Claims
- 1. A method of applying energy to the wall of an internal organ of a living subject comprising the steps of:
(a) positioning an expansible structure within the body of the subject in or adjacent to said organ and bringing said expansible structure to an expanded condition; and (b) directing energy onto an active region of said expansible structure so that energy is reflected from said active region and directed onto the wall of the internal organ, said expansible structure focusing said energy in a focal region.
- 2. A method as claimed in claim 1, wherein said energy reflection at said active region focuses said energy.
- 3. A method as claimed in claim 1, wherein the energy is directed onto said active region so that the energy is directed into a treatment region of the wall of said organ in the form of an elongated path extending along the wall of said organ.
- 4. A method as claimed in claim 3 wherein the energy is directed so that said focal region extends along said path within the organ wall at a depth from the surface of the organ wall.
- 5. A method as claimed in claim 1, wherein said expansible structure includes a first balloon, said step of bringing said reflector structure to said expanded configuration including inflating said first balloon.
- 6. A method as claimed in claim 5, wherein said first balloon defines a transmissive wall, said positioning step including positioning said first balloon so that said transmissive wall lies adjacent the wall of the organ, and said energy is directed onto said active region from within said first balloon so that the energy is reflected at said active region through the interior of the first balloon and through the transmissive wall into said focal region.
- 7. A method as claimed in claim 6, wherein said positioning step includes positioning the first balloon so that the transmissive wall lies adjacent the wall of the organ.
- 8. A method as claimed in claim 7, wherein said positioning step includes positioning the first balloon so that the transmissive wall is spaced from the wall of the organ and maintaining a layer of liquid between the transmissive wall and the wall of the organ, whereby energy directed through the transmissive wall passes through the layer of liquid.
- 9. A method as claimed in claim 8, wherein said step of inflating said first balloon includes inflating said first balloon with a biocompatible inflation liquid and said step of maintaining a layer of liquid includes discharging the inflation liquid to the exterior of the first balloon so that at least some of the discharged inflation liquid passes between the transmissive wall and the wall of the organ.
- 10. A method as claimed in claim 6, wherein said step of directing energy includes directing ultrasonic energy towards said active region, said expansible structure includes a second balloon, and said step of expanding said expansible structure includes the step of inflating said first balloon with a first fluid having a first acoustic impedance and inflating said second balloon with a second fluid having a second acoustic impedance different from said first acoustic impedance to thereby form a first reflective interface at said active region.
- 11. A method as claimed in claim 10, wherein said first fluid has an acoustic impedance close to the acoustic impedance of tissue in said wall.
- 12. A method as claimed in claim 10, wherein said first fluid is a liquid and said second fluid is a gas.
- 13. A method as claimed in claim 12, further comprising the step of detecting the disposition of said reflector structure by imaging the subject using an imaging modality in which said gas-filled second balloon provides contrast.
- 14. A method as claimed in claim 10, wherein said reflector structure includes a third balloon, the method further comprising the steps of inflating said second balloon with a fluid having acoustic impedance substantially equal to said first acoustic impedance and inflating said third balloon with a fluid having acoustic impedance different from said first acoustic impedance to an interface at a second active region having reflectivity greater than the reflectivity of the interface at the first said active region, and directing the ultrasonic energy onto said second active region so that the ultrasonic energy is reflected from said second active region into a second focal region different from the first focal region.
- 15. A method as claimed in claim 5, wherein said positioning step is performed so as to position said first balloon within a chamber of the heart and said path along a wall of the heart, and wherein said energy ablates tissue in the wall of the heart so as to form a first conduction block extending along said elongated path.
- 16. A method as claimed in claim 15, wherein said positioning step is performed so as to position said first balloon within a chamber of the heart and said path extends along the wall of the heart and at least partially around a first ostium of a first blood vessel communicating with such chamber.
- 17. A method as claimed in claim 16, wherein said first blood vessel is a pulmonary vein, said first ostium being disposed adjacent an opening of an atrial appendage, the method further comprising forming a second conduction block extending at least partially around the opening of the atrial appendage so that first and second conduction blocks cooperatively encompass and isolate a region of the heart wall including said first ostium and said opening of said atrial appendage.
- 18. A method as claimed in claim 16, wherein said path is substantially in the form of a closed loop encircling said first ostium.
- 19. A method as claimed in claim 3, wherein said step of directing energy is performed so as to direct the energy into said focal region along substantially the entire elongated path simultaneously.
- 20. A method as claimed in claim 1, wherein said energy-directing step includes directing the energy through an inflatable lens and varying the configuration of said inflatable lens so as to vary the location of said focal region.
- 21. A method as claimed in claim 1, wherein said energy-directing step includes directing the energy from a source to said active region and varying the positional relationship between said source and said active region so as to vary the location of said focal region.
- 22. A method of forming a conduction block in the wall of a heart of a mammalian subject comprising the steps of:
(a) applying energy to a treatment region extending along a loop-like path at least partially encircling a region so as to ablate tissue along said region; (b) detecting electrophysiologic signals within said region; and (c) terminating said energy-applying step in response to a change in said electrophysiologic signals.
- 23. A method as claimed in claim 22 wherein said energy-applying step is performed so as to apply energy along substantially the entire path simultaneously.
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] The present application is a divisional of U.S. patent application Ser. No. 09/905,227, filed Jul. 13, 2001, which claims benefit of U.S. Provisional Patent Application Serial 60/218,641, filed Jul. 13, 2000, the disclosures of which are incorporated by reference herein.
Provisional Applications (1)
|
Number |
Date |
Country |
|
60218641 |
Jul 2000 |
US |
Divisions (1)
|
Number |
Date |
Country |
Parent |
09905227 |
Jul 2001 |
US |
Child |
10227092 |
Aug 2002 |
US |