THERAPEUTIC COAGULATION INHIBITOR

Information

• Research Project
• 3502106

• ApplicationId

  3502106

• Core Project Number

  R43HL047268

• Full Project Number

  1R43HL047268-01

• Serial Number

  47268

• FOA Number

• Sub Project Id

• Project Start Date

  8/1/1991 - 33 years ago

• Project End Date

  1/31/1992 - 32 years ago

• Program Officer Name

• Budget Start Date

  8/1/1991 - 33 years ago

• Budget End Date

  1/31/1992 - 32 years ago

• Fiscal Year

  1991

• Support Year

  1

• Suffix

• Award Notice Date

  7/31/1991 - 33 years ago

Organizations

• COR THERAPEUTICS, INC.

DESCRIPTION (Investigator's Abstract): A Phase I study is proposed to screen commercially available snake venoms for selective antithrombotics, specifically inhibition of Factor VIII/Tissue Factor and prothrombinase. Ultrafiltrates of 70 snake venoms will be used to look for low MW inhibitors that would inhibit the above enzymes in chromogenic assays. Additional assays will be done to verify the efficacy, followed by biochemical purification and characterization. Cloning and large scale production will form the basis for Phase II study.

IC Name

• Activity

  R43

• Administering IC

  HL

• Application Type

  1

• Direct Cost Amount

• Indirect Cost Amount

• Total Cost

• Sub Project Total Cost

• ARRA Funded

• CFDA Code

  839

• Ed Inst. Type

• Funding ICs

• Funding Mechanism

• Study Section

  HEM

• Study Section Name

  Hematology Subcommittee 2

• Organization Name

  COR THERAPEUTICS, INC.

• Organization Department

• Organization DUNS

• Organization City

  SOUTH SAN FRANCISCO

• Organization State

  CA

• Organization Country

  UNITED STATES

• Organization Zip Code

  94080

• Organization District

  UNITED STATES