TAS::75 0849::TAS MULTIFUNCTIONAL SIRNA NANOPARTICLES FOR AML THERAPY

Information

• Research Project
• 8165848

• ApplicationId

  8165848

• Core Project Number

  261201000051C-0-0-1

• Full Project Number

  261201000051C-0-0-1

• Serial Number

  0

• FOA Number

• Sub Project Id

• Project Start Date

  9/24/2010 - 14 years ago

• Project End Date

  6/23/2011 - 13 years ago

• Program Officer Name

• Budget Start Date

  -

• Budget End Date

  -

• Fiscal Year

  2010

• Support Year

• Suffix

• Award Notice Date

  -

Organizations

• Nanomaterial Innovation Ltd.

This project will investigate transferrin (Tf) conjugated fluorescent nanoparticles loaded with an siRNA, LOR-1284, as a theranostic agent for acute myelogenous leukemia (AML). LOR-1284, a siRNA targeting the R2 subunit of ribonucleotide reductase (RNR), is a promising agent for overcoming RNR-mediated drug resistance in AML. The nanoparticles are designed to facilitate LOR-1284 delivery to AML cells (for therapy) while enabling easy detection of delivery efficiency to the AML cells in leukemia patients (for diagnosis). A novel microfluidic method has been developed for nanoparticle synthesis. This project will be carried out by a multidisciplinary team of investigators at NIL and at The Ohio State University.

IC Name

• Activity

  N43

• Administering IC

  CA

• Application Type

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

  200000

• Sub Project Total Cost

• ARRA Funded

  False

• CFDA Code

  395

• Ed Inst. Type

• Funding ICs

  NCI:200000\

• Funding Mechanism

  Contracts, Extramural

• Study Section

• Study Section Name

• Organization Name

  NANOMATERIAL INNOVATION, LTD

• Organization Department

• Organization DUNS

  167239057

• Organization City

  COLUMBUS

• Organization State

  OH

• Organization Country

  UNITED STATES

• Organization Zip Code

  432204949

• Organization District

  UNITED STATES