Claims
- 1. A compound of the formula: ##STR7## wherein Ar is phenyl, phenyl substituted one or more times by a radical selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkoxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.4 alkanoyl, hydroxyl, hydroxy-C.sub.1 -C.sub.6 -alkyl, carboxyl, C.sub.1 -C.sub.6 alkoxycarbonyl, carbamoyl, nitro, amino or halogen,
- A is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 aliphatic hydrocarbon which is unsubstituted or substituted by a hydroxyl group,
- n is 0, 1 or 2,
- B is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 -aliphatic hydrocarbon and
- R is 5-(1H)-tetrazolyl,
- --CO--NH--tetrazolyl or
- -- (1H)--tetrazolylthio; or
- a pharmacologically acceptable salt thereof.
- 2. The compound of claim 1, wherein Ar is phenyl, phenyl substituted one or more times by a radical selected from the group consisting of propyl, pentyl, allyl, methoxy, ethoxy, acetyl, hydroxyl, 1-hydroxyhexyl or halogen, A is methylene, ethylene, propylene, butylene, pentylene, but-2-enylene, but-2-ynylene or 2-hydroxypropylene, n is 1, B is methylene, ethylene, propylene, butylene or pentylene, R is 5-(1H)-tetrazolyl, --CO--NH--tetrazolyl or 5-(1H)-tetrazolylthio or a pharmacologically acceptable salt thereof.
- 3. The compound of claim 1, wherein Ar is phenyl substituted by a radical selected from the group consisting of propyl, allyl, hydroxyl, acetyl, chloro or 1-hydroxyhexyl, A is propylene, butylene, but-2-enylene or 2-hydroxy-propylene, n is 0, B is methylene, ethylene, propylene or pentylene and R is a 5-tetrazolylaminocarbonyl, 5-tetrazolyl or a 5-tetrazolylthio or a pharmacologically acceptable salt thereof.
- 4. The compound of claim 1 wherein Ar is 4-acetyl-3-hydroxy-2-propylphenyl, 3-(1-hydroxyhexyl) phenyl or 3,4-dichlorophenyl; A is but-2-ynylene, propylene, or butylene or hydroxy substituted propylene; B is ethylene, propylene, or pentylene and R is [N-hydroxy-N-methylaminocarbonyl,] 5-terazolylamino-carbonyl or 5-tetrazolyl, or a pharmaceutically acceptable salt thereof.
- 5. The compound of claim 1 wherein R is 5-tetrazolylaminocarbonyl or 5-tetrazolyl.
- 6. The compound of claim 1 wherein A is propylene, butylene, but-2-enylene, but-2-ynylene, or 2-hydroxypropylene.
- 7. The compound of claim 1 wherein B is ethylene, propylene or pentylene.
- 8. The compound of claim 1 designated N-[(1H)-tetrazol-5-yl]-S-[3-(3-{1-hydroxyhexyl}-phenoxy)-2-hydroxypropyl]-4-thio-butyric acid amide.
- 9. The compound of claim 1 designated N-[(1H)-tetrazol-5-yl]-S-[4-(3-{1-hydroxyhexyl}-phenoxy)-butyl]-3-thiopropionic acid amide.
- 10. The compound of claim 1 designated N-[(1H)-tetrazol-5-yl]-S-[3-(3,4-dichlorophenoxy)-propyl]-3-thiopropionic acid amide.
- 11. The compound of claim 1 designated 5-{S-3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propyl-5-thiopentyl}- (1H)-tetrazole.
- 12. The compound of claim 1 wherein Ar is phenyl, phenyl substituted one, two or three times and the substituents are selected from the group consisting of C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.4 -alkanoyl, hydroxyl, hydroxy-C.sub.1 -C.sub.6 -alkyl, carboxyl, C.sub.1 -C.sub.6 -alkoxy-carbonyl, carbamoyl, nitro, amino and halogen.
- 13. The compound of claim 1 designated 5-{S-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propyl]-2-thioethyl}-(1H)-tetrazole.
- 14. The compound of claim 1 designated 5-{S-[3-(4-acetyl-3-hydroxy-2-allylphenoxy)-propyl]-thiomethyl}-(1H)-tetrazole.
- 15. A pharmaceutical composition for combating allergic diseases containing an effective amount to combat allergic diseases of the compound of claim 1 in a pharmaceutically acceptable carrier.
- 16. The pharmaceutical composition of claim 15 wherein said compound is selected form one or more of the group consisting of 5-{S-[3-(4-acetyl-3-hydroxy-2-allylphenoxy)-propyl]-thiomethyl}1-(1H)-tetrazole; N-[(1H)-tetrazol-5-yl]-S-[3-(3,4-dichlorophenoxy)-propyl]-3-thiopropionic acid amide, 5-{S-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propyl]-5-thiopentyl}-(1H)-tetrazole and 5-{S-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)-propyl]-2-thioethyl}-1(1H)-tetrazole.
- 17. A method for combating allergic diseases in a patient suffering from an allergic disease comprising administering an effective amount to combat said allergic disease, of the compound of claim 1 or a pharmaceutically acceptable salt thereof.
- 18. The method of claim 13 wherein 0.1 to 50 mg/kg body weight is administered daily.
- 19. A method for combating allergic diseases in a patient suffering from an allergic disease comprising administering an effective amount to combat said allergic disease, of the pharmaceutical composition of claim 15.
- 20. A method for combating allergic diseases in a patient suffering from an allergic disease comprising administering an effective amount to combat said allergic disease of the pharmaceutical composition of claim 16.
Priority Claims (1)
Number |
Date |
Country |
Kind |
3604050 |
Feb 1986 |
DEX |
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Parent Case Info
This is a division application of application Ser. No. 011,096, filed Feb. 5, 1987, now U.S. Pat. No. 4,906,666.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
4875110 |
Baker et al. |
Jul 1989 |
|
Foreign Referenced Citations (1)
Number |
Date |
Country |
2184121 |
Jun 1987 |
GBX |
Divisions (1)
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Number |
Date |
Country |
Parent |
11096 |
Feb 1987 |
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