Claims
- 1. A compound of the formula I ##STR30## wherein R.sub.1 is in the 4-position and represents a C.sub.1-4 -alkyl, C.sub.3-7 -cycloalkyl or trifluoromethyl group,
- R.sub.2 represents a 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl group,
- R.sub.3 represents a C.sub.1-5 -alkyl group or cyclopropyl, and
- R.sub.4 denotes a 1H-tetrazolyl group or an R.sub.a O--CO-- group, wherein
- R.sub.a denotes a hydrogen atom or a straight-chained or branched C.sub.1-4 -alkyl group,
- or a pharmaceutically acceptable salt thereof.
- 2. In accordance with claim 1, a compound of the formula I, wherein
- R.sub.2 is in the 6-position,
- or a pharmaceutically acceptable salt thereof.
- 3. In accordance with claim 2, a compound of the formula I, wherein
- R.sub.1 represents a methyl group,
- R.sub.2 is in the 6-position and represents a 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl group,
- R.sub.3 represents a C.sub.1-5 -alkyl group, and
- R.sub.4 represents a carboxy or 1H-tetrazolyl group,
- or a pharmaceutically acceptable salt thereof.
- 4. 4'-[(2-Ethyl-4-methyl-6-(5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl)-benzimidazol-1-yl)-methyl]-biphenyl-2-carboxylic acid or a pharmaceutically acceptable salt thereof.
- 5. A pharmaceutical composition comprising a compound as in any one of claims 1, 2, 3 or 4.
- 6. A method for treating hypertension which comprises administering to a mammalian host suffering from the same an antihypertensive amount of a compound as in any one of claims 1, 2, 3 or 4.
Priority Claims (9)
Number |
Date |
Country |
Kind |
41 03 492.9 |
Feb 1991 |
DEX |
|
41 17 121.7 |
May 1991 |
DEX |
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41 37 812.1 |
Nov 1991 |
DEX |
|
42 01 554.5 |
Jan 1992 |
DEX |
|
42 12 250.3 |
Apr 1992 |
DEX |
|
42 19 782.1 |
Jun 1992 |
DEX |
|
42 24 133.2 |
Jul 1992 |
DEX |
|
42 24 752.7 |
Jul 1992 |
DEX |
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42 25 756.5 |
Aug 1992 |
DEX |
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RELATED APPLICATIONS
This application is a division of Ser. No. 08/385,936, filed on Feb. 9, 1995, which is a continuation-in-part of the following four prior applications:
US Referenced Citations (10)
Foreign Referenced Citations (6)
Number |
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2047496 |
Feb 1992 |
CAX |
0426021 |
May 1991 |
EPX |
0468470 |
Jan 1992 |
EPX |
0495626 |
Jul 1992 |
EPX |
0512314 |
Sep 1992 |
EPX |
92-04343 |
Mar 1992 |
WOX |
Divisions (1)
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Date |
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Parent |
385936 |
Feb 1995 |
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Continuations (3)
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Parent |
832193 |
Feb 1992 |
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Parent |
07315 |
Jan 1993 |
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Parent |
40778 |
Mar 1993 |
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Continuation in Parts (1)
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201139 |
Feb 1994 |
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