Claims
- 1. Tachykinins antagonist of general formula (I)
- wherein:
- Y is benzene optionally substituted with one or more substituents independently selected from the group consisting of halogen, alkyl radicals containing from 1 to 6 carbon atoms optionally substituted with no more than three fluorine atoms, oxyalkyl radicals containing from 1 to 6 carbon atoms, optionally substituted with no more than three fluorine atoms, --NH.sub.2, --NHR.sub.10, --OR.sub.10, --N(R.sub.10).sub.2, --CONHR.sub.10, --COR.sub.10, --COOR.sub.10, --R.sub.10 COOR.sub.11, --OR.sub.10 COOR.sub.11, --NHCOR.sub.10, nitro-radicals wherein R.sub.10 and R.sub.11 are hydrogen or an alkyl radical, linear or branched, containing from 1 to 6 carbon atoms, with the proviso that R.sub.10 cannot be H in the case of R.sub.10 COOR.sub.11, OR.sub.10 COOR.sub.11, and R.sub.10 CONHR.sub.11 ;
- X.sub.1 and X.sub.2, are the same or different from each other, are selected from the group consisting of --CONR.sub.8, --NR.sub.8 CO--, --CH.sub.2 NR.sub.8 --, --SO.sub.2 NR.sub.8 --, wherein R.sub.8 is selected from the group consisting of hydrogen or an alkyl-chain, linear or modified, containing from 1 to 6 carbon atoms;
- X.sub.3 is selected from the group consisting of --CONR.sub.7, and --NR.sub.7 CO--, and R.sub.7 is selected from the group consisting of an alkyl radical with no more than 15 carbon atoms;
- R.sub.1, R.sub.2 and R.sub.3, independently from each other, are hydrogen, halogen, or OR.sub.12 wherein R.sub.12 is selected from the group consisting of hydrogen, --CH.sub.2 O(CH.sub.2).sub.2 OCH.sub.3 or --CH.sub.2 O(CH.sub.2).sub.2 OCH.sub.2 CH.sub.3 ;
- A is CH; n is a number from 0 to 2;
- R.sub.5 and R.sub.6 are, independently from each other, selected from the group consisting of an aryl-alkyl radical containing no more than 15 carbon atoms, wherein the aryl moiety is selected from the group consisting of biphenyl, benzene, and naphtene, optionally substituted on the ring with one or more substituents, independently from each other, selected from the group consisting of halogen, an alkyl-radical containing from 1 to 6 carbon atoms, optionally substituted with no more than three fluorine atoms, an oxyalkyl-radical containing from 1 to 6 carbon atoms, optionally substituted with no more than three fluorine atoms, an --NH.sub.2, --NHR.sub.11, --OR.sub.10, --N(R.sub.10).sub.2, --CONHR.sub.10, --COR.sub.10, --COOR.sub.10, --R.sub.10 COOR.sub.11, --OR.sub.10 COOR.sub.11, --CONHR.sub.10, --R.sub.10 CONHR.sub.11, --NHCOR.sub.10, nitro-radicals, wherein R.sub.10 and R.sub.11, are hydrogen or an alkyl-radical, linear or branched, containing from 1 to 6 carbon atoms with the proviso that R.sub.10 cannot be H in the case of R.sub.10 COOR.sub.11, OR.sub.10 COOR.sub.11 and R.sub.10 CONHR.sub.11.
- 2. Compound according to claim 1 wherein the alkyl-radical is selected from the group consisting of methyl, ethyl, propyl, butyl and pentyl and the halogen is selected from the group consisting of fluorine, chlorine, bromine and iodine.
- 3. Compound of general formula (I) according to claim 1 as herein defined:
- i) 1-N-�N(benzoyl)-1-amino-cyclohexancarbonyl!-amino-1-�N(methyl)N(2-phenylacetyl)!amino-2(2-naphthyl)ethane
- ii) 1-N-�N(4-methyl-benzoyl)-1-amino-cyclohexancarbonyl!-amino-1-�N(methyl)N(2-phenylacetyl)!amino-2(2-naphthyl)ethane
- iii) 1-N-�N(4-metoxy-benzoyl)-1-amino-cyclohexancarbonyl!-amino-1-�N(methyl)N(2-phenylacetyl)!amino-2(2-naphthyl)ethane
- iv) 1-N-�N(4-chloro-benzoyl)-1-amino-cyclohexancarbonyl!-amino-1-�N(methyl)N(2-phenylacetyl)!amino-2(2-naphthyl)ethane
- v) 1-N-�N(3,4-chloro-benzoyl)-1-amino-cyclohexancarbonyl!-amino-1-�N(methyl)N(2-phenylacetyl)!amino-2(2-naphthyl)ethane.
- 4. Pharmaceutical composition comprising as active principle a therapeutically effective amount of compound of formula (I) according to claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
FI94A0009 |
Jan 1994 |
ITX |
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Parent Case Info
This is a division of application Ser. No. 08/676,514, filed as PCT/EP95/00193, Jan. 19, 1995 now U.S. Pat. No. 5,698,710.
Non-Patent Literature Citations (2)
Entry |
Villalgordo, J.M. et al.: Reaction of 3-Amino-2H-azirines with 2-Amino-4, 6-dinitrophenol: Synthesis of Quinazoline and 1,3-Benzoxazole Derivatives. Helv. Chim. Acta. vol. 73, pp. 959-974, 1990. |
Crisma, M. et al: Structural Versatility of Peptides from C.sup..alpha. -Dialkylated Glycines. Macromolecules, vol. 21, pp. 2071-2074, 1988. |
Divisions (1)
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Number |
Date |
Country |
Parent |
676514 |
Jul 1996 |
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