar elements across the figures.
The system 100 comprises at least one conveyor belt 10, a first sidewall portion 20 and a second sidewall portion 30. The at least one conveyor belt 10, and the first and second sidewall portions 20, 30 define a conveyor path portion. At least one of the first and second sidewall portions 20, 30 is a displaceable wall portion. The displaceable wall portion(s) is (are) configured to adjust a width of the conveyor path portion to a width of the conveyed article 200.
It is noted that the system 100 may comprise more than one conveyor belt. A plurality of conveyor belts may be arranged to provide a path from one workstation to a next. Each of the conveyor belts may transport articles along a straight line. At or near the end of such a conveyor belt, another conveyor belt may be arranged to transport the article further, possibly in a different direction. Between conveyor belts that are arranged to transport the article(s) in different directions, a suitable transition may be arranged, e.g., a rotating disc or plate as described hereinafter. In examples, the conveyor belts may be arranged in a substantially parallel arrangement, i.e. to create a wider conveying area. Such an arrangement may be used e.g. in combination with a discard unit described hereinafter.
The system 100 comprises an actuator 72 configured to move the displaceable wall portion in a straight path. Furthermore, the displaceable wall portion comprises a guided portion 50 configured to be displaced along a guide 60. Both the guided portion 50 and the guide 60 are configured to be cleaned according to GMP standards.
The actuator 72 in this example moves a bar 76 on which the guided portion 50 is mounted. The bar 76 is further connected to an upstanding rod 40. The upstanding rod 40 at its distal end is mechanically connected to the displaceable wall portion. Movement of the actuator 72 will result in a straight movement of the displaceable wall portion thanks to the guided portion 50 being arranged along a guide 60.
In further examples, the guided portion may be part of the actuator itself.
The actuator 72 may be driven by a drive 70, which may be e.g. an electric motor. When a new batch of articles with dimensions (and particularly a width) that is different from previous articles is to be handled, an operator may set a new width. E.g. a touchscreen or any other type of user interface may be used. Once the system 100 registers the new width, control signals are sent to drive 70 (and other drives of the same conveyor system 100) to drive the actuators 72 such that a width of the conveyor portion is adapted.
The first sidewall portion 20 or the second sidewall portion 30 or both the sidewall portions may be driven to adjust the width of the conveyor path. In such a case each of the sidewall portions 20, 30 can have independent actuators and independent drives 70.
The articles 200 in this example may be vials or small bottles. They may be transported while partially open, or close and may contain e.g. biological or pharmaceutical compositions. In one example, the articles 200 may be vials containing a liquid composition which are conveyed towards a freeze-drying system.
The guide(s) in these examples allow by themselves, or in combination with other guides only a linear displacement, i.e. the system has only one degree of freedom.
In the example shown in
The example of
The system may further comprise further straight conveyor sections arranged downstream of the curved conveyor section. E.g. a first straight conveyor section may form an approximately 90 degree angle with a further straight conveyor section. In between the first and further straight conveyor sections, a curved conveyor section may be arranged. In some examples, the first conveyor section may include a first conveyor belt, the further conveyor section a further conveyor belt, and a rotating circular plate with an independent drive may connect the first and further conveyor sections.
The straight conveyor section in this example may comprise a first displaceable wall portion, i.e. at least one of the sidewall portions as previously illustrated; and the curved conveyor section may comprise a second displaceable wall portion, i.e. at least one of the curved sidewall portions 20, 30. A curved sidewall portion may herein be regarded as a sidewall portion which has at least a curved portion. A curved sidewall portion may have a sidewall with a constant curvature, and in other examples a curved sidewall portion may have a sidewall with a straight portion and one or more curved portions, e.g. curved end portions.
The system 100 in
In some examples, the curved wall portion 20 may be arranged with the two ends 21, 22 below the respective ends of the neighboring wall portions 25, with the two ends 21, 22 above the respective ends of the neighboring wall portions or with one end 21 below and another end 22 above the respective ends of the neighboring wall portions 25. In examples, each end 21, 22 may be mechanically connected to the respective ends of the neighboring wall portion 25, i.e. with a rotatable link, to allow relative motion between wall portions 20, 25 and promote a synchronized motion.
Additionally, the embodiment in
The system 100 may comprise one or more rotatable linkages 74 configured to connect the actuator 72 with the bar 76 on which the guided portion 50 is mounted and contributing to transform the rotation of the actuator 72 into the linear motion of the upstanding rod 40, and, consequently, of the displaceable wall portion. In the present example, the actuator 72 is orientated substantially vertically, but other orientations and rotatable linkages 74 may be used to transform the rotation of the actuator 72 into a linear horizontal motion of the upstanding rod 40.
The use of rotatable linkages and/or rotatable actuators (instead of e.g. gears, or pistons) makes the system more suitable for aseptic environments, as the geometries of these elements avoid blind holes, difficult to clean areas etc. Moreover, in aseptic environments, liquid lubricants or pasty lubricants (e.g. grease, oil) are to be avoided as much as possible.
Further,
The open cross-section of the guide 60 in this example is delimited by an open line 61, i.e. along the periphery of the guide 60, which extends from a first end 62 of the open cross-section to a second end 63 of the open cross-section. Furthermore, the ratio defined by the length of the open line 61 to the shortest distance between the first and second ends 62, 63 of the open line (illustrated with a broken line) may be smaller than 2.2, specifically smaller than 2 and more specifically smaller than 1.75.
In examples, the guide 60 may have a substantially axisymmetric geometry. Further, the guide 60 may be rotatably mounted, e.g. the guide 60 may be configured to rotate about a support 66. The guide 60 may thus rotate as the guided portion is moved by the corresponding actuator(s). The rotation of the guide 60 relative to the guided portion 50 allows cleaning the surface of these two components, i.e. guide 60 and guided portion 50, without the need for disassembling them. This configuration may prevent the existence of hard-to-reach contact surfaces where debris may accumulate and pollute the remaining components of the system.
In some examples, the guide 60 may have a perimeter which is substantially smaller than the length of the path of the guided portion 50. More specifically, the perimeter may be at least 2 times smaller than length of the path of the guided portion 50, and more specifically at least 5 times smaller. This enables effective cleaning of the guides 60 that rotate with the linear motion of the guided portion 50 and reduce the potential accumulation of debris inside the guide 60.
The first sidewall portion 20 comprises a guided portion 50 with a through hole 53 defining a depth and a perimeter. The guides 60 in this case are rods which are configured to be inserted into the respective through holes 53 to guide the displacement of the guided portion. In the present example, the guided portion 50 comprises two through holes 53 through which the corresponding guides 60 are configured to be inserted, but the number of guided portions and guides may be varied.
In other examples, the guide 60 might comprise a through hole and the guided portion 50 may be configured to be inserted into the through hole.
In examples, the length of the path of the guided portion 50 is larger than the depth of the through hole 53, specifically at least 5 times larger than the depth of the through hole 53, and more specifically at least 10 times larger. This enables effectively cleaning the guides 60 that run along the through holes 53 and reduce the potential accumulation of debris inside the through hole 53.
In this example, the discard unit 80 comprises a first and second curved sidewall portions 27, 37 arranged opposite to each other, and defining, for practical purposes, a substantially constant width of the conveyor path. Further, the first curved sidewall portion 27 is configured to promote the displacement of the article 200 across (i.e. transverse to) the conveyor belt 10 arranged along this stretch of the conveyor path.
The second curved sidewall portion 37 has a sidewall segment with an opening, wherein the opening has a height above a plane defined by the conveyor belt 10 such that a tipped over article 202 passes through the opening.
In this example, a sidewall segment 371 is spaced above the plane defined by the conveyor belt 10 at a distance such that a tipped over article 202 can pass below the sidewall segment 371. I.e. the height of the space or gap may be just in excess of a maximum lateral, outside dimension of the articles 200 being conveyed. Thus, an article 202 that has tipped over may pass below the segment 371 into a discard tray 81, whereas upright articles 200 may follow the conveyor path.
In the exemplary embodiment of
In the illustrated embodiment, the operation of the bodies 86, 87 may be carried out by the rotation of their respective ends 861, 862. Other arrangements to operate the bodies 86, 87 of the shutter 85 can also be employed.
Further, the shutter 85 may be automatically driven to rotate one or more bodies 86, 87 from their open position to a closed position, or from a closed position to an open position.
The discard unit 80 or segment 371 of the conveyor system may be combined with any of the examples of
In some examples, the system 100 may be adapted for conveying articles 200 of e.g. two, three or four or more standard dimensions. When preparing the system 100 for a new batch of articles 200, simply one of the predefined articles 200 may be selected. In these examples, as the width of the conveyor portion is adapted, automatically shutter bodies 86, 87 are moved to their open or closed position to increase or reduce the height of the gap or opening in the sidewall. In yet further examples, the system 100 may comprise an imaging system to determine the dimensions of the articles to be conveyed.
In any of the previously illustrated examples, the height of the first and second sidewall portions 20, 30 may be adjustable relative to the conveyor belt 10. This allows placing the first and second sidewall portions 20, 30 to extend vertically higher than the center of gravity of the receptacles 200 being conveyed (for a broad type of receptacles and dimensions). This reduces the risk of a receptacle being tipped over the sidewall portions 20, 30 to ground.
Although only a number of examples have been disclosed herein, other alternatives, modifications, uses and/or equivalents thereof are possible. Furthermore, all possible combinations of the described examples are also covered. Thus, the scope of the present disclosure should not be limited by particular examples, but should be determined only by a fair reading of the claims that follow.
Embodiments are disclosed in the following clauses.
Clause 1. A system (100) for conveying articles (200) in an aseptic environment comprising a conveyor belt (10), a first sidewall portion (20) and a second sidewall portion (30), wherein
Clause 2. The system (100) according to clause 1, wherein the guide (60) has an open cross-section.
Clause 3. The system (100) according to clause 2, wherein the open cross-section is delimited by an open line (61) which extends from a first end (62) of the open cross-section to a second end (63) of the open cross-section, and wherein a ratio of a length of the open line (61) to a shortest distance between the first and second ends (62, 63) of the open line is smaller than 2.2 specially smaller than 2, and more specifically smaller than 1.75.
Clause 4. The system (100) according to any of clauses 2 or 3, wherein the displaceable wall portion comprises at least two guided portions (50), each guided portion (50) being configured to be displaced along a corresponding guide (60).
Clause 5. The system (100) according to any of clauses 1-4, wherein on of the guide (60) and guided portion (50) comprises a through hole (53), defining a depth and a perimeter, through which the other one of the guide (60) and guided portion (50) is configured to be inserted.
Clause 6. The system (100) according to clause 5, wherein a length of a path of the guided portion (50) is larger than the depth of the through hole (53), and more specifically 10 times or more larger than the depth of the through hole (53).
Clause 7. The system (100) according to any of clauses 1-6, wherein the actuator (72) is arranged at a lower vertical level than a neck (201) of the articles (200).
Clause 8. The system (100) according to any of clauses 1-7, wherein the system (100) further comprises a drive (70) arranged at a lower vertical level than the actuator (72) and mechanically coupled with the actuator (72).
Clause 9. The system (100) according to any of clauses 1-8, wherein the actuator is configured to move the displaceable wall portion in a straight path.
Clause 10. The system (100) according to clause 9, wherein the system (100) further comprises one or more rotatable linkages (74) configured to connect the actuator (72) with the bar (76) on which the guided portion (50) is mounted.
Clause 11. The system (100) according to any of clauses 1-10, wherein the system (100) defines a straight conveyor section and a curved conveyor section, and wherein the straight conveyor section comprises a first displaceable wall portion and the curved conveyor section comprises a second displaceable wall portion.
Clause 12. The system (100) according to clause 11, wherein the curved conveyor section comprises a curved wall portion, which is arranged in a staggered configuration with respect to a neighboring wall portion (25).
Clause 13. The system (100) according to any of clauses 1-12, further comprising a discard unit (80) configured to remove tipped articles (202) from the system, wherein
Clause 14. The system (100) according to clause 13, wherein the discard unit (80) comprises a shutter (85) located between the second curved sidewall portion (37) and the conveyor belt (10), the shutter (85) configured to be automatically activated.
Clause 15. A method (300) to adjust a width of a conveyor system (100) in an aseptic environment comprising at least one conveyor belt (10), a first sidewall portion (20) and a second sidewall portion (30), the method (300) comprising:
Number | Date | Country | Kind |
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22382316.2 | Apr 2022 | EP | regional |
This application claims the benefit and priority to International Application No. PCT/EP2023/058867, filed Apr. 4, 2023, which claims the benefit and priority to European Patent Application No. EP22382316.2 filed Apr. 4, 2022, each of which is incorporated by reference herein in its entirety.
Number | Date | Country | |
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Parent | PCT/EP2023/058867 | Apr 2023 | WO |
Child | 18906339 | US |