The Use of Titration & Solution Differential Scanning Calorimetry to Improve Undergraduate Research & Instruction in the Physical Chemistry & Biochemistry Laboratories

Information

• NSF Award
• 9452346

Owner

• University of the Sciences in Philadelphia

• Award Id

  9452346

• Award Effective Date

  9/1/1994 - 29 years ago

• Award Expiration Date

  8/31/1996 - 27 years ago

• Award Amount

  $ 45,000.00

• Award Instrument

  Standard Grant

9452346 Snow It is proposed to acquire a Microcal MSC-ITC/DSC Solution Calorimeter System in order to enhance our capabilities to (i) teach solution thermodynamics to the undergraduate students in our physical chemistry and biochemistry laboratories, and (ii) perform undergraduate research projects requiring the use of solution calorimetry. Two experiments using the solution differential scanning calorimeter(DSC) and the isothermal titration calorimeter (ITC) are to be developed for each laboratory. For the physical chemistry laboratory, it is proposed that the solution DSC be used to measure the thermodynamic properties of a drug-biological membrane interaction, while the titration calorimeter be used to determine the partition coefficient for the partioning of a drug in a biological membrane. For the biochemistry laboratory, it is proposed that the solution DSC be used to study the effects of saturated and cis unsaturated phospholipid systems on the physical properties of biological membranes, while the titration calorimeter be used to study the effects of binding of an enzyme to a substrate analogue. The use of these instruments will expose our students to this important area of physical-biochemistry, something we are unable to do effectively with our present equipment.

• Program Officer

  Gene G. Wubbels

• Min Amd Letter Date

  8/31/1994 - 29 years ago

• Max Amd Letter Date

  8/31/1994 - 29 years ago

• ARRA Amount

• Name

  University of the Sciences in Philadelphia

• City

  Philadelphia

• State

  PA

• Country

  United States

• Address

  600 South 43rd Street

• Postal Code

  191044418

• Phone Number

  2155967491

• First Name

  Julian

• Last Name

  Snow

• Start Date

  9/1/1994 12:00:00 AM

• First Name

  Jeff

• Last Name

  Gazzara

• Start Date

  9/1/1994 12:00:00 AM

• First Name

  Rick

• Last Name

  Hock

• Email Address

  hock@hslc.org

• Start Date

  9/1/1994 12:00:00 AM

• First Name

  Rodney

• Last Name

  Wigent

• Email Address

  r.wigent@pcps.edu

• Start Date

  9/1/1994 12:00:00 AM

• Name

  Other Applications NEC

• Code

  99

• Name

  Chemistry

• Code

  12

• Text

  UNDERGRAD INSTRM & LAB IMPROVE

• Code

  7400

• Text

  UNDERGRADUATE EDUCATION

• Code

  9178

• Text

  INSTRUMENTATION & LAB IMPROVE.

• Code

  9267

• Text

  SCIENCE, MATH, ENG & TECH EDUCATION