Claims
- 1. A compound of the formula 1in whichR1 is methyl or hydroxymethyl, one of the substituents R2a and R2b is hydrogen and the other is hydroxy, methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy, one of the substituents R3a and R3b is hydrogen and the other is hydroxy, methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy, where R2a or R2b on the one hand and R3a or R3b on the other hand are not simultaneously hydroxy, or a salt thereof.
- 2. A compound according to claim 1 having the following formula 1*in whichR1 is methyl or hydroxymethyl, one of the substituents R2a and R2b is hydrogen and the other is hydroxy, methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy, one of the substituents R3a and R3b is hydrogen and the other is hydroxy, methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy, where R2a or R2b on the one hand and R3a or R3b on the other hand are not simultaneously hydroxy, or a salt thereof.
- 3. A compound of formula 1* according to claim 2, in whichR1 is methyl, one of the substituents R2a and R2b is hydrogen and the other is methoxy, ethoxy, isopropoxy, methoxyethyoxy or methoxypropoxy, one of the substituents R3a and R3b is hydrogen and the other is hydroxy, or a salt thereof.
- 4. A compound of formula 1* according to claim 2 in whichR1 is methyl, one of the substituents R2a and R2b is hydrogen and the other is methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy, one of the substituents R3a and R3b is hydrogen and the other is methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy, or a salt thereof.
- 5. A compound of formula 1* according to claim 2, which R3b is hydrogen or a salt thereof.
- 6. A compound of formula 1* according to claim 2, which R2a and R3b are hydrogen.
- 7. A compound according to claim 1 having the following formula 1**in whichone of the substituents Ra and Rb is hydrogen and the other is methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy or a salt thereof.
- 8. A compound of formula 1** according to claim 7, in whichRa is hydrogen and Rb is methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy, or a salt thereof.
- 9. A compound according to claim 1 which is (7R, 8R, 9R)-2,3-Dimethyl-8-hydroxy-7-(2-methoxyethoxy)-0-phenyl-7,8,9,10-tetrahydro-imidazo[1,2-h][1,7]naphthyridine or a salt thereof.
- 10. A compound of the formula 1in whichR1 is methyl or hydroxymethyl, one of the substituents R2a and R2b is hydrogen and the other is hydroxy, methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxypropoxy, one of the substituents R3a and R3b is hydrogen and the other is hydroxy, methoxy, ethoxy, isopropoxy, methoxyethoxy or methoxy propoxy, where R2a or R2b on the one hand and R3or R3b on the other hand are not simultaneously hydroxy or a pharmacologically tolerable salt thereof.
- 11. A medicament composition comprising a compound as claimed in claim 10 and/or a pharmacologically tolerable salt thereof together a with customary pharmaceutical auxillary and/or excipient.
- 12. A method for producing a medicament composition by compounding an active ingredient for preventing or treating a gastrointestinal disease, or a pharmacologically-tolerable salt thereof, with a customary pharmaceutical auxiliary and/or excipient, wherein the active ingredient is a compound according to claim 10.
- 13. A method of treating or preventing an amenable gastrointestinal disease which comprises administering an effective amount of an active ingredient or a pharmacologically tolerable salt thereof to a subject subject to or afflicted with such disease, wherein the active ingredient is a compound according to claim 10.
Priority Claims (2)
Number |
Date |
Country |
Kind |
198 43 504 |
Sep 1998 |
DE |
|
98117988 |
Sep 1998 |
DE |
|
RELATED APPLICATION
This application is directed to subject matter related to that disclosed and claimed in U.S. Pat. No. 6,197,783.
PCT Information
Filing Document |
Filing Date |
Country |
Kind |
PCT/EP99/06899 |
|
WO |
00 |
Publishing Document |
Publishing Date |
Country |
Kind |
WO00/17200 |
3/30/2000 |
WO |
A |
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
6197783 |
Senn-Bilfinger |
Mar 2001 |
B1 |