Claims
- 1. A method of forming a multifunctional template utilizing a template of the structure below: where PG is a protecting group, said method comprising the following steps:(a) reacting, in solution, said template with at least one first reactant of the structure R1XH wherein a first modified product of the formula below is formed wherein said first reactant is selected from the group consisting of (b) separating said first modified product from unreacted first reactant; (c) reacting, in solution, said first-modified product with a second reactant to form a second-modified product, wherein said second reactant is selected from the group consisting of; (d) separating said second-modified product from unreacted second reactant; (e) reacting, in solution, said second-modified product with a third reactant to form a third-modified product, wherein said third reactant is selected from the group consisting of and(f) separating said third-modified product from unreacted third reactant.
- 2. A method of forming a multifunctional template utilizing a template of the structure below: where PC is a protecting group, said method comprising the following steps:(a) reacting, in solution, said template with at least one first reactant of the structure R1XH wherein a first modified product of the formula below is formed wherein said first reactant is selected from the group consisting of (b) separating said first modified product from unreacted first reactant; (c) reacting, in solution, said first-modified product with a second reactant to form a second-modified product, wherein said second reactant is selected from the group consisting of; (d) separating said second-modified product from unreacted second reactant; (e) reacting, in solution, said second-modified product with a third reactant to form a third-modified product, wherein said third reactant is selected from the group consisting of and(f) separating said third-modified product from unreacted third reactant.
- 3. A method of forming a multifunctional template utilizing a template of the structure below: where PG is a protecting group, said method comprising the following steps:(a) reacting, in solution, said template with at least one first reactant of the structure R1XH wherein a first modified product of the formula below is formed wherein said first reactant is selected from the group consisting of (b) separating said first modified product from unreacted first reactant; (c) reacting, in solution, said first-modified product with a second reactant to form a second-modified product, wherein said second reactant is selected from the group consisting of; (d) separating said second-modified product from unreacted second reactant; (e) reacting, in solution, said second-modified product with a third reactant to form a third-modified product, wherein said third reactant is selected from the group consisting of and(f) separating said third-modified product from unreacted third reactant.
RELATED APPLICATIONS
The instant application is a divisional of U.S. patent application Ser. No. 08/732,042, filed Oct. 16, 1996, now abandoned, the disclosure of which is hereby incorporated by reference in its entirety. This application claims priority to Boger et al., TEMPLATE FOR SOLUTION PHASE SYNTHESIS OF COMBINATORIAL LIBRARIES, U.S. Provisional Application No. 60/006,891, filed Oct. 17, 1995, which is incorporated herein by reference including drawings.
US Referenced Citations (3)
Non-Patent Literature Citations (2)
Entry |
March, J. Advanced Organic Chemistry: Reactions, Mechanisms and Structure, 4th Ed. 1992. New York; John Wiley & Sons, pp. 418-421. |
Cathala et al. “Macrobicyclic and Macrotricyclic Tetralactams with 1,10-Phananthroline Units. Dinuclear Eu3+ Cryptate of the Macrotricyclic Ligand”. Tetrahedron Letters, vol. 35, No. 12, pp. 1863-1866, 1994. |
Provisional Applications (1)
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Number |
Date |
Country |
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60/006891 |
Oct 1995 |
US |