Greenwald, Richard B., et al. Drug Delivery Systems Employing 1,4—or 1,6—Elimination: Poly (ethylene-glycol) Prodrugs of Amine-Containing Compounds, Journal of Medicinal Chemistry, vol. 42, No. 18, pp. 3657-3667, 1999. |
Maeda, H., et al., “Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review” J. Contr. Release 65 (2000) pp. 271-284. |
Zier et al. Polyethylene Glycol Bound Benzyl and Fluorenyl Derivatives . . . Tetrahedron Letters, vol. 35, No. 7, pp. 1039-1042 (1994). |
Record of Invention “2- and 4- Hydroxybenzyl Alcohol-Containing Linkers”, Zalipsky, Nov. 18, 1991. |
Declaration under 37 C.F.R. 1.132 of Richard B. Greenwald including Exhibits 1 and 2, Sep. 8, 1999. |
Declaration under 37 C.F.R. 1.132 of Jeffrey McGuire, Sep. 8, 1999. |
Shearwater Polymers, Inc., Catalog—Polyethylene Glycol Derivatives, 1997-1998; p. 8. |
Leenders, R.G.G.et al., Highly Diastereoselective Synthesis of Anomeric B-O-Glycopyranosyl Carbamates from Isocyanates, Synthesis Nov. 1996; pp 1309-1312. |
Leenders, R.G.G. et al. B-Glucuronyl Carbamate Based Pro-moieties Designed for Prodrugs in ADEPT, 1995; Tetrahedron Letters vol. 36, No. 10 pp. 1701-1704. |
Waldmann, H. et al, Synthesis of the Palmitoylated and Farnesylated C-Terminal Lipohexapeptide of the Human N-Ras Protein by Employing . . . , Angew. Chem Int. Ed. 1995, 34 No. 20 ; pp. 2259-2262. |
Jungheim, L.N. et al., Design of Antitumor Prodrugs: Substrates for Antibody Targeted Enzymes, Chem. Rev. 1994; 94 pp. 1553-1566. |
Bundgaard, H. The Double Prodrug Concept and its Applications, Advanced Drug Delivery Reviews, 3 1989 pp. 39-65. |
Wakselman, M. et al., An Alkali-labile Substituted Benzyloxycarbonyl Amino-protecting Group, JCS Chem. Comm1973; pp. 593-594. |
Carl, P.L., et al. A Novel Connector Linkage Applicable in Prodrug Design, Journal of Medicinal Chemistry, vol. 24, No. 5 (May 1981). |
Shan, D., et al., Prodrug Strategies Based on Intramolecular Cyclization Reactions, Journal of Pharmaceutical Sciences, Jul. 1997, vol. 86, No. 7, pp765-767. |