Claims
- 1. A compound of the formula I wherein R1 is methyl; wherein C1-C3 are positional isomers α and β in an α-βconfiguration; wherein C5-C6 double bond is cis or trans; wherein C7-C8 double bond is cis; wherein C14 hydrogen is α; wherein C16-C17 is a single bond; and wherein R2 is a substituent I-1
- 2. The compound of claim 1 wherein C5-C6 double bond is trans, namely the analog JS, 5,6-trans-7,8-cis-1α,25-dihydroxyvitamin D3.
- 3. The compound of claim 1 wherein C5-C6 double bond is cis, namely the analog JR, 5,6-cis-7,8-cis-1α,25-dihydroxyvitamin D3.
Parent Case Info
This application is a divisional of application Ser. No. 09/074,565, filed May 7, 1998, now U.S. Pat. No. 6,121,469, which is based on provisional application Ser. No. 60/060,173, filed Sep. 26, 1997 and is a continuation-in-part of application Ser. No. 08/706,356, filed Aug. 30, 1996, now abandoned, and of application Ser. No. 08/558,717, filed Nov. 16, 1995, now abandoned, which are continuations-in-part of application Ser. No. 08/249,385, filed May 25, 1994, now abandoned, which is a continuation of application Ser. No. 08/173,561, filed Dec. 23, 1993, now abandoned.
Government Interests
This invention was made with government support under Research Grant Nos. DK-09012 and DK-16,595, awarded by the National Institute of Health. The government has certain rights in this invention.
US Referenced Citations (13)
Foreign Referenced Citations (5)
Number |
Date |
Country |
1864992 |
Jun 1992 |
AU |
4-89473 |
Mar 1992 |
JP |
4-89474 |
Mar 1992 |
JP |
6-72994 |
Mar 1994 |
JP |
6-256300 |
Sep 1994 |
JP |
Non-Patent Literature Citations (4)
Entry |
Norman et al., “Selective biological response by target organs (intestine, kidney and bone) to 1,25-dihydroxyvitamin D3 and two analogues.” Cancer Res., vol. 53, pp. 3935-3942, Sep. 1, 1993.* |
Figadere et al., “Arocalciferols: Synthesis and biological evaluation of aromatic side-chain analogues of 1.alpha.,25-dihydroxyvitamin D3.”, J. Med. Chem., vol. 34, pp. 2452-2463, 1991.* |
Craig et al., J. Org. Chem., vol. 57, pp. 4374-4380, 1992.* |
PCT WO 94/07851 Apr. 14, 1994 C07C401/00, A61K31/59 Hansen, et al., Novel Vitamin D Analogues. |
Provisional Applications (1)
|
Number |
Date |
Country |
|
60/060173 |
Sep 1997 |
US |
Continuations (1)
|
Number |
Date |
Country |
Parent |
08/173561 |
Dec 1993 |
US |
Child |
08/249385 |
|
US |
Continuation in Parts (3)
|
Number |
Date |
Country |
Parent |
08/706356 |
Aug 1996 |
US |
Child |
09/074565 |
|
US |
Parent |
08/558717 |
Nov 1995 |
US |
Child |
08/706356 |
|
US |
Parent |
08/249385 |
May 1994 |
US |
Child |
08/558717 |
|
US |