Claims
- 1. A method of treating a subject with a BPI deficiency condition comprising administering to said subject an amount of BPI protein product effective to alleviate the BPI deficiency.
- 2. The method of claim 1 wherein the subject is an adult.
- 3. The method of claim 1 wherein the condition is a selective BPI deficiency.
- 4. The method of claim 1 wherein the subject is a newborn.
- 5. The method of claim 4 wherein the newborn is a premature newborn.
- 6. The method of claim 1 wherein the BPI protein product is rBPI21.
- 7. The method of claim 1 wherein the BPI protein product is an N-terminal fragment of BPI having a molecular weight approximately between about 20 to 25 kd.
- 8. The method of claim I wherein the BPI protein product is rBPI(10-193)ala132.
- 9. The method of claim 1 wherein the BPI protein product is rBPI50.
Parent Case Info
This application is a continuation-in-part of U.S. application Ser. No. 09/285,124 filed Apr. 1, 1999, now U.S. Pat. No. 6,153,584 incorporated herein by reference.
Foreign Referenced Citations (2)
Number |
Date |
Country |
WO 9806415 |
Feb 1919 |
WO |
WO 8901486 |
Feb 1989 |
WO |
Non-Patent Literature Citations (2)
Entry |
Elsbach “The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense” Jou. of Leukocyte Bio. 64:14-18 (1998). |
Levy et al., “Impaired Innate Immunity in the Newborn: Newborn Nautrophils are Deficient in Bactericidal/Permeability-Increasing Protein” Pediatrics 104:1327-1333 (1999). |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
09/285124 |
Apr 1999 |
US |
Child |
09/541821 |
|
US |