TREA

The role of selective brain penetrating GRPR antagonists in pruritis.

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Information

  • Research Project
  • 8338820
  • ApplicationId
    8338820
  • Core Project Number
    R21NS077348
  • Full Project Number
    5R21NS077348-02
  • Serial Number
    077348
  • FOA Number
    PAR-09-251
  • Sub Project Id
  • Project Start Date
    9/30/2011 - 13 years ago
  • Project End Date
    12/30/2013 - 11 years ago
  • Program Officer Name
    FARKAS, REBECCA M.
  • Budget Start Date
    7/1/2012 - 12 years ago
  • Budget End Date
    12/30/2013 - 11 years ago
  • Fiscal Year
    2012
  • Support Year
    02
  • Suffix
  • Award Notice Date
    6/19/2012 - 12 years ago
Organizations
Information

The role of selective brain penetrating GRPR antagonists in pruritis.

DESCRIPTION (provided by applicant): The goal is to discover novel selective CNS penetrant antagonists of the GRP receptor (GRPR) as probes to validate a new target implicated in pruritic responses. In this work, new compounds will be identified utilizing our assay cascade incorporating in vitro receptor pharmacology and novel in vivo screening tools for evaluating pruritic behavior. Candidate ligands will be designed and synthesized using a series of recognized approaches in medicinal chemistry to have a high likelihood of CNS penetration. Compounds that meet our in vitro criteria will be assessed in a series of pre-clinical pruritis models to evaluate the role of this receptor in pruritis. This work will determine the involvement of GRPR in the pruritic response and determine its utility as a potential drug target.

IC Name
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
  • Activity
    R21
  • Administering IC
    NS
  • Application Type
    5
  • Direct Cost Amount
    285192
  • Indirect Cost Amount
    61266
  • Total Cost
    184000
  • Sub Project Total Cost
  • ARRA Funded
    False
  • CFDA Code
    853
  • Ed Inst. Type
  • Funding ICs
    NINDS:184000\
  • Funding Mechanism
    Non-SBIR/STTR RPGs
  • Study Section
    ZRG1
  • Study Section Name
    Special Emphasis Panel
  • Organization Name
    EPIGEN BIOSCIENCES, INC.
  • Organization Department
  • Organization DUNS
    963248807
  • Organization City
    SAN DIEGO
  • Organization State
    CA
  • Organization Country
    UNITED STATES
  • Organization Zip Code
    921212734
  • Organization District
    UNITED STATES