Claims
- 1. A tetrazole derivative, or a salt thereof, represented by formula (1): wherein ##STR8## R.sup.1 and R.sup.2, independently, represent a hydrogen atom, a hydroxyl group, a lower alkyl group, an alkoxy group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms substituted with an alkoxy group having 1 to 6 carbon atoms, a halogen atom, a phenyl group, or a di-(C1-C4)alkylamino group; an alkanoyloxy group having 2 to 5 carbon atoms; or an alkanoyloxy group having 2 to 5 carbon atoms substituted with an amino group;
- R.sup.3 represents a hydrogen atom, a lower alkyl group, or a lower alkyl group substituted with a halogen atom, an amino group, a phenyl group, or a phenyl group substituted with a C1-C4 alkyl group;
- A represents a methyleneoxy group or a vinylene group;
- Z represents an unsubstituted benzimidazole or a benzimidazole group substituted with a C1-C4alkyl group or a (C1-C4)alkoxy(C1-C4)alkyl group;
- and a broken line indicates that there may be a double bond.
- 2. The tetrazole derivative or a salt thereof as defined in claim 1, wherein Z represents a benzimidazole group substituted with a C1-C4 alkyl group or a (C1-C4)alkoxy(C1-C4)alkyl group.
- 3. The tetrazole derivative or a salt thereof as defined in claim 1, wherein Z represents an unsubstituted benzimidazole group.
- 4. The tetrazole derivative or a salt thereof as defined in claim 1, wherein said lower alkyl group has 1 to 6 carbon atoms.
- 5. The tetrazole derivative or a salt thereof as defined in claim 1, wherein R.sup.3 is a hydrogen atom, a methyl group, or a dimethylaminomethyl group.
- 6. The tetrazole derivative or a salt thereof as defined in claim 1, which is an addition salt of a mineral acid or an inorganic acid.
- 7. The addition salt of the tetrazole derivative as defined in claim 6, which is selected from the group consisting of hydrochlorides, hydrobromides, hydroiodides, sulfates, phosphates, benzoates, methanesulfonates, ethanesulfonates, benzenesulfonates, p-toluenesulfonates, oxalates, maleates, fumarates, tartarates, and citrates.
- 8. The tetrazole derivative or a salt thereof as defined in claim 1, which is 3-{1-{3-[N-(2-Ethoxyethyl)benzimidazol-2-ylmethoxy]benzyl}tetrazolyl}-6-hydroxyquinolin-2-one, 3-{1-{4-[N-(2-Ethoxyethyl)benzimidazol-2-ylmethoxy]benzyl}tetrazolyl}-6-hydroxyquinolin-2-one, 3-{2-{4-[N-(2-Ethoxyethyl)benzimidazol-2-ylmethoxy]benzyl}tetrazolyl}-6-hydroxyquinolin-2-one, 3-{2-{4-[N-(2-Ethoxyethyl)benzimidazol-2-ylmethoxy]benzyl}tetrazolyl}-6-hydroxyquinolin-2-one, 3-{1-{4-[N-(2-Ethoxyethyl)benzimidazol-2-ylmethoxy]benzyl}tetrazolyl}-6-hydroxyquinolin-2-one, 3-{2-[3-(N-Methylbenzimidazol-2-ylmethoxy)benzyl]tetrazolyl}quinolin-2-one or 3-{1-[3-(N-Methylbenzimidazol-2-ylmethoxy)benzyl]tetrazolyl}quinolin-2-one
- 9. A composition, comprising the tetrazole derivative or a salt thereof as defined in claim 1, and a pharmaceutically acceptable carrier.
- 10. The composition of claim 9, which is in the form of a tablet, capsule, granule, powder, syrup or suppository.
- 11. A method of treating asthma, which method comprises administering to a patient in need thereof an effective amount of a tetrazole derivative or a salt thereof as described in claim 1.
Priority Claims (1)
Number |
Date |
Country |
Kind |
9-262356 |
Sep 1997 |
JPX |
|
Parent Case Info
This application is a Divisional of U.S. application Ser. No. 09/158,744, filed on Sep. 23, 1998.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5756518 |
Timmerman et al. |
May 1998 |
|
5885987 |
Timmerman et al. |
Mar 1999 |
|
Foreign Referenced Citations (2)
Number |
Date |
Country |
WO 8905294 |
Jun 1989 |
WOX |
0 658 554 A1 |
Jun 1995 |
WOX |
Divisions (1)
|
Number |
Date |
Country |
Parent |
158774 |
Sep 1998 |
|