Claims
- 1. A pharmaceutical composition for inhibiting the release of spasmogen mediators in the antigen-antibody reaction comprising an effective amount of a compound of the formula ##SPC4## wherein:
- X is 5-[1H]-tetrazolyl, and
- R.sub.1 is hydrogen or OR.sub.2, where R.sub.2 is lower alkyl containing up to 6 carbon atoms or lower alkyl containing up to 6 carbon atoms substituted by one or more hydroxy groups; or a pharmaceutically acceptable salt thereof, said compound being in association with a pharmaceutically acceptable carrier.
- 2. A composition as claimed in claim 1 for oral administration.
- 3. A composition as claimed in claim 2 in which the formulation is in the form of dosage unit each dosage unit containing from 5 to 1500 mg of active ingredient.
- 4. A composition as claimed in claim 1 for administration by inhalation.
- 5. A composition as claimed in claim 4 in the form of an aerosol to be dispensed from an aerosol pack in a metered dose of from 1 to 10 mg.
- 6. A composition as claimed in claim 1 in which said compound is 5-[7-(2-hydroxyethoxy)anthraquinone-2-yl]-1H-tetrazole.
- 7. A method of inhibiting the release of spasmogen mediators in the antigen-antibody reaction in the patient in need thereof which comprises administering an effective amount of the compound of the formula ##SPC5##
- wherein:
- X is 5-[1H]-tetrazolyl, and
- R.sub.1 is hydrogen or OR.sub.2, where R.sub.2 is lower alkyl containing up to 6 carbon atoms or lower alkyl containing up to 6 carbon atoms substituted by one or more hydroxy groups; or a pharmaceutically acceptable salt thereof.
- 8. The method of claim 7 wherein said compound is administered in combination with a bronchodilator.
- 9. The method of claim 7 wherein said compound is 5-[7-(2-hydroxyethoxy)anthraquinone-2-yl]-1H-tetrazole.
Priority Claims (1)
Number |
Date |
Country |
Kind |
56464/70 |
Nov 1970 |
UK |
|
Parent Case Info
This is a division of application Ser. No. 193,971 filed Oct. 29, 1971 now abandoned and refiled as U.S. Ser. No. 530,038 filed Sept. 5, 1974.
US Referenced Citations (4)
Non-Patent Literature Citations (3)
Entry |
Lobov et al., Chemical Abstracts, 66: 36740t (1967). |
McManus et al., J. Org. Chem. 24 1464-1467 (1959). |
Juby et al., J. Med. Chem. 11 pp. 111-117 (1968). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
193971 |
Oct 1971 |
|