Claims
- 1. Tetrahydro .beta.-carbolines of the formula: ##STR8## wherein R is OCH.sub.3 or F; R.sub.1 is H or CH.sub.3 and R.sub.2 is H.
- 2. A compound as described in claim 1 wherein R is OCH.sub.3, R.sub.1 is CH.sub.3 and R.sub.2 is H.
- 3. A compound as described in claim 1 wherein R is F, R.sub.1 is H and R.sub.2 is H.
- 4. A compound as described in claim 1 wherein R is F, R.sub.1 is CH.sub.3 and R.sub.2 is H.
- 5. A compound as described in claim 1 wherein R.sub.1 and R.sub.2 are H.
- 6. A compound as described in claim 1 wherein R.sub.1 is CH.sub.3 and R.sub.2 is H.
- 7. A compound as described in claim 1 in the form of its pharmaceutically acceptable, organic or inorganic acid addition salt.
- 8. A method of treating hypertension in an individual for whom such therapy is indicated which method comprises administering to such individual an antihypertensively effective amount of a compound characterized by the formula: ##STR9## wherein R is OCH.sub.3 or F; R.sub.1 is H or CH.sub.3 and R.sub.2 is H.
- 9. The method of claim 8 wherein the compound administered is further defined in that R is OCH.sub.3, R.sub.1 is CH.sub.3 and R.sub.2 is H.
- 10. The method of claim 8 wherein the compound administered is further defined in that R is F, R.sub.1 is H and R.sub.2 is H.
- 11. The method of claim 8 wherein the compound administered is further defined in that R is F, R.sub.1 is CH.sub.3 and R.sub.2 is H.
- 12. The method of claim 8 wherein the compound administered is further defined in that R.sub.1 and R.sub.2 are H.
- 13. The method of claim 8 wherein the compound administered is further defined in that R.sub.1 is CH.sub.3 and R.sub.2 is H.
- 14. The method of claim 8 wherein the compound administered is in the form of its pharmaceutically acceptable, organic or inorganic acid addition salt.
Parent Case Info
This is a division of application Ser. No. 176,407, filed Aug. 8, 1980 now U.S. Pat. No. 4,291,039 issued Oct. 22, 1981.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3202666 |
Szuszkovica |
Aug 1964 |
|
3202667 |
Szuszkovica et al. |
Aug 1965 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
655046 |
Sep 1965 |
ZAX |
Non-Patent Literature Citations (2)
Entry |
Harvey et al., Journal of the Chemical Society, London, pp. 153-159, 1941. |
Saxena et al., Chemical Abstracts, vol. 79, No. 11, 61, 395-k, Sep. 17, 1973. |
Divisions (1)
|
Number |
Date |
Country |
Parent |
176407 |
Aug 1980 |
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