Claims
- 1. Compounds of formula 4 ##STR10## and salts thereof, wherein A.sub.1 is an optionally esterified hydroxyl group wherein the esterifying group is acetate or benzoate;
- A.sub.2 is hydrogen;
- A.sub.3 and A.sub.4 independently of each other are straight or branched alkyl or alkenyl having 1-6 C-atoms;
- A.sub.5 is alkylene having 3-5 C-atoms;
- X is carbonyl or the group --CH(OH)--; and
- A.sub.6 is cyclohexyl or phenyl.
- 2. Compounds of formula 4 ##STR11## and salts thereof, wherein A.sub.1 is hydroxyl or esterified hydroxy wherein the esterifying group is acetate or benzoate;
- A.sub.2 is hydrogen;
- A.sub.3 is alkyl having 1-3 C-atoms;
- A.sub.4 is alkyl having 1-3 C-atoms;
- A.sub.5 is a straight alkylene chain having 2-4 C-atoms;
- X is carbonyl or the group CHOH; and
- A.sub.6 is cyclohexyl or phenyl.
- 3. Pharmaceutical compositions having opiate-antagonistic activity which comprise an opiate-antagonistically effective amount of at least one compound as claimed in claim 1 as the active substance and a pharmaceutically acceptable carrier.
- 4. Pharmaceutical compositions having opiate-antagonistic activity which comprise an opiate-antagonistically effective amount of at least one compound as claimed in claim 2 as the active substance, and a pharmaceutically acceptable carrier.
Priority Claims (1)
Number |
Date |
Country |
Kind |
8701617 |
Jul 1987 |
NLX |
|
Parent Case Info
This application is a continuation of application Ser. No. 215,559, filed July 6, 1988 now abandoned.
US Referenced Citations (3)
Non-Patent Literature Citations (2)
Entry |
Chemical Abstracts, 74:22700h (1971), "Butyrophenone Derivatives." |
M. Iorio et al., J. Med. Chem., 21(8), "Nalorphine-like properties of some 2,3-dimethyl-3-arylpiperdines (1978)". |
Continuations (1)
|
Number |
Date |
Country |
Parent |
215559 |
Jul 1988 |
|