Claims
- 1. A method of treating arrhythmia comprising administering an effective anti-arrhythmia amount of a tetrahydroprotoberberine quaternary ammonium compound having the formula: ##STR20## wherein R.sub.1 and R.sub.2 are CH.sub.3 O--, or taken together with the adherent carbon atoms to form a ring represented by the structure ##STR21## X is I, Cl or Br; and R' is --CH.sub.3 when X is I, R' is --C.sub.2 H.sub.5, --CH.sub.2 CH.dbd.CH.sub.2, --CH.sub.2 COOC.sub.2 H.sub.5 ##STR22## when X is Br, and R' is ##STR23## to a patient in need thereof.
- 2. The method according to claim 1 which comprises the administration of 7-(4-chlorobenzyl)-5,8,13,13a-tetrahydroberberine chloride.
- 3. A compound which is 7-(4-chlorobenzyl)-5,8,13,13a-tetrahydroberberine chloride.
Priority Claims (1)
Number |
Date |
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Kind |
91107511.9 |
Oct 1991 |
CNX |
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Parent Case Info
This application is a continuation of application Ser. No. 07/964,252 filed on Oct. 21, 1992, now abandoned.
Non-Patent Literature Citations (4)
Entry |
Wang Y. X. et al. Acta Pharmacological Sinica (1987) 8(3):220-223. |
Xu Z. et al. Acta Pharmacologica Sinica (1989) 110(4):320-324. |
Wang Y. et al. Acta Pharmacologica Sinica (1990) 11(5):422-427. |
Tanaka S. et al. Chemical Abstracts (1979), 90:138075t. |
Continuations (1)
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Number |
Date |
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Parent |
964252 |
Oct 1992 |
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