Claims
- 1. A method of lowering the activity of an .alpha..sub.2 -plasmin inhibitor which comprises administering to a human or an animal in need thereof an effective amount sufficient to lower the activity of an .alpha..sub.2 -plasmin inhibitor of a compound selected from the group consisting of:
- a. A compound of the formula ##STR3## ,a pharmaceutically acceptable acid addition salt thereof or a quaternary salt thereof wherein R.sup.1 is hydrogen, alkyl of 1 to 10 carbon atoms, carboxyalkyl of 1 to 10 carbon atoms in the alkyl moiety, lower alkyloxycarbonylalkyl of 1 to 10 carbon atoms in the alkyl moiety, hydroxyalkyl of 1 to 10 carbon atoms in the alkyl moiety, cycloalkyl lower alkyl wherein the cycloalkyl moiety is of 3 to 7 carbon atoms, aryl lower alkyl, aryloxy lower alkyl, alkenyl of 2 to 10 carbon atoms or arylalkenyl of 2 to 10 carbon atoms in the alkenyl moiety.
- 2. A method according to claim 1 wherein R.sup.1 is hydrogen, lower alkyl, carboxy lower alkyl, lower alkyloxy carbonyl lower alkyl, hydroxy lower alkyl, cycloalkyl lower alkyl of 3 to 5 carbon atoms in the cycloalkyl moiety, aryl lower alkyl, aryloxy lower alkyl, lower alkenyl or aryl lower alkenyl wherein the aryl moiety is phenyl or naphthyl.
Priority Claims (1)
Number |
Date |
Country |
Kind |
62-311348 |
Dec 1987 |
JPX |
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CROSS-REFERENCE
This is a division of Ser. No. 747,454 filed Aug. 12, 1991; now U.S. Pat. No. 5,192,772, which is a continuation of Ser. No. 281,495, filed Dec. 8, 1988, abandoned.
US Referenced Citations (6)
Foreign Referenced Citations (5)
Number |
Date |
Country |
0034784 |
Jul 1981 |
EPX |
202661 |
Jan 1986 |
EPX |
295538 |
Jun 1988 |
EPX |
2067989 |
Sep 1981 |
GBX |
8703903 |
Mar 1987 |
WOX |
Non-Patent Literature Citations (3)
Entry |
Dictionary of Organic Compounds, 5th Edition, 2nd Supplement, Chapman & Hall, publication 1984. |
Blomback et al., Plasma Proteins, 1976, pp. 288-308. |
Aoki and Harpel, Seminars in Thrombosis and Hemostasis-vol. 10, No. 1, 1984. |
Divisions (1)
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Number |
Date |
Country |
Parent |
747454 |
Aug 1991 |
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Continuations (1)
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Number |
Date |
Country |
Parent |
281495 |
Dec 1988 |
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