Claims
- 1. An assembly for dispensing fluid comprising
a dispenser having a chamber for containing a first material and an actuator for dispensing the first material from the chamber; and an applicator comprising
a first region for receiving the dispenser and a second region for receiving a container containing a second material, a first passage coupling the dispenser, when received by the first region, with the container, when received by the second region, so that the first material can be conveyed into the container in response to operation of the actuator, thereby forming a mixture of the first and second materials in the container, and a second passage that conveys the mixture from the container in response to operation of the actuator.
- 2. An assembly according to claim 1wherein one of the first and second materials includes a liquid.
- 3. An assembly according to claim 1wherein the second material includes a solid material.
- 4. An assembly according to claim 1wherein, upon mixing, the first and second materials cross-link.
- 5. As assembly according to claim 1wherein the second material includes a lyophilized material.
- 6. An assembly according to claim 5wherein the lyophilized material comprises a polymer.
- 7. An assembly according to claim 6wherein the polymer comprises a polyethylene glycol derivative.
- 8. An assembly according to claim 7wherein the polymer includes a 4-arm polyethylene glycol.
- 9. A formative component assembly to house a closure material, which, in use, is dispensed to seal a puncture site in a blood vessel, the closure material comprising a mixture of first and second materials which, upon mixing, undergo a reaction to form a solid closure material composition, the formative component assembly comprising
a dispenser having a chamber for containing a first material and an actuator for dispensing the first material from the chamber; and an applicator comprising
a first region for receiving the dispenser and a second region for receiving a container containing a second material, a first passage coupling the dispenser, when received by the first region, with the container, when received by the second region, so that the first material can be conveyed into the container in response to operation of the actuator, thereby forming a mixture of the first and second materials in the container, and a second passage that conveys the mixture from the container in response to operation of the actuator.
- 10. An assembly according to claim 9 wherein the second passage is sized and configured to couple with a catheter that conveys the mixture to a puncture site.
- 11. An assembly according to claim 10 further including a mixer assembly that couples the catheter with the second passage.
- 12. A method for dispensing fluid comprising the steps of
coupling a dispenser having a chamber for containing a first material and an actuator for dispensing the first material from the chamber with a container containing a second material; operating the actuator to convey the first material into the container, thereby forming a mixture of the first and second materials in the container; and operating the actuator to convey the mixture from the container.
- 13. A method of dispensing a closure material to seal a puncture site in a blood vessel, the closure material comprising a mixture of first and second materials which, upon mixing, undergo a reaction to form a solid closure material composition, comprising the steps of
coupling a dispenser having a chamber for containing the first material and an actuator for dispensing the first material from the chamber with a container containing the second material; operating the actuator to convey the first material into the container, thereby forming the mixture of the first and second materials in the container; and operating the actuator to convey the mixture from the container.
- 14. An assembly comprising
a biocompatible polymer comprising poly(ethylene glycol) (PEG) with a functionality of at least three in lyophilized form, and a container holding the polymer in lyophilized form.
- 15. An assembly according to claim 14wherein the PEG has a molecular weight of between about 10,000 and 15,000 g/mole.
- 16. An assembly according to claim 14wherein the PEG comprises a multi-armed polymer structure.
- 17. An assembly according to claim 14wherein the PEG has a functionality of four.
- 18. An assembly according to claim 14further including a buffered protein solution having a pH value of between about 7 and about 10, and a second container holding the buffered protein solution including a region adapted to be coupled to the first-defined container and an actuator for expelling the buffered protein solution into the first-defined container for mixing with the polymer in lyophilized form, wherein, upon mixing, the buffered protein solution and the polymer cross-link.
- 19. An assembly according to claim 18wherein the buffered protein solution comprises recombinant or natural human serum albumin at a concentration of about 25% or less.
- 20. An assembly according to claim 18wherein the buffered protein solution has a pH value of between about 8 and about 10.
- 21. A method of dispensing a polymer that is moisture sensitive comprising the steps of
(1) dissolving the polymer in an aqueous solution to form a dissolved polymer solution, (2) lyophilizing the dissolved polymer solution to form a lyophilized polymer, (3) reconstituting the lyophilized polymer mixture with an aqueous solution to form a reconstituted polymer solution, (4) dispensing the reconstituted polymer solution.
- 22. A method according to claim 21further including a step between step (2) and step (3) of storing the lyophilized polymer mixture in an inert atmosphere.
- 23. A method according to claim 21wherein the polymer comprise a polyethylene glycol (PEG) derivative.
- 24. A method according to claim 23wherein the PEG comprises a multi-armed polymer structure.
- 25. A method according to claim 23wherein the PEG has a functionality of four.
- 26. A method according to claim 21wherein, in step (3), the aqueous solution includes a buffered protein solution.
- 27. A method according to claim 26wherein the buffered protein solution comprises recombinant or natural human serum albumin at a concentration of about 25% or less.
RELATED APPLICATIONS
[0001] This application is a continuation-in-part of U.S. patent application Ser. No. 09/780,843, filed Feb. 9, 2001, and entitled “Systems, Methods, and Compositions for Achieving Closure of Vascular Puncture Sites,” which is a continuation-in-part of U.S. patent application Ser. No. 09/283,535, filed Apr. 1, 1999, and entitled “Compositions, Systems, And Methods For Arresting or Controlling Bleeding or Fluid Leakage in Body Tissue,” which is itself a continuation-in-part of U.S. patent application Ser. No. 09/188,083, filed Nov. 6, 1998 and entitled “Compositions, Systems, and Methods for Creating in Situ, Chemically Cross-linked, Mechanical Barriers.”
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
09780843 |
Feb 2001 |
US |
Child |
10141510 |
May 2002 |
US |
Parent |
09283535 |
Apr 1999 |
US |
Child |
09780843 |
Feb 2001 |
US |
Parent |
09188083 |
Nov 1998 |
US |
Child |
09283535 |
Apr 1999 |
US |