Claims
- 1. A method of treating a human with otitis media with effusion in which an effusion in the middle ear is not accompanied by signs of acute infection comprising administering to said human a therapeutically effective amount of a bactericidal/permeability-increasing protein (BPI) protein product.
- 2. The method of claim 1 wherein the BPI protein product is rBPI21.
- 3. The method of claim 1 wherein the BPI protein product is an N-terminal fragment of BPI having a molecular weight between 20 to 25 kd.
- 4. The method of claim 1 wherein the BPI protein product is rBPI(10-193)ala132.
- 5. The method of claim 1 wherein the BPI protein product is recombinant BPI holoprotein (rBPI).
- 6. The method of claim 1 wherein the human has tympanostomy tubes placed in the middle ear.
Parent Case Info
This application is a continuation of International Application No. PCT/US00/14496 filed May 24, 2000, which claims priority of U.S. Provisional Application Ser. No. 60/136,148 filed May 24, 1999.
The present invention relates generally to novel therapeutic uses of BPI protein products for treatment of otitis media with effusion in humans.
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Entry |
Horwitz et al. Expression and characterization of cysteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing protein. Protein Expr Purif. Aug. 1996;8(1):28-40.* |
Miller et al., “Bacterial Antigens and Neutrophil Granule Proteins in Middle Ear Effusions” Arch Otolaryngol Head Neck Surg 116:335-337 (1990). |
Nell et al., “Bacterial/Permeability-Increasing Protein Prevents Mucosal Damage in an Experimental Rat Model of Chronic Otitis Media with Effusion” Infection and Immunity 68:2992-2994 (2000). |
Nell et al., “Inhibition of Endotoxin Effects on Cultured Human Middle Ear Epithelium by Bactericidal Permeability-Increasing Protein” The American Journal of Otology 21:625-630 (2000). |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/136148 |
May 1999 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
PCT/US00/14496 |
May 2000 |
US |
Child |
09/586850 |
|
US |