Claims
- 1. A method of treating a cardiac arrhythmia in a mammmal which comprises:
- administering to said mammal an antiarrhythmic effective amount of a compound selected from the group consisting of ##STR8## and a pharmacologically acceptable, nontoxic acid addition salt thereof, wherein:
- R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen, halogeno, loweralkyl of 1 to 3 carbon atoms, loweralkoxy of 1 to 3 carbon atoms, amino, and nitro;
- R.sup.3 is selected from the group consisting of ethylene and trimethylene, and
- R.sup.4 is selected from the group consisting of 4-phenyl-1-piperidyl, 4-hydroxy-4-phenyl-1-piperidyl, 4-phenyl-1,2,3,6-tetrahydropyridyl, and 4-phenyl-1-piperazinyl.
- 2. A method as in claim 1 wherein said amount is from 5 to 500 mg/kg.
- 3. A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperazinyl)propyl]-5,5-diphenylhydantoin maleate.
- 4. A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5,5-diphenylhydantoin.
- 5. A method as in claim 1 wherein the compound is 3-[2-(4-phenyl-1-piperidyl)ethyl]-5,5-diphenylhydantoin .sup.. HCl.
- 6. A method as in claim 1 wherein the compound is 5,5-diphenyl-3-[2-(4-phenyl-1,2,3,6-tetrahydropyridyl) ethyl]hydantoin .sup.. HCl.
- 7. A method as in claim 1 wherein the compound is 5,5-diphenyl-3-[3-(4-hydroxy-4-phenyl-1-piperidyl)propyl]hydantoin .sup.. HCl.
- 8. A method as in claim 1 wherein the compound is 5,5-diphenyl-3-[2-(4-hydroxy-4-phenyl-1-piperidyl)ethyl] hydantoin .sup.. HCl.
- 9. A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5,5-di(4-chlorophenyl) hydantoin .sup.. HCl.
- 10. A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-methoxyphenyl)-5-phenylhydantoin .sup.. HCl.
- 11. A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5,5-di(4-methoxyphenyl) hydantoin .sup.. HCl.
- 12. A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-bromophenyl)-5 -phenylhydantoin .sup.. HCl.
- 13. A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-phenyl-5-(4-tolyl) hydantoin .sup.. maleate.
- 14. A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl)]-5,5-di(4-tolyl)hydantoin.
- 15. A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-nitrophenyl)-5-phenylhydantoin.
- 16. A method as in claim 1 wherein the compound is 3-[3-(4-phenyl-1-piperidyl)propyl]-5-(4-aminophenyl)-5-phenylhydantoin.
- 17. A method as in claim 1 wherein the compound is 3-[3-(4-hydroxy-4-phenyl-1-piperidyl)propyl]-5,5di(4-tolyl)hydantoin.
Parent Case Info
This is a division, of application Ser. No. 381,021, filed July 20, 1973, now U.S. Pat. No. 3,892,748.
US Referenced Citations (1)
Number |
Name |
Date |
Kind |
3892748 |
Hayao et al. |
Jul 1975 |
|
Non-Patent Literature Citations (2)
Entry |
Chemical Abstracts 55:21100a (1961). |
Chemical Abstracts 70:37780a (1969). |
Divisions (1)
|
Number |
Date |
Country |
Parent |
381021 |
Jul 1973 |
|