This invention is directed to a closure or cover type of seal structure for a septum or other cover for a vial including a housing disposable in enclosing, retaining engagement with the upper end of the vial and the septum or cover attached thereto. The housing further includes tamper evident capabilities, which prevent reattachment or reuse of the housing in the intended manner.
In the medical field, it is relatively common procedure to administer fluids to a patient by syringes, intravenous infusion (IV), etc. Such administration devices or assemblies are useful in the treatment of a number of medical conditions because a variety of fluids and/or medications can be administered to a patient utilizing such assemblies. By way of example, it is common for medical personnel to order that a patient be given a medication by injection. However, there are a number of safety issues associated with administering injections. One concern relates to avoiding contamination by bacteria, germs, or other harmful organisms. Because of this, and also due to the potential for theft of the medication and/or tampering in order to access the medication, one important concern relates to minimizing the number of people handling syringes. This concern is perhaps even more pronounced with regard to pre-filled syringes.
More specifically it is relatively common in a number of hospital settings for a number of syringes to be pre-loaded or pre-filled with certain medications by pharmacists or other authorized personnel, at an appropriate location, for subsequent dispensing of such prefilled syringes to one or more nursing stations or distribution areas and then, subsequently to the patient for direct use. The pharmacy or location where syringes are filled are often located in a remote part of the health facility relative to the location of the patient and the site of administration of the injection. From the foregoing, it may be understood that during the course of loading a syringe with a drug, and also afterwards when a prefilled syringe is delivered to a nurse's station, the syringe can easily be handled by a number of different individuals. This, in turn, increases the chance for the syringe to become contaminated which in turn, could possibly result in introduction of a contaminated substance into the body tissues of a patient. Consequently, a high level of importance is associated with maintaining the sterility of a syringe, from the time of it being filled to the time of injection administration.
Also, in the case of a very expensive drug or addictive drug such as, but not limited to, morphine, there is some danger that a prefilled syringe will be tampered with by person seeking to improperly gain access to the drug. A resulting danger also exists in the possibility of a saline solution or other substance being substituted for a dose of the medication intended to be administered. This could have extremely serious consequences to the patient, possibly including death. Therefore, the growing use of prefilled syringes raises problems relating to the determination of whether a prefilled syringe has been tampered with and and/or exposed to contamination. In order to address such problems, there is a need in the medical field for closures for syringes and/or other medical containers or administering devices, which maintain sterility while providing sufficient assurances that the contents of the syringe, medical container, administering devices, etc. have not been compromised.
Accordingly, tamper evident capabilities and/or structures associated with medical closures, covers, caps, etc. are important to protect the integrity of prefilled syringes, as well as other types of medical containers. Thus, and as a further example, vials are often filled with a previously prepared medication and are utilized in combination with a syringe. In use, the needle of the syringe penetrates and passes through a septum and into the interior of vial to establish access to the medication contained therein. As is well recognized in the medical profession, vials are medical containers recognized by appropriate governmental bodies and/or legislation (e.g., 503b) and hospital pharmacies for the containment of medications such as, but not limited to, medication prepared for the distribution of vaccines. As such, the open-end or access opening of the vial include a lid crimped or otherwise secured to the open end of the vial, wherein a penetrable septum may be structured as part of the vial lid.
In many cases, vials contain more than one dose of the contained medication or drug. After the first use, medical personnel commonly use tape placed over the septum and other portions of the vial lid to protect the contents of the vial. In other instances, and by way of example, a vial lid can also be utilized with a chemo vent needle, which is used to reconstitute medication at the hospital pharmacy. More specifically, vials used for chemotherapy drugs may contain a powder material. In order to accomplish conversion to a final drug it must be reconstituted, which in turn may involve breaking the original vial lid. To practice the aforementioned procedure, needles are required to prevent any toxic fumes escaping during the preparation and/or conversion. Once preparation is complete, an additional closure, cover, seal, etc. can be applied to the fully converted or prepared medication.
In order to address the problems and disadvantages of the type set forth above, especially with regard to protecting the contents of a vial containing one or more doses and/or the aforementioned chemotherapy medication, there is a need in the medical profession and related supply industries for a cover type seal structured to be secured to the vial and/or lid or cover of the vial in a manner which closes or seals the septum associated with the vial lid or cover. In addition, if any such proposed seal structure were developed, it would preferably also include tamper evident capabilities and/or structure which provides clear evidence that authorized or unauthorized prior access to the vial has been attempted.
The present invention is directed to a cover or closure type seal structure for a vial and/or vial cover including a housing. The housing includes a sidewall surrounding and at least partially defining the boundaries of the interior of the housing, wherein the interior of the housing is at least partially hollow. In addition, the sidewall terminates in a closed-end and an open-end which are substantially, oppositely disposed to one another. As will be explained in greater detail hereinafter, the open-end is dimensioned and configured to facilitate passage therethrough of the vial and a vial cover or lid, secured to the open-end or access opening of the vial.
Additional features of the seal structure include a retainer disposed within the interior of the housing. In at least one embodiment, the retainer is fixedly or integrally secured to the interior surface of the housing and more specifically, to the interior surface of the sidewall. Also, the retainer extends there-from, inwardly towards the center of the open or hollow interior of the housing. In the one or more preferred embodiments of the retainer, as explained in greater detail hereinafter, it is disposed and structured for retaining engagement with the vial and/or the vial cover or lid.
It is emphasized that the term “vial”, as used herein, is meant to include the vial itself as well as the cover or lid secured in overlying relation to the open end thereof. Moreover, as typically structured, the vial cover or lid may include a septum formed of a penetrable material which facilitates passage of a needle of a syringe or other medical device to pass therethrough into direct contact and/or communication with the medication contained within the vial. Accordingly, when describing the retainer being disposed in retaining engagement with the vial it is to be recognized that the actual “retaining engagement” may comprise the retainer being disposed, in whole or in part, in operative engagement with the vial itself or in the alternative with the vial cover and more specifically the periphery thereof, as will be described in greater detail hereinafter.
One or more embodiments of the retainer include it being at least partially defined by a plurality of retainer segments disposed in spaced, substantially coplanar relation to one another and collectively having an annular or circular configuration. As indicated, each of the retainer segments may be fixedly or integrally secured to the interior surface of the sidewall and extend inwardly, substantially towards the center of the hollow interior of the housing. The plurality of retainer segments are cooperatively disposed and structured to establish the aforementioned “retaining engagement” of the retainer with the vial and/or more specifically with an under portion of the outer periphery of the vial cover or lid.
The plurality of retainer segments may vary in size and configuration and may be collectively dimensioned with a remainder of the housing to accommodate a vial and/or vial cover or lid of different sizes. Further, in order to establish the intended “retaining engagement” with the vial each or at least a majority of the retainer segments have a cooperative configuration. In more specific terms, the undersurface portion of each of the retainer segments has a curved or beveled configuration which facilitates a sliding engagement of the vial and/or vial cover or lid with such beveled undersurface. In addition, the sidewall of the housing is structured to include at least a minimal degree of outward flexure. As a result, as the vial and/or vial cover or lid enter through the open end of the housing, they will be forced into the aforementioned sliding engagement with the beveled or curved undersurface portions of each or at least a majority of the plurality of retainer segments. Such forced, sliding engagement will cause at least a minimal outward flexure of the housing, which in turn will allow passage of at least a portion of the vial, such as the vial cover or lid to pass through the retainer and/or plurality of retainer segments and be operatively disposed between the retainer and the inner surface of the closed-end.
The aforementioned retaining engagement is further facilitated by the upper surface of each or at least a majority of the retainer segments being configured to establish an abutting, “removal preventing” engagement with the vial and/or vial cover or lid. More specifically, the upper surface of the one or more retainer segments may be substantially flat or planar and be operatively disposed immediately beneath and in engagement with the under portion of the neck of the vial and/or most probably the undersurface of the outer periphery of the vial cover and/or lid. It is to be noted that both the undersurface and upper surface of the plurality of retainer segments may vary in configuration from that specifically described herein. However, the configurations of the undersurface and the upper surface of the plurality of retainer segments should be sufficient to respectively facilitate the aforementioned sliding engagement of the undersurface of the retainer segments with the vial and the removal preventing engagement of the upper surface.
In addition, and in cooperation with the retainer, one or more preferred embodiments of the seal structure of the present invention further includes a pressure member. The pressure member has an at least minimally elongated configuration fixedly secured to the interior surface of the housing. As such, the pressure member includes a proximal end fixedly or integrally secured to the interior surface of the closed-end and extending downwardly or inwardly therefrom and in depending relation thereto. Moreover, the pressure member includes a distal end substantially oppositely located to the proximal end and in outwardly spaced relation from the interior surface of the closed-end of the housing. The dimension and configuration of the pressure member is cooperatively determined relative to the location and structure of the retainer. Therefore, the distal end of the pressure member is disposed in substantially aligned relation to the retainer and/or plurality of retainer segments so as to be substantially coplanar or minimally spaced out of such a coplanar relation with the retainer.
Accordingly, the pressure member is disposed, configured and structured such that the aforementioned distal end thereof is disposed in a pressure exerting engagement with the vial cover or lid and more specifically with the septum of the vial. Due to the cooperative configurations and dispositions of the retainer and the pressure member, specifically including the distal end of the pressure member, the distal end will be disposed in the aforementioned pressure exerting, at least partially sealing engagement with the vial cover or lid and even more specifically the septum associated with the vial cover or lid. Concurrently the retainer, including the plurality of retainer segments, will be disposed in the retaining engagement comprising the engaging relation with an under portion of the outer periphery of the vial cover or lid. As a result, the vial and more specifically the vial cover or lid will be securely retained on the interior of the housing by virtue of a substantially clamping action and engagement between the retainer and/or plurality of retainer segments and the pressure member and/or distal end thereof exerting pressure on the septum or other portion of the vial cover or lid. Such clamping action will result in a sealing engagement and or action of the vial cover and in particular the sealing, pressure exerting engagement of the distal end of the pressure member with the septum.
With further reference to the pressure member, at least one embodiment includes the provision of an antiseptic or disinfected connected to mounted on or otherwise operatively associated with the distal end. Moreover, the antiseptic, disinfectant or like composition may be on or within a pad, wherein the pad is fixedly secured to the distal end at a location which facilitates its direct engagement with the exterior surface of the septum, during the pressure exerting engagement of the pressure member/distal end with the vial cover. The aforementioned antiseptic pad may be made of a foam or other appropriate cushion-like material in order to engage the septum of the vial cover or lid without causing damage thereto.
As emphasized herein, the seal structure of the present invention includes tamper evident capabilities and/or structure. In at least one embodiment the tamper evident capability or structure includes a removable sidewall section initially integral with a remainder of the sidewall. Further, the removable sidewall section includes a detachable connection to the remainder of the sidewall. Such a detachable connection may comprise at least one, but preferably two elongated weakened seam lines each disposed on a different opposite side of the removable section and extending along a length thereof from the open end to the closed-end of the housing. The weakened seam lines are structured such that exertion of a pulling or other appropriately directed force on the removable section will cause a breakage, disconnection and/or separation of one or both of the weakened seam lines from the remainder of the sidewall, due to at least in part to reduction in the thickness of the sidewall along and entirety or at least a portion of the length of the weakened seam lines. In addition, the aforementioned pulling or other appropriately directed force exerted on the removable sidewall section may be facilitated by the inclusion of a pull tab secured to the removable section preferably at one end thereof coincident with the open end of the housing. The pull tab will extend outwardly from the exterior surface of the sidewall and otherwise be structured to facilitate the gripping or securement thereof by the hand or fingers of a user.
As should be apparent, partial or complete removal of the removable sidewall section will result in an inability to reconnect the replaceable sidewall section with remainder of the housing. As a result, the housing will not be able to be reconnected in its original operative configuration. In turn, the retainer and the pressure member will not be able to be disposed in retaining, clamping, sealing engagement with the vial and/or the vial cover. Clear evidence of authorized or unauthorized prior attempted access to or tampering with the vial will thereby be apparent.
Yet additional features of one or more embodiments of the seal structure of the present invention may include the dimensioning and configuring of the sidewall to include a display field disposed on the exterior surface of the sidewall. In addition, a machine-readable code will be disposed on the display field. The machine-readable code may take a variety of different code configurations or structures including conventional barcode, quick response code (QR), RFID tag, etc. As a result, the code may be an operative part of a tracking system or tracking capabilities associated with the seal structure of the present invention. Such a tracking system or tracking capability may be operative to facilitate the tracking of each such seal structure along a “path of distribution” from an initial point of manufacture, assembly, distribution, etc. to an endpoint such as a location of authorized use. Such a machine-readable code may be on or at least partially within the display field and include visually observable coded indicia providing adequate information or data regarding the origin, structure, utilization, etc. of the seal structure.
These and other objects, features and advantages of the present invention will become clearer when the drawings as well as the detailed description are taken into consideration.
For a fuller understanding of the nature of the present invention, reference should be had to the following detailed description taken in connection with the accompanying drawings in which:
Like reference numerals refer to like parts throughout the several views of the drawings.
The invention will now be described more fully hereinafter with reference to the accompanying drawings in which illustrative embodiments of the invention are shown. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein; rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art.
The present invention is directed to a cover or closure type seal structure generally indicated as 10 for a vial and/or vial cover (not shown in
Additional features of the seal structure 10 include a retainer generally indicated as 22 disposed within the interior 16 of the housing 12. In at least one embodiment, the retainer 22 is fixedly or integrally secured to the interior surface 24 of the sidewall and extends therefrom inwardly towards the center of the hollow interior 16 of the housing 12. In one or more embodiments and as will be explained in greater detail hereinafter, the retainer 22 is disposed and structured for retaining engagement with the vial and/or the vial cover or lid.
It is emphasized that the term “vial” as used herein is meant to include the vial itself as well as the cover or lid crimped or otherwise secured in overlying, covering relation to the open end thereof. Moreover, as typically structured, the vial cover or lid may include a septum formed of a penetrable material which facilitates passage of a needle of a syringe or other medical device to pass therethrough into direct contact, access and/or communication with the medication contained within the vial. Accordingly, when describing the retainer 22 being disposed in retaining engagement with the vial, it is to be recognized that the actual “retaining engagement” may comprise the retainer 22 being disposed, in whole or in part, in operative engagement with the vial cover or lid and more specifically the periphery thereof, as described hereinafter.
One or more additional embodiments of the retainer 22 include it being at least partially defined by a plurality of retainer segments 26 disposed in spaced relation to one another and collectively having an annular or circular configuration, as represented in
The plurality of retainer segments 26 may vary in size and configuration and may be collectively dimensioned with a remainder of the housing 12 to accommodate a vial and/or vial cover or lid of different sizes. Further, in order to establish the intended “retaining engagement” with the vial, each or at least a majority of the retainer segments have a cooperative configuration. In more specific terms, the undersurface portion 28 of each of the retainer segments 26 has a curved or beveled configuration, as represented in
The aforementioned retaining engagement is further facilitated by the upper surface of each or at least a majority of the retainer segments 26 being configured to establish an abutting, “removal preventing” engagement with the vial and/or vial cover or lid. More specifically, the upper surface 30 of the one or more retainer segments 26 may be substantially flat or planar and be operatively disposed immediately beneath and in engagement with the under portion of the neck of the vial and/or most probably the undersurface of the outer periphery of the vial cover and/or lid. It is to be noted that both the undersurface portion 28 and upper surface portion 30 of the plurality of retainer segments 26 may vary in configuration from that specifically described herein. However, the configurations of the undersurface 28 and the upper surface 30 of the plurality of retainer segments should be sufficient to respectively facilitate the aforementioned sliding engagement of the undersurface 28 of the retainer segments 26 with the vial and the removal preventing, abutting engagement of the upper surface 30.
In addition, and in cooperation with the retainer 22, one or more preferred embodiments of the seal structure 10 of the present invention further includes a pressure member 34. The pressure member 34 has an at least minimally elongated configuration fixedly secured to the interior surface of the housing 12. As such, the pressure member 34 includes a proximal end 34′ fixedly or integrally or fixedly secured to the interior surface 18′ of the closed-end 18 and extending downwardly or inwardly therefrom and in depending relation thereto. Moreover, the pressure member 34 includes a distal end 34″ substantially oppositely located to the proximal end 34′ and in outwardly spaced relation from the interior surface 18′ of the closed-end 18 of the housing 12. The dimension and configuration of the pressure member 34 is cooperatively determined relative to the location and structure of the retainer 22. Therefore, the distal end 34″ of the pressure member 34 is disposed in substantially aligned relation to the retainer 22 and/or plurality of retainer segments 26 so as to be substantially coplanar or minimally spaced out of such a coplanar relation with the retainer 22.
Accordingly, the pressure member 34 is disposed, configured and structured such that the aforementioned distal end 34″ thereof is disposed in a pressure exerting engagement with the vial cover or lid and more specifically with the septum of the vial lid. Due to the cooperative configurations and dispositions of the retainer 22 and the pressure member 34, specifically including the distal end 34″ of the pressure member 34, the distal end 34″ will be disposed in the aforementioned pressure exerting, at least partially sealing engagement with the vial cover or lid and the septum associated therewith. Concurrently, the retainer 22, including the plurality of retainer segments 26 will be disposed in the retaining engagement, which comprises the engaging relation of the upper surfaces 30 with an under portion of the outer periphery of the vial cover or lid. As a result, the vial and the vial cover or lid will be securely retained on the interior of the housing 12 by virtue of a substantially clamping action and engagement between the retainer 22 and plurality of retainer segments 26 and the pressure member 34 and distal end 34″ thereof exerting pressure on the septum or other portion of the vial cover or lid. Such clamping action will result in a sealing engagement and or action of the vial cover and in particular the sealing, pressure exerting engagement of the distal end 34″ of the pressure member 34 with the septum.
With further reference to the pressure member 34 and as represented in
As emphasized herein, the seal structure 10 of the present invention includes tamper evident capabilities and/or structure. Therefore, in at least one embodiment the tamper evident capability or structure includes a removable sidewall section 40 initially integral with a remainder of the sidewall 14. Further, the removable sidewall section 40 includes a detachable connection to the remainder of the sidewall 14. Such a detachable connection may be defined by and/or comprise at least one but preferably two elongated weakened seam lines 42 each disposed on a different opposite side of the removable section 40 and extending along a length thereof from the open end 20 to the closed-end 18 of the housing 12. The weakened seam lines 42 are structured such that exertion of a pulling or other appropriately directed force on the removable section 40 will cause a breakage, disconnection and/or separation of one or both of the weakened seam lines 42 from the remainder of the sidewall 14, due to at least in part to a reduction in the thickness of the sidewall 14 along and entirety or at least a portion of the length of the weakened seam lines 42. In addition, the aforementioned pulling or other appropriately directed force exerted on the removable sidewall section 40 may be facilitated by the inclusion of a pull tab 44 secured to the removable section 40 preferably at one end thereof which is aligned and/or coincident with the open end 20 of the housing 12. The pull tab 44 is fixedly secured to the removable sidewall section 40 and movable/removable there with as the removable section 40 breaks away from the remainder of the sidewall 14. As represented throughout the Figures, the pull tab 44 will extend outwardly from the exterior surface of the sidewall. To facilitate gripping of the pull tab 44, the exterior surface or other portion of the full tab 44 may be raised, roughened or otherwise structured, as at 48, to facilitate the gripping or securement thereof by the hand or fingers of a user.
As should be apparent, partial or complete removal of the removable sidewall section 40 will result in an inability to reconnect the replaceable sidewall section 40 with remainder of the sidewall 14 or housing 12. As a result, the housing 12 and/or sidewall 14 will not be able to be “closed” or reconnected in its original operative configuration, as represented in at least
Yet additional features of one or more embodiments of the seal structure of the present invention may include the dimensioning and configuring of the sidewall 14 to include a display field 50 disposed on the exterior surface of the sidewall 14, as clearly represented in
Yet another structural and operative feature which may be included in at least one embodiment of the seal structure 10 is represented in
Since many modifications, variations and changes in detail can be made to the described preferred embodiment of the invention, it is intended that all matters in the foregoing description and shown in the accompanying drawings be interpreted as illustrative and not in a limiting sense. Thus, the scope of the invention should be determined by the appended claims and their legal equivalents.
The present application is based on and a claim of priority is made under 35 U.S.C. Section 119(e) to a provisional patent application that is in the U.S. Patent and Trademark Office, namely, that having Ser. No. 63/131,124 and a filing date of Dec. 28, 2020, and which is incorporated herein by reference.
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