Claims
- 1. A method of producing optically active amines, and/or carbamates from optically active ureas comprising the steps of:
- (1) refluxing the optically active urea in alcohol solution wherein the alcohol is a C.sub.3 -C.sub.7 alcohol; and
- (2) isolating the optically active amines and/or carbamates.
- 2. A process of claim 1 wherein the urea/alcohol mixture contains catalytic amounts of an alkali metal.
- 3. A process of claim 2 wherein the alkali metal is sodium.
- 4. A process of claim 1 wherein the alcohol is butanol.
- 5. A process of claim 1 wherein the alcohol is pentanol.
- 6. A process of claim 5 wherein the alcohol is n-pentanol.
- 7. A process of claim 1 wherein the alcohol is hexanol.
- 8. A process of claim 7 wherein the alcohol is n-hexanol.
- 9. A process of claim 1 wherein the alcohol is a C.sub.3 -C.sub.6 alcohol.
- 10. A method of claim 1 wherein the optically active products are carbamates.
- 11. A method of claim 1 wherein the optically active products are amines.
- 12. A method of claim 1 wherein both optically active amines and optically active carbamates are products of the reaction.
- 13. A method of producing optically active isocyanates from optically active ureas comprising the steps of:
- (1) refluxing optically active urea in an alcohol solution wherein the alcohol is a C.sub.3 -C.sub.7 alcohol;
- (2) isolating the optically active carbamates, and/or amines;
- (3) isolating the optically active amines and/or carbamates; and
- (4) converting the amines to isocyanates and/or converting carbamates to isocyanates.
- 14. A process of claim 13 wherein optically amines are reacted with phosgene in steps (4) to provide isocyanates.
- 15. A process of claim 13 wherein the optically active carbamates are reacted with trichlorosilane in the presense of triethylamine in step (4) to provide the isocyanates.
- 16. A process of claim 13 wherein the alcohol is a C.sub.3 -C.sub.6 alcohol.
Parent Case Info
This application is a continuation-in-part of U.S. Ser. No. 06/811,425, filed Dec. 20, 1985, now abandoned.
US Referenced Citations (11)
Non-Patent Literature Citations (2)
Entry |
Fieser et al., "Reagents for Organic Synthesis", vol. 8*, p. 499 (1980). |
Fieser et al., "Reagents for Organic Synthesis", vol. 11, pp. 553-554 (1984). |
Continuation in Parts (1)
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Number |
Date |
Country |
Parent |
811425 |
Dec 1985 |
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