Claims
- 1. A compound having the general formula ##STR42## including pharmaceutically acceptable salts thereof, wherein R and R' taken together with the carbon atom to which they are attached form a 5- to 7-membered nitrogen-containing ring ##STR43## R.sub.1 is hydrogen, halogen, alkyl, haloalkyl, cyano, hydroxy, alkoxy, aryl, arylalkoxy, arylalkyl, or fluorosubstituted alkyl;
- R.sub.2 is hydrogen, halogen, alkyl, alkoxy, aryloxy, arylalkoxy, arylalkyl, cyano, hydroxy, alkanoyloxy, --O--C(O)--NY.sub.1 Y.sub.2, fluoro substituted alkoxy, fluoro substituted alkyl, (cycloalkyl)alkoxy, --NO.sub.2, --NH.sub.3 Y.sub.4, --S(O).sub.m alkyl, --S(O).sub.m aryl, --C(O)--Y.sub.5 or --O--C--(O)--Y.sub.6 ;
- m is 0, 1 or 2;
- q and r are independently 0, 1, 2 or 3, with the proviso that one of q and r must be other than zero;
- Y.sub.1 and Y.sub.2 are each independently hydrogen, alkyl, aryl or heteroaryl, or Y.sub.1 and Y.sub.2 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl or morpholinyl;
- Y.sub.3 and Y.sub.4 are each independently hydrogen, alkyl, alkanoyl, arylcarbonyl, heteroarylcarbonyl, or --C(O)--NY.sub.1 Y.sub.2 ;
- Y.sub.5 is hydroxy, alkoxy, aryloxy, amino, alkylamino or dialkylamino; and,
- Y.sub.6 is alkyl, alkoxy or aryloxy.
- 2. A compound of claim 1 having the name (1R*,2R*,4S*,9S*)-1,2,3,4-Tetrahydro-9-(4-methoxyphenyl)spiro[1,4-ethanonaphthalene-2,3'-pyrrolidine], monohydrochloride.
- 3. A compound having the name (1R*,2S*,4R*)-1,2,3,4-Tetrahydro-9-(4-methoxyphenyl)spiro-[1,4-ethenonaphthalene-2,3'-pyrrolidine], monohydrochloride.
- 4. A compound of claim 1 having the name (1R*,2S*,4S*,9S*)-1,2,3,4-Tetrahydro-9-(4-methoxyphenyl)spiro[1,4-ethanonaphthalene-2,3'-pyrrolidine], monohydrochloride.
- 5. A method of treating a cardiovascular disorder, comprising the step of administering a compound of claim 1 in an amount effective therefor to a subject in need thereof.
Parent Case Info
This is a division of application Ser. No. 07/560,518, filed on Jul. 31, 1990, now U.S. Pat. No. 5,202,486.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
3932512 |
Bharucha et al. |
Jan 1976 |
|
4680310 |
Hengartner et al. |
Jul 1987 |
|
Divisions (1)
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Number |
Date |
Country |
Parent |
560518 |
Jul 1990 |
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