Embodiments of the subject matter described herein relate generally to fluid infusion devices for delivering a medication fluid to the body of a user. More particularly, embodiments of the subject matter relate to systems and methods for fluid reservoir retention.
Certain diseases or conditions may be treated, according to modern medical techniques, by delivering a medication or other substance to the body of a patient, either in a continuous manner or at particular times or time intervals within an overall time period. For example, diabetes is commonly treated by delivering defined amounts of insulin to the patient at appropriate times. Some common modes of providing insulin therapy to a patient include delivery of insulin through manually operated syringes and insulin pens. Other modern systems employ programmable fluid infusion devices (e.g., insulin pumps) to deliver controlled amounts of insulin to a patient.
A fluid infusion device suitable for use as an insulin pump may be realized as an external device or an implantable device, which is surgically implanted into the body of the patient. External fluid infusion devices include devices designed for use in a generally stationary location (for example, in a hospital or clinic), and devices configured for ambulatory or portable use (to be carried by a patient). External fluid infusion devices may establish a fluid flow path from a fluid reservoir to the patient via, for example, a suitable hollow tubing. The hollow tubing may be connected to a hollow fluid delivery needle that is designed to pierce the patient's skin to deliver an infusion medium to the body. Alternatively, the hollow tubing may be connected directly to the patient's body through a cannula or set of micro-needles.
The fluid reservoir of an external fluid infusion device may be realized as a single-use prefilled disposable unit, a patient-filled unit, a refillable unit, or the like. The fluid reservoir for a typical fluid infusion device is implemented as a removable and replaceable component. In order to ensure proper fluid delivery, the fluid reservoir needs to be properly retained within the fluid infusion device.
Accordingly, it is desirable to provide systems and methods for retention of a removable fluid reservoir in a fluid infusion device to ensure proper insulin delivery. Furthermore, other desirable features and characteristics will become apparent from the subsequent detailed description and the appended claims, taken in conjunction with the accompanying drawings and the foregoing technical field and background.
According to various exemplary embodiments, a fluid infusion device is provided. The fluid infusion device can include a fluid reservoir having a barrel portion and a housing defining a receiving portion for removably receiving the fluid reservoir within the housing. The housing can have a first side including a first engagement system that cooperates with the barrel portion to bias the fluid reservoir relative to the housing in a direction substantially opposite a direction of fluid flow out of the fluid reservoir.
Also provided according to various exemplary embodiments is a fluid infusion device. The fluid infusion device can include a fluid reservoir having a first portion and a second portion. The fluid infusion device can also include a housing defining a receiving portion for removably receiving the fluid reservoir within the housing. The housing can have a first side adjacent to a second side. The first side can include a first engagement system that cooperates with the first portion and the second side can include a second engagement system that cooperates with the second portion. The first engagement system can include a wedge that biases the fluid reservoir relative to the housing in a direction substantially opposite a direction of fluid flow out of the fluid reservoir.
Various exemplary embodiments also provide a fluid infusion device. The fluid infusion device can include a fluid reservoir having a first portion, a second portion and a reservoir defined between the first portion and the second portion for receipt of insulin. The first portion can have a first alignment feature. The fluid infusion device can also include a first housing component including a first engagement system having a member movable by the first alignment feature between a first position and a second position. The fluid infusion device can include a second housing component coupled to the first housing component and including at least partially a second engagement system that cooperates with the second portion of the fluid reservoir. In the second position, the member can bias the fluid reservoir into contact with the second housing component.
In addition, various exemplary embodiments provide a housing for a fluid infusion device. The housing can include a first housing component including a first engagement system. The first housing component can define a first compartment and a second compartment. The first engagement system can be coupled to the second compartment and movable relative to the second compartment. The housing can also include a second housing component coupled to the first compartment of the first housing component. The second housing component can include a second engagement system. The second engagement system can be movable relative to the second housing component.
Various teachings provide a housing for a fluid infusion device. The housing can include a first side extending substantially perpendicular to a first end. The housing can also include a first engagement system coupled adjacent to the first end. A portion of the first engagement system can be movable relative to the first end in a direction substantially parallel to the first end. The housing can also include a second engagement system coupled to the first side. A portion of the second engagement system can be movable relative to the first side in a direction substantially perpendicular to the first side.
According to various exemplary embodiments, a fluid reservoir for use with a fluid infusion device is provided. The fluid reservoir can include a first portion having a first end and a second end. The first end can include an alignment feature and a delivery port. The fluid reservoir can include a second portion coupled to the second end of the first portion, with a portion of the second portion movable within the first portion to advance a fluid out of the delivery port. The fluid reservoir can also include a reservoir defined between the first portion and the second portion that receives the fluid.
Also provided according to various exemplary embodiments is a fluid reservoir for use with a fluid infusion device. The fluid reservoir can include a first portion having a first end and a second end. The first end can include a first alignment feature spaced apart from a second alignment feature and a delivery port adjacent to the first alignment feature. The fluid reservoir can include a second portion including a plunger and a housing. The plunger can be movable within the first portion to advance a fluid out of the delivery port and the housing can be coupled to the second end of the first portion. The fluid reservoir can include a reservoir defined between the first portion and the second portion that receives the fluid.
This summary is provided to introduce a selection of concepts in a simplified form that are further described below in the detailed description. This summary is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used as an aid in determining the scope of the claimed subject matter.
A more complete understanding of the subject matter may be derived by referring to the detailed description and claims when considered in conjunction with the following figures, wherein like reference numbers refer to similar elements throughout the figures.
The following detailed description is merely illustrative in nature and is not intended to limit the embodiments of the subject matter or the application and uses of such embodiments. As used herein, the word “exemplary” means “serving as an example, instance, or illustration.” Any implementation described herein as exemplary is not necessarily to be construed as preferred or advantageous over other implementations. Furthermore, there is no intention to be bound by any expressed or implied theory presented in the preceding technical field, background, brief summary or the following detailed description.
Certain terminology may be used in the following description for the purpose of reference only, and thus are not intended to be limiting. For example, terms such as “top”, “bottom”, “upper”, “lower”, “above”, and “below” could be used to refer to directions in the drawings to which reference is made. Terms such as “front”, “back”, “rear”, “side”, “outboard”, and “inboard” could be used to describe the orientation and/or location of portions of the component within a consistent but arbitrary frame of reference which is made clear by reference to the text and the associated drawings describing the component under discussion. Such terminology may include the words specifically mentioned above, derivatives thereof, and words of similar import. Similarly, the terms “first”, “second”, and other such numerical terms referring to structures do not imply a sequence or order unless clearly indicated by the context.
The following description relates to a fluid infusion device of the type used to treat a medical condition of a patient. The infusion device can be used for infusing fluid into the body of a user. The non-limiting examples described below relate to a medical device used to treat diabetes (more specifically, an insulin pump), although embodiments of the disclosed subject matter are not so limited. Accordingly, the infused medication fluid is insulin in certain embodiments. In alternative embodiments, however, many other fluids may be administered through infusion such as, but not limited to, disease treatments, drugs to treat pulmonary hypertension, iron chelation drugs, pain medications, anti-cancer treatments, medications, vitamins, hormones, or the like. For the sake of brevity, conventional features and characteristics related to infusion system operation, insulin pump and/or infusion set operation, fluid reservoirs, and fluid syringes may not be described in detail here. Examples of infusion pumps and/or related pump drive systems used to administer insulin and other medications may be of the type described in, but not limited to: U.S. Patent Publication No. 2009/0299290 A1; U.S. Patent Publication No. 2008/0269687; U.S. Pat. No. 7,828,764; and U.S. Pat. No. 7,905,868 (the entire content of these patent documents is incorporated by reference herein).
With brief reference to
With reference to
With reference to
In one example, with reference to
Further, it should be understood that in addition to the first compartment 118, second compartment 120 and wall 122, the top housing component 108 can include various other features and components that can enable the housing 102 to cooperate with the base plate 104 to deliver insulin to a user. For example, the top housing component 108 can include features that enable the housing 102 to be removably coupled to the base plate 104, etc. In addition, the first portion 126a and the second portion 126b of the second end 126 can be spaced apart from each other by a third portion 126c, which can be indented or positioned towards the first end 124 more than the first portion 126a and the second portion 126b. This spacing or configuration can enable the fluid path to be established between the housing 102 and the patient. In this regard, a mounting cap 127 including a sealing element (
With continued reference to
With reference to
In one example, the at least one coupling surface 138 can define a first coupling surface 138a and a second coupling surface 138b. The first coupling surface 138a can be spaced apart from the second coupling surface 138b, and can be configured to aid in coupling the bottom housing component 110 to the top housing component 108. In one example, the first coupling surface 138a and second coupling surface 138b can define a recess, which can receive a suitable adhesive along with a portion of the bottom housing component 110 for adhesively coupling the bottom housing component 110 to the top housing component 108. It should be noted that any suitable technique can be used to couple the bottom housing component 110 to the top housing component 108, such as the use of mechanical fasteners, press-fitting, etc.
The reservoir engagement portion 134 can include at least one contact surface 148, at least one retaining bore 150 and a constraining wall 152. In one example, the at least one contact surface 148 can include a first contact surface 148a (
The at least one retaining bore 150 can retain a portion of the reservoir engagement system 114. In one example, the at least one retaining bore 150 can include a first retaining bore 150a (
In one example, the first retaining bore 150a can include a lip 158, which can extend circumferentially about a least a portion of the first retaining bore 150a to aid in guiding and retaining a portion of the reservoir engagement system 114. It should be noted that the lip 158 is merely exemplary, as the first retaining bore 150a can comprise a recess defined within the second side 130. The second retaining bore 150b can comprise a recess defined within the sidewall 154 of the second end 126, and can include a slot 160. The slot 160 can assist in coupling the portion of the reservoir engagement system 114 to the top housing component 108. In one example, the slot 160 can receive an adhesive to fixedly couple a portion of the reservoir engagement system 114 to the top housing component 108. It should be noted that the use of the slot 160 is merely exemplary, as any suitable technique could be used to fixedly couple the portion of the reservoir engagement system 114 to the top housing component 108, such as a mechanical fastener, press-fit, etc.
With reference to
The wall 122 can cooperate with the bottom housing component 110 to couple the top housing component 108 to the bottom housing component 110. In one example, the wall 122 can comprise a tongue portion of a tongue and groove adhesive joint, which can cooperate with a corresponding portion of the bottom housing component 110. The wall 122 can have any suitable height, and for example, can have a varying height, which can correspond to the bottom housing component 110. It should be noted that the wall 122 and the height of the wall 122 is merely exemplary, the bottom housing component 110 could cooperate directly with the surface 108a, if desired.
With reference to
The at least one interference 162 can assist in coupling the bottom housing component 110 to the top housing component 108. In one example, the at least one interference 162 can mate with a recessed slot 174 (
The at least one relief 164 can provide clearance for a portion of the fluid reservoir 106. In one example, the at least one relief 164 can comprise a first relief 164a and a second relief 164b. The first relief 164a can be defined in the reservoir receiving portion 170, and the second relief 164b can be defined in the reservoir receiving portion 170 adjacent to the pinion engagement portion 168. Generally, the at least one relief 164 can provide clearance to accommodate for manufacturing tolerances in the production of the fluid reservoir 106. It should be noted that the use of the at least one relief 164 is merely exemplary, as other manufacturing processes may not require the use of at least one relief 164.
With reference to
With reference to
With reference to
With continued reference to
The at least one coupling flange 182 in one example, can comprise a first coupling flange 182a and a second coupling flange 182b. The first coupling flange 182a and second coupling flange 182b can mate with a corresponding one of the first coupling surface 138a and second coupling surface 138b to couple the bottom housing component 110 to the top housing component 108. Generally, the first coupling flange 182a and second coupling flange 182b can be shaped to enable an adhesive to be positioned between the first coupling flange 182a and second coupling flange 182b and respective ones of the first coupling surface 138a and a second coupling surface 138b to adhesively couple the bottom housing component 110 to the top housing component 108, however, as discussed, any suitable technique could be employed to couple the bottom housing component 110 to the top housing component 108.
With reference to
With reference now to
The at least one projection 202 can contact a portion of the fluid reservoir 106 to create an audible indicator that the fluid reservoir 106 is coupled to the housing 102. In one example, the at least one projection 202 can comprise a first projection 202a and a second projection 202b. The first projection 202a and the second projection 202b can extend outwardly away from the first side 194, and can each include a contact face 206. The contact faces 206 can contact the portion of the fluid reservoir 106, as will be discussed herein. In addition, the first projection 202a and the second projection 202b can be inclined relative to a surface 194a of the first side 194, to provide clearance to another portion of the fluid reservoir 106 such that generally only the contact faces 206 contact the fluid reservoir 106.
With reference to
The perimeter 198 of the snap housing 190 can include at least one or a plurality of retention flanges 208. The retention flanges 208 can be spaced about the perimeter of the snap housing 190, and can cooperate with the first retention flange 180a and second retention flange 180b of the bottom housing component 110 to retain the snap housing 190 within the pinion engagement portion 168. It should be noted that while a plurality of retention flanges 208 are illustrated and described herein, the snap housing 190 could be retained within the pinion engagement portion 168 via any suitable technique, including, but not limited to, a dovetail arrangement or slot and rail. As best illustrated in
With regard to
The reservoir engagement system 114 can be coupled to the reservoir engagement portion 134 of the top housing component 108. The reservoir engagement system 114 can be coupled to and can contact a portion of the fluid reservoir 106 to couple the fluid reservoir 106 to the housing 102. Generally, the reservoir engagement system 114 can engage the fluid reservoir 106 such that the fluid reservoir 106 is biased in the housing 102 in a direction opposite the flow of fluid out of the fluid reservoir 106. Thus, the reservoir engagement system 114 can be movable between a first position, in which the fluid reservoir 106 is not coupled to the housing 102 (
With regard to
The first contact portion 222 can contact or engage a portion of the fluid reservoir 106, and the second contact portion 224 can contact a second portion of the fluid reservoir 106, as will be discussed herein. In one example, the first contact portion 222 can comprise a substantially triangular projection, which can extend outwardly from the first side 216. In one example, the first contact portion 222 can have three sides 226. One of the sides 226 can include a contact face 226a. In one example, the contact face 226a can be formed on the side 226 adjacent to the second contact portion 224. In this example, the contact face 226a can have a slope, which can extend in a direction generally transverse to the longitudinal axis L2. It should be noted, however, that the contact face 226a can have any desired slope, and thus, the slope illustrated herein is merely exemplary. In one example, the slope angle can be less than about 45 degrees to reduce insertion forces associated with the insertion of the fluid reservoir 106. The contact face 226a can contact and guide a portion of the fluid reservoir 106 into the housing 102. The first contact portion 222 can also include a recess 222a, which can facilitate the forming of the wedge 210.
The second contact portion 224 can comprise a projection, which can project outwardly from the first side 216. In one example, the second contact portion 224 can include four sides 224a-224d. The first side 224a can have a length L (
With reference to
With continued reference to
With reference back to
The retention member 214 can couple the wedge 210 and the reservoir biasing member 212 to the top housing component 108. In one example, the retention member 214 can comprise a pin, which can have a first end 214a and a second end 214b. The first end 214a and the second end 214b can be fixedly coupled to the first retaining bore 150a and second retaining bore 150b, respectively, of the top housing component 108. In one example, the retention member 214 can be coupled to the top housing component 108 by adhesives, however, the retention member 214 can be coupled to the top housing component 108 via any suitable technique, such as press-fitting, mechanical fasteners, etc. As a further example, the retention member 214 can be coupled to the top housing component 108 through a press-fit and visible light cure adhesive.
With reference to
With regard to
The delivery port 240 can establish the fluid flow path to the patient. Generally, the fluid can flow from the reservoir 238 out the delivery port 240 into the cannula 107 for delivery to the patient. The delivery port 240 can include a pierceable septum if the fluid reservoir 106 is a prefilled unit. Alternatively, the delivery port 240 may include a vented opening to accommodate filling of the fluid reservoir 106 by the patient, a doctor, a caregiver, or the like. In one example, the delivery port 240 can be formed near or along a first side 234a of the first end 234 and the first alignment feature 242, second alignment feature 244 and third alignment feature 246 can be formed near or along a second side 234b of the first end 234.
The first alignment feature 242 can be substantially opposite the delivery port 240. The first alignment feature 242 can laterally align the fluid reservoir 106 relative to the housing 102. In one example, the first alignment feature 242 can comprise a geometric projection. For example, the first alignment feature 242 can include one or more walls 248. In one example, the walls 248 can cooperate to define a geometric projection having a substantially rectangular shape. In this example, one of the walls 248a can be arcuate, to conform with the surface 108a of the top housing component 108. It should be noted that the geometric shape formed by the walls 248 is merely exemplary, as the first alignment feature 242 can have any desired shape to constrain and align the fluid reservoir 106 relative to the housing 102. Generally, the first alignment feature 242 can be positioned near the first end 210a of the wedge 210 when the fluid reservoir 106 is coupled to the housing 102.
The second alignment feature 244 can be defined between the first alignment feature 242 and the third alignment feature 246. In one example, the second alignment feature 244 can comprise a wall. The second alignment feature 244 can have a first surface 250 and a second surface 252. The first surface 250 can extend outwardly from the first end 234 so as to be substantially perpendicular to a longitudinal axis of the barrel portion 230, while the second surface 252 can be arcuate. The arcuate shape of the second surface 252 can act as a ramp, which can cooperate with the third side 224c of the second contact portion 224 of the wedge 210. The contact between the second surface 252 and the wedge 210 can bias the fluid reservoir 106 in the direction opposite of the direction of fluid flow out of the reservoir 238, as illustrated in
The third alignment feature 246 can comprise a geometric projection, which can extend outwardly from the first end 234. In one example, the third alignment feature 246 can have sides 254, which can include a first side 254a, a second side 254b, a third side 254c and a fourth side 254d. Generally, the third alignment feature 246 can be sized to fit between the first contact portion 222 of the wedge 210 and the surface 108a of the top housing component 108. The second side 254b can be angled relative to the first side 254a and the third side 254c. A contact surface 256 can be formed between the second side 254b and the third side 254c, which can contact and move along the face 226a of the first contact portion 222 of the wedge 210 when the fluid reservoir 106 is coupled to the housing 102. The movement of the contact surface 256 along the first contact portion 222 can cause the wedge 210 to move from a first position to a second position against the force of the reservoir biasing member 212 towards the second side 130 of the top housing component 108. As will be discussed herein, once the contact surface 262 moves past the face 226a of the first contact portion 222, the reservoir biasing member 212 can move from the second, compressed position to the first, uncompressed position, which can move the second contact portion 224 of the wedge 210 into contact with the second alignment feature 244. The movement of the second contact portion 224 into contact with the second alignment feature 244 can cause audible feedback, such as a snap, which can be heard by the user. This can aid the user in determining that the fluid reservoir 106 is properly coupled to the housing 102. The fourth side 254d can be arcuate.
With reference to
The plunger guide 232 can be used to dispense fluid from the reservoir 238. The plunger guide 232 can include a plunger 263 and a housing 264. The plunger 263 can move relative to the housing 264. Generally, the plunger 263 can include a platform 266 and a rack 268 coupled to the platform 266. The platform 266 can include one or more sealing elements 266a, 266b, which can be circumferentially disposed about a perimeter of the platform 266. The sealing elements 266a, 266b can prevent fluid from escaping from the second end 236 of the reservoir 238 when the plunger guide 232 is coupled to the second end 236.
The rack 268 can be fixedly coupled to the platform 266 so that the advancement of the rack 268 can move the platform 266 within the reservoir 238. The rack 268 can include a plurality of teeth 268a, which can meshingly engage a plurality of teeth on a pinion coupled to the housing 102. The rack 268 can be driven by the pinion to advance the platform 266 within the reservoir 238 to dispense fluid out of the delivery port 240.
The housing 264 can include a base 270 and a rack receiving portion 272. The base 270 can be sized and configured to be received within and coupled to the second end 236 of the barrel portion 230. Generally, the base 270 can be substantially oval in shape, and can include a projection 270a. The projection 270a can be received within the slot 236a of the second end 236 of the barrel portion 230 to couple the housing 264 to the barrel portion 230. The cooperation between the projection 270a and slot 236a can provide error-proofing in the assembly of the housing 264 to the barrel portion 230. The base 270 can also define an opening, which can slidably receive a portion of the rack 268 therethrough. The opening of the base 270 can be in communication with the rack receiving portion 272.
The rack receiving portion 272 can extend outwardly from the base 270. The rack receiving portion 272 can include a bore or cavity 274, at least one contact surface 276 and a removal portion 278. In one example, the cavity 274 can be sized to movably or slidably receive the rack 268, and can be in communication with the opening of the base 270. The cavity 274 can also include a cutout portion 274a defined near a first end 272a of the rack receiving portion 272, which can enable the rack 268 to engage the pinion.
With reference to
In this regard, the first contact surface 276a and the second contact surface 276b can each include an insertion ramp 280, a recess 282 and a removal ramp 284, which can be unitarily formed. It should be noted that although the at least one contact surface 276 is described and illustrated herein as having two contact surfaces, the at least one contact surface 276 could have any number of contact surfaces, including, but not limited to a signal contact surface. The recess 282 can be defined between the insertion ramp 280 and the removal ramp 284, and can receive the contact faces 206 of the snap housing 190 when the fluid reservoir 106 is coupled to the housing 102. The insertion ramp 280 can have a slope, such that as the fluid reservoir 106 is inserted into the housing 102, the insertion ramp 280 can move the snap housing 190 against the force of the biasing member 192. Once the fluid reservoir 106 is properly coupled to the housing 102, the spring force from the biasing member 192 can move or push the snap housing 190 such that contact faces 206 contact the recess 282, as shown in
With reference back to
The removal portion 278 can be defined at a second end 272b of the rack receiving portion 272. In one example, the removal portion 278 can comprise a tab, which can be received within a slot 286 defined within the top housing component 108 (
In order to assemble the fluid infusion device 100, the bottom housing component 110 can be coupled to the top housing component 108. Then, in one example, the fluid reservoir 106 can be coupled to the housing 102 in a straight in insertion. In this example, the patient can press down on the barrel portion 230 to couple the fluid reservoir 106 to the housing 102. The application of force on the barrel portion 230 can cause the third alignment feature 246 to contact the face 226a of the first contact portion 222 of the wedge 210 (
Substantially simultaneously, as the third alignment feature 246 slides off the face 226a of the first contact portion 222, the continued application of the force to the barrel portion 230 can cause the insertion ramp 280 of the first contact surface 276a and second contact surface 276b to bias the snap housing 190 against the biasing member 192 (
In another example, the fluid reservoir 106 can be inserted into the housing 102 similar to the insertion of a battery into a battery housing. In this example, the barrel portion 230 can be inserted at an angle into the second compartment 120 of the top housing component 108, and generally rotated slightly so that the second surface 252 can contact the second contact portion 224 of the wedge 210. This contact can bias the wedge 210 against the force of the reservoir biasing member 212.
Then, the plunger guide 232 can be inserted into the reservoir receiving portion 170 of the bottom housing portion 110. The application of force to the plunger guide 232 can cause the insertion ramp 280 of the first contact surface 276a and second contact surface 276b to bias the snap housing 190 against the biasing member 192. Then, the contact faces 206 can snap into the recesses 282 of the first contact surface 276a and second contact surface 276b to provide additional audible feedback that the fluid reservoir 106 is coupled to the housing 102.
While at least one exemplary embodiment has been presented in the foregoing detailed description, it should be appreciated that a vast number of variations exist. It should also be appreciated that the exemplary embodiment or embodiments described herein are not intended to limit the scope, applicability, or configuration of the claimed subject matter in any way. Rather, the foregoing detailed description will provide those skilled in the art with a convenient road map for implementing the described embodiment or embodiments. It should be understood that various changes can be made in the function and arrangement of elements without departing from the scope defined by the claims, which includes known equivalents and foreseeable equivalents at the time of filing this patent application.
Number | Name | Date | Kind |
---|---|---|---|
2672868 | Hickey | Mar 1954 | A |
3631847 | Hobbs, II | Jan 1972 | A |
4212738 | Henne | Jul 1980 | A |
4270532 | Franetzki et al. | Jun 1981 | A |
4282872 | Franetzki et al. | Aug 1981 | A |
4373527 | Fischell | Feb 1983 | A |
4395259 | Prestele et al. | Jul 1983 | A |
4433072 | Pusineri et al. | Feb 1984 | A |
4443218 | DeCant, Jr. et al. | Apr 1984 | A |
4494950 | Fischell | Jan 1985 | A |
4542532 | McQuilkin | Sep 1985 | A |
4550731 | Batina et al. | Nov 1985 | A |
4559037 | Franetzki et al. | Dec 1985 | A |
4562751 | Nason et al. | Jan 1986 | A |
4671288 | Gough | Jun 1987 | A |
4678408 | Nason et al. | Jul 1987 | A |
4685903 | Cable et al. | Aug 1987 | A |
4731051 | Fischell | Mar 1988 | A |
4731726 | Allen, III | Mar 1988 | A |
4781798 | Gough | Nov 1988 | A |
4803625 | Fu et al. | Feb 1989 | A |
4809697 | Causey, III et al. | Mar 1989 | A |
4826810 | Aoki | May 1989 | A |
4871351 | Feingold | Oct 1989 | A |
4898578 | Rubalcaba, Jr. | Feb 1990 | A |
4936833 | Sams | Jun 1990 | A |
5003298 | Havel | Mar 1991 | A |
5011468 | Lundquist et al. | Apr 1991 | A |
5019974 | Beckers | May 1991 | A |
5050612 | Matsumura | Sep 1991 | A |
5078683 | Sancoff et al. | Jan 1992 | A |
5080653 | Voss et al. | Jan 1992 | A |
5097122 | Colman et al. | Mar 1992 | A |
5100380 | Epstein et al. | Mar 1992 | A |
5101814 | Palti | Apr 1992 | A |
5108819 | Heller et al. | Apr 1992 | A |
5153827 | Coutre et al. | Oct 1992 | A |
5165407 | Wilson et al. | Nov 1992 | A |
5247434 | Peterson et al. | Sep 1993 | A |
5262035 | Gregg et al. | Nov 1993 | A |
5262305 | Heller et al. | Nov 1993 | A |
5264104 | Gregg et al. | Nov 1993 | A |
5264105 | Gregg et al. | Nov 1993 | A |
5284140 | Allen et al. | Feb 1994 | A |
5299571 | Mastrototaro | Apr 1994 | A |
5307263 | Brown | Apr 1994 | A |
5317506 | Coutre et al. | May 1994 | A |
5320725 | Gregg et al. | Jun 1994 | A |
5322063 | Allen et al. | Jun 1994 | A |
5338157 | Blomquist | Aug 1994 | A |
5339821 | Fujimoto | Aug 1994 | A |
5341291 | Roizen et al. | Aug 1994 | A |
5350411 | Ryan et al. | Sep 1994 | A |
5356786 | Heller et al. | Oct 1994 | A |
5357427 | Langen et al. | Oct 1994 | A |
5368562 | Blomquist et al. | Nov 1994 | A |
5370622 | Livingston et al. | Dec 1994 | A |
5371687 | Holmes, II et al. | Dec 1994 | A |
5376070 | Purvis et al. | Dec 1994 | A |
5390671 | Lord et al. | Feb 1995 | A |
5391250 | Cheney, II et al. | Feb 1995 | A |
5403700 | Heller et al. | Apr 1995 | A |
5411647 | Johnson et al. | May 1995 | A |
5482473 | Lord et al. | Jan 1996 | A |
5485408 | Blomquist | Jan 1996 | A |
5497772 | Schulman et al. | Mar 1996 | A |
5505709 | Funderburk et al. | Apr 1996 | A |
5543326 | Heller et al. | Aug 1996 | A |
5569186 | Lord et al. | Oct 1996 | A |
5569187 | Kaiser | Oct 1996 | A |
5573506 | Vasko | Nov 1996 | A |
5582593 | Hultman | Dec 1996 | A |
5586553 | Halili et al. | Dec 1996 | A |
5593390 | Castellano et al. | Jan 1997 | A |
5593852 | Heller et al. | Jan 1997 | A |
5594638 | Illiff | Jan 1997 | A |
5609060 | Dent | Mar 1997 | A |
5611785 | Mito et al. | Mar 1997 | A |
5626144 | Tacklind et al. | May 1997 | A |
5630710 | Tune et al. | May 1997 | A |
5643212 | Coutre et al. | Jul 1997 | A |
5660163 | Schulman et al. | Aug 1997 | A |
5660176 | Iliff | Aug 1997 | A |
5665065 | Colman et al. | Sep 1997 | A |
5665222 | Heller et al. | Sep 1997 | A |
5685844 | Marttila | Nov 1997 | A |
5687734 | Dempsey et al. | Nov 1997 | A |
5704366 | Tacklind et al. | Jan 1998 | A |
5750926 | Schulman et al. | May 1998 | A |
5754111 | Garcia | May 1998 | A |
5764159 | Neftel | Jun 1998 | A |
5772635 | Dastur et al. | Jun 1998 | A |
5779665 | Mastrototaro et al. | Jul 1998 | A |
5788669 | Peterson | Aug 1998 | A |
5791344 | Schulman et al. | Aug 1998 | A |
5800420 | Gross et al. | Sep 1998 | A |
5807336 | Russo et al. | Sep 1998 | A |
5814015 | Gargano et al. | Sep 1998 | A |
5822715 | Worthington et al. | Oct 1998 | A |
5832448 | Brown | Nov 1998 | A |
5840020 | Heinonen et al. | Nov 1998 | A |
5861018 | Feierbach et al. | Jan 1999 | A |
5868669 | Iliff | Feb 1999 | A |
5871465 | Vasko | Feb 1999 | A |
5879143 | Cote | Mar 1999 | A |
5879163 | Brown et al. | Mar 1999 | A |
5885245 | Lynch et al. | Mar 1999 | A |
5897493 | Brown | Apr 1999 | A |
5899855 | Brown | May 1999 | A |
5904708 | Goedeke | May 1999 | A |
5913310 | Brown | Jun 1999 | A |
5917346 | Gord | Jun 1999 | A |
5918603 | Brown | Jul 1999 | A |
5925021 | Castellano et al. | Jul 1999 | A |
5933136 | Brown | Aug 1999 | A |
5935099 | Peterson et al. | Aug 1999 | A |
5940801 | Brown | Aug 1999 | A |
5956501 | Brown | Sep 1999 | A |
5960403 | Brown | Sep 1999 | A |
5965380 | Heller et al. | Oct 1999 | A |
5972199 | Heller et al. | Oct 1999 | A |
5978236 | Faberman et al. | Nov 1999 | A |
5997476 | Brown | Dec 1999 | A |
5999848 | Gord et al. | Dec 1999 | A |
5999849 | Gord et al. | Dec 1999 | A |
6009339 | Bentsen et al. | Dec 1999 | A |
6032119 | Brown et al. | Feb 2000 | A |
6043437 | Schulman et al. | Mar 2000 | A |
6081736 | Colvin et al. | Jun 2000 | A |
6083710 | Heller et al. | Jul 2000 | A |
6088608 | Schulman et al. | Jul 2000 | A |
6101478 | Brown | Aug 2000 | A |
6103033 | Say et al. | Aug 2000 | A |
6119028 | Schulman et al. | Sep 2000 | A |
6120676 | Heller et al. | Sep 2000 | A |
6121009 | Heller et al. | Sep 2000 | A |
6134461 | Say et al. | Oct 2000 | A |
6143164 | Heller et al. | Nov 2000 | A |
6162611 | Heller et al. | Dec 2000 | A |
6175752 | Say et al. | Jan 2001 | B1 |
6183412 | Benkowski et al. | Feb 2001 | B1 |
6246992 | Brown | Jun 2001 | B1 |
6259937 | Schulman et al. | Jul 2001 | B1 |
6329161 | Heller et al. | Dec 2001 | B1 |
6408330 | DeLaHuerga | Jun 2002 | B1 |
6424847 | Mastrototaro et al. | Jul 2002 | B1 |
6472122 | Schulman et al. | Oct 2002 | B1 |
6484045 | Holker et al. | Nov 2002 | B1 |
6484046 | Say et al. | Nov 2002 | B1 |
6503381 | Gotoh et al. | Jan 2003 | B1 |
6514718 | Heller et al. | Feb 2003 | B2 |
6544173 | West et al. | Apr 2003 | B2 |
6553263 | Meadows et al. | Apr 2003 | B1 |
6554798 | Mann et al. | Apr 2003 | B1 |
6558320 | Causey, III et al. | May 2003 | B1 |
6558351 | Steil et al. | May 2003 | B1 |
6560741 | Gerety et al. | May 2003 | B1 |
6565509 | Say et al. | May 2003 | B1 |
6579690 | Bonnecaze et al. | Jun 2003 | B1 |
6591125 | Buse et al. | Jul 2003 | B1 |
6592745 | Feldman et al. | Jul 2003 | B1 |
6605200 | Mao et al. | Aug 2003 | B1 |
6605201 | Mao et al. | Aug 2003 | B1 |
6607658 | Heller et al. | Aug 2003 | B1 |
6616819 | Liamos et al. | Sep 2003 | B1 |
6618934 | Feldman et al. | Sep 2003 | B1 |
6623501 | Heller et al. | Sep 2003 | B2 |
6641533 | Causey, III et al. | Nov 2003 | B2 |
6654625 | Say et al. | Nov 2003 | B1 |
6659980 | Moberg et al. | Dec 2003 | B2 |
6671554 | Gibson et al. | Dec 2003 | B2 |
6676816 | Mao et al. | Jan 2004 | B2 |
6689265 | Heller et al. | Feb 2004 | B2 |
6728576 | Thompson et al. | Apr 2004 | B2 |
6733471 | Ericson et al. | May 2004 | B1 |
6746582 | Heller et al. | Jun 2004 | B2 |
6747556 | Medema et al. | Jun 2004 | B2 |
6749740 | Liamos et al. | Jun 2004 | B2 |
6752787 | Causey, III et al. | Jun 2004 | B1 |
6809653 | Mann et al. | Oct 2004 | B1 |
6881551 | Heller et al. | Apr 2005 | B2 |
6892085 | McIvor et al. | May 2005 | B2 |
6893545 | Gotoh et al. | May 2005 | B2 |
6895263 | Shin et al. | May 2005 | B2 |
6916159 | Rush et al. | Jul 2005 | B2 |
6932584 | Gray et al. | Aug 2005 | B2 |
6932894 | Mao et al. | Aug 2005 | B2 |
6942518 | Liamos et al. | Sep 2005 | B2 |
7153263 | Carter et al. | Dec 2006 | B2 |
7153289 | Vasko | Dec 2006 | B2 |
7396330 | Banet et al. | Jul 2008 | B2 |
7828764 | Moberg et al. | Nov 2010 | B2 |
7905868 | Moberg et al. | Mar 2011 | B2 |
8512287 | Cindrich | Aug 2013 | B2 |
20010044731 | Coffman et al. | Nov 2001 | A1 |
20020013518 | West et al. | Jan 2002 | A1 |
20020055857 | Mault et al. | May 2002 | A1 |
20020082665 | Haller et al. | Jun 2002 | A1 |
20020137997 | Mastrototaro et al. | Sep 2002 | A1 |
20020161288 | Shin et al. | Oct 2002 | A1 |
20030060765 | Campbell et al. | Mar 2003 | A1 |
20030078560 | Miller et al. | Apr 2003 | A1 |
20030088166 | Say et al. | May 2003 | A1 |
20030144581 | Conn et al. | Jul 2003 | A1 |
20030152823 | Heller | Aug 2003 | A1 |
20030161744 | Vilks et al. | Aug 2003 | A1 |
20030176183 | Drucker et al. | Sep 2003 | A1 |
20030188427 | Say et al. | Oct 2003 | A1 |
20030199744 | Buse et al. | Oct 2003 | A1 |
20030208113 | Mault et al. | Nov 2003 | A1 |
20030220552 | Reghabi et al. | Nov 2003 | A1 |
20040061232 | Shah et al. | Apr 2004 | A1 |
20040061234 | Shah et al. | Apr 2004 | A1 |
20040064133 | Miller et al. | Apr 2004 | A1 |
20040064156 | Shah et al. | Apr 2004 | A1 |
20040073095 | Causey, III et al. | Apr 2004 | A1 |
20040074785 | Holker et al. | Apr 2004 | A1 |
20040093167 | Braig et al. | May 2004 | A1 |
20040097796 | Berman et al. | May 2004 | A1 |
20040102683 | Khanuja et al. | May 2004 | A1 |
20040111017 | Say et al. | Jun 2004 | A1 |
20040122353 | Shahmirian et al. | Jun 2004 | A1 |
20040167465 | Mihai et al. | Aug 2004 | A1 |
20040204673 | Flaherty | Oct 2004 | A1 |
20040263354 | Mann et al. | Dec 2004 | A1 |
20050038331 | Silaski et al. | Feb 2005 | A1 |
20050038680 | McMahon et al. | Feb 2005 | A1 |
20050154271 | Rasdal et al. | Jul 2005 | A1 |
20050192557 | Brauker et al. | Sep 2005 | A1 |
20060229694 | Schulman et al. | Oct 2006 | A1 |
20060238333 | Welch et al. | Oct 2006 | A1 |
20060293571 | Bao et al. | Dec 2006 | A1 |
20070078393 | Lynch et al. | Apr 2007 | A1 |
20070088521 | Shmueli et al. | Apr 2007 | A1 |
20070135866 | Baker et al. | Jun 2007 | A1 |
20080077081 | Mounce et al. | Mar 2008 | A1 |
20080154503 | Wittenber et al. | Jun 2008 | A1 |
20080269687 | Chong et al. | Oct 2008 | A1 |
20090081951 | Erdmann et al. | Mar 2009 | A1 |
20090082635 | Baldus et al. | Mar 2009 | A1 |
20090299290 | Moberg | Dec 2009 | A1 |
20100137790 | Yodfat | Jun 2010 | A1 |
20100325864 | Briones et al. | Dec 2010 | A1 |
20110160654 | Hanson et al. | Jun 2011 | A1 |
20110160655 | Hanson et al. | Jun 2011 | A1 |
20110160666 | Hanson et al. | Jun 2011 | A1 |
20110160667 | Bazargan et al. | Jun 2011 | A1 |
20120215179 | Halili et al. | Aug 2012 | A1 |
Number | Date | Country |
---|---|---|
4329229 | Mar 1995 | DE |
0319268 | Nov 1988 | EP |
0806738 | Nov 1997 | EP |
0880936 | Dec 1998 | EP |
1338295 | Aug 2003 | EP |
1631036 | Mar 2006 | EP |
2218831 | Nov 1989 | GB |
WO 9620745 | Jul 1996 | WO |
WO 9636389 | Nov 1996 | WO |
WO 9637246 | Nov 1996 | WO |
WO 9721456 | Jun 1997 | WO |
WO 9820439 | May 1998 | WO |
WO 9824358 | Jun 1998 | WO |
WO 9842407 | Oct 1998 | WO |
WO 9849659 | Nov 1998 | WO |
WO 9859487 | Dec 1998 | WO |
WO 9908183 | Feb 1999 | WO |
WO 9910801 | Mar 1999 | WO |
WO 9918532 | Apr 1999 | WO |
WO 9922236 | May 1999 | WO |
WO 0010628 | Mar 2000 | WO |
WO 0019887 | Apr 2000 | WO |
WO 0048112 | Aug 2000 | WO |
WO 02058537 | Aug 2002 | WO |
WO 03001329 | Jan 2003 | WO |
WO 03094090 | Nov 2003 | WO |
WO 2005065538 | Jul 2005 | WO |
Entry |
---|
PCT Search Report (PCT/US02/03299), Oct. 31, 2002, Medtronic Minimed, Inc. |
(Animas Corporation, 1999). Animas . . . bringing new life to insulin therapy. |
Bode B W, et al. (1996). Reduction in Severe Hypoglycemia with Long-Term Continuous Subcutaneous Insulin Infusion in Type I Diabetes. Diabetes Care, vol. 19, No. 4, 324-327. |
Boland E (1998). Teens Pumping it Up! Insulin Pump Therapy Guide for Adolescents. 2nd Edition. |
Brackenridge B P (1992). Carbohydrate Gram Counting a Key to Accurate Mealtime Boluses in Intensive Diabetes Therapy. Practical Diabetology, vol. 11, No. 2, pp. 22-28. |
Brackenridge, B P et al. (1995). Counting Carbohydrates How to Zero in on Good Control. MiniMed Technologies Inc. |
Farkas-Hirsch R et al. (1994). Continuous Subcutaneous Insulin Infusion: A Review of the Past and Its Implementation for the Future. Diabetes Spectrum From Research to Practice, vol. 7, No. 2, pp. 80-84, 136-138. |
Hirsch I B et al. (1990). Intensive Insulin Therapy for Treatment of Type I Diabetes. Diabetes Care, vol. 13, No. 12, pp. 1265-1283. |
Kulkarni K et al. (1999). Carbohydrate Counting a Primer for Insulin Pump Users to Zero in on Good Control. MiniMed Inc. |
Marcus A O et al. (1996). Insulin Pump Therapy Acceptable Alternative to Injection Therapy. Postgraduate Medicine, vol. 99, No. 3, pp. 125-142. |
Reed J et al. (1996). Voice of the Diabetic, vol. 11, No. 3, pp. 1-38. |
Skyler J S (1989). Continuous Subcutaneous Insulin Infusion [CSII] With External Devices: Current Status. Update in Drug Delivery Systems, Chapter 13, pp. 163-183. Futura Publishing Company. |
Skyler J S et al. (1995). The Insulin Pump Therapy Book Insights from the Experts. MiniMe•Technologies. |
Strowig S M (1993). Initiation and Management of Insulin Pump Therapy. The Diabetes Educator, vol. 19, No. 1, pp. 50-60. |
Walsh J, et al. (1989). Pumping Insulin: The Art of Using an Insulin Pump. Published by MiniMed•Technologies. |
(Intensive Diabetes Management, 1995). Insulin Infusion Pump Therapy. pp. 66-78. |
Disetronic My Choice™ D-TRON™ Insulin Pump Reference Manual. (no date). |
Disetronic H-TRON® plus Quick Start Manual. (no date). |
Disetronic My Choice H-TRONplus Insulin Pump Reference Manual. (no date). |
Disetronic H-Tron®plus Reference Manual. (no date). |
(MiniMed, 1996). The MiniMed 506. 7 pages. Retrieved on Sep. 16, 2003 from the World Wide Web: http://web.archive.org/web/19961111054527/www.minimed.com/files/506—pic.htm. |
(MiniMed, 1997). MiniMed 507 Specifications. 2 pages. Retrieved on Sep. 16, 2003 from the World Wide Web: http://web.archive.org/web/19970124234841/www.minimed.com/files/mmn075.htm. |
(MiniMed, 1996). FAQ: The Practical Things . . . pp. 1-4. Retrieved on Sep. 16, 2003 from the World Wide Web: http://web.archive.org/web/19961111054546/www.minimed.com/files/faq—pract.htm. |
(MiniMed, 1997). Wanted: a Few Good Belt Clips! 1 page. Retrieved on Sep. 16, 2003 from the World Wide Web: http://web.archive.org/web/19970124234559/www.minimed.com/files/mmn002.htm. |
(MiniMed Technologies, 1994). MiniMed 506 Insulin Pump User's Guide. |
(MiniMed Technologies, 1994). MiniMed™ Dosage Calculator Initial Meal Bolus Guidelines / MiniMed™ Dosage Calculator Initial Basal Rate Guidelines Percentage Method. 4 pages. |
(MiniMed, 1996). MiniMed™ 507 Insulin Pump User's Guide. |
(MiniMed, 1997). MiniMed™ 507 Insulin Pump User's Guide. |
(MiniMed, 1998). MiniMed 507C Insulin Pump User's Guide. |
(MiniMed International, 1998). MiniMed 507C Insulin Pump for those who appreciate the difference. |
(MiniMed Inc., 1999). MiniMed 508 Flipchart Guide to Insulin Pump Therapy. |
(MiniMed Inc., 1999). Insulin Pump Comparison / Pump Therapy Will Change Your Life. |
(MiniMed, 2000). MiniMed® 508 User's Guide. |
(MiniMed Inc., 2000). MiniMed® Now [I] Can Meal Bolus Calculator / MiniMed® Now [I] Can Correction Bolus Calculator. |
(MiniMed Inc., 2000). Now [I] Can MiniMed Pump Therapy. |
(MiniMed Inc., 2000). Now [I] Can MiniMed Diabetes Management. |
(Medtronic MiniMed, 2002). The 508 Insulin Pump A Tradition of Excellence. |
(Medtronic MiniMed, 2002). Medtronic MiniMed Meal Bolus Calculator and Correction Bolus Calculator. Intemational Version. |
Abel, P., et al., “Experience with an implantable glucose sensor as a prerequiste of an artificial beta cell,” Biomed. Biochim. Acta 43 (1984) 5, pp. 577-584. |
Bindra, Dilbir S., et al., “Design and in Vitro Studies of a Needle-Type Glucose Sensor for a Subcutaneous Monitoring,” American Chemistry Society, 1991, 63, pp. 1692-1696. |
Boguslavsky, Leonid, et al., “Applications of redox polymers in biosensors,” Sold State Ionics 60, 1993, pp. 189-197. |
Geise, Robert J., et al., “Electropolymerized 1,3-diaminobenzene for the construction of a 1,1′-dimethylferrocene mediated glucose biosensor,” Analytica Chimica Acta, 281, 1993, pp. 467-473. |
Gernet, S., et al., “A Planar Glucose Enzyme Electrode,” Sensors and Actuators, 17, 1989, pp. 537-540. |
Gernet, S., et al., “Fabrication and Characterization of a Planar Electromechanical Cell and its Application as a Glucose Sensor,” Sensors and Actuators, 18, 1989, pp. 59-70. |
Gorton, L., et al., “Amperometric Biosensors Based on an Apparent Direct Electron Transfer Between Electrodes and Immobilized Peroxiases,” Analyst, Aug. 1991, vol. 117, pp. 1235-1241. |
Gorton, L., et al., “Amperometric Glucose Sensors Based on Immobilized Glucose-Oxidizing Enymes and Chemically Modified Electrodes,” Analytica Chimica Acta, 249, 1991, pp. 43-54. |
Gough, D. A., et al., “Two-Dimensional Enzyme Electrode Sensor for Glucose,” Analytical Chemistry, vol. 57, No. 5, 1985, pp. 2351-2357. |
Gregg, Brian A., et al., “Cross-Linked Redox Gels Containing Glucose Oxidase for Amperometric Biosensor Applications,” Analytical Chemistry, 62, pp. 258-263. |
Gregg, Brian A., et al., “Redox Polymer Films Containing Enzymes. 1. A Redox-Conducting Epoxy Cement: Synthesis, Characterization, and Electrocatalytic Oxidation of Hydroquinone,” The Joumal of Physical Chemistry, vol. 95, No. 15, 1991, pp. 5970-5975. |
Hashiguchi, Yasuhiro, MD, et al., “Development of a Miniaturized Glucose Monitoring System by Combining a Needle-Type Glucose Sensor With Microdialysis Sampling Method,” Diabetes Care, vol. 17, No. 5, May 1994, pp. 387-389. |
Heller, Adam, “Electrical Wiring of Redox Enzymes,” Acc. Chem. Res., vol. 23, No. 5, May 1990, pp. 128-134. |
Jobst, Gerhard, et al., “Thin-Film Microbiosensors for Glucose-Lactate Monitoring,” Analytical Chemistry, vol. 68, No. 18, Sep. 15, 1996, pp. 3173-3179. |
Johnson, K.W., et al., “In vivo evaluation of an electroenzymatic glucose sensor implanted in subcutaneous tissue,” Biosensors & Bioelectronics, 7, 1992, pp. 709-714. |
Jönsson, G., et al., “An Electromechanical Sensor for Hydrogen Peroxide Based on Peroxidase Adsorbed on a Spectrographic Graphite Electrode,” Electroanalysis, 1989, pp. 465-468. |
Kanapieniene, J. J., et al., “Miniature Glucose Biosensor with Extended Linearity,” Sensors and Actuators, B. 10, 1992, pp. 37-40. |
Kawamori, Ryuzo, et al., “Perfect Normalization of Excessive Glucagon Responses to Intraveneous Arginine in Human Diabetes Mellitus With the Artificial Beta-Cell,” Diabetes vol. 29, Sep. 1980, pp. 762-765. |
Kimura, J., et al., “An Immobilized Enzyme Membrane Fabrication Method,” Biosensors 4, 1988, pp. 41-52. |
Koudelka, M., et al., “In-vivo Behaviour of Hypodermically Implanted Microfabricated Glucose Sensors,” Biosensors & Bioelectronics 6, 1991, pp. 31-36. |
Koudelka, M., et al., “Planar Amperometric Enzyme-Based Glucose Microelectrode,” Sensors & Actuators, 18, 1989, pp. 157-165. |
Mastrototaro, John J., et al., “An electroenzymatic glucose sensor fabricated on a flexible substrate,” Sensors & Actuators, B. 5, 1991, pp. 139-144. |
Mastrototaro, John J., et al., “An Electroenzymatic Sensor Capable of 72 Hour Continuous Monitoring of Subcutaneous Glucose,” 14th Annual International Diabetes Federation Congress, Washington D.C., Jun. 23-28, 1991. |
McKean, Brian D., et al., “A Telemetry-Instrumentation System for Chronically Implanted Glucose and Oxygen Sensors,” IEEE Transactions on Biomedical Engineering, Vo. 35, No. 7, Jul. 1988, pp. 526-532. |
Monroe, D., “Novel Implantable Glucose Sensors,” ACL, Dec. 1989, pp. 8-16. |
Morff, Robert J., et al., “Microfabrication of Reproducible, Economical, Electroenzymatic Glucose Sensors,” Annuaal International Conference of teh IEEE Engineering in Medicine and Biology Society, Vo. 12, No. 2, 1990, pp. 483-484. |
Moussy, Francis, et al., “Performance of Subcutaneously Implanted Needle-Type Glucose Sensors Employing a Novel Trilayer Coating,” Analytical Chemistry, vol. 65, No. 15, Aug. 1, 1993, pp. 2072-2077. |
Nakamoto, S., et al., “A Lift-Off Method for Patterning Enzyme-Immobilized Membranes in Multi-Biosensors,” Sensors and Actuators 13, 1988, pp. 165-172. |
Nishida, Kenro, et al., “Clinical applications of teh wearable artifical endocrine pancreas with the newly designed needle-type glucose sensor,” Elsevier Sciences B.V., 1994, pp. 353-358. |
Nishida, Kenro, et al., “Development of a ferrocene-mediated needle-type glucose sensor covereed with newly designd biocompatible membrane, 2-methacryloyloxyethylphosphorylcholine -co-n-butyl nethacrylate,” Medical Progress Through Technology, vol. 21, 1995, pp. 91-103. |
Poitout, V., et al., “A glucose monitoring system for on line estimation oin man of blood glucose concentration using a miniaturized glucose sensor implanted in the subcutaneous tissue adn a wearable control unit,” Diabetologia, vol. 36, 1991, pp. 658-663. |
Reach, G., “A Method for Evaluating in vivo the Functional Characteristics of Glucose Sensors,” Biosensors 2, 1986, pp. 211-220. |
Shaw, G. W., et al., “In vitro testing of a simply constructed, highly stable glucose sensor suitable for implantation in diabetic patients,” Biosensors & Bioelectronics 6, 1991, pp. 401-406. |
Shichiri, M., “A Needle-Type Glucose Sensor—A Valuable Tool Not Only for a Self-Blood Glucose Monitoring but for a Wearable Artifiical Pancreas,” Life Support Systems Proceedings, XI Annual Meeting ESAO, Alpbach-Innsbruck, Austria, Sep. 1984, pp. 7-9. |
Shichiri, Motoaki, et al., “An artificial endocrine pancreas—problems awaiting solution for long-term clinical applications of a glucose sensor,” Frontiers Med. Biol. Engng., 1991, vol. 3, No. 4, pp. 283-292. |
Shichiri, Motoaki, et al., “Closed-Loop Glycemic Control with a Wearable Artificial Endocrine Pancreas—Variations in Daily Insulin Requirements to Glycemic Response,” Diabetes, vol. 33, Dec. 1984, pp. 1200-1202. |
Shichiri, Motoaki, et al., “Glycaemic Control in a Pacreatectomized Dogs with a Wearable Artificial Endocrine Pancreas,” Diabetologia, vol. 24, 1983, pp. 179-184. |
Shichiri, M., et al., “In Vivo Characteristics of Needle-Type Glucose Sensor—Measurements of Subcutaneous Glucose Concentrations in Human Volunteers,” Hormone and Metabolic Research, Supplement Series Vol. No. 20, 1988, pp. 17-20. |
Shichiri, M., et al., “Membrane design for extending the long-life of an implantable glucose sensor,” Diab. Nutr. Metab., vol. 2, No. 4, 1989, pp. 309-313. |
Shichiri, Motoaki, et al., “Normalization of the Paradoxic Secretion of Glucagon in Diabetes Who Were Controlled by the Artificial Beta Cell,” Diabetes, vol. 28, Apr. 1979, pp. 272-275. |
Shichiri, Motoaki, et al., “Telemetry Glucose Monitoring Device with Needle-Type Glucose Sensor: A useful Tool for Blood Glucose Monitoring in Diabetic Individuals,” Diabetes Care, vol. 9, No. 3, May-Jun. 1986, pp. 298-301. |
Shichiri, Motoaki, et al., “Wearable Artificial Endocrine Pancreas with Needle-Type Glucose Sensor,” The Lancet, Nov. 20, 1982, pp. 1129-1131. |
Shichiri, Motoaki, at al., “The Wearable Artificial Endocrine Pancreas with a Needle-Type Glucose Sensor: Perfect Glycemic Control in Ambulatory Diabetes,” Acta Paediatr Jpn 1984, vol. 26, pp. 359-370. |
Shinkai, Seiji, “Molecular Recognitiion of Mono- and Di-saccharides by Phenylboronic Acids in Solvent Extraction and as a Monolayer,” J. Chem. Soc., Chem. Commun., 1991, pp. 1039-1041. |
Shults, Mark C., “A Telemetry-Instrumentation System for Monitoring Multiple Subcutaneously Implanted Glucose Sensors,” IEEE Transactions on Biomedical Engineering, vol. 41, No. 10, Oct. 1994, pp. 937-942. |
Sternberg, Robert, et al., “Study and Development of Multilayer Needle-type Enzyme-based Glucose Microsensors,” Biosensors, vol. 4, 1988, pp. 27-40. |
Tamiya, E., et al., “Micro Glucose Sensors using Electron Mediators Immobilized on a Polypyrrole-Modified Electrode,” Sensors and Actuators, vol. 18, 1989, pp. 297-307. |
Tsukagoshi, Kazuhiko, et al., “Specific Complexation with Mono- and Disaccharides that can be Detected by Circular Dichroism,” J. Org. Chem., vol. 56, 1991, pp. 4089-4091. |
Urban, G., et al., “Miniaturized multi-enzyme biosensors integrated with pH sensors on flexible polymer carriers for in vivo applciations,” Biosensors & Bioelectronics, vol. 7, 1992, pp. 733-739. |
Ubran, G., et al., “Miniaturized thin-film biosensors using covalently immobilized glucose oxidase,” Biosensors & Bioelectronics, vol. 6, 1991, pp. 555-562. |
Velho, G., et al., “In vivo calibration of a subcutaneous glucose sensor for determination of subcutaneous glucose kinetics,” Diab. Nutr. Metab., vol. 3, 1988, pp. 227-233. |
Wang, Joseph, et al., “Needle-Type Dual Microsensor for the Simultaneous Monitoring of Glucose and Insulin,” Analytical Chemistry, vol. 73, 2001, pp. 844-847. |
Yamasaki, Yoshimitsu, et al., “Direct Measurement of Whole Blood Glucose by a Needle-Type Sensor,” Clinics Chimica Acta, vol. 93, 1989, pp. 93-98. |
Yokoyama, K., “Integrated Biosensor for Glucose and Galactose,” Analytica Chimica Acta, vol. 218, 1989, pp. 137-142. |
Number | Date | Country | |
---|---|---|---|
20140207065 A1 | Jul 2014 | US |