Claims
- 1. A compound of formula: ##STR9## wherein Q is chosen from the group consisting of pyridyl, pyrazyl, pyrimidyl, quinolyl, indolyl and 7-azaindolyl or any of these substituted with one or two substituents chosen from alkyl, alkoxy, hydroxy, halo, cyano, nitro, hydroxyalkyl, alkoxyalkyl, alkanoyl, fluoroalkyl or the N-oxide of any of these;
- Y is an alkylene bridge of 3-9 carbon atoms;
- R.sub.1 and R.sub.2 are each independently chosen from hydrogen, halo, alkyl, alkenyl, amino, alkylthio, hydroxy, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkoxy, nitro, carboxy, alkoxycarbonyl, dialkylaminoalkyl, alkylaminoalkyl, aminoalkyl, difluoromethyl, trifluoromethyl or cyano;
- R.sub.3 is alkoxycarbonyl, alkyltetrazolyl or substituted or unsubstituted heterocyclyl chosen from benzoxazolyl oxazolyl oxadiazolyl isoxazolyl, wherein the substitution is with alkyl, alkoxyalkyl, cycloalkyl, halo alkyl, hydroxyalkyl, alkoxy, hydroxy, furyl, thienyl or fluoroalkyl; or a pharmaceutically acceptable acid addition salt thereof.
- 2. A compound according to claim 1 wherein Y is a linear hydrocarbon chain of 3 to five carbons.
- 3. A compound according to claim 2 wherein R.sub.3 is substituted oxadiazolyl or tetrazolyl.
- 4. A compound according to claim 3 wherein R.sub.3 is chosen from the group consisting of 5-trifluoromethyl-1,2,4-oxadiazolyl, 5-fluoromethyl-1,2,4-oxadiazolyl, 5-difluoromethyl-1,2,4-oxadiazolyl and 5-methyl-2H-tetrazolyl.
- 5. A compound according to claim 4 wherein Q is unsubstituted or singly substituted or the N-oxide thereof.
- 6. A compound according to claim 5 wherein R.sub.1 and R.sub.2 represent 3,5-dimethyl and Y is 1,3-propylene.
- 7. A compound according to claim 6 wherein Q is 2-pyridyl or 3-pyridyl singly substituted with fluoro, methyl or trifluoromethyl.
- 8. A pharmaceutical composition containing as an active ingredient an antipicornavirally effective amount of a compound according to claim 1.
- 9. A pharmaceutical composition containing as an active ingredient an antipicornavirally effective amount of a compound according to claim 3.
- 10. A pharmaceutical composition containing as an active ingredient an antipicornavirally effective amount of a compound according to claim 5.
- 11. A pharmaceutical composition containing as an active ingredient an antipicornavirally effective amount of a compound according to claim 7.
- 12. A method of preventing or treating picornaviral infection in a mammalian host comprising administering an antipicornavirally effective amount of a compound according to claim 1.
- 13. A method of preventing or treating picornaviral infection in a mammalian host comprising administering an antipicornavirally effective amount of a compound according to claim 3.
- 14. A method of preventing or treating picornaviral infection in a mammalian host comprising administering an antipicornavirally effective amount of a compound according to claim 5.
- 15. A method of preventing or treating picornaviral infection in a mammalian host comprising administering an antipicornavirally effective amount of a compound according to claim 7.
- 16. A method of combating picornaviruses comprising contacting the locus of said viruses with an antipicornavirally effective amount of a compound according to claim 1.
- 17. A method of combating picornaviruses comprising contacting the locus of said viruses with an antipicornavirally effective amount of a compound according to claim 3.
- 18. A method of combating picornaviruses comprising contacting the locus of said viruses with an antipicornavirally effective amount of a compound according to claim 5.
- 19. A method of combating picornaviruses comprising contacting the locus of said viruses with an antipicornavirally effective amount of a compound according to claim 7.
Parent Case Info
This application is a continuation of application Ser. No. 08/242,508, filed May 13, 1994, now abandoned.
US Referenced Citations (11)
Foreign Referenced Citations (1)
Number |
Date |
Country |
WO9205163 |
Apr 1992 |
WOX |
Continuations (1)
|
Number |
Date |
Country |
Parent |
242508 |
May 1994 |
|