Research Project
10441828
Using Integrative Data Analysis to Examine the Impact of Psychosocial Treatments for Black Cocaine Users Enrolled in the NIDA Drug Abuse Treatment Clinical Trials Network (CTN) Specific Aims Recent reports reveal that the acceleration of opioid-involved overdose deaths for Black people now outpaces that of White people.1 This increase is attributable to the presence of synthetic opioids (fentanyl) in the cocaine supply in approximately one third of opioid overdose deaths. The limited body of work available suggests that treatment effectiveness may vary across racial- ethnic groups. Yet, only a subset of these studies have specifically looked at cocaine use. The CTN provides a unique but underexplored collection of studies that can improve our knowledge on effective psychosocial treatments for Black people who use cocaine. The proposed study will combine data from 7 CTN treatment studies (total N = 1442 Black participants) that in combination present mixed findings. Using multiple emerging measurement/data analysis frameworks (integrative data analysis (IDA), meta-analysis of individual patient data (MIPD), causal moderation analysis), the goal of the proposed study is to evaluate the effectiveness of substance use disorder treatments for Black people who use cocaine. The project has three specific aims: Aim 1: Estimate scale scores of cocaine use severity while considering study-level measurement non-invariance. Aim 2: Compare the effectiveness of evidence-based treatment models for cocaine use severity. Aim 3: Explore individual- and study-level moderators, such as concomitant opioid use, age, sex, employment, pre-treatment psychiatric status, and retention to evaluate subgroup differences in treatment effectiveness.
