Claims
- 1. A taste masked pharmaceutical composition comprising a microcapsule, said microcapsule comprising a pharmaceutically active agent core coated with a taste masking effective amount of a water-insoluble enteric coating, wherein said pharmaceutically active agent is an antibiotic drug selected from a naphthyridone-carboxylic acid antibiotic or a quinolone-carboxylic acid antibiotic, and wherein the coating comprises a weakly acidic methacrylic acid-ethyl acrylate copolymer.
- 2. The formulation of claim 1 wherein the antibiotic drug is selected from levofloxacin, ciprofloxacin, norfioxacin, ofloxacin or enoxacin.
- 3. The formulation of claim 2 wherein the antibiotic drug is levofloxacin.
- 4. The formulation of claim 3 wherein levofloxacin is present in a range of from about 1 gram to about 5 grams of levofloxacin per 100 mL of a reconstituted formulation.
- 5. The formulation of claim 4 wherein levofloxacin is present in a range of from about 2.5 grams to about 5 grams of levofloxacin per 100 mL of a reconstituted formulation.
- 6. The formulation of claim 4 wherein levofloxacin is present in a range selected from about 1 gram of levofloxacin per 100 mL of a reconstituted formulation, from about 2.5 grams of levofloxacin per 100 mL of a reconstituted formulation or from about 5 grams of levofloxacin per 100 mL of a reconstituted formulation.
- 7. The formulation of claim 1 wherein the taste masking effective amount of the coating is a weight ratio of coating weight to weight of the active agent in a range of from about 0.5 to about 1.5 or from about 1.5 to about 0.5.
- 8. The formulation of claim 1 wherein the taste masking effective amount of the coating is a weight ratio of coating weight to weight of the active agent in a range of from about 0.75 to about 1.25 or from about 1.25 to about 0.75.
- 9. The formulation of claim 1 wherein the taste masking effective amount of the coating is a weight ratio of coating weight to weight of the active agent of about 1.0 to about 1.0.
- 10. The formulation of claim 1 wherein the weakly acidic methacrylic acid-ethyl acrylate copolymer is selected from a copolymer designed to dissolve at a pH greater than about pH 5.5.
- 11. The formulation of claim 10 wherein the mcthacrylic acid-ethyl acrylate copolymer is a copolymer designed to dissolve at a pH range of from about pH 5.5 to about pH 8.
- 12. The formulation of claim 1 wherein the active agent is levofloxacin: wherein the weakly acidic methacrylic acid-ethyl acrylate copolymer is a copolymer designed to dissolve at a pH range of from about pH 5.5 to about pH 8: and, wherein the taste masking effective amount of the coating is a weight ratio of coating weight to weight of levofloxacin of about 1.0 to about 1.0.
CROSS REFERENCE TO RELATED APPLICATIONS
This application claims benefit of provisional application Serial No. 60/273,473, filed Mar. 5, 2001, which is incorporated by reference herein.
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|
Number |
Date |
Country |
|
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Mar 2001 |
US |