Claims
- 1. A therapeutic method to treat fungal infection comprising administering to a mammal afflicted with a fungal infection, an effective antifungal amount of a compound of the formula: ##STR5## wherein Ar is (C.sub.6 -C.sub.12)aryl, (5- to 12-membered)heteroaryl comprising 1-3 N, S or non-peroxide O, wherein N is unsubstituted or is substituted with H, (C.sub.1 -C.sub.4)alkyl or benzyl; X is H, CN, CHO, OH, acetyl, CF.sub.3, O(C.sub.1 -C.sub.4)alkyl, NO.sub.2, NH.sub.2, halogen or halo-(C.sub.1 -C.sub.4)alkyl; each of Y is H, (C.sub.1 -C.sub.4)alkyl or aralkyl; Y' is H, (C.sub.1 -C.sub.4)alkyl, phenyl or methoxyphenyl; each Z is individually H, (C.sub.1 -C.sub.4)alkyl, halogen or halo(C.sub.1 -C.sub.4)alkyl; and n is 0-1; or a pharmaceutically acceptable salt thereof.
- 2. The method of claim 1 wherein n is 1 and Ar is at the 5-position.
- 3. The method of claims 1 or 2 wherein Ar is phenyl.
- 4. The method of claims 1 or 2 wherein Ar is 2-pyridyl.
- 5. The method of claim 3 wherein X is halogen.
- 6. The method of claim 5 wherein X is Cl.
- 7. The method of claim 6 wherein X--Ar is p-chlorophenyl.
- 8. The method of claim 7 wherein Y' is H; each Y is H; and each Z is H.
- 9. The method of claim 1 wherein n is 0.
- 10. The method of claim 9 wherein X is Cl.
- 11. The method of claim 9 wherein X is Br.
- 12. The method of claims 10 or 11 wherein Y' is H, CH.sub.3, ethyl or 4-methoxyphenyl; each Y is H; and each Z is H.
- 13. The method of claim 1 wherein Z is H, F, CH.sub.3 or CF.sub.3.
- 14. The method of claim 1 wherein Ar is benzo.
- 15. The method of claim 13 wherein Ar is 4,5-benzo.
- 16. The method of claim 13 wherein Ar is 5,6-benzo.
- 17. The method of claim 1 wherein said compound is systemically administered.
- 18. The method of claim 17 wherein said compound is orally administered.
- 19. The method of claim 1 wherein said compound is parenterally administered.
- 20. The method of claim 19 wherein said c ompound is topically administered.
- 21. The method of claim 19 wherein said compound is administered intravenously.
- 22. The method of claim 1 wherein the mammal is a human.
- 23. The method of claim 1 wherein the fungal infection is a systemic infection.
- 24. The method of claim 1 wherein the compound is administered in combination with a pharmaceutically acceptable vehicle.
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a continuation-in-part of Ser. No. 08/618,988, filed Mar. 20, 1996, pending.
Government Interests
This invention was made with the support of NIH Grant CA 39962. The Government has certain rights in the invention.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5639755 |
Dykstra et al. |
Jun 1997 |
|
5643935 |
Dykstra et al. |
Jul 1997 |
|
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
618988 |
Mar 1996 |
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