Claims
- 1. A composition for inhibiting exogenous neurotropic or neurotoxinic compounds comprising an inhibitorily effective amount of 2-methyl-1-(1-piperidinyl)-1-(2-thienyl)-cyclohexane in substantially pure racemic, diastereoisomeric or enantiomeric form and at least one member of the group consisting of an anticonvulsive substance, an anticholinergic substance and a substance which reactivates cholinesterases.
- 2. A composition of claim 1 wherein the anticholinergic substance is selected from the group consisting of atropine, scopolamine, atropine N-oxide, dihexyverine and tiemonium methylsulfate.
- 3. A composition of claim 1 wherein the anticonvulsive substance is selected from the group consisting of phenobarbital, primidone, carbamazepine, ethosuximide, phenytoin, sodium valproate, progabide, gabapentin, vigabatrin, loprazolam and a benzodiazepine selected from the group consisting of clonazepam, clobazam, diazepam and prodiazepam.
- 4. A composition of claim 1 wherein the substance which reactivates cholinesterases is selected from the group consisting of pralidoxime, obidoxime and HI6.
- 5. A composition of claim 1 wherein the first compound is in its cis diastereoisomeric form.
- 6. A composition of claim 1 having a reversible cholinesterase inhibitor selected from the group consisting of pyridostigmine and physostigmine.
- 7. A composition for inhibiting exogenous neurotropic or neurotoxinic effects comprising an inhibitorily effective amount of 2-methyl-1-(1-piperidinyl)-1-(2-thienyl)-cyclohexane in substantially pure racemic, diastereoisomeric or enantiomeric form and at least one anticonvulsive substance, at least one anticholinergic substance and at least one substance which reactivates cholinesterases.
Priority Claims (2)
Number |
Date |
Country |
Kind |
96 14996 |
Dec 1996 |
FR |
|
97 07361 |
Jun 1997 |
FR |
|
PRIOR APPLICATION
This application is a division of U.S. patent application Ser. No. 09/189,887 filed Nov. 11, 1998, now abandoned, which is a continuation-in-part application of U.S. patent application Ser. No. 09/180,384 filed Jan. 11, 1999, now U.S. Pat. No. 6,207,685 which is the national phase of PCT application PCT/FR97/02219 filed Dec. 5, 1997 claiming the benefit of French Application Serial No. 96/14996 filed Dec. 6, 1996 and Ser. No. 97/07361 filed Jun. 13, 1997.
US Referenced Citations (2)
Number |
Name |
Date |
Kind |
5179109 |
Kamenka et al. |
Jan 1993 |
A |
6207685 |
Lallement et al. |
Mar 2001 |
B1 |
Non-Patent Literature Citations (3)
Entry |
Michaud et al. ‘Homochiral structures derived from 1-[1-(2-thienyl)cyclohexyl]piperidine(TCP) are potent non-competitive antagonists of glutamate at NMDA receptor sites’ 1994, European J. Med. Chem. vol. 29, p. 869-976.* |
Medline Abstract, AN 89143311, 1989, Green et al.* |
Medline Abstract, AN 93386465, 1993, Lallement et al. |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09/180384 |
Jan 1999 |
US |
Child |
09/834552 |
|
US |