Claims
- 1. A method of treating a pulmonary dysfunction complication in a human suffering from hemorrhage due to trauma comprising the step of administering a therapeutically effective amount of a bactericidal/permeability-increasing (BPI) protein product to said human.
- 2. The method of claim 1 wherein the BPI protein product is an amino-terminal fragment of BPI protein having a molecular weight of about 21 kD to 25 kD.
- 3. The method of claim 1 wherein the BPI protein product is rBPI.sub.23 or a dimeric form thereof.
- 4. The method of claim 1 wherein the BPI protein product is rBPI.sub.21.
- 5. The method of claim 1 wherein said pulmonary dysfunction complication is pneumonia.
- 6. The method of claim 1 wherein the human suffering from hemorrhage due to trauma is additionally administered at least two units of packed red blood cells.
- 7. The method of claim 1 wherein the BPI protein product is administered to said human before development of the pulmonary dysfunction complication.
Parent Case Info
This is a continuation-in-part application of U.S. Ser. No. 08/652,292, filed May 23, 1996, now abandoned, incorporated herein by reference.
US Referenced Citations (21)
Foreign Referenced Citations (31)
Number |
Date |
Country |
WO 8901486 |
Feb 1989 |
WOX |
WO 9009183 |
Aug 1990 |
WOX |
WO 9101639 |
Feb 1991 |
WOX |
WO 9203535 |
Mar 1992 |
WOX |
WO 9209621 |
Jun 1992 |
WOX |
WO 9305797 |
Apr 1993 |
WOX |
WO 9306228 |
Apr 1993 |
WOX |
WO 9323434 |
Nov 1993 |
WOX |
WO 9323540 |
Nov 1993 |
WOX |
WO 9417819 |
Aug 1994 |
WOX |
WO 9418323 |
Aug 1994 |
WOX |
WO 9420128 |
Sep 1994 |
WOX |
WO 9420129 |
Sep 1994 |
WOX |
WO 9420532 |
Sep 1994 |
WOX |
WO 9421280 |
Sep 1994 |
WOX |
WO 9425476 |
Nov 1994 |
WOX |
WO 9500641 |
Jan 1995 |
WOX |
WO 9501428 |
Jan 1995 |
WOX |
WO 9502414 |
Jan 1995 |
WOX |
WO 9508344 |
Mar 1995 |
WOX |
WO 9508773 |
Mar 1995 |
WOX |
WO 9510297 |
Apr 1995 |
WOX |
WO 9519179 |
Jul 1995 |
WOX |
WO 9519180 |
Jul 1995 |
WOX |
WO 9519372 |
Jul 1995 |
WOX |
WO 9519784 |
Jul 1995 |
WOX |
WO 9520163 |
Jul 1995 |
WOX |
WO 9524209 |
Sep 1995 |
WOX |
WO 9601647 |
Jan 1996 |
WOX |
WO 9608509 |
Mar 1996 |
WOX |
WO 9621436 |
Jul 1996 |
WOX |
Continuation in Parts (1)
|
Number |
Date |
Country |
Parent |
652292 |
May 1996 |
|